{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:19:03Z","timestamp":1786997943633,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000387","name":"Meningitis UK","doi-asserted-by":"crossref","award":["6008"],"award-info":[{"award-number":["6008"]}],"id":[{"id":"10.13039\/501100000387","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000387","name":"Meningitis UK","doi-asserted-by":"crossref","award":["6015"],"award-info":[{"award-number":["6015"]}],"id":[{"id":"10.13039\/501100000387","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Wellcome Trust"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.vaccine.2013.03.033","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T23:22:08Z","timestamp":1365204128000},"page":"2584-2590","source":"Crossref","is-referenced-by-count":8,"title":["Immunization with recombinant Chaperonin60 (Chp60) outer membrane protein induces a bactericidal antibody response against Neisseria meningitidis"],"prefix":"10.1016","volume":"31","author":[{"given":"Renee","family":"Phillips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette N.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ming","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena K.","family":"Bielecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Chiu","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Heckels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron","family":"Christodoulides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9580","key":"10.1016\/j.vaccine.2013.03.033_bib0005","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/S0140-6736(07)61016-2","article-title":"Epidemic meningitis, meningococcaemia, and Neisseria meningitidis","volume":"369","author":"Stephens","year":"2007","journal-title":"Lancet"},{"issue":"16","key":"10.1016\/j.vaccine.2013.03.033_bib0010","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1056\/NEJMra0906357","article-title":"Current concepts. Advances in the development of vaccines against Neisseria meningitidis","volume":"362","author":"Tan","year":"2010","journal-title":"N Engl J Med"},{"issue":"January (2)","key":"10.1016\/j.vaccine.2013.03.033_bib0015","first-page":"173","article-title":"Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trial","volume":"299","author":"Snape","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0020","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(83)90340-9","article-title":"Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis","volume":"ii","author":"Finne","year":"1983","journal-title":"Lancet"},{"issue":"June (Suppl. 2)","key":"10.1016\/j.vaccine.2013.03.033_bib0025","doi-asserted-by":"crossref","first-page":"B3","DOI":"10.1016\/j.vaccine.2009.04.071","article-title":"Properties and clinical performance of vaccines containing outer membrane vesicles from Neisseria meningitidis","volume":"27","author":"Holst","year":"2009","journal-title":"Vaccine"},{"issue":"May (Suppl. 2)","key":"10.1016\/j.vaccine.2013.03.033_bib0030","doi-asserted-by":"crossref","first-page":"B87","DOI":"10.1016\/j.vaccine.2012.01.033","article-title":"The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens","volume":"30","author":"Serruto","year":"2012","journal-title":"Vaccine"},{"issue":"July (7)","key":"10.1016\/j.vaccine.2013.03.033_bib0035","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1517\/14712598.2011.585965","article-title":"Recombinant protein meningococcal serogroup B vaccine combined with outer membrane vesicles","volume":"11","author":"Bai","year":"2011","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0040","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/INF.0b013e31827b0d24","article-title":"A randomized, controlled, phase 1\/2 trial of a Neisseria meningitidis serogroup B bivalent rLP2086 vaccine in healthy children and adolescents","volume":"32","author":"Nissen","year":"2012","journal-title":"Pediatr Infect Dis J"},{"issue":"9816","key":"10.1016\/j.vaccine.2013.03.033_bib0045","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0140-6736(11)61934-X","article-title":"Prevention of serogroup B meningococcal disease","volume":"379","author":"Stephens","year":"2012","journal-title":"Lancet"},{"issue":"March (Suppl. 2)","key":"10.1016\/j.vaccine.2013.03.033_bib0050","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1086\/648966","article-title":"Review of meningococcal group B vaccines","volume":"50","author":"Granoff","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"11","key":"10.1016\/j.vaccine.2013.03.033_bib0055","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1128\/IAI.00701-09","article-title":"Immunoproteomic analysis of the development of natural immunity in subjects colonized by Neisseria meningitidis reveals potential vaccine candidates","volume":"77","author":"Williams","year":"2009","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2013.03.033_bib0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005940","article-title":"Towards the immunoproteome of Neisseria meningitidis","volume":"4","author":"Mendum","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1574-6968.1992.tb05536.x","article-title":"Identification and characterization of a cross-reactive and a unique b-cell epitope on the hsp60 homolog from Neisseria gonorrhoeae","volume":"99","author":"Pannekoek","year":"1992","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0070","doi-asserted-by":"crossref","first-page":"6928","DOI":"10.1128\/jb.174.21.6928-6937.1992","article-title":"Identification and molecular analysis of a 63-kilodalton stress protein from Neisseria gonorrhoeae","volume":"174","author":"Pannekoek","year":"1992","journal-title":"J Bacteriol"},{"issue":"3","key":"10.1016\/j.vaccine.2013.03.033_bib0075","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0092-8674(00)80928-9","article-title":"The Hsp70 and Hsp60 chaperone machines","volume":"92","author":"Bukau","year":"1998","journal-title":"Cell"},{"issue":"1\u20133","key":"10.1016\/j.vaccine.2013.03.033_bib0080","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.molimm.2010.08.001","article-title":"GroEL