{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:23:52Z","timestamp":1783700632692,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Australian National Health & Medical Research Council","award":["NHMRC APP613622"],"award-info":[{"award-number":["NHMRC APP613622"]}]},{"name":"Australian Centre for Vaccine Development"},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001792","name":"James Cook University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001791","name":"Griffith University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001791","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Post Doctoral Research Fellowship","award":["2013001978"],"award-info":[{"award-number":["2013001978"]}]},{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Queensland Tropical Health Alliance"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.vaccine.2015.07.099","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T17:16:56Z","timestamp":1439918216000},"page":"5172-5180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effective cutaneous vaccination using an inactivated chikungunya virus vaccine delivered by Foroderm"],"prefix":"10.1016","volume":"33","author":[{"given":"Penny A.","family":"Rudd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Raphael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miko","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin L.","family":"Nufer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy T.T.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Prow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhung","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne A.","family":"Schroder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarl W.","family":"Prow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Suhrbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2015.07.099_bib0200","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/j.vaccine.2013.03.022","article-title":"Frontiers of transcutaneous vaccination systems: novel technologies and devices for vaccine delivery","volume":"31","author":"Matsuo","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0205","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1517\/17425247.2014.885947","article-title":"Cutaneous immunization: an evolving paradigm in influenza vaccines","volume":"11","author":"Gill","year":"2014","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0210","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2014008126","article-title":"Novel strategies for effective transdermal drug delivery: a review","volume":"31","author":"Jain","year":"2014","journal-title":"Crit Rev Ther Drug Carrier Syst"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0215","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.addr.2012.04.005","article-title":"Microneedles for drug and vaccine delivery","volume":"64","author":"Kim","year":"2012","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0220","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/smll.201000331","article-title":"Nanopatch-targeted skin vaccination against West Nile Virus and Chikungunya virus in mice","volume":"6","author":"Prow","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0225","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1038\/jid.2014.174","article-title":"Colocalization of cell death with antigen deposition in skin enhances vaccine immunogenicity","volume":"134","author":"Depelsenaire","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0230","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1517\/17425247.2012.676038","article-title":"Microneedle-mediated vaccine delivery: harnessing cutaneous immunobiology to improve efficacy","volume":"9","author":"Al-Zahrani","year":"2012","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0235","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jconrel.2013.07.025","article-title":"Elongate microparticles for enhanced drug delivery to ex vivo and in vivo pig skin","volume":"172","author":"Raphael","year":"2013","journal-title":"J Control Release"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0240","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/adhm.201300517","article-title":"High aspect ratio elongated microparticles for enhanced topical drug delivery in human volunteers","volume":"3","author":"Raphael","year":"2014","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0245","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nrrheum.2012.64","article-title":"Arthritogenic alphaviruses\u2014an overview","volume":"8","author":"Suhrbier","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0250","doi-asserted-by":"crossref","first-page":"e2921","DOI":"10.1371\/journal.pntd.0002921","article-title":"Arrival of chikungunya virus in the new world: prospects for spread and impact on public health","volume":"8","author":"Weaver","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0255","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5365\/wpsar.2013.4.2.003","article-title":"The threat of chikungunya in Oceania","volume":"4","author":"Horwood","year":"2013","journal-title":"West Pac Surveill Response J"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0260","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.344.6185.678","article-title":"Infectious diseases. Crippling virus set to conquer Western Hemisphere","volume":"344","author":"Enserink","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0265","doi-asserted-by":"crossref","first-page":"681","DOI":"10.4269\/ajtmh.2000.62.681","article-title":"Phase II safety and immunogenicity study of live chikungunya virus vaccine TSI-GSD-218","volume":"62","author":"Edelman","year":"2000","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0270","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/S0140-6736(14)61185-5","article-title":"Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial","volume":"384","author":"Chang","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0275","doi-asserted-by":"crossref","first-page":"e2124","DOI":"10.1371\/journal.pntd.0002124","article-title":"Effective chikungunya virus-like particle vaccine produced in insect cells","volume":"7","author":"Metz","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0280","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1128\/JVI.03418-13","article-title":"A novel poxvirus-based vaccine, MVA-CHIKV, is highly immunogenic and protects mice against chikungunya infection","volume":"88","author":"Garcia-Arriaza","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0285","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1016\/j.vaccine.2011.01.108","article-title":"A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis","volume":"29","author":"Wang","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0290","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1128\/JVI.02603-09","article-title":"Chikungunya