{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:33:03Z","timestamp":1771925583252,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.vaccine.2015.03.026","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T05:30:18Z","timestamp":1432618218000},"page":"B6-B13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"S2","title":["The narcolepsy-pandemic influenza story: Can the truth ever be unraveled?"],"prefix":"10.1016","volume":"33","author":[{"given":"Miriam CJM","family":"Sturkenboom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"May","key":"10.1016\/j.vaccine.2015.03.026_bib0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2014.01.033","article-title":"Narcolepsy, 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: what is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants","volume":"50","author":"Ahmed","year":"2014","journal-title":"J Autoimmun"},{"key":"10.1016\/j.vaccine.2015.03.026_bib0220","doi-asserted-by":"crossref","DOI":"10.2807\/ese.17.04.20064-en","article-title":"Influenza A(H1N1)pdm09 vaccination policies and coverage in Europe","volume":"17","author":"Mereckiene","year":"2012","journal-title":"Euro Surveill"},{"key":"10.1016\/j.vaccine.2015.03.026_bib0225","series-title":"Narcolepsy in association with pandemic influenza vaccination (a multi-country European epidemiological investigation)","author":"European Centre for Disease Prevention and Control","year":"2012"},{"issue":"Jun (26)","key":"10.1016\/j.vaccine.2015.03.026_bib0230","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1016\/j.vaccine.2011.04.005","article-title":"Safety monitoring of Influenza A\/H1N1 pandemic vaccines in EudraVigilance","volume":"29","author":"Kurz","year":"2011","journal-title":"Vaccine"},{"issue":"Dec (9707)","key":"10.1016\/j.vaccine.2015.03.026_bib0235","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(09)61877-8","article-title":"Importance of background rates of disease in assessment of vaccine safety during mass immunisation with pandemic H1N1 influenza vaccines","volume":"374","author":"Black","year":"2009","journal-title":"Lancet"},{"issue":"Jul","key":"10.1016\/j.vaccine.2015.03.026_bib0240","doi-asserted-by":"crossref","first-page":"d3908","DOI":"10.1136\/bmj.d3908","article-title":"Guillain\u2013Barre syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccine: multinational case-control study in Europe","volume":"343","author":"Dieleman","year":"2011","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.vaccine.2015.03.026_bib0245","doi-asserted-by":"crossref","first-page":"e82222","DOI":"10.1371\/journal.pone.0082222","article-title":"Guillain\u2013Barr\u00e9 syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccines: a multinational self-controlled case series in Europe","volume":"9","author":"Romio","year":"2014","journal-title":"PLoS ONE"},{"issue":"Apr (9876)","key":"10.1016\/j.vaccine.2015.03.026_bib0250","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0140-6736(12)62189-8","article-title":"Association between Guillain\u2013Barr\u00e9 syndrome and influenza A (H1N1) 2009 monovalent inactivated vaccines in the USA: a meta-analysis","volume":"381","author":"Salmon","year":"2013","journal-title":"Lancet"},{"issue":"Sep (40)","key":"10.1016\/j.vaccine.2015.03.026_bib0255","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1016\/j.vaccine.2013.06.032","article-title":"International collaboration to assess the risk of Guillain Barr\u00e9 Syndrome following Influenza A (H1N1) 2009 monovalent vaccines","volume":"31","author":"Dodd","year":"2013","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2015.03.026_bib0260","doi-asserted-by":"crossref","first-page":"e33723","DOI":"10.1371\/journal.pone.0033723","article-title":"Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland","volume":"7","author":"Partinen","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2015.03.026_bib0265","series-title":"European medicines agency starts review of Pandemrix","author":"European Medicines Agency","year":"2010"},{"issue":"Nov","key":"10.1016\/j.vaccine.2015.03.026_bib0270","article-title":"Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development","author":"Jacob","year":"2014","journal-title":"Brain Behav Immun"},{"issue":"12","key":"10.1016\/j.vaccine.2015.03.026_bib0275","doi-asserted-by":"crossref","first-page":"e114361","DOI":"10.1371\/journal.pone.0114361","article-title":"Antigenic differences between AS03 adjuvanted influenza A (H1N1) pandemic vaccines: implications for Pandemrix-associated narcolepsy risk","volume":"9","author":"Vaarala","year":"2014","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1016\/j.vaccine.2015.03.026_bib0280","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/joim.12159","article-title":"Combining multiple healthcare databases for postmarketing drug and vaccine safety surveillance: why and how?","volume":"275","author":"Trifir\u00f2","year":"2014","journal-title":"J Intern