{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:18:41Z","timestamp":1788236321911,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","issue":"50","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.vaccine.2014.09.056","type":"journal-article","created":{"date-parts":[[2014,10,19]],"date-time":"2014-10-19T04:15:53Z","timestamp":1413692153000},"page":"6805-6811","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Oral immunization against porcine pleuropneumonia using the cubic phase of monoolein and purified toxins of Actinobacillus pleuropneumoniae"],"prefix":"10.1016","volume":"32","author":[{"given":"Jorge","family":"Lopez-Bermudez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Quintanar-Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Lara Puente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"T\u00f3rtora Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Su\u00e1rez G\u00fcemez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Cipri\u00e1n Carrasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Mendoza Elvira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2014.09.056_bib0005","series-title":"Diseases of swine","first-page":"343","article-title":"Actinobacillus pleuropneumoniae","author":"Taylor","year":"1999"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1017\/S1466252300000074","article-title":"Actinobacillus pleuropneumoniae surface polysaccharides: their role in diagnosis and immunogenicity","volume":"1","author":"Dubreuil","year":"2000","journal-title":"Anim Health Res Rev"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0378-1135(01)00428-X","article-title":"Proposal of a new serovar of Actinobacillus pleuropneumoniae: serovar 15","volume":"84","author":"Blackall","year":"2002","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0020","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0966-842X(00)88939-8","article-title":"Virulence in Actinobacillus pleuropneumoniae and RTX toxins","volume":"3","author":"Frey","year":"1995","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0025","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0378-1135(95)00184-0","article-title":"Comparison of virulence of different Actinobacillus pleuropneumoniae serotypes and biotypes using an aerosol infection model","volume":"49","author":"Jacobsen","year":"1996","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0030","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.4049\/jimmunol.153.5.2110","article-title":"Resistance of Actinobacillus pleuropneumoniae to bactericidal antibody and complement is mediated by capsular polysaccharide and blocking antibody specific for lipopolysaccharide","volume":"153","author":"Ward","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0035","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/mpat.1999.0347","article-title":"Isolation and characterization of a capsule-deficient mutant of Actinobacillus pleuropneumoniae serotype 1","volume":"28","author":"Rioux","year":"2000","journal-title":"Microb Pathog"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0040","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1286-4579(01)01534-9","article-title":"Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection","volume":"4","author":"Bosse","year":"2002","journal-title":"Microbes Infect"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0045","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0966-842X(96)10054-8","article-title":"Role of lipo-oligosaccharides and lipopolysaccharides in bacterial adherence","volume":"4","author":"Jacques","year":"1996","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0050","first-page":"81","article-title":"Surface polysaccharides and iron-uptake systems of Actinobacillus pleuropneumoniae","volume":"68","author":"Jacques","year":"2004","journal-title":"Can J Vet Res"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0055","first-page":"45","article-title":"Adhesin\u2013receptor interactions in Pasteurellaceae","volume":"22","author":"Jacques","year":"1998","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0060","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1099\/00221287-139-8-1723","article-title":"Actinobacillus pleuropneumoniae RTX-toxins: uniform designation of haemolysins, cytolysins, pleurotoxin and their genes","volume":"139","author":"Frey","year":"1993","journal-title":"J Gen Microbiol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0065","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1128\/IAI.64.11.4415-4423.1996","article-title":"Channel-forming activity and channel size of the RTX toxins ApxI, ApxII, and ApxIII of Actinobacillus pleuropneumoniae","volume":"64","author":"Maier","year":"1996","journal-title":"Infect Immun"},{"issue":"8","key":"10.1016\/j.vaccine.2014.09.056_bib0070","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1099\/13500872-145-8-2105","article-title":"Characterization of apxIVA, a new RTX determinant of Actinobacillus pleuropneumoniae","volume":"145","author":"Schaller","year":"1999","journal-title":"Microbiology"},{"issue":"1","key":"10.1016\/j.vaccine.2014.09.056_bib0075","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2958.2008.06409.x","article-title":"Mutation