provides protection against Bacillus anthracis infection in BALB\/c mice","volume":"48","author":"Sinha","year":"2010","journal-title":"Mol Immunol"},{"issue":"9\u201310","key":"10.1016\/j.vaccine.2013.03.033_bib0085","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0264-410X(00)00237-1","article-title":"Immunity to Chlamydia pneumoniae induced by vaccination with DNA vectors expressing a cytoplasmic protein (Hsp60) or outer membrane proteins (MOMP and Omp2)","volume":"19","author":"Penttila","year":"2000","journal-title":"Vaccine"},{"issue":"11.","key":"10.1016\/j.vaccine.2013.03.033_bib0090","article-title":"Structure-based vaccines provide protection in a mouse model of Ehrlichiosis","volume":"6","author":"Thomas","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.vaccine.2013.03.033_bib0095","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1128\/CMR.12.1.19","article-title":"Role of heat shock proteins in protection from and pathogenesis of infectious diseases","volume":"12","author":"Zugel","year":"1999","journal-title":"Clin Microbiol Rev"},{"issue":"9","key":"10.1016\/j.vaccine.2013.03.033_bib0100","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1128\/IAI.00753-07","article-title":"Vaccination with heat shock protein 60 induces a protective immune response against experimental Paracoccidioides brasiliensis pulmonary infection","volume":"76","author":"Ascenco Soares RdB","year":"2008","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2013.03.033_bib0105","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-0765.2005.00832.x","article-title":"Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria","volume":"41","author":"Lee","year":"2006","journal-title":"J Periodont Res"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0110","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2249.1993.tb08188.x","article-title":"Immunogenicity of the meningococcal stress protein msp63 during natural infection","volume":"93","author":"Pannekoek","year":"1993","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"10.1016\/j.vaccine.2013.03.033_bib0115","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2958.1995.tb02242.x","article-title":"Construction of recombinant Neisserial Hsp60 proteins and mapping of antigenic domains","volume":"15","author":"Pannekoek","year":"1995","journal-title":"Mol Microbiol"},{"issue":"9","key":"10.1016\/j.vaccine.2013.03.033_bib0120","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1128\/IAI.05019-11","article-title":"The Neisseria meningitidis macrophage infectivity potentiator protein induces cross-strain serum bactericidal activity and is a potential serogroup B vaccine candidate","volume":"79","author":"Hung","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0125","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/infdis\/149.2.166","article-title":"Antigenic variation during infection with Neisseria gonorrhoeae: detection of antibodies to surface proteins in sera of patients with gonorrhea","volume":"149","author":"Zak","year":"1984","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0130","series-title":"Meningococcal vaccines","first-page":"167","article-title":"Recombinant proteins in vaccine development","author":"Christodoulides","year":"2001"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0135","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1099\/00221287-144-11-3027","article-title":"Immunisation with recombinant class 1 outer membrane protein from Neisseria meningitidis: influence of liposomes and adjuvants on antibody avidity, recognition of native protein and the induction of a bactericidal immune response against meningococci","volume":"144","author":"Christodoulides","year":"1998","journal-title":"Microbiology"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0140","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0003-2697(87)90587-2","article-title":"Tricine-sodium dodecyl sulphate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100kDa","volume":"166","author":"Schagger","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0145","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1128\/JB.154.1.269-277.1983","article-title":"Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels","volume":"154","author":"Hitchcock","year":"1983","journal-title":"J Bacteriol"},{"issue":"December (50)","key":"10.1016\/j.vaccine.2013.03.033_bib0150","doi-asserted-by":"crossref","first-page":"8420","DOI":"10.1016\/j.vaccine.2007.09.053","article-title":"Lipoprotein NMB0928 from Neisseria meningitidis serogroup B as a novel vaccine candidate","volume":"25","author":"Delgado","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0155","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vaccine.2005.07.056","article-title":"Multivalent liposome-based vaccines containing different serosubtypes of PorA protein induce cross-protective bactericidal immune responses against Neisseria meningitidis","volume":"24","author":"Humphries","year":"2006","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.vaccine.2013.03.033_bib0160","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1084\/jem.20020407","article-title":"NadA, a novel vaccine candidate of Neisseria meningitidis","volume":"195","author":"Comanducci","year":"2002","journal-title":"J Exp Med"},{"issue":"March (6)","key":"10.1016\/j.vaccine.2013.03.033_bib0165","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1084\/jem.20021911","article-title":"Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870","volume":"197","author":"Masignani","year":"2003","journal-title":"J Exp Med"},{"issue":"November (49)","key":"10.1016\/j.vaccine.2013.03.033_bib0170","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1016\/j.vaccine.2009.09.005","article-title":"Assessment of vaccine potential of the Neisseria-specific protein NMB0938","volume":"27","author":"Sardinas","year":"2009","journal-title":"Vaccine"},{"issue":"April (17)","key":"10.1016\/j.vaccine.2013.03.033_bib0175","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1016\/j.vaccine.2006.02.003","article-title":"Vaccine potential of the Neisseria meningitidis lactoferrin-binding proteins LbpA and LbpB","volume":"24","author":"Pettersson","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0180","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1099\/00221287-139-8-1729","article-title":"Immunisation with synthetic peptides containing epitopes of the class 1 outer membrane protein of Neisseria meningitidis: production of bactericidal antibodies on immunisation with a cyclic peptide","volume":"139","author":"Christodoulides","year":"1993","journal-title":"J Gen Microbiol"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0185","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1128\/IAI.69.6.3809-3816.2001","article-title":"Immunisation with recombinant Opc outer membrane protein from Neisseria meningitidis: influence of sequence variation and levels of expression on the bactericidal immune response against meningococci","volume":"69","author":"Jolley","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0190","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00041-13","article-title":"The adhesin complex protein (ACP) of Neisseria meningitidis is a new adhesin with vaccine potential","volume":"4","author":"Hung","year":"2013","journal-title":"MBio"},{"issue":"November (5 Pt 1)","key":"10.1016\/j.vaccine.2013.03.033_bib0195","first-page":"L1026","article-title":"Induction of stress proteins in human endothelial cells by heavy metal ions and heat shock","volume":"277","author":"Wagner","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0200","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1186\/1471-2105-11-595","article-title":"BIGSdb: scalable analysis of bacterial genome variation at the population level","volume":"11","author":"Jolley","year":"2010","journal-title":"BMC Bioinform"},{"key":"10.1016\/j.vaccine.2013.03.033_bib0205","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1128\/IAI.70.8.4028-4034.2002","article-title":"Immunisation with recombinant PorB outer membrane protein induces a bactericidal immune response against Neisseria meningitidis","volume":"70","author":"Wright","year":"2002","journal-title":"Infect Immun"},{"issue":"13","key":"10.1016\/j.vaccine.2013.03.033_bib0210","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.vaccine.2011.08.123","article-title":"Induction of immune responses by purified outer membrane protein complexes from Neisseria meningitidis","volume":"30","author":"Marzoa","year":"2012","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2013.03.033_bib0215","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1084\/jem.181.3.943","article-title":"Activation of T-cells recognizing self 60-kD heat-shock protein can protect against experimental arthritis","volume":"181","author":"Anderton","year":"1995","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.vaccine.2013.03.033_bib0220","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1046\/j.1365-2249.1997.3611265.x","article-title":"Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behcet's disease (BD) in Japan","volume":"108","author":"Kaneko","year":"1997","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"10.1016\/j.vaccine.2013.03.033_bib0225","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1161\/01.ATV.17.3.536","article-title":"Epitope specificity of anti-heat shock protein 65\/60 serum antibodies in atherosclerosis","volume":"17","author":"Metzler","year":"1997","journal-title":"Arterio Thromb Vasc Biol"},{"issue":"3","key":"10.1016\/j.vaccine.2013.03.033_bib0230","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1086\/514218","article-title":"Humoral immune response to conserved epitopes of Chlamydia trachomatis and human 60-kDa heat-shock protein in women with pelvic inflammatory disease","volume":"177","author":"Domeika","year":"1998","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.vaccine.2013.03.033_bib0235","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0165-2478(01)00336-4","article-title":"Antibodies against different epitopes of heat-shock protein 60 in children with type I diabetes mellitus","volume":"80","author":"Horvath","year":"2002","journal-title":"Immunol Lett"},{"issue":"6","key":"10.1016\/j.vaccine.2013.03.033_bib0240","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1161\/01.ATV.0000071701.62486.49","article-title":"Cross-reactive B-cell epitopes of microbial and human heat shock protein 60\/65 in atherosclerosis","volume":"23","author":"Perschinka","year":"2003","journal-title":"Arterio Throm Vasc Biol"},{"issue":"3","key":"10.1016\/j.vaccine.2013.03.033_bib0245","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0167-5699(93)90210-C","article-title":"Sequence homologies between Hsp60 and autoantigens","volume":"14","author":"Jones","year":"1993","journal-title":"Immunol Today"},{"issue":"2","key":"10.1016\/j.vaccine.2013.03.033_bib0250","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.it.2010.11.001","article-title":"The HSP60 immune system network","volume":"32","author":"Quintana","year":"2011","journal-title":"Trend Immunol"},{"issue":"42\u201343","key":"10.1016\/j.vaccine.2013.03.033_bib0255","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.1016\/j.vaccine.2006.06.019","article-title":"A conjugate vaccine composed of a heat shock protein 60 T-cell epitope peptide (p458) and Neisseria meningitidis type B capsular polysaccharide","volume":"24","author":"Amir-Kroll","year":"2006","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1300368X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1300368X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T20:35:47Z","timestamp":1595622947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X1300368X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":51,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0264410X1300368X"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2013.03.033","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}