{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:22:03Z","timestamp":1790166123421,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"46","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.vaccine.2015.09.008","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T12:13:52Z","timestamp":1442319232000},"page":"6351-6359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Safety and immunogenicity of different doses and schedules of a live attenuated tetravalent dengue vaccine (TDV) in healthy adults: A Phase 1b randomized study"],"prefix":"10.1016","volume":"33","author":[{"given":"Richard","family":"Rupp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary Joseph","family":"Luckasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith Lee","family":"Kirstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Osorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Santangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha","family":"Raanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Kathryn","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilad S.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan T.","family":"Stinchcomb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2015.09.008_bib0105","series-title":"Dengue: guidelines for diagnosis, treatment, prevention and control","author":"World Health Organization","year":"2009"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0110","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0115","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/S0140-6736(07)60645-X","article-title":"The burden of dengue infection","volume":"369","author":"Halstead","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0120","series-title":"Global Strategy for dengue prevention and control, 2012\u20132020","author":"WHO","year":"2012"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0125","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1016\/j.vaccine.2015.05.010","article-title":"The dengue vaccine pipeline: Implications for the future of dengue control","volume":"33","author":"Schwartz","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0130","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.4269\/ajtmh.2005.73.1063","article-title":"Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua","volume":"73","author":"Hammond","year":"2005","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0135","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.imbio.2008.11.008","article-title":"Role of antibodies in controlling dengue virus infection","volume":"214","author":"van der Schaar","year":"2009","journal-title":"Immunobiology"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0140","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.vaccine.2004.03.069","article-title":"Dengue virus: molecular basis of cell entry and pathogenesis, 25\u201327 June 2003, Vienna, Austria","volume":"23","author":"Halstead","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0145","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1038\/nrmicro2460","article-title":"Dengue: a continuing global threat","volume":"8","author":"Guzman","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0150","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1016\/j.vaccine.2011.07.020","article-title":"Development of DENVax: a chimeric dengue-2 PDK-53-based tetravalent vaccine for protection against dengue fever","volume":"29","author":"Osorio","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0155","doi-asserted-by":"crossref","first-page":"11436","DOI":"10.1128\/JVI.77.21.11436-11447.2003","article-title":"Dengue 2 PDK-53 virus as a chimeric carrier for tetravalent dengue vaccine development","volume":"77","author":"Huang","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0160","doi-asserted-by":"crossref","first-page":"e2243","DOI":"10.1371\/journal.pntd.0002243","article-title":"Genetic and phenotypic characterization of manufacturing seeds for a tetravalent dengue vaccine (DENVax)","volume":"7","author":"Huang","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0165","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S1473-3099(14)70811-4","article-title":"Safety and immunogenicity of a recombinant live attenuated tetravalent dengue vaccine (DENVax) in flavivirus-naive healthy adults in Colombia: a randomised, placebo-controlled, Phase 1 study","volume":"14","author":"Osorio","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0170","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiv179","article-title":"Safety and immunogenicity of a live attenuated tetravalent dengue vaccine candidate in flavivirus-na\u00efve adults: a randomized, double-blind Phase I clinical trial","author":"George","year":"2015","journal-title":"Journal of Infectious Diseases"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0175","doi-asserted-by":"crossref","first-page":"978","DOI":"10.4269\/ajtmh.2011.10-0592","article-title":"Efficacy of a tetravalent chimeric dengue vaccine (DENVax) in Cynomolgus macaques","volume":"84","author":"Osorio","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0180","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/infdis\/jir279","article-title":"Interference and facilitation between dengue serotypes in a tetravalent live dengue virus vaccine candidate","volume":"204","author":"Anderson","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0185","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4269\/ajtmh.2009.80.302","article-title":"Evaluation of interferences between dengue vaccine serotypes in a monkey model","volume":"80","author":"Guy","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0190","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3389\/fimmu.2014.00263","article-title":"A rapid immunization strategy with a live-attenuated tetravalent dengue vaccine elicits protective neutralizing antibody responses in non-human primates","volume":"5","author":"Ambuel","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0195","series-title":"Common terminology criteria for adverse events (CTCAE) Version 4.03.2","author":"U.S. Department of Health and Human Services NIoH, National Cancer Institute","year":"2009"},{"key":"10.1016\/j.vaccine.2015.09.008_bib0200","series-title":"Guidance for industry toxicity grading scale for healthy adult and adolescent volunteers enrolled in preventive vaccine clinical trials","author":"Food and Drug Administration Center for Biologics Evaluation and Research","year":"2007"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15012517?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15012517?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T11:51:11Z","timestamp":1567165871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X15012517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":20,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0264410X15012517"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.09.008","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and immunogenicity of different doses and schedules of a live attenuated tetravalent dengue vaccine (TDV) in healthy adults: A Phase 1b randomized study","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}