Med"},{"issue":"3","key":"10.1016\/j.vaccine.2015.03.026_bib0285","doi-asserted-by":"crossref","first-page":"e33536","DOI":"10.1371\/journal.pone.0033536","article-title":"AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland","volume":"7","author":"Nohynek","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2015.03.026_bib0290","series-title":"A registry based comparative cohort study in four Swedish counties of the risk for narcolepsy after vaccination with Pandemrix \u2013 a first and preliminary report, by the 2011 [March 28]","author":"Medical Products Agency","year":"2011"},{"key":"10.1016\/j.vaccine.2015.03.026_bib0295","unstructured":"MPA, Occurrence of narcolepsy with cataplexy among children and adolescents in relation to the H1N1 pandemic and Pandemrix vaccinations \u2013 Results of a case inventory study by the MPA in Sweden during 2009\u20132010. Available from: \u3008https:\/\/www.lakemedelsverket.se\/upload\/nyheter\/2011\/Fallinventeringsrapport_pandermrix_110630.pdf\u3009. (accessed March 23, 2015)"},{"issue":"2","key":"10.1016\/j.vaccine.2015.03.026_bib0300","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/joim.12150","article-title":"Risks of neurological and immune-related diseases, including narcolepsy, after vaccination with Pandemrix: a population- and registry-based cohort study with over 2 years of follow-up","volume":"275","author":"Persson","year":"2014","journal-title":"J Intern Med"},{"issue":"14","key":"10.1016\/j.vaccine.2015.03.026_bib0305","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1212\/WNL.0b013e31828ab26f","article-title":"Increased childhood incidence of narcolepsy in western Sweden after H1N1 influenza vaccination","volume":"80","author":"Szak\u00e1cs","year":"2013","journal-title":"Neurology"},{"issue":"17","key":"10.1016\/j.vaccine.2015.03.026_bib0310","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2014.19.17.20789","article-title":"Investigation of an association between onset of narcolepsy and vaccination with pandemic influenza vaccine, Ireland April 2009\u2013December 2010","volume":"19","author":"O\u2019Flanagan","year":"2014","journal-title":"Euro Surveill: bulletin Europeen sur les maladies transmissibles = Eur Commun Dis Bull"},{"issue":"9","key":"10.1016\/j.vaccine.2015.03.026_bib0315","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.sleep.2013.03.020","article-title":"Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A","volume":"14","author":"Heier","year":"2013","journal-title":"Sleep Med"},{"issue":"52","key":"10.1016\/j.vaccine.2015.03.026_bib0320","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1016\/j.vaccine.2012.10.030","article-title":"No association between influenza A (H1N1) pdm09 vaccination and narcolepsy in South Korea: an ecological study","volume":"30","author":"Choe","year":"2012","journal-title":"Vaccine"},{"issue":"20","key":"10.1016\/j.vaccine.2015.03.026_bib0325","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1212\/WNL.0000000000000987","article-title":"Vaccine safety datalink. Narcolepsy and influenza A(H1N1) pandemic 2009 vaccination in the United States","volume":"83","author":"Duffy","year":"2014","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.vaccine.2015.03.026_bib0330","doi-asserted-by":"crossref","first-page":"e108489","DOI":"10.1371\/journal.pone.0108489","article-title":"Risk of narcolepsy associated with inactivated adjuvanted (AS03) A\/H1N1 (2009) pandemic influenza vaccine in Quebec","volume":"9","author":"Montplaisir","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2015.03.026_bib0335","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.conb.2011.09.003","article-title":"Narcolepsy with hypocretin\/orexin deficiency, infections and autoimmunity of the brain","volume":"21","author":"Kornum","year":"2011","journal-title":"Curr Opin Neurobiol"},{"issue":"Jan (9197)","key":"10.1016\/j.vaccine.2015.03.026_bib0340","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(99)05582-8","article-title":"Hypocretin (orexin) deficiency in human narcolepsy","volume":"355","author":"Nishino","year":"2000","journal-title":"Lancet"},{"issue":"Apr (2)","key":"10.1016\/j.vaccine.2015.03.026_bib0345","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.smrv.2007.07.010","article-title":"Narcolepsy: immunological aspects","volume":"12","author":"Overeem","year":"2008","journal-title":"Sleep Med Rev"},{"issue":"Oct (5)","key":"10.1016\/j.vaccine.2015.03.026_bib0350","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/jsr.12044","article-title":"Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study","volume":"22","author":"Luca","year":"2013","journal-title":"J Sleep Res"},{"issue":"Jun","key":"10.1016\/j.vaccine.2015.03.026_bib0355","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaut.2013.02.003","article-title":"Genetic association, seasonal infections and autoimmune basis of narcolepsy","volume":"43","author":"Singh","year":"2013","journal-title":"J