in the LPS outer core biosynthesis gene, galU, affects LPS interaction with the RTX toxins ApxI and ApxII and cytolytic activity of Actinobacillus pleuropneumoniae serotype 1","volume":"70","author":"Ramjeet","year":"2008","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0080","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1016\/S0264-410X(00)00076-1","article-title":"A genetically-defined riboflavin auxotroph of Actinobacillus pleuropneumoniae as a live attenuated vaccine","volume":"18","author":"Fuller","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0085","first-page":"63","article-title":"Vaccines for Actinobacillus pleuropneumoniae","volume":"20","author":"Potter","year":"1996","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0090","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0168-1656(00)00310-2","article-title":"Improved protection against lung colonization by Actinobacillus pleuropneumoniae ghosts: characterization of a genetically inactivated vaccine","volume":"83","author":"Huter","year":"2000","journal-title":"J Biotechnol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0095","first-page":"1","article-title":"Oral immunization using formalin-inactivated Actinobacillus pleuropneumoniae antigens entrapped in microspheres with aqueous dispersion polymers prepared using a co-spray drying process","volume":"1","author":"Wei Liao Ch","year":"2002","journal-title":"Prev Vet Med"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0100","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1081\/DDC-100101304","article-title":"Monoolein: a review of the pharmaceutical applications","volume":"26","author":"Ganem-Quintanar","year":"2000","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-5173(96)04805-3","article-title":"Binding of drugs to monoglyceride-based drug delivery systems","volume":"147","author":"Chang Ch","year":"1997","journal-title":"Int J Pharm"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0110","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0168-3659(96)01596-9","article-title":"Effect of dissolution media and additives on the drug release from cubic phase delivery systems","volume":"46","author":"Chang","year":"1997","journal-title":"J Control Release"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0115","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3109\/03639049609063214","article-title":"A cubic-phase oral drug delivery system for controlled release of AG337","volume":"22","author":"Longer","year":"1996","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0120","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1039\/C0CP01539C","article-title":"Monoolein: a magic lipid?","volume":"13","author":"Kulkarni","year":"2011","journal-title":"Phys Chem Chem Phys"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0125","first-page":"116","article-title":"A cubic-phase delivery system composed of glyceryl monooleate and water for sustained release of water-soluble drugs","author":"Wyatt","year":"1992","journal-title":"Pharm Technol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0130","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jcis.2011.01.047","article-title":"Interactions of biomacromolecules with reverse hexagonal liquid crystals: drug delivery and crystallization applications","volume":"356","author":"Libster","year":"2011","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.vaccine.2014.09.056_bib0135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0005-2736(83)90451-0","article-title":"A cubic protein-monoolein-water phase","volume":"729","author":"Ericksson","year":"1983","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ijpharm.2013.03.016","article-title":"Interaction of dispersed cubic phases with blood components","volume":"448","author":"Bode","year":"2013","journal-title":"Int J Pharm"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0145","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1574-6968.1988.tb02795.x","article-title":"Purification and partial characterization of a hemolysin produced by Actinobacillus pleuropneumoniae type strain 4047","volume":"55","author":"Frey","year":"1988","journal-title":"FEMS Microbiol Lett"},{"issue":"4","key":"10.1016\/j.vaccine.2014.09.056_bib0150","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1128\/IAI.60.4.1558-1567.1992","article-title":"Effects of Actinobacillus pleuropneumoniae hemolysin on porcine neutrophil function","volume":"60","author":"Udeze","year":"1992","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0155","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"issue":"9","key":"10.1016\/j.vaccine.2014.09.056_bib0160","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1128\/IAI.62.9.4063-4065.1994","article-title":"Production of apx toxins by field strains of Actinobacillus pleuropneumoniae and Actinobacillus suis","volume":"62","author":"Elbarte","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0165","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1128\/JCM.27.6.1187-1191.1989","article-title":"Serotype related differences in production and type of heat-labile hemolysin and