{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:29:30Z","timestamp":1784194170883,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"38","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:00:00Z","timestamp":1472774400000},"content-version":"am","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.vaccine.2015.07.073","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T19:12:36Z","timestamp":1438456356000},"page":"4820-4826","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Peru-15 (Choleragarde\u00ae), a live attenuated oral cholera vaccine, is safe and immunogenic in human immunodeficiency virus (HIV)-seropositive adults in Thailand"],"prefix":"10.1016","volume":"33","author":[{"given":"W.","family":"Ratanasuwan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.K.","family":"Sah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Suwanagool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Anekthananon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Techasathit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.L.","family":"Grahek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.","family":"Clemens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.F.","family":"Wierzba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2015.07.073_bib0175","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2471\/BLT.11.093427","article-title":"The global burden of cholera","volume":"90","author":"Ali","year":"2012","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0180","unstructured":"(WHO) WHO. (2013) Cholera, 2012. Wkly Epidemiol Rec 88: 321-336."},{"key":"10.1016\/j.vaccine.2015.07.073_bib0185","unstructured":"UNAIDS (2014) Global Statistics. UNAIDS Fact Sheet 2014."},{"key":"10.1016\/j.vaccine.2015.07.073_bib0190","unstructured":"UNAIDS (2013) 2013 UNAIDS Report on the global AIDS epidemic."},{"key":"10.1016\/j.vaccine.2015.07.073_bib0195","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1097\/00002030-199510000-00019","article-title":"HIV seropositivity and cholera in refugee children from Rwanda","volume":"9","author":"Rey","year":"1995","journal-title":"AIDS"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0200","doi-asserted-by":"crossref","first-page":"973","DOI":"10.4269\/ajtmh.2006.75.973","article-title":"Review of reported cholera outbreaks worldwide, 1995\u20132005","volume":"75","author":"Griffith","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0205","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1365-3156.2008.02051.x","article-title":"Is HIV infection associated with an increased risk for cholera? Findings from a case-control study in Mozambique","volume":"13","author":"von Seidlein","year":"2008","journal-title":"Trop Med Int Health"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0210","unstructured":"Cholera vaccines: WHO position paper. Wkly Epidemiol Rec 85:117\u201328."},{"key":"10.1016\/j.vaccine.2015.07.073_bib0215","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1097\/00002030-199308000-00010","article-title":"Intestinal antibody responses to oral vaccination in HIV-infected individuals","volume":"7","author":"Eriksson","year":"1993","journal-title":"AIDS"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0220","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S1473-3099(13)70273-1","article-title":"5 year efficacy of a bivalent killed whole-cell oral cholera vaccine in Kolkata, India: a cluster-randomised, double-blind, placebo-controlled trial","volume":"13","author":"Bhattacharya","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0225","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/infdis\/172.4.1126","article-title":"Peru-15, an improved live attenuated oral vaccine candidate for Vibrio cholerae O1","volume":"172","author":"Kenner","year":"1995","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0230","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1086\/514025","article-title":"Evaluation of Peru-15, a new live oral vaccine for cholera, in volunteers","volume":"176","author":"Sack","year":"1997","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0235","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1128\/iai.65.6.2107-2111.1997","article-title":"Comparison of alternative buffers for use with a new live oral cholera vaccine, Peru-15, in outpatient volunteers","volume":"65","author":"Sack","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0240","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1128\/IAI.70.4.1965-1970.2002","article-title":"Randomized, controlled human challenge study of the safety, immunogenicity, and protective efficacy of a single dose of Peru-15, a live attenuated oral cholera vaccine","volume":"70","author":"Cohen","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0245","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1086\/432074","article-title":"Randomized, controlled study of the safety and immunogenicity of Peru-15, a live attenuated oral vaccine candidate for cholera, in adult volunteers in Bangladesh","volume":"192","author":"Qadri","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0250","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.vaccine.2006.08.031","article-title":"Peru-15, a live attenuated oral cholera vaccine, is safe and immunogenic in Bangladeshi toddlers and infants","volume":"25","author":"Qadri","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0255","first-page":"927","article-title":"Two consecutive outbreaks of food-borne cholera associated with consumption of chicken rice in northwestern