Autoimmun"},{"issue":"1","key":"10.1016\/j.vaccine.2015.03.026_bib0360","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/sleep\/30.1.13","article-title":"The epidemiology of narcolepsy","volume":"30","author":"Longstreth","year":"2007","journal-title":"Sleep"},{"issue":"Jan (6)","key":"10.1016\/j.vaccine.2015.03.026_bib0365","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.vaccine.2012.12.014","article-title":"Narcolepsy as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation","volume":"31","author":"Poli","year":"2013","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2015.03.026_bib0370","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/ana.22587","article-title":"Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in china","volume":"70","author":"Han","year":"2011","journal-title":"Ann Neurol"},{"issue":"4","key":"10.1016\/j.vaccine.2015.03.026_bib0375","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/ana.23799","article-title":"Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic","volume":"73","author":"Han","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1016\/j.vaccine.2015.03.026_bib0380","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S1473-3099(13)70238-X","article-title":"Pandemic influenza A H1N1 vaccines and narcolepsy: vaccine safety surveillance in action","volume":"14","author":"Barker","year":"2014","journal-title":"Lancet Infect Dis"},{"issue":"Jul (247)","key":"10.1016\/j.vaccine.2015.03.026_bib0385","doi-asserted-by":"crossref","first-page":"247rt1","DOI":"10.1126\/scitranslmed.3009995","article-title":"Retraction of the research article: \u201cCD4+ T cell autoimmunity to hypocretin\/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy\u201d","volume":"6","author":"De la Herr\u00e1n-Arita","year":"2014","journal-title":"Sci Transl Med"},{"issue":"9","key":"10.1016\/j.vaccine.2015.03.026_bib0390","doi-asserted-by":"crossref","first-page":"e108538","DOI":"10.1371\/journal.pone.0108538","article-title":"Effectiveness of pandemic and seasonal influenza vaccines in preventing laboratory-confirmed influenza in adults: a clinical cohort study during Epidemic Seasons 2009\u20132010 and 2010\u20132011 in Finland","volume":"9","author":"Syrj\u00e4nen","year":"2014","journal-title":"PLoS ONE"},{"issue":"10","key":"10.1016\/j.vaccine.2015.03.026_bib0395","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/cid\/cir182","article-title":"Effectiveness of an adjuvanted monovalent vaccine against the 2009 pandemic strain of influenza A(H1N1)v in Stockholm County, Sweden","volume":"52","author":"\u00d6rtqvist","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"8","key":"10.1016\/j.vaccine.2015.03.026_bib0400","doi-asserted-by":"crossref","first-page":"e68402","DOI":"10.1371\/journal.pone.0068402","article-title":"No serological evidence of influenza A H1N1pdm09 virus infection as a contributing factor in childhood Narcolepsy after Pandemrix vaccination campaign in Finland","volume":"8","author":"Mel\u00e9n","year":"2013","journal-title":"PLoS ONE"},{"issue":"Aug (Pt 8)","key":"10.1016\/j.vaccine.2015.03.026_bib0405","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1093\/brain\/awt187","article-title":"Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France","volume":"136","author":"Dauvilliers","year":"2013","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.vaccine.2015.03.026_bib0410","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/dmcn.12522","article-title":"Clinical features of narcolepsy in children vaccinated with AS03 adjuvanted pandemic A\/H1N1 2009 influenza vaccine in England","volume":"56","author":"Winstone","year":"2014","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.vaccine.2015.03.026_bib0415","doi-asserted-by":"crossref","first-page":"f794","DOI":"10.1136\/bmj.f794","article-title":"Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A\/H1N1 2009 influenza vaccine: retrospective analysis","volume":"346","author":"Miller","year":"2013","journal-title":"BMJ"},{"issue":"Oct","key":"10.1016\/j.vaccine.2015.03.026_bib0420","doi-asserted-by":"crossref","first-page":"d5956","DOI":"10.1136\/bmj.d5956","article-title":"Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden","volume":"343","author":"Bardage","year":"2011","journal-title":"BMJ"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15003254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15003254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T11:03:34Z","timestamp":1566731014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X15003254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":42,"alternative-id":["S0264410X15003254"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.03.026","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The narcolepsy-pandemic influenza story: Can the truth ever be unraveled?","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.03.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}