{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T17:26:23Z","timestamp":1794245183591,"version":"4.9.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"15","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.vaccine.2014.01.057","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T22:45:20Z","timestamp":1391813120000},"page":"1661-1669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":99,"title":["The link between genetic variation and variability in vaccine responses: Systematic review and meta-analyses"],"prefix":"10.1016","volume":"32","author":[{"given":"Brunella","family":"Posteraro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Pastorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Di Giannantonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ianuale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosarita","family":"Amore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Boccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.vaccine.2014.01.057_bib0005","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1056\/NEJMra1204186","article-title":"Designing tomorrow's vaccines","volume":"368","author":"Nabel","year":"2013","journal-title":"N Engl J Med"},{"issue":"6136","key":"10.1016\/j.vaccine.2014.01.057_bib0010","doi-asserted-by":"crossref","first-page":"1232910","DOI":"10.1126\/science.1232910","article-title":"Accelerating next-generation vaccine development for global disease prevention","volume":"340","author":"Koff","year":"2013","journal-title":"Science"},{"issue":"7348","key":"10.1016\/j.vaccine.2014.01.057_bib0015","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10124","article-title":"2020 vision for vaccines against HIV, tuberculosis and malaria","volume":"473","author":"Rappuoli","year":"2011","journal-title":"Nature"},{"issue":"18","key":"10.1016\/j.vaccine.2014.01.057_bib0020","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1001\/jama.298.18.2155","article-title":"Historical comparisons of morbidity and mortality for vaccine-preventable diseases in the United States","volume":"298","author":"Roush","year":"2007","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.vaccine.2014.01.057_bib0025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.smim.2013.04.007","article-title":"Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century","volume":"25","author":"Poland","year":"2013","journal-title":"Semin Immunol"},{"issue":"Suppl 10A","key":"10.1016\/j.vaccine.2014.01.057_bib0030","doi-asserted-by":"crossref","first-page":"34S","DOI":"10.1016\/j.amjmed.2005.07.012","article-title":"Prevention of hepatitis B in nonresponders to initial hepatitis B virus vaccination","volume":"118","author":"Sjogren","year":"2005","journal-title":"Am J Med"},{"issue":"2","key":"10.1016\/j.vaccine.2014.01.057_bib0035","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.vaccine.2011.11.085","article-title":"The re-emergence of measles in developed countries: time to develop the next-generation measles vaccines?","volume":"30","author":"Poland","year":"2012","journal-title":"Vaccine"},{"issue":"49","key":"10.1016\/j.vaccine.2014.01.057_bib0040","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1016\/j.vaccine.2008.06.057","article-title":"Vaccine immunogenetics: bedside to bench to population","volume":"26","author":"Poland","year":"2008","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.vaccine.2014.01.057_bib0045","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1089\/omi.2011.0012","article-title":"The top five game changers in vaccinology: toward rational and directed vaccine development","volume":"15","author":"Kennedy","year":"2011","journal-title":"OMICS"},{"issue":"6","key":"10.1016\/j.vaccine.2014.01.057_bib0050","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/sj.clpt.6100415","article-title":"Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics","volume":"82","author":"Poland","year":"2007","journal-title":"Clin Pharmacol Ther"},{"issue":"40","key":"10.1016\/j.vaccine.2014.01.057_bib0055","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1016\/j.vaccine.2013.06.108","article-title":"The effect of HLA on immunological response to hepatitis B vaccine in healthy people: a meta-analysis","volume":"31","author":"Li","year":"2013","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.vaccine.2014.01.057_bib0060","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.vaccine.2012.01.025","article-title":"Multigenic control of measles vaccine immunity mediated by polymorphisms in measles receptor, innate pathway, and cytokine genes","volume":"30","author":"Kennedy","year":"2012","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0065","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/aje\/kwi184","article-title":"Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review","volume":"162","author":"Thakkinstian","year":"2005","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.vaccine.2014.01.057_bib0070","series-title":"Cochrane handbook for systematic reviews of interventions, version 5.0.2","author":"Higgins","year":"2011"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0075","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/mutage\/ger065","article-title":"p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature","volume":"27","author":"De Feo","year":"2012","journal-title":"Mutagenesis"},{"issue":"4","key":"10.1016\/j.vaccine.2014.01.057_bib0080","first-page":"354","article-title":"The PRISMA statement for reporting systematic reviews and meta-analysis of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"Ital J Public Health"},{"issue":"5","key":"10.1016\/j.vaccine.2014.01.057_bib0085","first-page":"261","article-title":"The influence of the HLA-DRB1*13 allele on measles vaccine response","volume":"44","author":"Hayney","year":"1996","journal-title":"J Investig Med"},{"issue":"3-4","key":"10.1016\/j.vaccine.2014.01.057_bib0090","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0264-410X(01)00346-2","article-title":"Identification of an association between HLA class II alleles and low antibody levels after measles immunization","volume":"20","author":"Poland","year":"2001","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.vaccine.2014.01.057_bib0095","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1086\/340573","article-title":"Associations between human leukocyte