{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T18:55:04Z","timestamp":1767034504475},"reference-count":45,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.vaccine.2014.08.067","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T02:30:54Z","timestamp":1410834654000},"page":"7154-7160","source":"Crossref","is-referenced-by-count":14,"title":["Analysis of safety data in children after receiving two doses of ProQuad\u00ae (MMRV)"],"prefix":"10.1016","volume":"32","author":[{"given":"Stephanie O.","family":"Klopfer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon E.","family":"Stek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Petrecz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith S.","family":"Reisinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven B.","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle G.","family":"Goveia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ouzama","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie L.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony D.","family":"Grosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle L.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara J.","family":"Kuter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian P.","family":"Sch\u00f6del","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2014.08.067_bib0005","series-title":"Epidemiology and prevention of vaccine-preventable diseases","year":"2009"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0010","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/INF.0b013e3180616c8f","article-title":"Increasing coverage and efficiency of measles, mumps, and rubella vaccine and introducing universal varicella vaccination in Europe: a role for the combined vaccine","volume":"26","author":"Vesikari","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0015","first-page":"Q1","article-title":"Recommended immunization schedules for persons aged 0\u201318 years: United States, 2008","volume":"57","author":"Centers for Disease Control and Prevention","year":"2008","journal-title":"MMWR"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0020","first-page":"1","article-title":"Measles, mumps, and rubella-vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"47","author":"Watson","year":"1998","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0025","first-page":"1","article-title":"Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"56","author":"Marin","year":"2007","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0030","series-title":"ProQuad\u00ae [package insert]","author":"ProQuad\u00ae","year":"2014"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0035","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1097\/00006454-200111001-00002","article-title":"Principles of pediatric combination vaccines and practical issues related to use in clinical practice","volume":"20","author":"Decker","year":"2001","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0040","first-page":"1","article-title":"Combination vaccines for childhood immunization","volume":"48","author":"MMWR","year":"1999","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0045","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1097\/00006454-200111001-00009","article-title":"Economic value to parents of reducing the pain and emotional distress of childhood vaccine injections","volume":"20","author":"Meyerhoff","year":"2001","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0050","first-page":"1038","article-title":"The effect of additional shots on the vaccine administration process: results of a time-motion study in 2 settings","volume":"6","author":"Pellissier","year":"2000","journal-title":"Am J Manage Care"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0055","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/01.inf.0000076750.50830.25","article-title":"Impact of the introduction of a combined Haemophilus B conjugate vaccine and hepatitis B recombinant vaccine on vaccine coverage rates in a large West Coast health maintenance organization","volume":"22","author":"Davis","year":"2003","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0060","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/archpedi.1994.02170090057008","article-title":"Potential impact on vaccination coverage levels by administering vaccines simultaneously and reducing dropout rates","volume":"148","author":"Dietz","year":"1994","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0065","doi-asserted-by":"crossref","first-page":"e1299","DOI":"10.1542\/peds.2006-2283","article-title":"Comparison of the safety and immunogenicity of a refrigerator-stable versus a frozen formulation of ProQuad (measles, mumps, rubella, and varicella virus vaccine live)","volume":"119","author":"Bernstein","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0070","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4161\/hv.2.5.3246","article-title":"Safety and immunogenicity of a combination measles, mumps, rubella and varicella vaccine (ProQuad)","volume":"2","author":"Kuter","year":"2006","journal-title":"Hum Vaccin"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0075","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/01.inf.0000220209.35074.0b","article-title":"The safety and immunogenicity of a quadrivalent measles, mumps, rubella and varicella vaccine in healthy children: a study of manufacturing consistency and persistence of antibody","volume":"25","author":"Lieberman","year":"2006","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0080","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1542\/peds.2005-0092","article-title":"A combination measles, mumps, rubella, and varicella vaccine (ProQuad) given to 4- to 6-year-old healthy children vaccinated previously with M-M-RII and Varivax","volume":"117","author":"Reisinger","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0085","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/01.inf.0000172902.25009.a1","article-title":"Evaluation of a quadrivalent measles, mumps, rubella and varicella vaccine in healthy children","volume":"24","author":"Shinefield","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0090","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1097\/01.inf.0000172901.29621.e9","article-title":"Dose-response study of a quadrivalent measles, mumps, rubella and varicella vaccine in healthy children","volume":"24","author":"Shinefield","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0095","series-title":"Clinical review of studies submitted in support of licensure of ProQuad\u2122","author":"FDA Center for Biologics Evaluation and Research","year":"2005"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0100","first-page":"921","article-title":"National, state, and local area vaccination coverage among children aged 19\u201335 months\u2014United States, 2008","volume":"58","author":"Centers for Disease Control and Prevention","year":"2009","journal-title":"MMWR"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0105","first-page":"733","article-title":"National, state, and