heat-labile cytotoxin of Actinobacillus (Haemophilus) pleuropneumoniae","volume":"27","author":"Kamp","year":"1989","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0170","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0264-410X(98)00216-3","article-title":"Immunogenicity of Actinobacillus ApxIA toxin epitopes fused to the E. coli heat-labile enterotoxin B subunit","volume":"17","author":"Bagdasarian","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0175","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1128\/CDLI.6.4.630-632.1999","article-title":"A novel enzyme-linked immunosorbent assay using the recombinant Actinobacillus pleuropneumoniae ApxII antigen for diagnosis of pleuropneumonia in pig herds","volume":"6","author":"Leiner","year":"1999","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0180","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-1135(99)00157-1","article-title":"Evaluation of an indirect enzyme-linked immunosorbent assay (ELISA) for detection of antibodies to the Apx toxins of Actinobacillus pleuropneumoniae","volume":"71","author":"Nielsen","year":"2000","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0185","series-title":"Diagn\u00f3stico Veterinario. Requisitos, proceso, interpretaci\u00f3n, ventajas y desventajas de t\u00e9cnicas diagn\u00f3sticas, M\u00e9xico, 1a. Edici\u00f3n, SARH, CENID-Microbiolog\u00eda-INIFAP, PAIEPEME, SMPV","first-page":"120","article-title":"Diagn\u00f3stico Serol\u00f3gico de Enfermedades Virales","author":"Ram\u00edrez","year":"1993"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0190","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1177\/104063870701900303","article-title":"An indirect enzyme-linked immunosorbent assay for detection of antibodies to Actinobacillus pleuropneumoniae serovar 7 in pig serum","volume":"19","author":"Klausen","year":"2007","journal-title":"J Vet Diagn Invest"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0195","series-title":"Memorias del XLII Congreso Nacional de AMVEC","first-page":"p.251","article-title":"Dise\u00f1o y elaboraci\u00f3n de una c\u00e1mara de nebulizaci\u00f3n para cerdos","author":"Sotres","year":"2007"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0200","series-title":"Proceedings 20th international pig veterinary society congress","first-page":"103","article-title":"Experimental infection with Mycoplasma hyopneumoniae in SPF pigs using an aerosol chamber","author":"Lara","year":"2008"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0205","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.vetmic.2006.10.010","article-title":"Interactions of highly and low virulent Mycoplasma hyopneumoniae isolates with the respiratory tract of pigs","volume":"120","author":"Meyns","year":"2007","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0325","unstructured":"NORMA Official Mexicana NOM-062-ZOO-1999, Especificaciones t\u00e9cnicas para la producci\u00f3n, cuidado y uso de los animales de laboratorio. Pag web http:\/\/es.scribd.com\/doc\/13274537\/NOM062ZOO1999."},{"key":"10.1016\/j.vaccine.2014.09.056_bib0215","first-page":"434","article-title":"Mycoplasma hyopneumoniae increases the susceptibility of pigs to experimental Pasteurella multocida pneumonia","volume":"52","author":"Cipri\u00e1n","year":"1988","journal-title":"Can J Vet Res"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0220","series-title":"SAS\/STAT language and procedures user guide release 6.03","author":"SAS Institute Inc.","year":"1989"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0225","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1128\/JCM.15.6.1019-1023.1982","article-title":"Evaluation of slide agglutination and ring precipitation tests for capsular serotyping of Haemophilus pleuropneumoniae","volume":"15","author":"Mittal","year":"1982","journal-title":"J Clin Microbiol"},{"issue":"4\u20135","key":"10.1016\/j.vaccine.2014.09.056_bib0230","first-page":"113","article-title":"Pleuropneumonia in swine caused by Haemophilus pleuropneumoniae parahaemolyticus, III. Observations on the clinical manifestations in the livestock and its therapeutic and immunoprophylactic possibilities","volume":"34","author":"Christensen","year":"1982","journal-title":"Nord Vet Med"},{"issue":"2","key":"10.1016\/j.vaccine.2014.09.056_bib0235","first-page":"34","article-title":"Vaccination against pleuropneumonia of pigs caused by Haemophilus pleuropneumoniae","volume":"22","author":"Rosendal","year":"1981","journal-title":"Can Vet J"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0240","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2460\/ajvr.1990.51.05.711","article-title":"Characterization of an attenuated strain of Actinobacillus pleuropneumoniae, serotype 1","volume":"51","author":"Rosendal","year":"1990","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0245","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1128\/IAI.61.5.1682-1686.1993","article-title":"Safety, stability and efficacy of non-encapsulated mutants of Actinobacillus pleuropneumoniae for use in live vaccines","volume":"61","author":"Inzana","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0250","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1128\/jb.177.24.7265-7270.1995","article-title":"Characterization