{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:04:22Z","timestamp":1759010662445},"reference-count":46,"publisher":"Elsevier BV","issue":"24","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004807","name":"DFG","doi-asserted-by":"publisher","award":["BE 2157\/3-1"],"award-info":[{"award-number":["BE 2157\/3-1"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.vaccine.2015.04.049","type":"journal-article","created":{"date-parts":[[2015,4,25]],"date-time":"2015-04-25T21:04:57Z","timestamp":1429995897000},"page":"2771-2777","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["BclA and toxin antigens augment each other to protect NMRI mice from lethal Bacillus anthracis challenge"],"prefix":"10.1016","volume":"33","author":[{"given":"Susanne M.","family":"K\u00f6hler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Les W.","family":"Baillie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2015.04.049_bib0235","series-title":"Anthrax. Current topics in microbiology and immunology","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-662-05767-4_1","article-title":"Introduction: anthrax history, disease and ecology","author":"Turnbull","year":"2002"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0240","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1056\/NEJM199909093411107","article-title":"Anthrax","volume":"341","author":"Dixon","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0245","first-page":"363","article-title":"Association of the Encapsulation of Bacillus anthracis with a 60 Megadalton Plasmid","volume":"131","author":"Uchida","year":"1985","journal-title":"J Gen Microbiol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0250","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1128\/IAI.39.1.371-376.1983","article-title":"Evidence for plasmid-mediated toxin production in Bacillus anthracis","volume":"39","author":"Mikesell","year":"1983","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0255","first-page":"460","article-title":"The chemical basis of the virulence of Bacillus anthracis. V: The specific toxin produced by B. anthracis in vivo","volume":"36","author":"Smith","year":"1955","journal-title":"Br J Exp Pathol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0260","series-title":"Bacterial protein toxins","first-page":"445","article-title":"Anthrax toxin","author":"Leppla","year":"2000"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0265","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0264-410X(91)90237-Z","article-title":"Anthrax vaccines: past, present and future","volume":"9","author":"Turnbull","year":"1991","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0270","first-page":"155","article-title":"Development of novel vaccines against anthrax in man","volume":"44","author":"Stepanov","year":"2006","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0275","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.vaccine.2003.07.004","article-title":"Defining a serological correlate of protection in rabbits for a recombinant anthrax vaccine","volume":"22","author":"Little","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0280","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1128\/IAI.69.7.4509-4515.2001","article-title":"Protection against anthrax lethal toxin challenge by genetic immunization with a plasmid encoding the lethal factor protein","volume":"69","author":"Price","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0285","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1128\/IAI.70.3.1653-1656.2002","article-title":"A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection","volume":"70","author":"Flick-Smith","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0290","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1128\/IAI.01242-06","article-title":"Oral administration of a Salmonella enterica-based vaccine expressing Bacillus anthracis protective antigen confers protection against aerosolized B. anthracis","volume":"75","author":"Stokes","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0295","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1016\/j.vaccine.2010.07.075","article-title":"An anthrax subunit vaccine candidate based on protective regions of Bacillus anthracis protective antigen and lethal factor","volume":"28","author":"Baillie","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0300","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1128\/IAI.00884-07","article-title":"Recombinant exosporium protein BclA of Bacillus anthracis is effective as a booster for mice primed with suboptimal amounts of protective antigen","volume":"75","author":"Brahmbhatt","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0305","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1099\/mic.0.28788-0","article-title":"Significant passive protective effect against anthrax by antibody to Bacillus anthracis inactivated spores that lack two virulence plasmids","volume":"152","author":"Enkhtuya","year":"2006","journal-title":"Microbiology"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0310","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/IAI.70.2.661-664.2002","article-title":"Anthrax spores make an essential contribution to vaccine efficacy","volume":"70","author":"Brossier","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0315","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2958.2000.03000.x","article-title":"A collagen-like surface glycoprotein is a structural component of the Bacillus anthracis exosporium","volume":"45","author":"Sylvestre","year":"2002","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0320","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1128\/JB.185.6.1903-1910.2003","article-title":"Identification of the immunodominant protein and other proteins of the Bacillus anthracis exosporium","volume":"185","author":"Steichen","year":"2003","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0325","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1128\/JB.187.15.5310-5317.2005","article-title":"Orientation within the exosporium and structural stability of the collagen-like glycoprotein BclA of Bacillus anthracis","volume":"187","author":"Boydston","year":"2005","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0330","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/bit.21637","article-title":"Construction, crystal structure and application of a recombinant protein that lacks the collagen-like region of BclA from Bacillus anthracis spores","volume":"99","author":"Liu","year":"2007","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0335","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1016\/j.vaccine.2005.08.033","article-title":"pDNAVACCultra vector family: high throughput intracellular targeting DNA vaccine plasmids","volume":"24","author":"Williams","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0340","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/343074a0","article-title":"Class II MHC molecules can use the endogenous pathway of antigen presentation","volume":"343","author":"Nuchtern","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0345","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1128\/IAI.67.9.4780-4786.1999","article-title":"Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences","volume":"67","author":"Li","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0350","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.4049\/jimmunol.162.2.1150","article-title":"Involvement