virus arthritis in adult wild-type mice","volume":"84","author":"Gardner","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0295","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1128\/CVI.00546-14","article-title":"An inactivated Ross river virus vaccine is well tolerated and immunogenic in an adult population in a randomized phase 3 trial","volume":"22","author":"Wressnigg","year":"2015","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0300","doi-asserted-by":"crossref","first-page":"e3354","DOI":"10.1371\/journal.pntd.0003354","article-title":"Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection","volume":"8","author":"Poo","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0305","doi-asserted-by":"crossref","first-page":"e2423","DOI":"10.1371\/journal.pntd.0002423","article-title":"A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease","volume":"7","author":"Selvarajah","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0310","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.clim.2013.10.004","article-title":"Neutralizing monoclonal antibodies to the E2 protein of chikungunya virus protects against disease in a mouse model","volume":"149","author":"Goh","year":"2013","journal-title":"Clin Immunol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0315","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1016\/j.vaccine.2011.03.089","article-title":"Evaluation of an inactivated Ross River virus vaccine in active and passive mouse immunization models and establishment of a correlate of protection","volume":"29","author":"Holzer","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0320","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.4269\/ajtmh.2007.76.1189","article-title":"Seroprevalence of chikungunya virus infection on Grande Comore Island, union of the Comoros, 2005","volume":"76","author":"Sergon","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0325","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.3201\/eid1212.060710","article-title":"Chikungunya disease outbreak, Reunion Island","volume":"12","author":"Josseran","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0330","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0140-6736(99)06527-7","article-title":"The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt","volume":"355","author":"Frank","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0335","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/jid.2011.418","article-title":"Ingenol mebutate field-directed treatment of UVB-damaged skin reduces lesion formation and removes mutant p53 patches","volume":"132","author":"Cozzi","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0340","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1128\/JVI.00956-12","article-title":"Interferon response factors 3 and 7 protect against chikungunya virus hemorrhagic fever and shock","volume":"86","author":"Rudd","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0345","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0022-1759(98)00015-5","article-title":"The need for IgG2c specific antiserum when isotyping antibodies from C57BL\/6 and NOD mice","volume":"212","author":"Martin","year":"1998","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0350","doi-asserted-by":"crossref","first-page":"6915","DOI":"10.1128\/IAI.71.12.6915-6920.2003","article-title":"Th1-directing adjuvants increase the immunogenicity of oligosaccharide-protein conjugate vaccines related to Streptococcus pneumoniae type 3","volume":"71","author":"Lefeber","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0355","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1128\/JVI.75.9.4103-4109.2001","article-title":"Arbovirus of marine mammals: a new alphavirus isolated from the elephant seal louse, Lepidophthirus macrorhini","volume":"75","author":"La Linn","year":"2001","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0360","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-4614-6217-0_13","article-title":"Targeting the skin for microneedle delivery of influenza vaccine","volume":"785","author":"Koutsonanos","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0365","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2340\/00015555-0875","article-title":"Variation in epidermal morphology in human skin at different body sites as measured by reflectance confocal microscopy","volume":"90","author":"Robertson","year":"2010","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0370","first-page":"109","article-title":"Routine skin preparation with 70% isopropyl alcohol swab: is it necessary before an injection? Quasi study","volume":"12","author":"Khawaja","year":"2013","journal-title":"JLUMHS"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0375","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.ajic.2012.11.009","article-title":"Isopropyl alcohol skin antisepsis does not reduce incidence of infection following insulin injection","volume":"41","author":"O\u2019Neill","year":"2013","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0380","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3109\/08830185.2013.773326","article-title":"Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects","volume":"32","author":"Kuroda","year":"2013","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymeth.2006.05.016","article-title":"Pathogen recognition and development of particulate vaccines: does size matter","volume":"40","author":"Xiang","year":"2006","journal-title":"Methods"},{"key":"10.1016\/j.vaccine.2015.07.099_bib0390","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1007\/s11095-013-1092-6","article-title":"Development and clinical study of a self-dissolving microneedle patch for transcutaneous immunization device","volume":"30","author":"Hirobe","year":"2013","journal-title":"Pharm Res"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15011032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15011032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T14:36:06Z","timestamp":1567089366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X15011032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":39,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0264410X15011032"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.07.099","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effective cutaneous vaccination using an inactivated chikungunya virus vaccine delivered by Foroderm","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.07.099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}