{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:32:58Z","timestamp":1779118378925,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"40","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Institute of Health","award":["2P01 AI056320, 1R01AI100138 and R01 AI076408"],"award-info":[{"award-number":["2P01 AI056320, 1R01AI100138 and R01 AI076408"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.vaccine.2014.07.050","type":"journal-article","created":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T13:01:08Z","timestamp":1406379668000},"page":"5212-5220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Fc receptor-targeting of immunogen as a strategy for enhanced antigen loading, vaccination, and protection using intranasally administered antigen-pulsed dendritic cells"],"prefix":"10.1016","volume":"32","author":[{"given":"Giang H.","family":"Pham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibiana V.","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund J.","family":"Gosselin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2014.07.050_bib0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0010","doi-asserted-by":"crossref","first-page":"869718","DOI":"10.1155\/2013\/869718","article-title":"Targeting antigens to dendritic cell receptors for vaccine development","volume":"2013","author":"Apostolopoulos","year":"2013","journal-title":"J Drug Deliv"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0015","first-page":"9","article-title":"Dendritic cell based vaccines for HIV infection: the way ahead","author":"Garcia","year":"2013","journal-title":"Hum Vac Immunother"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0020","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1172\/JCI67550","article-title":"Antigen-activated dendritic cells ameliorate influenza A infections","volume":"123","author":"Boonnak","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0025","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nri2173","article-title":"Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting","volume":"7","author":"Tacken","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0030","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.4049\/jimmunol.0900364","article-title":"Targeting a mimotope vaccine to activating Fcgamma receptors empowers dendritic cells to prime specific CD8+ T cell responses in tumor-bearing mice","volume":"183","author":"Gil","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0035","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.4049\/jimmunol.180.8.5548","article-title":"Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensis","volume":"180","author":"Rawool","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0040","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1146\/annurev.immunol.18.1.709","article-title":"Regulation of antibody responses via antibodies, complement, and Fc receptors","volume":"18","author":"Heyman","year":"2000","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0045","doi-asserted-by":"crossref","first-page":"6738","DOI":"10.4049\/jimmunol.165.12.6738","article-title":"Targeting weak antigens to CD64 elicits potent humoral responses in human CD64 transgenic mice","volume":"165","author":"Keler","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1172\/JCI118420","article-title":"Antigen targeting to myeloid-specific human Fc gamma RI\/CD64 triggers enhanced antibody responses in transgenic mice","volume":"97","author":"Heijnen","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0055","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.4049\/jimmunol.149.11.3477","article-title":"Enhanced antigen presentation using human Fc gamma receptor (monocyte\/macrophage)-specific immunogens","volume":"149","author":"Gosselin","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0060","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1128\/IAI.05511-11","article-title":"Mucosal immunization with an unadjuvanted vaccine that targets Streptococcus pneumoniae PspA to human Fcgamma receptor type I protects against pneumococcal infection through complement- and lactoferrin-mediated bactericidal activity","volume":"80","author":"Bitsaktsis","year":"2012","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0065","doi-asserted-by":"crossref","first-page":"846","DOI":"10.4049\/jimmunol.170.2.846","article-title":"A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation","volume":"170","author":"Sedlik","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0070","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/icb.2012.66","article-title":"Multiple mechanisms mediate enhanced immunity generated by mAb-inactivated F. tularensis immunogen","volume":"91","author":"Iglesias","year":"2013","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0075","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0169-409X(01)00162-4","article-title":"Nasal vaccines","volume":"51","author":"Davis","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0080","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2172-11-60","article-title":"In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine","volume":"11","author":"Vilekar","year":"2010","journal-title":"BMC Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0085","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/B978-0-12-417028-5.00002-8","article-title":"Dendritic cell migration through the lymphatic vasculature to lymph nodes","volume":"120","author":"Platt","year":"2013","journal-title":"Adv Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0090","doi-asserted-by":"crossref","first-page":"8440","DOI":"10.4049\/jimmunol.177.12.8440","article-title":"Regulated expression of FcgammaR in human dendritic cells controls cross-presentation of antigen\u2013antibody complexes","volume":"177","author":"Liu","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0095","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.4049\/jimmunol.0803242","article-title":"Differential requirements for protection against mucosal challenge with Francisella tularensis in the presence versus absence of cholera toxin B and inactivated F. tularensis","volume":"182","author":"Bitsaktsis","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0100","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1189\/jlb.0411197","article-title":"Development of tolerogenic dendritic cells and regulatory T cells favors exponential bacterial growth and survival during early respiratory tularemia","volume":"90","author":"Periasamy","year":"2011","journal-title":"J Leuk Biol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0105","doi-asserted-by":"crossref","first-page":"8009","DOI":"10.1128\/IAI.73.12.8009-8016.2005","article-title":"Essential role for humoral immunity during Ehrlichia infection in immunocompetent mice","volume":"73","author":"Yager","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0110","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1128\/IAI.72.4.2222-2228.2004","article-title":"Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide, protect SCID mice against fatal Rickettsia conorii infection","volume":"72","author":"Feng","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0115","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S1074-7613(01)00139-X","article-title":"Intracellular antibody neutralizes Listeria growth","volume":"14","author":"Edelson","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0120","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0966-842X(98)01208-6","article-title":"Antibody-mediated protection against intracellular pathogens","volume":"6","author":"Casadevall","year":"1998","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0125","doi-asserted-by":"crossref","first-page":"6874","DOI":"10.1016\/j.vaccine.2008.09.077","article-title":"Levofloxacin rescues mice from lethal intra-nasal infections with virulent Francisella tularensis and induces immunity and production of protective