{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:55:55Z","timestamp":1791741355339,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"45","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Royal Golden Jubilee Ph.D. Program","award":["PHD\/0007\/2548"],"award-info":[{"award-number":["PHD\/0007\/2548"]}]},{"name":"Health Cluster"},{"name":"Melioidosis Research Center, Khon Kaen University, Thailand"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.vaccine.2014.08.035","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T08:20:43Z","timestamp":1410855643000},"page":"5983-5988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of the protective effects of killed Burkholderia pseudomallei and CpG oligodeoxynucleotide against live challenge"],"prefix":"10.1016","volume":"32","author":[{"given":"Apichaya","family":"Puangpetch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Y.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rojana","family":"Saengsot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasana W.","family":"Sermswan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surasakdi","family":"Wongratanacheewin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2014.08.035_bib0005","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0035-9203(00)90333-X","article-title":"Melioidosis: acute and chronic disease, relapse and re-activation","volume":"94","author":"Currie","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0010","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/clinids\/11.3.413","article-title":"Melioidosis: review and update","volume":"11","author":"Leelarasamee","year":"1989","journal-title":"Rev Infect Dis"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0015","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1128\/CMR.18.2.383-416.2005","article-title":"Melioidosis: epidemiology, pathophysiology, and management","volume":"18","author":"Cheng","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0020","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4269\/ajtmh.2010.10-0038","article-title":"Increasing incidence of human melioidosis in Northeast Thailand","volume":"82","author":"Limmathurotsakul","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0025","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0140-6736(03)13374-0","article-title":"Melioidosis","volume":"361","author":"White","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0030","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1099\/jmm.0.47596-0","article-title":"Burkholderia pseudomallei aerosol infection results in differential inflammatory responses in BALB\/c and C57Bl\/6 mice","volume":"57","author":"Tan","year":"2008","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0035","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1128\/IAI.67.7.3593-3600.1999","article-title":"Obligatory role of gamma interferon for host survival in a murine model of infection with Burkholderia pseudomallei","volume":"67","author":"Santanirand","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0040","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/QCO.0b013e328322e727","article-title":"Immunity to Burkholderia pseudomallei","volume":"22","author":"Wiersinga","year":"2009","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0045","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fmicb.2011.00198","article-title":"Development of vaccines against Burkholderia pseudomallei","volume":"2","author":"Patel","year":"2011","journal-title":"Front Microbiol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0050","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1128\/IAI.71.4.1622-1629.2003","article-title":"Flagella are virulence determinants of Burkholderia pseudomallei","volume":"71","author":"Chua","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0055","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1099\/jmm.0.47043-0","article-title":"Polysaccharides and virulence of Burkholderia pseudomallei","volume":"56","author":"Sarkar-Tyson","year":"2007","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0060","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1099\/mic.0.27146-0","article-title":"Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis","volume":"150","author":"Stevens","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0065","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1128\/IAI.00404-07","article-title":"Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis","volume":"75","author":"Harland","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0070","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1574-695X.2007.00345.x","article-title":"Evaluating Burkholderia pseudomallei Bip proteins as vaccines and Bip antibodies as detection agents","volume":"52","author":"Druar","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0075","doi-asserted-by":"crossref","first-page":"e6496","DOI":"10.1371\/journal.pone.0006496","article-title":"Immunogenic Burkholderia pseudomallei outer membrane proteins as potential candidate vaccine targets","volume":"4","author":"Hara","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0080","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1086\/508217","article-title":"A live experimental vaccine against Burkholderia pseudomallei elicits CD4+ T cell-mediated immunity, priming T cells specific for 2 type III secretion system proteins","volume":"194","author":"Haque","year":"2006","journal-title":"J Infect Dis"},{"issue":"Suppl 1","key":"10.1016\/j.vaccine.2014.08.035_bib0085","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1016\/S0035-9203(08)70022-1","article-title":"Induction of protective immunity against Burkholderia pseudomallei using attenuated mutants with defects in the intracellular life cycle","volume":"102","author":"Breitbach","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0090","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1099\/0022-1317-51-12-1055","article-title":"Passive protection against Burkholderia pseudomallei infection in mice by monoclonal antibodies against capsular polysaccharide, lipopolysaccharide or proteins","volume":"51","author":"Jones","year":"2002","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0095","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1128\/IAI.59.7.2252-2258.1991","article-title":"Outer