antigen homozygosity and antibody levels to measles vaccine","volume":"185","author":"St. Sauver","year":"2002","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0100","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-2370.2003.00382.x","article-title":"Lack of association between transporter associated with antigen processing (TAP) and HLA-DM gene polymorphisms and antibody levels following measles vaccination","volume":"30","author":"Dhiman","year":"2003","journal-title":"Eur J Immunogenet"},{"issue":"1","key":"10.1016\/j.vaccine.2014.01.057_bib0105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0198-8859(02)00741-3","article-title":"The association of class I HLA alleles and antibody levels after a single dose of measles vaccine","volume":"64","author":"Jacobson","year":"2003","journal-title":"Hum Immunol"},{"key":"10.1016\/j.vaccine.2014.01.057_bib0110","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.vaccine.2003.11.016","article-title":"Associations between human leukocyte antigen (HLA) alleles and very high levels of measles antibody following vaccination","volume":"22","author":"Ovsyannikova","year":"2004","journal-title":"Vaccine"},{"issue":"15\u201316","key":"10.1016\/j.vaccine.2014.01.057_bib0115","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.humimm.2004.07.001","article-title":"The contribution of HLA class I antigens in immune status following two doses of rubella vaccination","volume":"65","author":"Ovsyannikova","year":"2004","journal-title":"Hum Immunol"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0120","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jaci.2007.04.036","article-title":"Variations in measles vaccine-specific humoral immunity by polymorphisms in SLAM and CD46 measles virus receptors","volume":"120","author":"Dhiman","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.vaccine.2014.01.057_bib0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1086\/510596","article-title":"Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes","volume":"195","author":"Dhiman","year":"2007","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.vaccine.2014.01.057_bib0130","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/CVI.00247-06","article-title":"Relationship between HLA polymorphisms and gamma interferon and interleukin-10 cytokine production in healthy individuals after rubella vaccination","volume":"14","author":"Ovsyannikova","year":"2007","journal-title":"Clin Vaccine Immunol"},{"issue":"49","key":"10.1016\/j.vaccine.2014.01.057_bib0135","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1016\/j.vaccine.2009.08.109","article-title":"Replication of rubella vaccine population genetic studies: validation of HLA genotype and humoral response associations","volume":"27","author":"Ovsyannikova","year":"2009","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2014.01.057_bib0140","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1086\/649588","article-title":"Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination","volume":"201","author":"Ovsyannikova","year":"2010","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.vaccine.2014.01.057_bib0145","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00439-009-0763-1","article-title":"Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes","volume":"127","author":"Ovsyannikova","year":"2010","journal-title":"Hum Genet"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0150","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000331585","article-title":"The association of CD46, SLAM and CD209 cellular receptors gene SNPs with variations in measles vaccine-induced immune responses: a replication study and examination of novel polymorphisms","volume":"72","author":"Ovsyannikova","year":"2011","journal-title":"Hum Hered"},{"issue":"45","key":"10.1016\/j.vaccine.2014.01.057_bib0155","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1016\/j.vaccine.2011.08.083","article-title":"Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination","volume":"29","author":"Haralambieva","year":"2011","journal-title":"Vaccine"},{"issue":"25-26","key":"10.1016\/j.vaccine.2014.01.057_bib0160","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1016\/S0264-410X(02)00267-0","article-title":"IL-1\u03b2 gene polymorphisms influence hepatitis B vaccination","volume":"20","author":"Yucesoy","year":"2002","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2014.01.057_bib0165","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/hep.20142","article-title":"HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination","volume":"39","author":"Wang","year":"2004","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.vaccine.2014.01.057_bib0170","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0198-8859(98)00014-7","article-title":"The influence of major histocompatibility complex class II genes and T-cell V\u03b2 repertoire on response to immunization with HBsAg","volume":"59","author":"H\u00f6hler","year":"1998","journal-title":"Hum Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2014.01.057_bib0175","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1399-0039.1998.tb03058.x","article-title":"Haplotypes comprising subtypes of the DQB1*06 allele direct the antibody response after immunization with hepatitis B surface antigen","volume":"52","author":"Lang\u00f6-Warensj\u00f6","year":"1998","journal-title":"Tissue Antigens"},{"issue":"11\u201312","key":"10.1016\/j.vaccine.2014.01.057_bib0180","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0264-410X(98)00389-2","article-title":"The influence of host factors and immunogenetics on lymphocyte responses to Hepagene vaccination","volume":"17","author":"McDermott","year":"1999","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0185","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/clim.2000.4933","article-title":"Humoral response to recombinant hepatitis B virus vaccine at birth: role of HLA and beyond","volume":"97","author":"Martinetti","year":"2000","journal-title":"Clin Immunol"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0190","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0168-8278(02)00205-2","article-title":"C4A deficiency and nonresponse to hepatitis B vaccination","volume":"37","author":"H\u00f6hler","year":"2002","journal-title":"J