of Actinobacillus pleuropneumoniae riboflavin biosynthesis genes","volume":"177","author":"Fuller","year":"1995","journal-title":"J Bacteriol"},{"issue":"3","key":"10.1016\/j.vaccine.2014.09.056_bib0255","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1128\/IAI.33.3.673-676.1981","article-title":"Toxicity of Haemophilus pleuropneumoniae for porcine lung macrophages, peripheral blood monocytes, and testicular cells","volume":"33","author":"Bendixen","year":"1981","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0260","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1128\/IAI.60.2.479-484.1992","article-title":"Protective local and systemic antibody responses of swine exposed to an aerosol of Actinobacillus pleuropneumoniae serotype 1","volume":"60","author":"Boss\u00e9","year":"1992","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0265","series-title":"IPVS Proc.","first-page":"214","article-title":"Efficacy of an Actinobacillus pleuropneumoniae subunit vaccine in the control of pleuropneumonia: a field trial","author":"Martelli","year":"1996"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0270","first-page":"63","article-title":"Vaccines for Actinobacillus pleuropneumoniae","volume":"20","author":"Potter","year":"1996","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.vaccine.2014.09.056_bib0275","first-page":"83","article-title":"Secreted proteases from Actinobacillus pleuropneumoniae serotype 1 degrade porcine gelatine, hemoglobin and IgA","volume":"58","author":"Negrete-Abascal Tenorio","year":"1994","journal-title":"Can J Vet Res"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0280","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0009-3084(80)90026-2","article-title":"Structural relationships between lamellar, cubic, and hexagonal phases in monoglyceride-water systems possibility of cubic structures in biological systems","volume":"27","author":"Engstr\u00f6m","year":"1980","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0285","doi-asserted-by":"crossref","first-page":"9874","DOI":"10.1021\/la401580y","article-title":"Control and analysis of oriented thin films of lipid inverse bicontinuous cubic phases using grazing incidence small-angle X-ray scattering","volume":"29","author":"Rittman","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0290","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpharm.2013.04.079","article-title":"Characterization and optimization of GMO-based gels with long term release for intraarticular administration","volume":"451","author":"Reeff","year":"2013","journal-title":"Int J Pharm"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0295","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1084\/jem.119.3.357","article-title":"Porcine contagious pleuropneumonia. I. Experimental transmission, etiology and pathology","volume":"119","author":"Shope","year":"1964","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0300","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.2460\/javma.1983.182.12.1331","article-title":"Haemophilus pleuropneumoniae infection in swine: a review","volume":"182","author":"Sebunya","year":"1983","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0305","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.2460\/javma.1994.204.09.1334","article-title":"Porcine pleuropneumonia","volume":"204","author":"Fenwick","year":"1994","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0310","series-title":"Development and formulation of veterinary dosage forms","author":"Hardee","year":"1990"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0315","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1128\/IAI.63.8.3048-3053.1995","article-title":"Oral immunization of pigs with viable or inactivated Actinobacillus pleuropneumoniae serotype 9 induces pulmonary and systemic antibodies and protects against homologous aerosol challenge","volume":"63","author":"Hensel","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2014.09.056_bib0320","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/02652040010019442","article-title":"Release characteristics of the microspheres prepared by co-spray drying Actinobacillus pleuropneumoniae antigens and aqueous ethylcellulose dispersion","volume":"18","author":"Liao","year":"2001","journal-title":"J Microencapsulation"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14013346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X14013346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T06:30:07Z","timestamp":1746426607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X14013346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":64,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0264410X14013346"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.09.056","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral immunization against porcine pleuropneumonia using the cubic phase of monoolein and purified toxins of Actinobacillus pleuropneumoniae","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2014.09.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}