of MIIC-like late endosomes in B cell receptor mediated antigen processing in murine B cells","volume":"162","author":"Drake","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0355","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1083\/jcb.101.1.85","article-title":"Identification of two lysosomal membrane glycoproteins","volume":"101","author":"Chen","year":"1985","journal-title":"J Cell Biol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0360","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/j.1460-2075.1992.tb05080.x","article-title":"Ubiquitin as a degradation signal","volume":"11","author":"Johnson","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0365","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1128\/IAI.68.6.3097-3102.2000","article-title":"Vaccination against tuberculosis: expression of a ubiquitin-conjugated tuberculosis protein enhances antimycobacterial immunity","volume":"68","author":"Delogu","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0370","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ni1243","article-title":"IPS-1, an adaptor triggering RIG-I- and MDA5-mediated type 1 interferon induction","volume":"6","author":"Kawai","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.it.2005.11.004","article-title":"CARD games between virus and host get a new player","volume":"27","author":"Johnson","year":"2006","journal-title":"Trends Immunol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0380","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1600-065X.2008.00727.x","article-title":"RNA recognition and signal transduction by RIG-1-like receptors","volume":"227","author":"Yonehama","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0385","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.4049\/jimmunol.180.10.7019","article-title":"Enhancement of DNA vaccine potency through co-administration of CIITA DNA with DNA vaccines via gene gun","volume":"180","author":"Kim","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0390","first-page":"1","article-title":"CIITA and its dual roles in MHC gene transcription","volume":"4","author":"Ballachanda","year":"2013","journal-title":"Front Immun"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0395","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.imbio.2005.05.015","article-title":"Synthetic bacterial lipopeptide analogs: structural requirements for adjuvanticity","volume":"210","author":"Ghielmetti","year":"2005","journal-title":"Immunbiology"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0400","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1515\/BC.2001.070","article-title":"Peptide vaccines and peptide libraries","volume":"382","author":"Wiesm\u00fcller","year":"2001","journal-title":"Biol Chem"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0405","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijmm.2003.12.002","article-title":"Protection of mice against challenge with Bacillus anthracis STI spores after DNA vaccination","volume":"294","author":"Hahn","year":"2004","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0410","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.micpath.2005.02.001","article-title":"The detection of protective antigen (PA) associated with spores of Bacillus anthracis and the effects of anti-PA antibodies on spore germination and macrophage interactions","volume":"38","author":"Cote","year":"2005","journal-title":"Microb Pathog"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0415","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1016\/S0264-410X(01)00234-1","article-title":"In vitro correlate of immunity in a rabbit model of inhalational anthrax","volume":"19","author":"Pitt","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0420","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1128\/CVI.00099-13","article-title":"Evaluation of immunogenicity and efficacy of anthrax vaccine adsorbed for postexposure prophylaxis","volume":"20","author":"Ionin","year":"2013","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0425","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1128\/CVI.00015-08","article-title":"Immunogenicity of Bacillus anthracis Protective Antigen Domains and Efficacy of Elicited Antibody Responses Depend on Host Genetic Background","volume":"15","author":"Abboud","year":"2008","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0430","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1016\/j.vaccine.2005.08.031","article-title":"DNA vaccination against anthrax in mice\u2014combination of anti-spore and anti-toxin components","volume":"24","author":"Hahn","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0435","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.4049\/jimmunol.158.5.2278","article-title":"Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization","volume":"158","author":"Feltquate","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0440","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1016\/S0264-410X(02)00250-5","article-title":"Gene gun bombardment with gold particles displays a particular Th2-promoting signal that overrules the Th1-inducing effect of immunostimulatory CpG motifs in DNA vaccines","volume":"20","author":"Weiss","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0445","doi-asserted-by":"crossref","first-page":"13601","DOI":"10.1073\/pnas.0405557101","article-title":"A cationic lipid-formulated plasmid DNA vaccine confers sustained antibody-mediated protection against aerosolized anthrax spores","volume":"101","author":"Hermanson","year":"2004","journal-title":"PNAS"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0450","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1099\/jmm.0.045393-0","article-title":"Characterization of a multi-component anthrax vaccine designed to target the initial stages of infection as well as toxaemia","volume":"61","author":"Cote","year":"2012","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0455","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/eji.200838058","article-title":"Anthrax protective antigen administered by DNA vaccination to distinct subcellular locations potentiates humoral and cellular immune responses","volume":"39","author":"Midha","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.vaccine.2015.04.049_bib0460","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1016\/j.vaccine.2008.07.015","article-title":"Recombinant Bacillus anthracis spore proteins enhance protection of mice primed with suboptimal amounts of protective antigen","volume":"26","author":"Cybulski","year":"2008","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15005137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15005137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T16:19:06Z","timestamp":1691597946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X15005137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":46,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0264410X15005137"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.04.049","relation":{},"ISSN":["0264-410X"],"issn-type":[{"type":"print","value":"0264-410X"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BclA and toxin antigens augment each other to protect NMRI mice from lethal Bacillus anthracis challenge","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.04.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}