antibody","volume":"26","author":"Klimpel","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0130","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1128\/IAI.00605-10","article-title":"Antibodies contribute to effective vaccination against respiratory infection by type A Francisella tularensis strains","volume":"79","author":"Mara-Koosham","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0135","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1196\/annals.1409.014","article-title":"Innate and adaptive immunity to Francisella","volume":"1105","author":"Elkins","year":"2007","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0140","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.molimm.2012.10.043","article-title":"Correlates of protection following vaccination of mice with gene deletion mutants of Francisella tularensis subspecies tularensis strain, SCHU S4 that elicit varying degrees of immunity to systemic and respiratory challenge with wild-type bacteria","volume":"54","author":"Ryden","year":"2013","journal-title":"Mol Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0145","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.immuni.2009.08.025","article-title":"Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis","volume":"31","author":"Lin","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0150","doi-asserted-by":"crossref","first-page":"e11176","DOI":"10.1371\/journal.pone.0011176","article-title":"The involvement of IL-17A in the murine response to sub-lethal inhalational infection with Francisella tularensis","volume":"5","author":"Markel","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0155","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1128\/IAI.00203-13","article-title":"Interleukin-17 protects against the francisella tularensis live vaccine strain but not against a virulent F. tularensis type A strain","volume":"81","author":"Skyberg","year":"2013","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0160","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/IAI.61.2.689-698.1993","article-title":"Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from l-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice","volume":"61","author":"Green","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0165","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/379346a0","article-title":"Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice","volume":"379","author":"Takai","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0170","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.molimm.2011.12.007","article-title":"Increased incidence of anti-GBM disease in Fcgamma receptor 2b deficient mice, but not mice with conditional deletion of Fcgr2b on either B cells or myeloid cells alone","volume":"50","author":"Sharp","year":"2012","journal-title":"Mol Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0175","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.4049\/jimmunol.1301430","article-title":"Immunotherapy targeting inhibitory Fcgamma receptor IIB (CD32b) in the mouse is limited by monoclonal antibody consumption and receptor internalization","volume":"191","author":"Williams","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0180","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.1210801","article-title":"Immunology. The adjuvant effects of antibodies","volume":"333","author":"Smyth","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0185","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1084\/jem.20020338","article-title":"Inducing tumor immunity through the selective engagement of activating Fcgamma receptors on dendritic cells","volume":"195","author":"Kalergis","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0190","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.2741\/1452","article-title":"Current vaccine adjuvants: an overview of a diverse class","volume":"9","author":"Kensil","year":"2004","journal-title":"Front Biosci"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0195","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.4049\/jimmunol.168.5.2240","article-title":"Antigen-antibody immune complexes empower dendritic cells to efficiently prime specific CD8+ CTL responses in vivo","volume":"168","author":"Schuurhuis","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0200","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1002\/eji.200737620","article-title":"Immunization with heat-killed Francisella tularensis LVS elicits protective antibody-mediated immunity","volume":"37","author":"Lavine","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0205","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1128\/IAI.68.4.1988-1996.2000","article-title":"Purified lipopolysaccharide from Francisella tularensis live vaccine strain (LVS) induces protective immunity against LVS infection that requires B cells and gamma interferon","volume":"68","author":"Dreisbach","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0210","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1128\/IAI.62.8.3129-3137.1994","article-title":"Transfer of immunity against lethal murine Francisella infection by specific antibody depends on host gamma interferon and T cells","volume":"62","author":"Rhinehart-Jones","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0215","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.vaccine.2004.10.034","volume":"23","author":"Conlan","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0220","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.4049\/jimmunol.1000362","article-title":"Lung CD4\u2013CD8-double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain","volume":"184","author":"Cowley","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0225","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1172\/JCI24772","article-title":"Activating inhibitory IgG Fc receptors on human DCs mediate opposing functions","volume":"115","author":"Boruchov","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0230","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.immuni.2005.09.013","article-title":"Cell surface recycling of internalized antigen permits dendritic cell priming of B cells","volume":"23","author":"Bergtold","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0235","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cellimm.2003.09.008","article-title":"Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI\/III-mediated immune complex uptake","volume":"225","author":"Yada","year":"2003","journal-title":"Cell Immunol"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0240","doi-asserted-by":"crossref","first-page":"e11144","DOI":"10.1371\/journal.pone.0011144","article-title":"CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells","volume":"5","author":"Yewdall","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0245","doi-asserted-by":"crossref","first-page":"F23","DOI":"10.1084\/jem.194.5.F23","article-title":"Killing of dendritic cells: a life cut short or a purposeful death?","volume":"194","author":"Ronchese","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2014.07.050_bib0250","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijmm.2007.07.003","article-title":"Mechanisms of dendritic cell-based vaccination against infection","volume":"298","author":"Fajardo-Moser","year":"2008","journal-title":"Int J Med Microbiol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14009931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14009931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T14:12:29Z","timestamp":1689430349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X14009931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":50,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0264410X14009931"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.07.050","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fc receptor-targeting of immunogen as a strategy for enhanced antigen loading, vaccination, and protection using intranasally administered antigen-pulsed dendritic cells","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.07.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}