{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:10:49Z","timestamp":1790673049929,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"38","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"SKLID Development","award":["2008SKLID2583"],"award-info":[{"award-number":["2008SKLID2583"]}]},{"name":"CSTC","award":["2011BB5005"],"award-info":[{"award-number":["2011BB5005"]}]},{"DOI":"10.13039\/501100001809","name":"Chinese National Natural Science Foundation","doi-asserted-by":"crossref","award":["812111251"],"award-info":[{"award-number":["812111251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Chinese National Natural Science Foundation","doi-asserted-by":"crossref","award":["81290340"],"award-info":[{"award-number":["81290340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Chinese National Natural Science Foundation","doi-asserted-by":"crossref","award":["81290345"],"award-info":[{"award-number":["81290345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.vaccine.2013.07.004","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T17:00:51Z","timestamp":1373648451000},"page":"4209-4215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The genetically modified suilysin, rSLYP353L, provides a candidate vaccine that suppresses proinflammatory response and reduces fatality following infection with Streptococcus suis"],"prefix":"10.1016","volume":"31","author":[{"given":"Huamao","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hefang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiqi","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2013.07.004_bib0005","series-title":"Disease of swine","first-page":"769","article-title":"Steptococcus suis","author":"Higgins","year":"2005"},{"issue":"May (5)","key":"10.1016\/j.vaccine.2013.07.004_bib0010","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3201\/eid1405.070437","article-title":"Spread of Streptococcus suis sequence type 7, China","volume":"14","author":"Ye","year":"2008","journal-title":"Emerg. Infect. Dis."},{"issue":"August (8)","key":"10.1016\/j.vaccine.2013.07.004_bib0015","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3201\/eid1708.060232","article-title":"Streptococcus suis sequence type 7 outbreak, Sichuan, China","volume":"12","author":"Ye","year":"2006","journal-title":"Emerg. Infect. Dis."},{"issue":"December (6)","key":"10.1016\/j.vaccine.2013.07.004_bib0020","first-page":"427","article-title":"[Homogeneity study on the Streptococcus suis isolated from human and swine]","volume":"21","author":"Zhu","year":"2000","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"issue":"June (6)","key":"10.1016\/j.vaccine.2013.07.004_bib0025","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3201\/eid1206.051194","article-title":"Human Streptococcus suis outbreak, Sichuan, China","volume":"12","author":"Yu","year":"2006","journal-title":"Emerg. Infect. Dis."},{"issue":"June (6)","key":"10.1016\/j.vaccine.2013.07.004_bib0030","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jinf.2005.02.012","article-title":"Streptococcus suis infection: a series of 41 cases from Chiang Mai University Hospital","volume":"52","author":"Wangkaew","year":"2006","journal-title":"J. Infect."},{"issue":"January (1)","key":"10.1016\/j.vaccine.2013.07.004_bib0035","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1086\/594370","article-title":"Clinical, experimental, and genomic differences between intermediately pathogenic, highly pathogenic, and epidemic Streptococcus suis","volume":"199","author":"Ye","year":"2009","journal-title":"J. Infect. Dis."},{"issue":"January (1)","key":"10.1016\/j.vaccine.2013.07.004_bib0040","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1574-695X.2003.tb00648.x","article-title":"Pro-inflammatory cytokine and chemokine release by human brain microvascular endothelial cells stimulated by Streptococcus suis serotype 2","volume":"35","author":"Vadeboncoeur","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"June (1)","key":"10.1016\/j.vaccine.2013.07.004_bib0045","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1574-695X.2006.00067.x","article-title":"Proinflammatory cytokine and chemokine modulation by Streptococcus suis in a whole-blood culture system","volume":"47","author":"Segura","year":"2006","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"September (9)","key":"10.1016\/j.vaccine.2013.07.004_bib0050","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1128\/IAI.67.9.4646-4654.1999","article-title":"Heat-killed Streptococcus suis capsular type 2 strains stimulate tumor necrosis factor alpha and interleukin-6 production by murine macrophages","volume":"67","author":"Segura","year":"1999","journal-title":"Infect. Immun."},{"issue":"August (8)","key":"10.1016\/j.vaccine.2013.07.004_bib0055","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1128\/IAI.70.8.4312-4322.2002","article-title":"Streptococcus suis interactions with the murine macrophage cell line J774: adhesion and cytotoxicity","volume":"70","author":"Segura","year":"2002","journal-title":"Infect. Immun."},{"issue":"February (2)","key":"10.1016\/j.vaccine.2013.07.004_bib0060","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1365-2249.2002.01768.x","article-title":"CD14-dependent and -independent cytokine and chemokine production by human THP-1 monocytes stimulated by Streptococcus suis capsular type 2","volume":"127","author":"Segura","year":"2002","journal-title":"Clin. Exp. Immunol."