Thailand","volume":"43","author":"Swaddiwudhipong","year":"2012","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0260","doi-asserted-by":"crossref","first-page":"875","DOI":"10.4269\/ajtmh.2010.09-0537","article-title":"A cholera outbreak of the Vibrio cholerae O1 El Tor variant carrying classical CtxB in northeastern Thailand in 2007","volume":"82","author":"Okada","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0265","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/sim.4780091208","article-title":"Test statistics and sample size formulae for comparative binomial trials with null hypothesis of non-zero risk difference or non-unity relative risk","volume":"9","author":"Farrington","year":"1990","journal-title":"Stat Med"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0270","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1128\/IAI.69.10.6084-6090.2001","article-title":"Diminished diarrheal response to Vibrio cholerae strains carrying the replicative form of the CTX(Phi) genome instead of CTX(Phi) lysogens in adult rabbits","volume":"69","author":"Faruque","year":"2001","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.vaccine.2015.07.073_bib0275","doi-asserted-by":"crossref","first-page":"e2323","DOI":"10.1371\/journal.pone.0002323","article-title":"A randomized, placebo-controlled trial of the bivalent killed, whole-cell, oral cholera vaccine in adults and children in a cholera endemic area in Kolkata, India","volume":"3","author":"Mahalanabis","year":"2008","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.vaccine.2015.07.073_bib0280","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/infdis\/155.1.79","article-title":"B subunit-whole cell and whole cell-only oral vaccines against cholera: studies on reactogenicity and immunogenicity","volume":"155","author":"Clemens","year":"1987","journal-title":"J Infect Dis"},{"issue":"9","key":"10.1016\/j.vaccine.2015.07.073_bib0285","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1128\/iai.61.9.3994-3997.1993","article-title":"Safety, immunogenicity, and excretion pattern of single-dose live oral cholera vaccine CVD 103-HgR in Peruvian adults of high and low socioeconomic levels","volume":"61","author":"Gotuzzo","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0295","first-page":"63","article-title":"A single dose of live oral cholera vaccine CVD 103-HgR is safe and immunogenic in HIV-infected and HIV-noninfected adults in Mali","volume":"76","author":"Peryy","year":"1998","journal-title":"Bull World Health Organization"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0300","first-page":"173","article-title":"Immunizations in HIV-infected adults","volume":"9","author":"Rivas","year":"2007","journal-title":"AIDS Rev"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0305","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1586\/erv.09.137","article-title":"Development of Peru-15 (CholeraGarde), a live-attenuated oral cholera vaccine: 1991-2009","volume":"8","author":"Chowdhury","year":"2009","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0310","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0264-410X(99)00321-7","article-title":"Vaccination and HIV: a review of the literature","volume":"18","author":"Rousseau","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0315","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1056\/NEJM199605093341903","article-title":"Effect of immunization with a common recall antigen on viral expression in patients infected with Human Immunodeficiency Virus Type 1","volume":"334","author":"Stanley","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0320","doi-asserted-by":"crossref","first-page":"F145","DOI":"10.1097\/00002030-199814000-00001","article-title":"Increase in plasma viral load after oral cholera immunization of HIV-infected subjects","volume":"12","author":"Ortig\u00e3o-de-Sampaio","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0325","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/QAD.0b013e3280ad3d93","article-title":"Immunization of the HIV infected traveller","volume":"21","author":"Chadwick","year":"2007","journal-title":"AIDS"},{"issue":"7","key":"10.1016\/j.vaccine.2015.07.073_bib0330","article-title":"Susceptibility to intestinal infection and diarrhoea in Zambian adults in relation to HIV status and CD4 count","volume":"9","author":"Kelly","year":"2009","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0335","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/00002030-199406000-00009","article-title":"Immune response following oral administration of cholera toxin B subunit to HIV-1-infected UK and Kenyan subjects","volume":"8","author":"Lewis","year":"1994","journal-title":"AIDS"},{"key":"10.1016\/j.vaccine.2015.07.073_bib0340","series-title":"Cholera Vaccines. Vaccines","first-page":"141","author":"Clemens","year":"2012"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15010506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15010506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:21:31Z","timestamp":1759400491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X15010506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":33,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0264410X15010506"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.07.073","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peru-15 (Choleragarde\u00ae), a live attenuated oral cholera vaccine, is safe and immunogenic in human immunodeficiency virus (HIV)-seropositive adults in Thailand","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.07.073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}