{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:28:35Z","timestamp":1791052115337,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.vaccine.2013.03.008","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T02:31:09Z","timestamp":1363141869000},"page":"2358-2365","source":"Crossref","is-referenced-by-count":39,"title":["Intradermally-administered influenza virus vaccine is safe and immunogenic in healthy adults 18\u201364 years of age"],"prefix":"10.1016","volume":"31","author":[{"given":"Geoffrey J.","family":"Gorse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann R.","family":"Falsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Fling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry L.","family":"Poling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia B.","family":"Strout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2013.03.008_bib0005","unstructured":"Centers for Disease Control and Prevention. Update: Influenza activity\u2013United States, 2010\u201311 season, and composition of the 2011\u201312 influenza vaccine. MMWR 2011; 60:705\u201312."},{"key":"10.1016\/j.vaccine.2013.03.008_bib0010","unstructured":"Centers for Disease Control and Prevention. Prevention and control of influenza with vaccines. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010. MMWR 2010; 59 (No.RR-8):1\u201362."},{"key":"10.1016\/j.vaccine.2013.03.008_bib0015","unstructured":"US Department of Health and Human Services. Immunization and infectious diseases. Washington, DC: US Department of Health and Human Services; 2011. Available at http:\/\/www.healthypeople.gov\/2020\/topicsobjectives2020\/objectiveslist.aspx?topicID=23 [accessed: 13.05.2011]."},{"key":"10.1016\/j.vaccine.2013.03.008_bib0020","unstructured":"Centers for Disease Control and Prevention. Place of influenza vaccination among adults\u2013United States, 2010\u201311 influenza season. MMWR 2011; 60:781\u20135."},{"key":"10.1016\/j.vaccine.2013.03.008_bib0025","unstructured":"Centers for Disease Control and Prevention. State-specific influenza vaccination coverage among adults aged \u226518 years\u2013United States, 2003\u201304, and 2005\u201306 influenza seasons. MMWR 2007; 56:953\u20139."},{"key":"10.1016\/j.vaccine.2013.03.008_bib0030","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/1471-2458-8-272","article-title":"Influenza vaccination coverage rates in five European countries during season 2006\/07 and trends over six consecutive seasons","volume":"8","author":"Blank","year":"2008","journal-title":"BMC Public Health"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0035","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.amjmed.2008.05.005","article-title":"Barriers to adult immunization","volume":"121","author":"Johnson","year":"2008","journal-title":"Am J Med"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0040","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/0264-410X(91)90287-G","article-title":"Intradermal hepatitis B vaccination in a large hospital employee population","volume":"9","author":"Coleman","year":"1991","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0045","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/08860220601166263","article-title":"Low dose intradermal vaccination is superior to high dose intramuscular vaccination for hepatitis B in unresponsive hemodialysis patients","volume":"29","author":"Micozkadioglu","year":"2007","journal-title":"Ren Fail"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0050","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1086\/497266","article-title":"Reduced-dose intradermal vaccination against hepatitis A with an aluminum-free vaccine is immunogenic and can lower costs","volume":"41","author":"Pancharoen","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0055","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0035-9203(99)90309-7","article-title":"Immunogenicity and safety of low-dose intradermal rabies vaccination given during an Expanded Programme on Immunization session in Viet Nam: results of a comparative randomized trial","volume":"93","author":"Lang","year":"1999","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0060","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.2105\/AJPH.69.12.1247","article-title":"A comparison of the intradermal and subcutaneous routes of influenza vaccination with A\/New Jersey\/76 (swine flu) and A\/Victoria\/75: report of a study and review of the literature","volume":"69","author":"Halperin","year":"1979","journal-title":"Am J Public Health"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0065","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.trstmh.2007.11.010","article-title":"Long-term anti-rabies antibody persistence following intramuscular or low-dose intradermal vaccination of young Vietnamese children","volume":"102","author":"Vien","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0070","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1097\/00006454-199811000-00007","article-title":"Persistence of antibodies in children after intradermal or intramuscular administration of preexposure primary and booster immunizations with purified Vero cell rabies vaccine","volume":"17","author":"Sabchareon","year":"1998","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0075","unstructured":"WHO expert consultation on rabies. World Health Organ Tech Rep Ser 2005; 931:1\u201388."