{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:40:03Z","timestamp":1789080003889,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.vaccine.2013.12.070","type":"journal-article","created":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:30:50Z","timestamp":1391214650000},"page":"1280-1286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Immuno-proteomic analysis of human immune responses to experimental Neisseria meningitidis outer membrane vesicle vaccines identifies potential cross-reactive antigens"],"prefix":"10.1016","volume":"32","author":[{"given":"Jeannette N.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Weynants","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan T.","family":"Poolman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Heckels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron","family":"Christodoulides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2013.12.070_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-61779-346-2_1","article-title":"Neisseria meningitidis: biology, microbiology, and epidemiology","volume":"799","author":"Rouphael","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"16","key":"10.1016\/j.vaccine.2013.12.070_bib0010","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1056\/NEJMra0906357","article-title":"Current concepts. Advances in the development of vaccines against Neisseria meningitidis","volume":"362","author":"Tan","year":"2010","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.vaccine.2013.12.070_bib0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1001\/jama.2007.29-c","article-title":"Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trial","volume":"299","author":"Snape","year":"2008","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.vaccine.2013.12.070_bib0020","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4161\/hv.19619","article-title":"Development of a group A meningococcal conjugate vaccine, MenAfriVac(TM)","volume":"8","author":"Frasch","year":"2012","journal-title":"Hum Vaccines Immunother"},{"issue":"ii","key":"10.1016\/j.vaccine.2013.12.070_bib0025","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(83)90340-9","article-title":"Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis","author":"Finne","year":"1983","journal-title":"Lancet"},{"issue":"Suppl. 2","key":"10.1016\/j.vaccine.2013.12.070_bib0030","doi-asserted-by":"crossref","first-page":"B3","DOI":"10.1016\/j.vaccine.2009.04.071","article-title":"Properties and clinical performance of vaccines containing outer membrane vesicles from Neisseria meningitidis","volume":"27","author":"Holst","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2013.12.070_bib0035","first-page":"195","article-title":"Vaccine against group B Neisseria meningitidis: protection trial and mass vaccination results in Cuba","volume":"14","author":"Sierra","year":"1991","journal-title":"NIPH Ann"},{"key":"10.1016\/j.vaccine.2013.12.070_bib0040","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/0140-6736(92)93086-3","article-title":"Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil","volume":"340","author":"Demoraes","year":"1992","journal-title":"Lancet"},{"issue":"17\u201318","key":"10.1016\/j.vaccine.2013.12.070_bib0045","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/j.vaccine.2005.01.063","article-title":"MeNZB: a safe and highly immunogenic tailor-made vaccine against the New Zealand Neisseria meningitidis serogroup B disease epidemic strain","volume":"23","author":"Oster","year":"2005","journal-title":"Vaccine"},{"issue":"29","key":"10.1016\/j.vaccine.2013.12.070_bib0050","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1073\/pnas.0603940103","article-title":"A universal vaccine for serogroup B meningococcus","volume":"103","author":"Giuliani","year":"2006","journal-title":"PNAS"},{"issue":"Suppl 2","key":"10.1016\/j.vaccine.2013.12.070_bib0055","doi-asserted-by":"crossref","first-page":"B87","DOI":"10.1016\/j.vaccine.2012.01.033","article-title":"The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens","volume":"30","author":"Serruto","year":"2012","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2013.12.070_bib0060","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4161\/hv.18500","article-title":"Bexsero: a multicomponent vaccine for prevention of meningococcal disease","volume":"8","author":"Gorringe","year":"2012","journal-title":"Hum Vaccines Immunother"},{"issue":"4","key":"10.1016\/j.vaccine.2013.12.070_bib0065","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1128\/IAI.72.4.2088-2100.2004","article-title":"Vaccine potential of the Neisseria meningitidis 2086 lipoprotein","volume":"72","author":"Fletcher","year":"2004","journal-title":"Infect Immun"},{"issue":"37","key":"10.1016\/j.vaccine.2013.12.070_bib0070","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1016\/j.vaccine.2010.06.083","article-title":"Broad vaccine coverage predicted for a bivalent recombinant factor H binding protein based vaccine to prevent serogroup B meningococcal disease","volume":"28","author":"Jiang","year":"2010","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.vaccine.2013.12.070_bib0075","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/j.vaccine.2009.12.027","article-title":"Frequency of factor H-binding protein modular groups and susceptibility to cross-reactive bactericidal activity in invasive meningococcal isolates","volume":"28","author":"Pajon","year":"2010","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.vaccine.2013.12.070_bib0080","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/pmic.200500164","article-title":"Outer membrane vesicles from group B Neisseria meningitidis delta gna33 mutant: proteomic and immunological comparison with detergent-derived outer membrane vesicles","volume":"6","author":"Ferrari","year":"2006","journal-title":"Proteomics"},{"issue":"6","key":"10.1016\/j.vaccine.2013.12.070_bib0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005940","article-title":"Towards