{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:19:06Z","timestamp":1790176746246,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7142104"],"award-info":[{"award-number":["7142104"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20906095"],"award-info":[{"award-number":["20906095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11405199"],"award-info":[{"award-number":["11405199"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402861"],"award-info":[{"award-number":["81402861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["KFJ-EW-STS-027"],"award-info":[{"award-number":["KFJ-EW-STS-027"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["KFJ-EW-STS-098"],"award-info":[{"award-number":["KFJ-EW-STS-098"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.vaccine.2015.02.045","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T05:59:36Z","timestamp":1425016776000},"page":"2066-2072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Conjugation of \u03b2-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine"],"prefix":"10.1016","volume":"33","author":[{"given":"Weilin","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2015.02.045_bib0185","first-page":"237","article-title":"Meningococcal disease: changes in epidemiology and prevention","volume":"4","author":"Chang","year":"2012","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0190","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/1469-0691.12647","article-title":"Neisseria meningitidis; clones, carriage, and disease","volume":"20","author":"Read","year":"2014","journal-title":"Clin Microbiol Infect"},{"issue":"Suppl. 2","key":"10.1016\/j.vaccine.2015.02.045_bib0195","first-page":"B10","article-title":"History of meningococcal vaccines and their serological correlates of protection","volume":"30","author":"Vipond","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0200","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0929-6646(09)60371-5","article-title":"Safety and immunogenicity of a tetravalent polysaccharide vaccine against meningococcal disease","volume":"108","author":"Shao","year":"2009","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0205","first-page":"237","article-title":"Meningococcal disease: changes in epidemiology and prevention","volume":"4","author":"Chang","year":"2012","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0210","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4161\/hv.19517","article-title":"Meningococcal polysaccharide vaccine failure in a patient with C7 deficiency and a decreased anti-capsular antibody response","volume":"8","author":"Keiser","year":"2012","journal-title":"Hum Vaccine Immunother"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0215","doi-asserted-by":"crossref","first-page":"e608","DOI":"10.1016\/j.ijid.2012.04.006","article-title":"The tetravalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine is immunogenic with a clinically acceptable safety profile in subjects previously vaccinated with a tetravalent polysaccharide vaccine","volume":"16","author":"Dbaibo","year":"2012","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0220","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1586\/erv.12.32","article-title":"MenACWY-TT vaccine for active immunization against invasive meningococcal disease","volume":"11","author":"Papaevangelou","year":"2012","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0225","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/01.inf.0000259996.95965.ef","article-title":"Use of meningococcal vaccines in the United States","volume":"26","author":"Bilukha","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0230","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1016\/j.vaccine.2009.07.036","article-title":"Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages","volume":"27","author":"Broker","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0235","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1586\/erv.10.147","article-title":"Menveo\u00ae): a novel quadrivalent meningococcal CRM197 conjugate vaccine against serogroups A, C, W-135 and Y","volume":"10","author":"Cooper","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0240","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4161\/hv.19619","article-title":"Development of a group A meningococcal conjugate vaccine, MenAfriVac(TM)","volume":"8","author":"Frasch","year":"2012","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0245","first-page":"153","article-title":"Preparation of polysaccharide-conjugate vaccines","volume":"87","author":"Peeters","year":"2003","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0250","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1016\/j.vaccine.2013.09.065","article-title":"Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm","volume":"31","author":"Wu","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0255","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jconrel.2013.03.008","article-title":"PEG as a spacer arm markedly increases the immunogenicity of meningococcal group Y polysaccharide conjugate vaccine","volume":"172","author":"Huang","year":"2013","journal-title":"J Control Release"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0260","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jconrel.2014.06.027","article-title":"Designing and building the next generation of improved vaccine adjuvants","volume":"190","author":"Brito","year":"2014","journal-title":"J Control Release"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0265","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/emmm.201403876","article-title":"Vaccines for the 21st century","volume":"6","author":"Delany","year":"2014","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0270","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1440-1711.1999.00848.x","article-title":"The effect of molecular weight and \u03b2-1,6-linkages on priming of macrophage function in mice by (1,3)-\u03b2-d-glucan","volume":"77","author":"Cleary","year":"1999","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0275","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5306\/wjco.v2.i2.115","article-title":"Glucan-immunostimulant, adjuvant, potential