{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:16:23Z","timestamp":1790162183865,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","award":["G1100085"],"award-info":[{"award-number":["G1100085"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.vaccine.2015.02.041","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T10:32:31Z","timestamp":1425465151000},"page":"1808-1814","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Helicobacter hepaticus infection in BALB\/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis"],"prefix":"10.1016","volume":"33","author":[{"given":"Isabelle C.","family":"Arnold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hutchings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivanela","family":"Kondova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariann","family":"Hey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Powrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Beverley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elma","family":"Tchilian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2015.02.041_bib0155","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nrmicro2797","article-title":"Global tuberculosis control: lessons learnt and future prospects","volume":"10","author":"Lienhardt","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0160","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/003655401300077144","article-title":"BCG: the challenge continues","volume":"33","author":"Fine","year":"2001","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0165","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/IAI.70.2.672-678.2002","article-title":"Failure of the Mycobacterium bovis BCG vaccine: some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis","volume":"70","author":"Brandt","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0170","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.vaccine.2012.12.024","article-title":"Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A","volume":"31","author":"Beverley","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0175","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1084\/jem.20091473","article-title":"Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway","volume":"208","author":"Potian","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0180","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1016\/j.vaccine.2008.04.083","article-title":"Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-beta production","volume":"26","author":"Elias","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008804","article-title":"Infection with Helicobacter pylori is associated with protection against tuberculosis","volume":"5","author":"Perry","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0190","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1172\/JCI45041","article-title":"Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells","volume":"121","author":"Arnold","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0195","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1538\/expanim.62.41","article-title":"Current microbiological status of laboratory mice and rats in experimental facilities in Japan","volume":"62","author":"Hayashimoto","year":"2013","journal-title":"Exp Anim"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0200","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1128\/IAI.66.11.5157-5166.1998","article-title":"Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism","volume":"66","author":"Kullberg","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0205","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/mi.2013.11","article-title":"Th17-cell plasticity in Helicobacter hepaticus-induced intestinal inflammation","volume":"6","author":"Morrison","year":"2013","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0210","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-1-4939-1212-4_18","article-title":"Experimental mouse models of T cell-dependent inflammatory bowel disease","volume":"1193","author":"Song-Zhao","year":"2014","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008235","article-title":"Immunization of mice with a recombinant adenovirus vaccine inhibits the early growth of Mycobacterium tuberculosis after infection","volume":"4","author":"Ronan","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0220","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1084\/jem.20021345","article-title":"CD4+ CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms","volume":"197","author":"Maloy","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0225","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.4049\/jimmunol.181.7.4955","article-title":"Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol chellenge in mice","volume":"181","author":"Forbes","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0230","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1084\/jem.20020556","article-title":"Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis","volume":"196","author":"Kullberg","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0235","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/mi.2011.7","article-title":"The role of IL-10 in immune regulation during M. tuberculosis infection","volume":"4","author":"Redford","year":"2011","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0240","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0140-6736(95)92348-9","article-title":"Variation in protection by BCG: implications of and for heterologous immunity","volume":"346","author":"Fine","year":"1995","journal-title":"Lancet"},{"issue":"Suppl. 1","key":"10.1016\/j.vaccine.2015.02.041_bib0245","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/S1472-9792(12)70005-7","article-title":"Tuberculosis vaccines: a strategic blueprint for the next decade","volume":"92","author":"Brennan","year":"2012","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0250","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.cell.2012.04.037","article-title":"Gut immune maturation depends on colonization with a host-specific microbiota","volume":"149","author":"Chung","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0255","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1126\/science.1219328","article-title":"Microbial exposure during early life has persistent effects on natural killer T cell function","volume":"336","author":"Olszak","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0260","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.1073\/pnas.0909122107","article-title":"Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota","volume":"107","author":"Round","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0265","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.chom.2008.09.009","article-title":"Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine","volume":"4","author":"Ivanov","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0270","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/mi.2010.3","article-title":"Segmented filamentous bacteria take the stage","volume":"3","author":"Ivanov","year":"2010","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0275","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge","volume":"8","author":"Khader","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0280","doi-asserted-by":"crossref","first-page":"11810","DOI":"10.1073\/pnas.1410579111","article-title":"Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10","volume":"111","author":"Engler","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0285","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1128\/IAI.73.10.6852-6961.2005","article-title":"Colonization of the cecal mucosa by Helicobacter hepaticus impacts the diversity of the indigenous microbiota","volume":"73","author":"Kuehl","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0290","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.immuni.2014.08.009","article-title":"TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination","volume":"41","author":"Oh","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0295","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006843","article-title":"A human type 5 adenovirus-based tuberculosis vaccine induces robust T cell responses in humans despite preexisting anti-adenovirus immunity","volume":"5","author":"Smaill","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.vaccine.2015.02.041_bib0300","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/mi.2013.99","article-title":"Harnessing local and systemic immunity for vaccines against tuberculosis","volume":"7","author":"Beverley","year":"2014","journal-title":"Mucosal Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15002303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15002303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T10:14:45Z","timestamp":1598782485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X15002303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":30,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S0264410X15002303"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.02.041","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Helicobacter hepaticus infection in BALB\/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.02.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2015 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}