{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:37:35Z","timestamp":1783510655743,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"40","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["BIO2011-23555"],"award-info":[{"award-number":["BIO2011-23555"]}]},{"name":"European FP7 grant NEWTBVAC","award":["241745"],"award-info":[{"award-number":["241745"]}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"crossref","award":["BES-2009-013037"],"award-info":[{"award-number":["BES-2009-013037"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"crossref","award":["B149\/2010"],"award-info":[{"award-number":["B149\/2010"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.vaccine.2014.07.047","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T04:30:10Z","timestamp":1406262610000},"page":"5192-5197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice"],"prefix":"10.1016","volume":"32","author":[{"given":"Luis","family":"Solans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Uranga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nacho","family":"Aguilo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Arnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Belen","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Monzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jose","family":"Badiola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Gicquel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2993-5478","authenticated-orcid":false,"given":"Carlos","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2014.07.047_bib0005","unstructured":"WHO. Tuberculosis. 2013 (accessed 11.06.13)."},{"key":"10.1016\/j.vaccine.2014.07.047_bib0010","series-title":"Information sheet: observed rate of vaccine reactions bacille Calmette\u2013Gh\u00e9rin (BCG) vaccine","author":"WHO","year":"2012"},{"issue":"July (4)","key":"10.1016\/j.vaccine.2014.07.047_bib0015","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.tube.2007.11.010","article-title":"Adverse reactions to Mycobacterium bovis bacille Calmette\u2013Guerin (BCG) vaccination against tuberculosis in humans, veterinary animals and wildlife species","volume":"88","author":"Murphy","year":"2008","journal-title":"Tuberculosis (Edinb)"},{"issue":"September (9641)","key":"10.1016\/j.vaccine.2014.07.047_bib0020","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0140-6736(08)61318-5","article-title":"Vaccination programmes safer in the HIV era","volume":"372","author":"Mak","year":"2008","journal-title":"Lancet"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2014.07.047_bib0025","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.vaccine.2006.07.020","article-title":"The risk of disseminated Bacille Calmette\u2013Guerin (BCG) disease in HIV-infected children","volume":"25","author":"Hesseling","year":"2007","journal-title":"Vaccine"},{"issue":"December (12)","key":"10.1016\/j.vaccine.2014.07.047_bib0030","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1586\/14760584.2013.856765","article-title":"Recent developments in tuberculosis vaccines","volume":"12","author":"Marinova","year":"2013","journal-title":"Expert Rev Vaccines"},{"issue":"October (42)","key":"10.1016\/j.vaccine.2014.07.047_bib0035","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1016\/j.vaccine.2013.07.051","article-title":"Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials","volume":"31","author":"Arbues","year":"2013","journal-title":"Vaccine"},{"issue":"May (29)","key":"10.1016\/j.vaccine.2014.07.047_bib0040","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1016\/j.vaccine.2005.03.001","article-title":"New live mycobacterial vaccines: the Geneva consensus on essential steps towards clinical development","volume":"23","author":"Kamath","year":"2005","journal-title":"Vaccine"},{"issue":"March (11)","key":"10.1016\/j.vaccine.2014.07.047_bib0045","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.vaccine.2009.12.083","article-title":"The second Geneva consensus: commendations for novel live TB vaccines","volume":"28","author":"Walker","year":"2010","journal-title":"Vaccine"},{"issue":"October (5389)","key":"10.1016\/j.vaccine.2014.07.047_bib0050","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1126\/science.282.5389.759","article-title":"Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene","volume":"282","author":"Berthet","year":"1998","journal-title":"Science"},{"issue":"July (4)","key":"10.1016\/j.vaccine.2014.07.047_bib0055","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tube.2004.11.002","article-title":"Mutation in the P36 gene of Mycobacterium bovis provokes attenuation of the bacillus in a mouse model","volume":"85","author":"Bigi","year":"2005","journal-title":"Tuberculosis (Edinb)"},{"issue":"August (Pt 8)","key":"10.1016\/j.vaccine.2014.07.047_bib0060","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1099\/00221287-147-8-2315","article-title":"Erp, an extracellular protein family specific to mycobacteria","volume":"147","author":"de Mendonca-Lima","year":"2001","journal-title":"Microbiology"},{"issue":"January (1)","key":"10.1016\/j.vaccine.2014.07.047_bib0065","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1462-5822.2003.00237.x","article-title":"The allele encoding the mycobacterial Erp protein affects lung disease in mice","volume":"5","author":"de Mendonca-Lima","year":"2003","journal-title":"Cell Microbiol"},{"issue":"June (6)","key":"10.1016\/j.vaccine.2014.07.047_bib0070","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1128\/IAI.02061-05","article-title":"Mycobacterium marinum Erp is a virulence determinant required for cell wall integrity and intracellular survival","volume":"74","author":"Cosma","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.07.047_bib0075","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/0470846526.ch12","article-title":"Analysis of the genome of Mycobacterium tuberculosis H37Rv","volume":"217","author":"Cole","year":"1998","journal-title":"Novartis Found Symp"},{"issue":"September (5)","key":"10.1016\/j.vaccine.2014.07.047_bib0080","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.tube.2012.06.002","article-title":"Genetic engineering of Mycobacterium tuberculosis: a review","volume":"92","author":"Lamrabet","year":"2012","journal-title":"Tuberculosis (Edinb)"},{"issue":"April (17)","key":"10.1016\/j.vaccine.2014.07.047_bib0085","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1016\/j.vaccine.2006.03.017","article-title":"The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs","volume":"24","author":"Martin","year":"2006","journal-title":"Vaccine"},{"issue":"March (13)","key":"10.1016\/j.vaccine.2014.07.047_bib0090","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.1073\/pnas.0700869104","article-title":"Genome plasticity of BCG and impact on vaccine efficacy","volume":"104","author":"Brosch","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"May (5)","key":"10.1016\/j.vaccine.2014.07.047_bib0095","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1128\/IAI.68.5.2888-2898.2000","article-title":"Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis","volume":"68","author":"Hondalus","year":"2000","journal-title":"Infect Immun"},{"issue":"July (7)","key":"10.1016\/j.vaccine.2014.07.047_bib0100","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1128\/IAI.71.7.4190-4192.2003","article-title":"Vaccine efficacy of a lysine auxotroph of Mycobacterium tuberculosis","volume":"71","author":"Pavelka","year":"2003","journal-title":"Infect Immun"},{"issue":"October (10)","key":"10.1016\/j.vaccine.2014.07.047_bib0105","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nm765","article-title":"A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis","volume":"8","author":"Sambandamurthy","year":"2002","journal-title":"Nat Med"},{"issue":"May (5)","key":"10.1016\/j.vaccine.2014.07.047_bib0110","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1128\/IAI.72.5.3031-3037.2004","article-title":"Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs","volume":"72","author":"Sampson","year":"2004","journal-title":"Infect Immun"},{"issue":"February (2)","key":"10.1016\/j.vaccine.2014.07.047_bib0115","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1128\/IAI.73.2.1196-1203.2005","article-title":"Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis","volume":"73","author":"Sambandamurthy","year":"2005","journal-title":"Infect Immun"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14009906?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14009906?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T03:12:24Z","timestamp":1589253144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X14009906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":23,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0264410X14009906"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.07.047","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.07.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}