{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:19:37Z","timestamp":1778545177675,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"35","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program","doi-asserted-by":"crossref","award":["2011CB504903"],"award-info":[{"award-number":["2011CB504903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National High-Tech R&D Program","award":["2012AA02A404"],"award-info":[{"award-number":["2012AA02A404"]}]},{"name":"Important National Science & Technology Specific Projects","award":["2012ZX09101319002"],"award-info":[{"award-number":["2012ZX09101319002"]}]},{"name":"Important National Science & Technology Specific Projects","award":["2014ZX09102042"],"award-info":[{"award-number":["2014ZX09102042"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171573"],"award-info":[{"award-number":["81171573"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31370192"],"award-info":[{"award-number":["31370192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Natural Science Foundation","award":["2013FA024"],"award-info":[{"award-number":["2013FA024"]}]},{"name":"Yunnan Natural Science Foundation","award":["2012ZA009"],"award-info":[{"award-number":["2012ZA009"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.vaccine.2014.06.062","type":"journal-article","created":{"date-parts":[[2014,6,21]],"date-time":"2014-06-21T08:30:31Z","timestamp":1403339431000},"page":"4436-4442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Coxsackievirus A 16 infection does not interfere with the specific immune response induced by an enterovirus 71 inactivated vaccine in rhesus monkeys"],"prefix":"10.1016","volume":"32","author":[{"given":"Jingjing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longding","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchun","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanlong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuaiyao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2014.06.062_bib0005","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3201\/eid1301.020112","article-title":"Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore","volume":"9","author":"Chan","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1574-6976.2002.tb00601.x","article-title":"An overview of the evolution of enterovirus 71 and its clinical and public health significance","volume":"26","author":"McMinn","year":"2002","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0015","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1086\/314032","article-title":"Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the outbreak study group","volume":"31","author":"Chan","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0020","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An epidemic of enterovirus 71 infection in Taiwan Taiwan Enterovirus Epidemic Working Group","volume":"341","author":"Ho","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0025","first-page":"629","article-title":"Deaths among children during an outbreak of hand, foot, and mouth disease\u2014Taiwan, Republic of China, April\u2013July 1998","volume":"47","author":"MMWR","year":"1998","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0030","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0022-3476(98)70155-6","article-title":"Fatal enterovirus 71 encephalomyelitis","volume":"133","author":"Lum","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0035","doi-asserted-by":"crossref","first-page":"12","DOI":"10.7883\/yoken.52.12","article-title":"Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997\u20131998","volume":"52","author":"Shimizu","year":"1999","journal-title":"Jpn J Infect Dis"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0040","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1586\/14760584.2014.897617","article-title":"Development of enterovirus 71 vaccines: from the lab bench to Phase III clinical trials","volume":"13","author":"Li","year":"2014","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0045","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.vaccine.2011.11.087","article-title":"Selection and characterization of vaccine strain for enterovirus 71 vaccine development","volume":"30","author":"Chang","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0050","doi-asserted-by":"crossref","first-page":"e59501","DOI":"10.1371\/journal.pone.0059501","article-title":"Adaptation of enterovirus 71 to adult interferon deficient mice","volume":"8","author":"Caine","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0055","first-page":"211","article-title":"Progress in research of new human enterovirus types","volume":"29","author":"Chen","year":"2013","journal-title":"Bing Du Xue Bao"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2014.03.012","article-title":"A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits a balanced protective immunity against both viruses","author":"Cai","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0065","doi-asserted-by":"crossref","first-page":"e69858","DOI":"10.1371\/journal.pone.0069858","article-title":"Protective efficacy of VP1-specific neutralizing antibody associated with a reduction of viral load and pro-inflammatory cytokines in human SCARB2-transgenic mice","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.virusres.2013.04.015","article-title":"Analysis and solution of false-positives when testing CVA16 sera using an antibody assay against the EV71 virus","volume":"176","author":"Wang","year":"2013","journal-title":"Virus Res"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0075","doi-asserted-by":"crossref","first-page":"e1025","DOI":"10.1016\/j.ijid.2013.04.003","article-title":"Characterization of enterovirus 71 and coxsackievirus A16 isolated in hand, foot, and mouth disease patients in Guangdong, 2010","volume":"17","author":"He","year":"2013","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0080","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/labinvest.2011.82","article-title":"Pathogenesis study of enterovirus 71 infection in rhesus