drug","volume":"2","author":"Vetvicka","year":"2011","journal-title":"World J Clin Oncol"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0280","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00253-008-1618-8","article-title":"Conjugation of protein antigen to microparticulate \u03b2-glucan from Saccharomyces cerevisiae: a new adjuvant for intradermal and oral immunizations","volume":"80","author":"Berner","year":"2008","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0285","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jconrel.2010.01.007","article-title":"Conjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigen","volume":"143","author":"Sl\u00fctter","year":"2010","journal-title":"J Control Release"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0290","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1128\/CVI.05515-11","article-title":"Seroprevalence of serum bactericidal antibodies against group W135 and Y meningococci in England in 2009","volume":"19","author":"Trotter","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0295","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2165\/11206930-000000000-00000","article-title":"Meningococcal quadrivalent (serogroups A, C, W135, and Y) conjugate vaccine (Menveo\u00ae): profile report","volume":"14","author":"Deeks","year":"2012","journal-title":"Paediatr Drugs"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0300","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0264-410X(94)00007-A","article-title":"Immunogenicity of meningococcal B polysaccharide conjugated to tetanus toxoid or CRM197 via adipic acid dihydrazide","volume":"13","author":"Bartoloni","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0305","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1128\/CVI.00049-07","article-title":"Epitope specificities of the group Y and W-135 polysaccharides of Neisseria meningitidis","volume":"14","author":"Moore","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0310","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/0006-3002(57)90254-8","article-title":"Quantitative estimation of sialic acids","volume":"24","author":"Svennerholm","year":"1957","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0315","first-page":"29","article-title":"A method for quantitative test of unconjugated meningoccocal polysaccharide (PS) in PS-tetanus toxoid conjugate preparations","volume":"30","author":"Zhu","year":"2002","journal-title":"Chin Prog Microbiol Immunol"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0320","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0003-2697(66)90275-2","article-title":"Determination of free amino groups in proteins by trinitrobenzenesulfonic acid","volume":"14","author":"Habeeb","year":"1966","journal-title":"Anal Biochem"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0325","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/abio.1996.0048","article-title":"A rapid formaldehyde assay using Purpald Reagent: application under periodation conditions","volume":"234","author":"Quensenberry","year":"1996","journal-title":"Anal Biochem"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0330","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.vaccine.2004.10.021","article-title":"Size determination of bacterial capsular oligosaccharides used to prepare conjugate vaccines against Neisseria meningitidis groups Y and W135","volume":"23","author":"Bardotti","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0335","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1128\/IAI.69.3.1568-1573.2001","article-title":"Serological basis for use of meningococcal serogroup C conjugate vaccines in the United Kingdom: re-evaluation of correlates of protection","volume":"69","author":"Borrow","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0340","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1016\/j.vaccine.2005.01.051","article-title":"Meningococcal surrogates of protection-serum bactericidal antibody activity","volume":"23","author":"Borrow","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0345","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1128\/IAI.71.6.3402-3408.2003","article-title":"Disparity in functional activity between serum anticapsular antibodies induced in adults by immunization with an investigational group A and C Neisseria meningitides-diphtheria toxoid conjugate vaccine and by a polysaccharide vaccine","volume":"71","author":"Harris","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0350","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1128\/IAI.67.9.4862-4869.1999","article-title":"B- and T-cell immune responses to pneumococcal conjugate vaccines: divergence between carrier and polysaccharide-specific immunogenicity","volume":"67","author":"McCool","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0355","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1016\/j.vaccine.2009.05.091","article-title":"Immunoadjuvant capacity of flagellin and mannosamine-coated poly(anhydride) nanoparticles in oral vaccination","volume":"27","author":"Salman","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.02.045_bib0360","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1021\/bc060165i","article-title":"Incorporation of CpG oligonucleotide ligand into protein-loaded particle vaccines promotes antigen-specific CD8 T-cell immunity","volume":"18","author":"Standley","year":"2007","journal-title":"Bioconjugate Chem"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15002340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15002340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T10:17:01Z","timestamp":1598782621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X15002340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":36,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S0264410X15002340"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.02.045","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conjugation of \u03b2-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.02.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}