the immunoproteome of Neisseria meningitidis","volume":"4","author":"Mendum","year":"2009","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.vaccine.2013.12.070_bib0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4161\/hv.5.5.7367","article-title":"Proteomic study via a non-gel based approach of meningococcal outer membrane vesicle vaccine obtained from strain CU385: a road map for discovering new antigens","volume":"5","author":"Gil","year":"2009","journal-title":"Hum Vaccines"},{"issue":"11","key":"10.1016\/j.vaccine.2013.12.070_bib0095","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1002\/pmic.200500821","article-title":"Proteomic analysis of a meningococcal outer membrane vesicle vaccine prepared from the group B strain NZ98\/254","volume":"6","author":"Vipond","year":"2006","journal-title":"Proteomics"},{"issue":"3","key":"10.1016\/j.vaccine.2013.12.070_bib0100","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1128\/IAI.01424-06","article-title":"Proteomic analysis of outer membranes and vesicles from wild-type serogroup B Neisseria meningitidis and a lipopolysaccharide-deficient mutant","volume":"75","author":"Williams","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2013.12.070_bib0105","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1574-695X.2002.tb00608.x","article-title":"Neisseria meningitidis serogroup B: laboratory correlates of protection","volume":"34","author":"Vermont","year":"2002","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"9","key":"10.1016\/j.vaccine.2013.12.070_bib0110","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1128\/CVI.00129-10","article-title":"Three doses of an experimental detoxified L3-derived lipooligosaccharide meningococcal vaccine offer good safety but low immunogenicity in healthy young adults","volume":"17","author":"Bonvehi","year":"2010","journal-title":"Clin Vaccine Immunol"},{"issue":"11","key":"10.1016\/j.vaccine.2013.12.070_bib0115","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1128\/IAI.00411-07","article-title":"Additive and synergistic bactericidal activity of antibodies directed against minor outer membrane proteins of Neisseria meningitidis","volume":"75","author":"Weynants","year":"2007","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2013.12.070_bib0120","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1128\/IAI.01108-08","article-title":"Genetically modified L3,7 and L2 lipooligosaccharides from Neisseria meningitidis serogroup B confer a broad cross-bactericidal response","volume":"77","author":"Weynants","year":"2009","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2013.12.070_bib0125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1128\/CVI.00230-06","article-title":"Immunogenicity and safety of three doses of a bivalent (B:4:p1.19,15 and B:4:p1. 7-2,4) meningococcal outer membrane vesicle vaccine in healthy adolescents","volume":"14","author":"Boutriau","year":"2007","journal-title":"Clin Vaccine Immunol"},{"issue":"11","key":"10.1016\/j.vaccine.2013.12.070_bib0130","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1128\/IAI.00701-09","article-title":"Immunoproteomic analysis of the development of natural immunity in subjects colonized by Neisseria meningitidis reveals potential vaccine candidates","volume":"77","author":"Williams","year":"2009","journal-title":"Infect Immun"},{"issue":"25","key":"10.1016\/j.vaccine.2013.12.070_bib0135","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.93.25.14440","article-title":"Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels","volume":"93","author":"Shevchenko","year":"1996","journal-title":"PNAS"},{"issue":"11","key":"10.1016\/j.vaccine.2013.12.070_bib0140","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1002\/pmic.200500502","article-title":"Outer membrane vesicles of the VA-MENGOC-BC vaccine against serogroup B of Neisseria meningitidis: analysis of protein components by two-dimensional gel electrophoresis and mass spectrometry","volume":"6","author":"Uli","year":"2006","journal-title":"Proteomics"},{"issue":"6","key":"10.1016\/j.vaccine.2013.12.070_bib0145","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/(SICI)1522-2683(20000401)21:6<1054::AID-ELPS1054>3.0.CO;2-8","article-title":"Membrane proteins and proteomics: un amour impossible?","volume":"21","author":"Santoni","year":"2000","journal-title":"Electrophoresis"},{"issue":"46","key":"10.1016\/j.vaccine.2013.12.070_bib0150","doi-asserted-by":"crossref","first-page":"38383","DOI":"10.1074\/jbc.M508063200","article-title":"Biochemical and functional characterization of membrane blebs purified from Neisseria meningitidis serogroup B","volume":"280","author":"Post","year":"2005","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.vaccine.2013.12.070_bib0155","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/mas.20175","article-title":"Proteomics in gram-negative bacterial outer membrane vesicles","volume":"27","author":"Lee","year":"2008","journal-title":"Mass Spectrom Rev"},{"issue":"3","key":"10.1016\/j.vaccine.2013.12.070_bib0160","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.mib.2006.04.008","article-title":"Technologies for bacterial surface proteomics","volume":"9","author":"Cordwell","year":"2006","journal-title":"Curr Opin Microbiol"},{"issue":"6","key":"10.1016\/j.vaccine.2013.12.070_bib0165","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/(SICI)1522-2683(20000401)21:6<1037::AID-ELPS1037>3.0.CO;2-V","article-title":"The current state of two-dimensional electrophoresis with immobilized pH gradients","volume":"21","author":"Gorg","year":"2000","journal-title":"Electrophoresis"},{"key":"10.1016\/j.vaccine.2013.12.070_bib0170","doi-asserted-by":"crossref","DOI":"10.1021\/pr301208g","article-title":"Quantitative proteomics reveals distinct differences in the protein content of outer membrane vesicle vaccines","author":"van de Waterbeemd","year":"2013","journal-title":"J