monkeys","volume":"91","author":"Zhang","year":"2011","journal-title":"Lab Invest"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0085","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1016\/j.vaccine.2011.06.044","article-title":"Immunoprotection elicited by an enterovirus type 71 experimental inactivated vaccine in mice and rhesus monkeys","volume":"29","author":"Dong","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0090","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s11427-012-4313-z","article-title":"A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B)","volume":"55","author":"Yang","year":"2012","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0095","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.4161\/hv.6.12.12982","article-title":"Optimized development of a candidate strain of inactivated EV71 vaccine and analysis of its immunogenicity in rhesus monkeys","volume":"6","author":"Dong","year":"2010","journal-title":"Hum Vaccines"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0100","series-title":"Guide for the care and use of laboratory animals","author":"Anim","year":"2011"},{"key":"#cr-split#-10.1016\/j.vaccine.2014.06.062_bib0180.1","unstructured":"Ministry of Science and Technology of the People's Republic of China. China The Guidance to experimental animal welfare and ethical treatment. [updated 2006 Sep 30"},{"key":"#cr-split#-10.1016\/j.vaccine.2014.06.062_bib0180.2","unstructured":"cited 2014 Mar 1]. Available from: http:\/\/www.most.gov.cn\/fggw\/zfwj\/zfwj2006\/200609\/t20060930_54389.htm."},{"key":"10.1016\/j.vaccine.2014.06.062_bib0110","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1099\/vir.0.82172-0","article-title":"Quantitative analysis of poliomyelitis-like paralysis in mice induced by a poliovirus replicon","volume":"87","author":"Arita","year":"2006","journal-title":"J Gen Virol"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0115","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/s10875-012-9690-3","article-title":"Analysis of the Th1\/Th2 reaction in the immune response induced by EV71 inactivated vaccine in neonatal rhesus monkeys","volume":"32","author":"Liang","year":"2012","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0120","series-title":"Guide for the care and use of laboratory animals","year":"2011"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0125","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1097\/00006454-199912000-00013","article-title":"Comparison of enterovirus 71 and coxsackievirus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998","volume":"18","author":"Chang","year":"1999","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.virol.2010.12.058","article-title":"Neonatal rhesus monkey is a potential animal model for studying pathogenesis of EV71 infection","volume":"412","author":"Liu","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0135","doi-asserted-by":"crossref","first-page":"e54451","DOI":"10.1371\/journal.pone.0054451","article-title":"Study of the integrated immune response induced by an inactivated EV71 vaccine","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0140","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/1471-2334-12-224","article-title":"Excessive proinflammatory cytokine and chemokine responses of human monocyte-derived macrophages to enterovirus 71 infection","volume":"12","author":"Gong","year":"2012","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0145","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa1303224","article-title":"An inactivated enterovirus 71 vaccine in healthy children","volume":"370","author":"Li","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0150","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0140-6736(12)61764-4","article-title":"Immunogenicity and safety of an enterovirus 71 vaccine in healthy Chinese children and infants: a randomised, double-blind, placebo-controlled phase 2 clinical trial","volume":"381","author":"Zhu","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0155","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/S0140-6736(13)61049-1","article-title":"Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","volume":"381","author":"Zhu","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0160","first-page":"2014","article-title":"Comparative study of the immunogenicity in mice and monkeys of an inactivated CA16 vaccine made from a human diploid cell line","author":"Yang","year":"2014","journal-title":"Hum Vaccines Immunotherapeutics"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0165","doi-asserted-by":"crossref","first-page":"11967","DOI":"10.1128\/JVI.00902-12","article-title":"A neonatal mouse model of coxsackievirus A16 for vaccine evaluation","volume":"86","author":"Mao","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0170","doi-asserted-by":"crossref","first-page":"e80515","DOI":"10.1371\/journal.pone.0080515","article-title":"Seroprevalence of human enterovirus 71 and coxsackievirus A16 in Guangdong, China, in pre- and post-2010 HFMD epidemic period","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2014.06.062_bib0175","first-page":"361","article-title":"Epidemiological and etiological characteristics of hand-foot-mouth disease in Ningbo, Zhejiang province, 2008\u20132011","volume":"34","author":"Xu","year":"2013","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14008639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14008639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:22:35Z","timestamp":1759400555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X14008639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":36,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0264410X14008639"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.06.062","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coxsackievirus A 16 infection does not interfere with the specific immune response induced by an enterovirus 71 inactivated vaccine in rhesus monkeys","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.06.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}