local area vaccination coverage among children aged 19\u201335 months\u2014United States, 2012","volume":"62","author":"Centers for Disease Control and Prevention","year":"2013","journal-title":"MMWR"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0110","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1542\/peds.2005-1201","article-title":"Uptake of varicella vaccination among young children in the United States: a success story in eliminating racial and ethnic disparities","volume":"117","author":"Luman","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0115","first-page":"625","article-title":"National, regional, state, and selected local area vaccination coverage among adolescents aged 13\u201317 years\u2014United States, 2013","volume":"63","author":"Centers for Disease Control and Prevention","year":"2014","journal-title":"MMWR"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0120","doi-asserted-by":"crossref","first-page":"e1387","DOI":"10.1542\/peds.2010-2132","article-title":"Immunogenicity and safety of MMRV and PCV-7 administered concomitantly in healthy children","volume":"128","author":"Leonardi","year":"2011","journal-title":"Pediatrics"},{"issue":"8","key":"10.1016\/j.vaccine.2014.08.067_bib0125","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.4161\/hv.24873","article-title":"Concomitant administration of hepatitis a vaccine with measles\/mumps\/rubella\/varicella and pneumococcal vaccines in healthy 12 to 23 month-old children","volume":"9","author":"Yetman","year":"2013","journal-title":"Hum Vaccines"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0130","series-title":"M-M-R\u00aeII [package insert]","author":"M-M-R\u00aeII","year":"2014"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0135","series-title":"VARIVAX\u00ae [package insert]","author":"VARIVAX\u00ae","year":"2013"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0140","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<891::AID-SIM780>3.0.CO;2-B","article-title":"Equivalence test and confidence interval for the difference in proportions for the paired-sample design","volume":"17","author":"Tango","year":"1998","journal-title":"Stat Med"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0145","first-page":"1","article-title":"General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"55","author":"Kroger","year":"2006","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0150","series-title":"Red book: 2009 report of the Committee on Infectious Diseases","author":"American Academy of Pediatrics","year":"2009"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0155","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1136\/bmj.295.6608.1264","article-title":"Swedish experience of two dose vaccination programme aiming at eliminating measles, mumps, and rubella","volume":"295","author":"B\u00f6ttiger","year":"1987","journal-title":"Br Med J"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0160","first-page":"1","article-title":"Summary of notifiable diseases\u2014United States, 2006","volume":"55","author":"McNabb","year":"2008","journal-title":"MMWR"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0165","unstructured":"EUVAC.NET. A surveillance network for vaccine-preventable diseases. Available at: \u3008http:\/\/www.euvac.net\/graphics\/euvac\/vaccination\/vaccination.html\u3009 Accessed: December 18, 2009."},{"key":"10.1016\/j.vaccine.2014.08.067_bib0170","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMoa003077","article-title":"The risk of seizures after receipt of whole-cell pertussis or measles, mumps, and rubella vaccine","volume":"345","author":"Barlow","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0175","first-page":"89","article-title":"Fever: pathogenesis and treatment","volume":"vol. 1","author":"Lorin","year":"1998"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0180","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1542\/pir.18-1-5","article-title":"Febrile seizures","volume":"18","author":"Hirtz","year":"1997","journal-title":"Pediatr Rev"},{"issue":"8","key":"10.1016\/j.vaccine.2014.08.067_bib0185","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1542\/pir.13-8-298","article-title":"Decision making and the child with febrile seizures","volume":"13","author":"Freeman","year":"1992","journal-title":"Pediatr Rev"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0190","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/bmj.303.6814.1373","article-title":"Risk of epilepsy after febrile convulsions: a national cohort study","volume":"303","author":"Verity","year":"1991","journal-title":"Br Med J"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0195","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1056\/NEJM199210153271603","article-title":"A prospective study of recurrent febrile seizures","volume":"327","author":"Berg","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0200","first-page":"13079","article-title":"Practice parameter: long\u2013term treatment of the child with simple febrile seizures","volume":"103","author":"Bergman","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0205","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1016\/j.vaccine.2009.05.056","article-title":"Observational safety study of febrile convulsion following first dose MMRV vaccination in a managed care setting","volume":"27","author":"Jacobsen","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0210","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1542\/peds.2010-0665","article-title":"Measles\u2013mumps\u2013rubella\u2013varicella combination vaccine and the risk of febrile seizures","volume":"126","author":"Klein","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0215","first-page":"1","article-title":"Use of combination measles, mumps, rubella, and varicella vaccine","volume":"58","author":"Marin","year":"2010","journal-title":"MMWR"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0220","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1542\/peds.2011-3198","article-title":"Measles-containing vaccines and febrile seizures in children age 4 to 6 years","volume":"129","author":"Klein","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.vaccine.2014.08.067_bib0225","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1503\/cmaj.140078","article-title":"Risk of febrile seizures after first dose of measles-mumps-rubella-varicella vaccine: a population-based cohort study","volume":"186","author":"MacDonald","year":"2014","journal-title":"Can Med Assoc J"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14012250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14012250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T16:21:54Z","timestamp":1538238114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X14012250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":45,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0264410X14012250"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.08.067","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}