{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T18:15:13Z","timestamp":1785089713864,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.vaccine.2014.04.047","type":"journal-article","created":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T07:00:16Z","timestamp":1399014016000},"page":"3495-3500","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Non-invasive pneumococcal serotypes and antimicrobial susceptibilities in a paediatric hospital in the era of conjugate vaccines"],"prefix":"10.1016","volume":"32","author":[{"given":"Martha","family":"McElligott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imelda","family":"Vickers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Cafferkey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Cunney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Humphreys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2014.04.047_bib0005","doi-asserted-by":"crossref","first-page":"e60848","DOI":"10.1371\/journal.pone.0060848","article-title":"Epidemiology of Streptococcus pneumoniae serogroup 6 isolates from IPD in children and adults in Germany","volume":"8","author":"van der Linden","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0010","series-title":"Surveillance of Invasive Pneumococcal Disease in Europe","author":"European Centre for Disease Control","year":"2010"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0015","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1473-3099(04)00938-7","article-title":"Streptococcus pneumoniae colonisation: the key to pneumococcal disease","volume":"4","author":"Bogaert","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0020","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/01.inf.0000220231.79968.f6","article-title":"Site-specific disease potential of individual Streptococcus pneumoniae serotypes in pediatric invasive disease, acute otitis media and acute conjunctivitis","volume":"25","author":"Shouval","year":"2006","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0025","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/1471-2334-11-239","article-title":"Increase in serotype 19A prevalence and amoxicillin non-susceptibility among paediatric Streptococcus pneumoniae isolates from middle ear fluid in a passive laboratory-based surveillance in Spain, 1997\u20132009","volume":"11","author":"Fenoll","year":"2011","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0030","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s10096-011-1251-9","article-title":"Epidemiology of Streptococcus pneumoniae in France before introduction of the PCV-13 vaccine","volume":"30","author":"Grall","year":"2011","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0035","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/INF.0b013e31824214ac","article-title":"Pneumococcal carriage and antibiotic resistance in young children before 13-valent conjugate vaccine","volume":"3","author":"Wroe","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0040","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1056\/NEJMoa051642","article-title":"Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae","volume":"6","author":"Kyaw","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0045","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1471-2334-12-207","article-title":"Prevention of pneumococcal diseases in the post-seven valent vaccine era: a European perspective","volume":"12","author":"Weil-Olivier","year":"2012","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0050","unstructured":"Routine Childhood Immunisation Schedule, <http:\/\/www.immunisation.ie\/en\/Downloads\/NIACGuidelines\/PDFFile_17423_en.pdf%3Fgt; [last accessed February 2014]."},{"key":"10.1016\/j.vaccine.2014.04.047_bib0055","unstructured":"Summary Immunisation Uptake Statistics, <http:\/\/www.hpsc.ie\/hpsc\/A-Z\/VaccinePreventable\/Vaccination\/ImmunisationUptakeStatistics\/Immunisationuptakestatisticsat12and24monthsofage\/File,954,en.pdf%3Fgt; [last accessed February 2014]."},{"issue":"Suppl. 3","key":"10.1016\/j.vaccine.2014.04.047_bib0060","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1469-0691.2009.02726.x","article-title":"Impact of pneumococcal conjugate vaccine on infections caused by antibiotic-resistant Streptococcus pneumoniae","volume":"15","author":"Dagan","year":"2009","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0065","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1128\/JCM.41.8.3641-3648.2003","article-title":"Penicillin susceptibility and epidemiological typing of invasive pneumococcal isolates in the Republic of Ireland","volume":"41","author":"Bennett","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0070","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1017\/S0950268810001743","article-title":"Serotype distribution of Streptococcus pneumoniae causing invasive disease in the Republic of Ireland","volume":"139","author":"Vickers","year":"2011","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0075","series-title":"Epidemiology of invasive Streptococcus pneumoniae infection in Ireland","author":"Health Protection Surveillance Centre","year":"2011"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0080","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1128\/JCM.35.5.1077-1079.1997","article-title":"Comparison of four different sampling methods for detecting pharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children","volume":"35","author":"Rapola","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0085","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10096-010-1108-7","article-title":"Multiplex PCR to determine Streptococcus pneumoniae serotypes causing otitis media in the Republic of Ireland with further characterisation of antimicrobial susceptibilities and genotypes","volume":"30","author":"Vickers","year":"2011","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0090","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.vaccine.2009.12.078","article-title":"Capacity of serotype 19A and 15B\/C Streptococcus pneumoniae isolates for experimental otitis media: implications for the conjugate vaccine","volume":"28","author":"Laufer","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0095","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1086\/606118","article-title":"First report of putative Streptococcus pneumoniae serotype 6D among nasopharyngeal isolates from Fijian children","volume":"200","author":"Jin","year":"2009","journal-title":"J Infect Dis"},{"issue":"August (8)","key":"10.1016\/j.vaccine.2014.04.047_bib0100","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1128\/JCM.00484-09","article-title":"Simple, accurate, serotype-specific PCR assay to differentiate Streptococcus pneumoniae serotypes 6A, 6B, and 6C","volume":"47","author":"Jin","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0105","series-title":"Performance standards for antimicrobial susceptibility testing; twenty-third information