Hepatol"},{"issue":"2","key":"10.1016\/j.vaccine.2014.01.057_bib0195","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1006\/viro.2002.1467","article-title":"Role of G protein \u03b23 subunit C825 T and HLA class II polymorphisms in the immune response after HBV vaccination","volume":"297","author":"Lindemann","year":"2002","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.vaccine.2014.01.057_bib0200","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1086\/338014","article-title":"Associations between human leukocyte antigens and nonresponsiveness to influenza vaccine","volume":"185","author":"Gelder","year":"2002","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0205","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1128\/CVI.05379-11","article-title":"Single nucleotide polymorphisms in the Toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccine","volume":"19","author":"Moore","year":"2011","journal-title":"Clin Vaccine Immunol"},{"issue":"7","key":"10.1016\/j.vaccine.2014.01.057_bib0210","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1002\/eji.1830220733","article-title":"Genetic control of nonresponsiveness to hepatitis B virus vaccine by an extended HLA haplotype","volume":"22","author":"Hatae","year":"1992","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2014.01.057_bib0215","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/intimm\/8.4.525","article-title":"Contribution of HLA class I and class II alleles to the regulation of antibody production to hepatitis B surface antigen in humans","volume":"8","author":"Mineta","year":"1996","journal-title":"Int Immunol"},{"issue":"10","key":"10.1016\/j.vaccine.2014.01.057_bib0220","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00439-013-1320-5","article-title":"Responses to booster hepatitis B vaccination are significantly correlated with genotypes of human leukocyte antigen (HLA)-DPB1 in neonatally vaccinated adolescents","volume":"132","author":"Wu","year":"2013","journal-title":"Hum Genet"},{"issue":"14","key":"10.1016\/j.vaccine.2014.01.057_bib0225","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/0264-410X(93)90173-U","article-title":"Association of HLA-DR14-DR52 with low responsiveness to hepatitis B vaccine in Chinese residents in Taiwan","volume":"11","author":"Hsu","year":"1993","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.vaccine.2014.01.057_bib0230","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.humimm.2012.03.004","article-title":"TLR3 and RIG-I gene variants: associations with functional effects on receptors expression and responses to measles virus and vaccine in vaccinated infants","volume":"73","author":"Clifford","year":"2012","journal-title":"Hum Immunol"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0235","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/gene.2010.1","article-title":"New genetic associations detected in a host response study to hepatitis B vaccine","volume":"11","author":"Davila","year":"2010","journal-title":"Genes Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2014.01.057_bib0240","first-page":"92","article-title":"HLA-DRB1, DQA1 and DQB1 alleles and haplotypes frequencies in Iranian healthy adult responders and non-responders to recombinant hepatitis B vaccine","volume":"5","author":"Amirzargar","year":"2008","journal-title":"Iran J Immunol"},{"issue":"39","key":"10.1016\/j.vaccine.2014.01.057_bib0245","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.1016\/j.vaccine.2012.07.010","article-title":"Association of polymorphism of cytokine and TLR-2 genes with long-term immunity to hepatitis B in children vaccinated early in life","volume":"30","author":"Wang","year":"2012","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0250","doi-asserted-by":"crossref","first-page":"e1898","DOI":"10.1371\/journal.pone.0001898","article-title":"Host genetic factors and vaccine-induced immunity to hepatitis B virus infection","volume":"3","author":"Hennig","year":"2008","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0255","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1744-313X.2008.00765.x","article-title":"MHC architecture and evolution: implications for disease association studies","volume":"35","author":"Traherne","year":"2008","journal-title":"Int J Immunogenet"},{"issue":"12","key":"10.1016\/j.vaccine.2014.01.057_bib0260","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nri3084","article-title":"Towards a systems understanding of MHC class I and MHC class II antigen presentation","volume":"11","author":"Neefjes","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.vaccine.2014.01.057_bib0265","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fimmu.2013.00081","article-title":"Variation between populations in the innate immune response to vaccine adjuvants","volume":"4","author":"Kollmann","year":"2013","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.vaccine.2014.01.057_bib0270","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nrmicro1550","article-title":"Global measles elimination","volume":"4","author":"Moss","year":"2006","journal-title":"Nat Rev Microbiol"},{"issue":"3","key":"10.1016\/j.vaccine.2014.01.057_bib0275","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1462-5822.2003.00264.x","article-title":"Toll receptors and pathogen resistance","volume":"5","author":"Takeda","year":"2003","journal-title":"Cell Microbiol"},{"issue":"5","key":"10.1016\/j.vaccine.2014.01.057_bib0280","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1128\/JVI.80.5.2463-2471.2006","article-title":"Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection","volume":"80","author":"Speelmon","year":"2006","journal-title":"J Virol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14001091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14001091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T12:58:39Z","timestamp":1565182719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X14001091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":56,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0264410X14001091"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.01.057","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The link between genetic variation and variability in vaccine responses: Systematic review and meta-analyses","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.01.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}