},{"issue":"April (4)","key":"10.1016\/j.vaccine.2013.07.004_bib0065","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/intimm\/dxm003","article-title":"TLR2-dependent recognition of Streptococcus suis is modulated by the presence of capsular polysaccharide which modifies macrophage responsiveness","volume":"19","author":"Graveline","year":"2007","journal-title":"Int. Immunol."},{"issue":"August (3)","key":"10.1016\/j.vaccine.2013.07.004_bib0070","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.4049\/jimmunol.179.3.1842","article-title":"Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection","volume":"179","author":"Dominguez-Punaro","year":"2007","journal-title":"J. Immunol."},{"issue":"January (1)","key":"10.1016\/j.vaccine.2013.07.004_bib0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0882-4010(02)00192-4","article-title":"Role of suilysin in pathogenesis of Streptococcus suis capsular serotype 2","volume":"34","author":"Lun","year":"2003","journal-title":"Microb. Pathog."},{"issue":"September (6)","key":"10.1016\/j.vaccine.2013.07.004_bib0080","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/infdis\/jir415","article-title":"Critical role for Streptococcus suis cell wall modifications and suilysin in resistance to complement-dependent killing by dendritic cells","volume":"204","author":"Lecours","year":"2011","journal-title":"J. Infect. Dis."},{"issue":"September (12)","key":"10.1016\/j.vaccine.2013.07.004_bib0085","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/vr.137.12.295","article-title":"Production of suilysin, the thiol-activated haemolysin of Streptococcus suis, by field isolates from diseased pigs","volume":"137","author":"Jacobs","year":"1995","journal-title":"Vet. Rec."},{"issue":"June (6)","key":"10.1016\/j.vaccine.2013.07.004_bib0090","first-page":"792","article-title":"Biological profiles of recombinant Suilysin","volume":"49","author":"Du","year":"2009","journal-title":"Wei Sheng Wu Xue Bao"},{"key":"10.1016\/j.vaccine.2013.07.004_bib0095","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/978-90-481-8622-8_20","article-title":"The cholesterol-dependent cytolysin family of gram-positive bacterial toxins","volume":"51","author":"Heuck","year":"2010","journal-title":"Subcell. Biochem."},{"issue":"September (10)","key":"10.1016\/j.vaccine.2013.07.004_bib0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/vr.139.10.225","article-title":"Protection of experimentally infected pigs by suilysin, the thiol-activated haemolysin of Streptococcus suis","volume":"139","author":"Jacobs","year":"1996","journal-title":"Vet. Rec."},{"issue":"January (1)","key":"10.1016\/j.vaccine.2013.07.004_bib0105","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s13238-010-0012-3","article-title":"Crystal structure of cytotoxin protein suilysin from Streptococcus suis","volume":"1","author":"Xu","year":"2010","journal-title":"Protein Cell"},{"issue":"7","key":"10.1016\/j.vaccine.2013.07.004_bib0110","doi-asserted-by":"crossref","first-page":"e6072","DOI":"10.1371\/journal.pone.0006072","article-title":"Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis","volume":"4","author":"Holden","year":"2009","journal-title":"PLoS ONE"},{"issue":"August (5739)","key":"10.1016\/j.vaccine.2013.07.004_bib0115","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1126\/science.309.5739.1308a","article-title":"Infectious diseases. WHO probes deadliness of China's pig-borne disease","volume":"309","author":"Normile","year":"2005","journal-title":"Science"},{"issue":"July (1)","key":"10.1016\/j.vaccine.2013.07.004_bib0120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.micpath.2006.04.001","article-title":"Phagocytosis and killing of Streptococcus suis by porcine neutrophils","volume":"41","author":"Chabot-Roy","year":"2006","journal-title":"Microb. Pathog."},{"issue":"September (17)","key":"10.1016\/j.vaccine.2013.07.004_bib0125","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1002\/pmic.200800007","article-title":"Identification of immunogenic cell wall-associated proteins of Streptococcus suis serotype 2","volume":"8","author":"Zhang","year":"2008","journal-title":"Proteomics"},{"issue":"January (2)","key":"10.1016\/j.vaccine.2013.07.004_bib0130","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1574-6968.2010.02162.x","article-title":"HtpS, a novel immunogenic cell surface-exposed protein of Streptococcus suis, confers protection in mice","volume":"314","author":"Shao","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"issue":"April (4)","key":"10.1016\/j.vaccine.2013.07.004_bib0135","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/CDLI.12.4.484-490.2005","article-title":"Identification of the gene encoding a 38-kilodalton immunogenic and protective antigen of Streptococcus suis","volume":"12","author":"Okwumabua","year":"2005","journal-title":"Clin. Diagn. Lab. Immunol."},{"issue":"January (1)","key":"10.1016\/j.vaccine.2013.07.004_bib0140","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1128\/IAI.74.1.305-312.2006","article-title":"Identification of a surface protein of Streptococcus suis and evaluation of its immunogenic and protective capacity in pigs","volume":"74","author":"Li","year":"2006","journal-title":"Infect. Immun."