supplement. CLSI document M100-S23","author":"Clinical Laboratory Standards Institute","year":"2013"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0110","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1086\/343824","article-title":"Antimicrobial use and serotype distribution of nasopharyngeal Streptococcus pneumoniae isolates recovered from Greek children younger than 2 years old","volume":"35","author":"Syrogiannopoulos","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0115","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1097\/00006454-200211000-00007","article-title":"Multinational study of pneumococcal serotypes causing acute otitis media in children","volume":"21","author":"Hausdorff","year":"2002","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0120","doi-asserted-by":"crossref","first-page":"E298","DOI":"10.1111\/1469-0691.12196","article-title":"Streptococcus pneumoniae ocular infections, prominent role of unencapsulated isolates in conjunctivitis","volume":"19","author":"Marimon","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0125","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.vaccine.2011.01.027","article-title":"Pneumococcal serotype distribution and antimicrobial resistance in Chinese children hospitalized for pneumonia","volume":"29","author":"Yao","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0130","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1086\/374624","article-title":"Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential","volume":"187","author":"Brueggemann","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0135","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1128\/JCM.01763-10","article-title":"Analysis of invasiveness of pneumococcal serotypes and clones circulating in Portugal before widespread use of conjugate vaccines reveals heterogeneous behavior of clones expressing the same serotype","volume":"49","author":"S\u00e1-Le\u00e3o","year":"2011","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0140","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2431-9-52","article-title":"Streptococcus pneumoniae serotype 3 among Costa Rican children with otitis media: clinical, epidemiological characteristics and antimicrobial resistance patterns","volume":"9","author":"Abdelnour","year":"2009","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0145","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1016\/j.vaccine.2009.03.017","article-title":"Pneumococcal serotype 3 otitis media, limited effect of polysaccharide conjugate immunisation and strain characteristics","volume":"27","author":"Poolman","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0150","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijantimicag.2012.03.001","article-title":"Variations in serotypes and susceptibility of adult non-invasive Streptococcus pneumoniae isolates between the periods before (May 2000\u2013May 2001) and 10 years after (May 2010\u2013May 2011) introduction of conjugate vaccines for child immunisation in Spain","volume":"40","author":"Fenoll","year":"2012","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0155","doi-asserted-by":"crossref","first-page":"8882","DOI":"10.1016\/j.vaccine.2011.09.074","article-title":"Dynamics of Streptococcus pneumoniae nasopharyngeal carriage with high heptavalent pneumococcal conjugate vaccine coverage in Central Greece","volume":"29","author":"Grivea","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0160","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1016\/j.vaccine.2011.04.004","article-title":"Declining serotype coverage of new pneumococcal conjugate vaccines relating to the carriage of Streptococcus pneumoniae in young children","volume":"29","author":"Tocheva","year":"2011","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.vaccine.2014.04.047_bib0165","doi-asserted-by":"crossref","first-page":"e1000081","DOI":"10.1371\/journal.pmed.1000081","article-title":"Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study","volume":"6","author":"Harboe","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0170","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1086\/498043","article-title":"Postvaccine genetic structure of Streptococcus pneumoniae serotype 19A from children in the United States","volume":"192","author":"Pai","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0175","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1128\/AAC.01201-12","article-title":"Serotype distribution and antimicrobial resistance of invasive pneumococcal disease strains in the Comunidad Valenciana, Spain, during the winter of 2009\u20132010: low PCV7 coverage and high levofloxacin resistance","volume":"56","author":"Gant","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0180","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/1471-2334-12-255","article-title":"Macrolide resistance determinants among Streptococcus pneumoniae isolates from carriers in Central Greece","volume":"12","author":"Grivea","year":"2012","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0185","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1542\/peds.2008-3099","article-title":"Continued impact of pneumococcal conjugate vaccine on carriage in young children","volume":"124","author":"Huang","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0190","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3201\/eid1907.121830","article-title":"Pneumococcal serotypes before and after introduction of conjugate vaccines, United States, 1999\u20132011(1)","volume":"19","author":"Richter","year":"2013","journal-title":"Emerg Infect Dis"},{"issue":"11","key":"10.1016\/j.vaccine.2014.04.047_bib0195","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/j.1469-0691.2009.02775.x","article-title":"Changes in pneumococcal serotypes and antibiotypes carried by vaccinated and unvaccinated day-care centre attendees in Portugal, a country with widespread use of the seven-valent pneumococcal conjugate vaccine","volume":"15","author":"S\u00e1-Le\u00e3o","year":"2009","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.vaccine.2014.04.047_bib0200","series-title":"Surveillance of Antimicrobial Consumption in Europe","year":"2010"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14005854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14005854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T18:54:40Z","timestamp":1597776880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X14005854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":40,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0264410X14005854"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.04.047","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-invasive pneumococcal serotypes and antimicrobial susceptibilities in a paediatric hospital in the era of conjugate vaccines","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.04.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}