membrane protein A (OmpA) contributes to serum resistance and pathogenicity of Escherichia coli K-1","volume":"59","author":"Weiser","year":"1991","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0100","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1574-695X.1998.tb01219.x","article-title":"Antisera to selected outer membrane proteins of Vibrio cholerae protect against challenge with homologous and heterologous strains of V. cholerae","volume":"22","author":"Das","year":"1998","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0105","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.0105-2896.2004.00148.x","article-title":"Use of CpG oligodeoxynucleotides as immune adjuvants","volume":"199","author":"Klinman","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0110","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1146\/annurev.immunol.20.100301.064842","article-title":"CpG motifs in bacterial DNA and their immune effects","volume":"20","author":"Krieg","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0115","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0264-410X(00)00208-5","article-title":"Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants","volume":"19","author":"McCluskie","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0120","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.4049\/jimmunol.173.8.5148","article-title":"CpG oligodeoxynucleotides stimulate protective innate immunity against pulmonary Klebsiella infection","volume":"173","author":"Deng","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0125","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.4049\/jimmunol.161.5.2428","article-title":"CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge","volume":"161","author":"Krieg","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0130","doi-asserted-by":"crossref","first-page":"4494","DOI":"10.1128\/IAI.72.8.4494-4502.2004","article-title":"Immunostimulatory CpG oligodeoxynucleotide confers protection in a murine model of infection with Burkholderia pseudomallei","volume":"72","author":"Wongratanacheewin","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0135","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1128\/JCM.28.12.2627-2631.1990","article-title":"Modification of the silver staining technique to detect lipopolysaccharide in polyacrylamide gels","volume":"28","author":"Fomsgaard","year":"1990","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0140","doi-asserted-by":"crossref","first-page":"735","DOI":"10.4269\/ajtmh.1999.61.735","article-title":"Short report: evaluation of a monoclonal antibody-based latex agglutination test for rapid diagnosis of septicemic melioidosis","volume":"61","author":"Samosornsuk","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0145","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.4049\/jimmunol.148.12.4072","article-title":"Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity","volume":"148","author":"Yamamoto","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0150","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.4049\/jimmunol.156.12.4570","article-title":"Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides","volume":"156","author":"Cowdery","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0155","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.4049\/jimmunol.162.4.2291","article-title":"Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria","volume":"162","author":"Elkins","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0160","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1128\/CVI.05545-11","article-title":"Cationic liposomes extend the immunostimulatory effect of CpG oligodeoxynucleotide against Burkholderia pseudomallei infection in BALB\/c mice","volume":"19","author":"Puangpetch","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0165","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1128\/CVI.00011-07","article-title":"Use of protein-specific monoclonal antibody-based latex agglutination for rapid diagnosis of Burkholderia pseudomallei infection in patients with community-acquired septicemia","volume":"14","author":"Ekpo","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0170","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/infdis\/jir301","article-title":"Combining vaccination and postexposure CpG therapy provides optimal protection against lethal sepsis in a biodefense model of human melioidosis","volume":"204","author":"Easton","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0175","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.0141-9838.2004.00684.x","article-title":"CpG-containing ODN has a limited role in the protection against Toxoplasma gondii","volume":"26","author":"Saavedra","year":"2004","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0180","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.vaccine.2003.08.035","article-title":"Incorporation of CpG oligodeoxynucleotide fails to enhance the protective efficacy of a subunit vaccine against Mycobacterium tuberculosis","volume":"22","author":"Hsieh","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0185","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1016\/j.vaccine.2009.04.075","article-title":"The co-administration of CpG-ODN influenced protective activity of influenza M2e vaccine","volume":"27","author":"Wu","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.08.035_bib0190","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1128\/IAI.68.5.2948-2953.2000","article-title":"CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis","volume":"68","author":"Freidag","year":"2000","journal-title":"Infect Immun"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1401158X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1401158X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T15:32:09Z","timestamp":1689521529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X1401158X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":38,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0264410X1401158X"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.08.035","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the protective effects of killed Burkholderia pseudomallei and CpG oligodeoxynucleotide against live challenge","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}