{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:28:40Z","timestamp":1789450120593,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.vaccine.2014.03.010","type":"journal-article","created":{"date-parts":[[2014,3,23]],"date-time":"2014-03-23T00:45:40Z","timestamp":1395535540000},"page":"2604-2609","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Changes in meningococcal C epidemiology and vaccine effectiveness after vaccine introduction and schedule modification"],"prefix":"10.1016","volume":"32","author":[{"given":"M.","family":"Garrido-Estepa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Le\u00f3n-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Herruzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2014.03.010_bib0005","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1016\/j.vaccine.2005.03.045","article-title":"Impact and effectiveness of meningococcal C conjugate vaccine following its introduction in Spain","volume":"23","author":"Larrauri","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0010","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0140-6736(04)16725-1","article-title":"Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction","volume":"364","author":"Trotter","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0015","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1128\/CVI.00384-09","article-title":"Kinetics of antibody persistence following administration of a combination meningococcal serogroup C and haemophilus influenzae type b conjugate vaccine in healthy infants in the United Kingdom primed with a monovalent meningococcal serogroup C vaccine","volume":"17","author":"Borrow","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0020","doi-asserted-by":"crossref","first-page":"e12144","DOI":"10.1371\/journal.pone.0012144","article-title":"Immunity against Neisseria meningitidis serogroup C in the Dutch population before and after introduction of the meningococcal c conjugate vaccine","volume":"5","author":"de Voer","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0025","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1086\/652765","article-title":"Antibody persistence after serogroup C meningococcal conjugate immunization of United Kingdom primary-school children in 1999-2000 and response to a booster: a phase 4 clinical trial","volume":"50","author":"Perrett","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0030","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1097\/INF.0b013e3181d9e653","article-title":"Antibody persistence 12 months after a booster dose of meningococcal-C conjugated vaccine in the second year of life","volume":"29","author":"Diez-Domingo","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0035","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1097\/INF.0b013e318262528c","article-title":"Persistence of antibody response following a booster dose of Hib-MenC-TT glycoconjugate vaccine to five years: a follow-up study","volume":"31","author":"Khatami","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0040","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/00006454-200208000-00010","article-title":"Safety and immunogenicity of meningococcus serogroup C conjugate vaccine administered as a primary or booster vaccination to healthy four-year-old children","volume":"21","author":"McVernon","year":"2002","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0045","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1136\/archdischild-2013-303893","article-title":"Long-term seroprotection after an adolescent booster meningococcal serogroup C vaccination","volume":"98","author":"de Whalley","year":"2013","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0050","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1086\/317646","article-title":"Ability of 3 different meningococcal C conjugate vaccines to induce immunologic memory after a single dose in UK toddlers","volume":"183","author":"Richmond","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0055","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1016\/j.vaccine.2009.05.047","article-title":"Investigation of serum bactericidal activity in childhood and adolescence 3-6 years after vaccination with a single dose of serogroup C meningococcal conjugate vaccine","volume":"27","author":"Sakou","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0060","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1136\/bmj.39563.545255.AE","article-title":"Seroprotection against serogroup C meningococcal disease in adolescents in the United Kingdom: observational study","volume":"336","author":"Snape","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0065","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1128\/CVI.00279-08","article-title":"Seroprevalence of antibodies against serogroup C meningococci in England in the postvaccination era","volume":"15","author":"Trotter","year":"2008","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0070","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1016\/j.vaccine.2006.02.010","article-title":"Relative efficacy of different immunization schedules for the prevention of serogroup C meningococcal disease: a model-based evaluation","volume":"24","author":"De","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0075","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2334-12-35","article-title":"Is a single dose of meningococcal serogroup C conjugate vaccine sufficient for protection? experience from the Netherlands","volume":"12","author":"Kaaijk","year":"2012","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0080","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1016\/j.vaccine.2013.04.070","article-title":"Single priming dose of meningococcal group C conjugate vaccine (NeisVac-C(R)) in infants","volume":"31","author":"Poellabauer","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0085","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1128\/CVI.00420-08","article-title":"Immunogenicity of a reduced schedule of meningococcal group C conjugate vaccine given concomitantly with the Prevenar and Pediacel vaccines in healthy infants in the United Kingdom","volume":"16","author":"Southern","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0090","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1016\/j.vaccine.2007.04.071","article-title":"Vaccinating adolescents against meningococcal disease in Canada: a cost-effectiveness analysis","volume":"25","author":"De","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0095","first-page":"72","article-title":"Updated recommendations for use of meningococcal conjugate vaccines-Advisory Committee on Immunization Preactices (ACIP), 2010","author":"Centers for Disease Control and Prevention","year":"2011","journal-title":"Morbid Mortal Wkly Re"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF01682161","article-title":"Increasing incidence of meningococcal disease in Spain associated with a new variant of serogroup C","volume":"17","author":"Berron","year":"1998","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0105","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2807\/esm.02.10.00146-en","article-title":"Changing epidemiology of meningococcal disease in Spain, 1989-1997","volume":"2","author":"Mateo","year":"1997","journal-title":"Euro Surveill"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0110","unstructured":"Vaccination coverages. Ministry of Health, Social Services and Equality. 2013. Available at: http:\/\/www.msssi.gob.es\/en\/profesionales\/saludPublica\/prevPromocion\/vacunaciones\/coberturas.htm."},{"key":"10.1016\/j.vaccine.2014.03.010_bib0115","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/ije\/22.4.742","article-title":"Estimation of vaccine effectiveness using the screening method","volume":"22","author":"Farrington","year":"1993","journal-title":"Int J Epidemiol"},{"issue":"Suppl 2","key":"10.1016\/j.vaccine.2014.03.010_bib0120","doi-asserted-by":"crossref","first-page":"B20","DOI":"10.1016\/j.vaccine.2009.04.067","article-title":"Meningococcal C conjugate vaccine: the experience in England and Wales","volume":"27","author":"Campbell","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0125","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1574-695X.1999.tb01716.x","article-title":"Recent emergence of serogroup C meningococcal disease in Greece","volume":"23","author":"Kremastinou","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.vaccine.2014.03.010_bib0130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1086\/504804","article-title":"Increased case-fatality rate associated with outbreaks of Neisseria meningitidis infection, compared with sporadic meningococcal disease, in the United States, 1994-2002","volume":"43","author":"Brooks","year":"2006","journal-title":"Clin Infect Dis"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14003545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14003545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T20:43:34Z","timestamp":1648673014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X14003545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":26,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0264410X14003545"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.03.010","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in meningococcal C epidemiology and vaccine effectiveness after vaccine introduction and schedule modification","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}