},{"issue":"September (38)","key":"10.1016\/j.vaccine.2013.07.004_bib0145","doi-asserted-by":"crossref","first-page":"6514","DOI":"10.1016\/j.vaccine.2011.07.010","article-title":"Evaluation of the immunogenicity and the protective efficacy of a novel identified immunogenic protein, SsPepO, of Streptococcus suis serotype 2","volume":"29","author":"Li","year":"2011","journal-title":"Vaccine"},{"issue":"September (9)","key":"10.1016\/j.vaccine.2013.07.004_bib0150","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1021\/pr800196v","article-title":"Identification and characterization of novel immunogenic proteins of Streptococcus suis serotype 2","volume":"7","author":"Geng","year":"2008","journal-title":"J. Proteome Res."},{"issue":"October (2)","key":"10.1016\/j.vaccine.2013.07.004_bib0155","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1017\/S0022172400063312","article-title":"Streptococcal infection in young pigs. V. An immunogenic polysaccharide from Streptococcus suis type 2 with particular reference to vaccination against streptococcal meningitis in pigs","volume":"85","author":"Elliott","year":"1980","journal-title":"J. Hyg. (Lond.)"},{"issue":"June (1)","key":"10.1016\/j.vaccine.2013.07.004_bib0160","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1574-6968.2010.01944.x","article-title":"Evaluation of the protective efficacy of a newly identified immunogenic protein, HP0272, of Streptococcus suis","volume":"307","author":"Chen","year":"2010","journal-title":"FEMS Microbiol. Lett."},{"issue":"10","key":"10.1016\/j.vaccine.2013.07.004_bib0165","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm1633","article-title":"Adaptive immune cells temper initial innate responses","volume":"13","author":"Kim","year":"2007","journal-title":"Nat. Med."},{"issue":"April (4)","key":"10.1016\/j.vaccine.2013.07.004_bib0170","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1128\/IAI.69.4.2732-2735.2001","article-title":"Generation and characterization of a defined mutant of Streptococcus suis lacking suilysin","volume":"69","author":"Allen","year":"2001","journal-title":"Infect. Immun."},{"issue":"Jun (1)","key":"10.1016\/j.vaccine.2013.07.004_bib0175","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1017\/S1466252307001247","article-title":"Streptococcus suis infections in humans: the Chinese experience and the situation in North America","volume":"8","author":"Gottschalk","year":"2007","journal-title":"Anim. Health Res. Rev."},{"issue":"April (1\u20132)","key":"10.1016\/j.vaccine.2013.07.004_bib0180","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.vetmic.2011.10.014","article-title":"The role of toll-like receptors in the pathogenesis of Streptococcus suis","volume":"156","author":"Zheng","year":"2012","journal-title":"Vet. Microbiol."},{"issue":"May (1\u20132)","key":"10.1016\/j.vaccine.2013.07.004_bib0185","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jneuroim.2011.02.005","article-title":"Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis","volume":"234","author":"Zheng","year":"2011","journal-title":"J. Neuroimmunol."},{"issue":"September (3)","key":"10.1016\/j.vaccine.2013.07.004_bib0190","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1365-2249.2008.03722.x","article-title":"Mitogenic effect contributes to increased virulence of Streptococcus suis sequence type 7 to cause streptococcal toxic shock-like syndrome","volume":"153","author":"Zheng","year":"2008","journal-title":"Clin. Exp. Immunol."},{"issue":"6","key":"10.1016\/j.vaccine.2013.07.004_bib0195","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1128\/IAI.01317-12","article-title":"Exacerbated type II interferon response drives hypervirulence and toxic shock by an emergent epidemic strain of Streptococcus suis","volume":"81","author":"Lachance","year":"2013","journal-title":"Infect. Immun."},{"issue":"December (2\u20134)","key":"10.1016\/j.vaccine.2013.07.004_bib0200","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.vetimm.2009.05.009","article-title":"Intranasal immunization with a live Streptococcus suis isogenic ofs mutant elicited suilysin-neutralization titers but failed to induce opsonizing antibodies and protection","volume":"132","author":"Kock","year":"2009","journal-title":"Vet. Immunol. Immunopathol."}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X13009250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X13009250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T12:57:04Z","timestamp":1596113824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X13009250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":40,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0264410X13009250"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2013.07.004","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The genetically modified suilysin, rSLYP353L, provides a candidate vaccine that suppresses proinflammatory response and reduces fatality following infection with Streptococcus suis","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2013.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}