Proteome Res"},{"key":"10.1016\/j.vaccine.2013.12.070_bib0175","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0882-4010(91)90041-8","article-title":"Blocking of bactericidal killing of Neisseria meningitidis by antibodies directed against class 4 outer membrane protein","volume":"11","author":"Munkley","year":"1991","journal-title":"Microb Pathog"},{"issue":"3","key":"10.1016\/j.vaccine.2013.12.070_bib0180","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1128\/IAI.67.3.1267-1276.1999","article-title":"Functional activities and epitope specificity of human and murine antibodies against the class 4 outer membrane protein (Rmp) of Neisseria meningitidis","volume":"67","author":"Rosenqvist","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2013.12.070_bib0185","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1128\/IAI.57.5.1590-1598.1989","article-title":"Human immune response to meningococcal outer membrane protein epitopes after natural infection or vaccination","volume":"57","author":"Mandrell","year":"1989","journal-title":"Infect Immun"},{"issue":"7","key":"10.1016\/j.vaccine.2013.12.070_bib0190","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1128\/IAI.01338-10","article-title":"The potential of recombinant Opa proteins as vaccine candidates against hyperinvasive meningococci","volume":"79","author":"Callaghan","year":"2011","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.vaccine.2013.12.070_bib0195","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1128\/IAI.00222-07","article-title":"Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function","volume":"75","author":"Lee","year":"2007","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.vaccine.2013.12.070_bib0200","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1574-6976.2010.00260.x","article-title":"Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria","volume":"35","author":"Sadarangani","year":"2011","journal-title":"FEMS Microbiol Rev"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2013.12.070_bib0205","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0022-1759(00)00245-3","article-title":"IgG antibody levels to meningococcal porins in patient sera: comparison of immunoblotting and ELISA measurements","volume":"244","author":"Wedege","year":"2000","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.vaccine.2013.12.070_bib0210","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1128\/IAI.70.8.4028-4034.2002","article-title":"Immunisation with recombinant PorB outer membrane protein induces a bactericidal immune response against Neisseria meningitidis","volume":"70","author":"Wright","year":"2002","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.vaccine.2013.12.070_bib0215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1128\/IAI.65.1.55-63.1997","article-title":"Evaluation of recombinant transferrin-binding protein B variants from Neisseria meningitidis for their ability to induce cross-reactive and bactericidal antibodies against a genetically diverse collection of serogroup B strains","volume":"65","author":"Rokbi","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2013.12.070_bib0220","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1128\/IAI.62.7.2984-2990.1994","article-title":"Immune responses in humans and animals to meningococcal transferrin-binding proteins: implications for vaccine design","volume":"62","author":"Ala\u2019aldeen","year":"1994","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.vaccine.2013.12.070_bib0225","doi-asserted-by":"crossref","first-page":"e5198","DOI":"10.1371\/journal.pone.0005198","article-title":"Host iron binding proteins acting as niche indicators for Neisseria meningitidis","volume":"4","author":"Jordan","year":"2009","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.vaccine.2013.12.070_bib0230","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0928-8244(97)00109-0","article-title":"Bactericidal activity of antibodies elicited against the Neisseria meningitidis 37-kDa ferric binding protein (FbpA) with different adjuvants","volume":"20","author":"Gomez","year":"1998","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.vaccine.2013.12.070_bib0235","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1128\/IAI.63.5.1624-1630.1995","article-title":"Cloning and characterization of the meningococcal polyphosphate kinase gene-production of polyphosphate synthesis mutants","volume":"63","author":"Tinsley","year":"1995","journal-title":"Infect Immun"},{"issue":"44","key":"10.1016\/j.vaccine.2013.12.070_bib0240","doi-asserted-by":"crossref","first-page":"34259","DOI":"10.1074\/jbc.M110.154393","article-title":"The role of the exopolyphosphatase PPX in avoidance by Neisseria meningitidis of complement-mediated killing","volume":"285","author":"Zhang","year":"2010","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.vaccine.2013.12.070_bib0245","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1128\/JB.186.1.244-247.2004","article-title":"Necessity of meningococcal gamma-glutamyl aminopeptidase for Neisseria meningitidis growth in rat cerebrospinal fluid (CSF) and CSF-like medium","volume":"186","author":"Takahashi","year":"2004","journal-title":"J Bacteriol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14000851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14000851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T23:34:50Z","timestamp":1597448090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X14000851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0264410X14000851"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2013.12.070","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immuno-proteomic analysis of human immune responses to experimental Neisseria meningitidis outer membrane vesicle vaccines identifies potential cross-reactive antigens","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2013.12.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}