},{"key":"10.1016\/j.vaccine.2013.03.008_bib0080","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1056\/NEJMoa043540","article-title":"Dose sparing with intradermal injection of influenza vaccine","volume":"351","author":"Kenney","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0085","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1056\/NEJMoa043555","article-title":"Serum antibody responses after intradermal vaccination against influenza","volume":"351","author":"Belshe","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0090","doi-asserted-by":"crossref","first-page":"6755","DOI":"10.1016\/j.vaccine.2007.06.066","article-title":"Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults","volume":"25","author":"Belshe","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0095","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.vaccine.2006.08.026","article-title":"Antibody responses after dose-sparing intradermal influenza vaccination","volume":"25","author":"Auewarakul","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0100","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1016\/j.vaccine.2008.09.078","article-title":"Seasonal influenza vaccine delivered by intradermal microinjection: a randomized controlled safety and immunogenicity trial in adults","volume":"26","author":"Leroux-Roels","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1741-7015-7-13","article-title":"Intradermal influenza vaccination of healthy adults using a new microinjection system: a 3-year randomized controlled safety and immunogenicity trial","volume":"7","author":"Beran","year":"2009","journal-title":"BMC Med"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0110","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.vaccine.2008.10.077","article-title":"Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults","volume":"27","author":"Van Damme","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0115","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1086\/590434","article-title":"Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: a randomized controlled trial","volume":"198","author":"Holland","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0120","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1016\/j.vaccine.2009.10.033","article-title":"Intradermal influenza vaccine for older adults: a randomized controlled multicenter phase III study","volume":"27","author":"Arnou","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0125","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1586\/14760584.7.8.1201","article-title":"Intradermal, epidermal, and transcutaneous vaccination: from immunology to clinical practice","volume":"7","author":"Nicolas","year":"2008","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0130","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.smim.2005.05.009","article-title":"Cutaneous dendritic cells","volume":"17","author":"Valladeau","year":"2005","journal-title":"Semin Immunol"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0135","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1016\/j.vaccine.2007.05.046","article-title":"Echographic measurement of skin thickness in adults by high frequency ultrasound to assess the appropriate microneedle length for intradermal delivery of vaccines","volume":"25","author":"Laurent","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0140","doi-asserted-by":"crossref","first-page":"8833","DOI":"10.1016\/j.vaccine.2007.10.020","article-title":"Evaluation of the clinical performance of a new intradermal vaccine administration technique and associated delivery system","volume":"25","author":"Laurent","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0145","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.1016\/j.vaccine.2011.06.010","article-title":"Comparison of the immunogenicity and safety of a split-virion, inactivated trivalent influenza vaccine (Fluzone\u00ae) administered by intradermal and intramuscular route in healthy adults","volume":"29","author":"Frenck","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0150","series-title":"Advanced laboratory techniques for influenza diagnosis, Immunology series no. 6","year":"1975"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0155","unstructured":"United Nations Development Programme (UNDP)\/World Bank\/World Health Organization (WHO) Special Programme for Research and Training in Tropical Diseases (TDR). Handbook: good laboratory practice (GLP). Available at: http:\/\/apps.who.int\/tdr\/publications\/training-guideline-publications\/good-laboratory-practice-handbook\/pdf\/glp-handbook.pdf [accessed: 1.05.2009]."},{"key":"10.1016\/j.vaccine.2013.03.008_bib0160","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/jmv.1890140211","article-title":"Immune response of adults to sequential influenza vaccination","volume":"14","author":"Powers","year":"1984","journal-title":"J Med Virol"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0165","unstructured":"U.S. Department of Health and Human Services, Food and Drug Administration, Center for Biologics Evaluation and Research. Guidance for Industry: Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials. 9\/27\/2007. http:\/\/www.fda.gov\/BiologicsBloodVaccines\/GuidanceComplianceRegulatoryInformation\/guidances\/vaccines\/ucm074775.htm [accessed: 20.11.12]."},{"key":"10.1016\/j.vaccine.2013.03.008_bib0170","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1586\/erv.10.134","article-title":"Intanza\u00ae: a new intradermal vaccine for seasonal influenza","volume":"9","author":"Atmar","year":"2010","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0175","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1086\/529197","article-title":"Biology of immune responses to vaccines in elderly persons","volume":"26","author":"Weinberger","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0180","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12325-011-0090-5","article-title":"Acceptance and opinions of Intanza\/ID flu intradermal influenza vaccine in the Czech Republic and Turkey","volume":"29","author":"Prymula","year":"2012","journal-title":"Adv Ther"},{"key":"10.1016\/j.vaccine.2013.03.008_bib0185","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s12325-011-0042-0","article-title":"Acceptance of Intanza\u00ae 9\u03bcg intradermal influenza vaccine in routine clinical practice in Australia and Argentina","volume":"28","author":"Eizenberg","year":"2011","journal-title":"Adv Ther"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X13002673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X13002673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:50:16Z","timestamp":1539823816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X13002673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":37,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0264410X13002673"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2013.03.008","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}