{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:44:52Z","timestamp":1770511492287,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Key Basic Research and Development Project","award":["2010CB530000"],"award-info":[{"award-number":["2010CB530000"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81171602"],"award-info":[{"award-number":["81171602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National S & T Major Program","award":["2012ZX10004-220"],"award-info":[{"award-number":["2012ZX10004-220"]}]},{"name":"Fundamental Research Funds for the Central Universities (2013)"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81101270"],"award-info":[{"award-number":["81101270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.vaccine.2014.01.039","type":"journal-article","created":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:30:46Z","timestamp":1391214646000},"page":"1338-1345","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Surface display of Clonorchis sinensis enolase on Bacillus subtilis spores potentializes an oral vaccine candidate"],"prefix":"10.1016","volume":"32","author":[{"given":"Xiaoyun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuerong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinbing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2014.01.039_bib0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1473-3099(04)01252-6","article-title":"Clonorchiasis: a key foodborne zoonosis in China","volume":"5","author":"Lun","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.parint.2011.06.007","article-title":"Clonorchis sinensis and clonorchiasis, an update","volume":"61","author":"Hong","year":"2012","journal-title":"Parasitol Int"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0015","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/gb-2011-12-10-r107","article-title":"The draft genome of the carcinogenic human liver fluke Clonorchis sinensis","volume":"12","author":"Wang","year":"2011","journal-title":"Genome Biol"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0020","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.vaccine.2008.02.015","article-title":"Oral administration of a Bacillus subtilis spore-based vaccine expressing Clonorchis sinensis tegumental protein 22.3kDa confers protection against Clonorchis sinensis","volume":"26","author":"Zhou","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0025","doi-asserted-by":"crossref","first-page":"e33703","DOI":"10.1371\/journal.pone.0033703","article-title":"Identification and characterization of paramyosin from cyst wall of metacercariae implicated protective efficacy against Clonorchis sinensis infection","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0014-5793(04)00306-0","article-title":"Identification of enolase as a plasminogen-binding protein in excretory\u2013secretory products of Fasciola hepatica","volume":"563","author":"Bernal","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0035","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1128\/IAI.01352-07","article-title":"Immunogenic and plasminogen-binding surface-associated alpha-enolase of Trichomonas vaginalis","volume":"76","author":"Mundodi","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-5793(00)01494-0","article-title":"ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1)","volume":"473","author":"Feo","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0045","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1016\/j.vaccine.2012.02.075","article-title":"Ascaris suum enolase is a potential vaccine candidate against ascariasis","volume":"30","author":"Chen","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0050","doi-asserted-by":"crossref","first-page":"5526","DOI":"10.1016\/j.vaccine.2011.05.030","article-title":"Immunisation with the glycolytic enzyme enolase confers effective protection against Candida albicans infection in mice","volume":"29","author":"Li","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0055","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.molbiopara.2011.02.011","article-title":"Clonorchis sinensis enolase: identification and biochemical characterization of a glycolytic enzyme from excretory\/secretory products","volume":"177","author":"Wang","year":"2011","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0060","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.vaccine.2009.10.127","article-title":"Mucosal delivery of antigens using adsorption to bacterial spores","volume":"28","author":"Huang","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0065","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2859-9-2","article-title":"Expression and display of UreA of Helicobacter acinonychis on the surface of Bacillus subtilis spores","volume":"9","author":"Hinc","year":"2010","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0070","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/JB.01103-09","article-title":"Localization of proteins to different layers and regions of Bacillus subtilis spore coats","volume":"192","author":"Imamura","year":"2010","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0075","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00436-007-0762-x","article-title":"Immunogenicity of recombinant Bacillus subtilis spores expressing Clonorchis sinensis tegumental protein","volume":"102","author":"Zhou","year":"2008","journal-title":"Parasitol Res"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0080","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1128\/AEM.00151-11","article-title":"Production of N-acetyl-d-neuraminic acid by use of an efficient spore surface display system","volume":"77","author":"Xu","year":"2011","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0085","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/plas.2000.1510","article-title":"Construction and characterization of Streptococcus suis\u2013Escherichia coli shuttle cloning vectors","volume":"45","author":"Takamatsu","year":"2001","journal-title":"Plasmid"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0090","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.vaccine.2003.09.031","article-title":"Display of heterologous antigens on the Bacillus subtilis spore coat using CotC as a fusion partner","volume":"22","author":"Mauriello","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0095","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1086\/644602","article-title":"Streptococcus suis enolase functions as a protective antigen displayed on the bacterial cell surface","volume":"200","author":"Feng","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0100","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.vaccine.2008.12.047","article-title":"Identification and characterization of a novel protective antigen, Enolase of Streptococcus suis serotype 2","volume":"27","author":"Zhang","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0105","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1086\/594372","article-title":"Oral therapeutic vaccination with Streptococcus sobrinus recombinant enolase confers protection against dental caries in rats","volume":"199","author":"Dinis","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0110","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0264-410X(97)00289-2","article-title":"Correlation of specific antibody titre and avidity with protection in cattle immunized against Fasciola hepatica","volume":"16","author":"Mulcahy","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0115","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1016\/j.vaccine.2013.09.027","article-title":"Vaccine potential of recombinant saposin-like protein 2 against Fasciolosis gigantica in mice","volume":"31","author":"Kueakhai","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0120","doi-asserted-by":"crossref","first-page":"428593","DOI":"10.1155\/2010\/428593","article-title":"Immunity against helminths: interactions with the host and the intercurrent infections","volume":"2010","author":"Moreau","year":"2010","journal-title":"J Biomed Biotechnol"},{"issue":"1","key":"10.1016\/j.vaccine.2014.01.039_bib0125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijpara.2011.11.001","article-title":"Free radicals enzymatically triggered by Clonorchis sinensis excretory\u2013secretory products cause NF-\u03baB-mediated inflammation in human cholangiocarcinoma cells","volume":"42","author":"Nam","year":"2012","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0130","doi-asserted-by":"crossref","first-page":"979","DOI":"10.4161\/hv.20694","article-title":"Bacillus subtilis: a temperature resistant and needle free delivery system of immunogens","volume":"8","author":"Amuguni","year":"2012","journal-title":"Hum Vaccines Immunother"},{"key":"10.1016\/j.vaccine.2014.01.039_bib0135","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1007\/s00436-009-1606-7","article-title":"Immunogenicity of self-adjuvanticity oral vaccine candidate based on use of Bacillus subtilis spore displaying Schistosoma japonicum 26kDa GST protein","volume":"105","author":"Li","year":"2009","journal-title":"Parasitol Res"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14000735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14000735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T00:54:51Z","timestamp":1538873691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X14000735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0264410X14000735"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.01.039","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surface display of Clonorchis sinensis enolase on Bacillus subtilis spores potentializes an oral vaccine candidate","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.01.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}