{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:38:51Z","timestamp":1792712331211,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"42","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003195","name":"Dutch Ministry of Economic Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003195","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.vaccine.2015.09.020","type":"journal-article","created":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T14:08:17Z","timestamp":1442671697000},"page":"5539-5545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Development of a competitive ELISA for NS3 antibodies as DIVA test accompanying the novel Disabled Infectious Single Animal (DISA) vaccine for Bluetongue"],"prefix":"10.1016","volume":"33","author":[{"given":"Mirriam G.J.","family":"Tacken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz J.","family":"Daus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke","family":"Feenstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 G.P.","family":"van Gennip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet A.","family":"van Rijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2015.09.020_bib0255","series-title":"Terrestrial animal health code","author":"OIE","year":"2014"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0260","doi-asserted-by":"crossref","first-page":"351","DOI":"10.20506\/rst.5.2.256","article-title":"The epidemiology of bluetongue","volume":"5","author":"Taylor","year":"1986","journal-title":"Rev Sci Tech Off Int Epizoot"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0265","series-title":"Infectious diseases of livestock","first-page":"1201","article-title":"Bluetongue","author":"Verwoerd","year":"2004"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0270","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrmicro1090","article-title":"Climate change and the recent emergence of bluetongue in Europe","volume":"3","author":"Purse","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0275","first-page":"51","article-title":"Identification of the serotype-specific and group-specific antigens of bluetongue virus","volume":"48","author":"Huismans","year":"1981","journal-title":"Onderstepoort J Vet Res"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0280","doi-asserted-by":"crossref","first-page":"e32601","DOI":"10.1371\/journal.pone.0032601","article-title":"Identification and differentiation of the twenty six bluetongue virus serotypes by RT-PCR amplification of the serotype-specific genome segment 2","volume":"7","author":"Maan","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0285","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3201\/eid1412.080818","article-title":"Genetic characterization of Toggenburg Orbivirus, a new bluetongue virus, from goats, Switzerland","volume":"14","author":"Hofmann","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0290","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3201\/eid1705.101742","article-title":"Novel bluetongue virus serotype from Kuwait","volume":"17","author":"Maan","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0295","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.3201\/eid2012.140924","article-title":"Novel bluetongue virus in goats, Corsica, France, 2014","volume":"20","author":"Zientara","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0300","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0147-9571(94)90044-2","article-title":"The epidemiology of bluetongue","volume":"17","author":"Gibbs","year":"1994","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0305","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1136\/vr.162.13.422-a","article-title":"Culicoides chiopterus as a potential vector of bluetongue virus in Europe","volume":"162","author":"Dijkstra","year":"2008","journal-title":"Vet Rec"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0310","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/vr.161.16.564","article-title":"Potential new Culicoides vector of bluetongue virus in northern Europe","volume":"161","author":"Meiswinkel","year":"2007","journal-title":"Vet Rec"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0315","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00436-007-0519-6","article-title":"First occurrence of Culicoides obsoletus-transmitted bluetongue virus epidemic in Central Europe","volume":"101","author":"Mehlhorn","year":"2007","journal-title":"Parasitol Res"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0320","series-title":"Biology of animal infections: bluetongue","first-page":"23","article-title":"Bluetongue virus, other orbiviruses and other reoviruses: their relationships and taxonomy","author":"Attoui","year":"2009"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0325","series-title":"VIIIth report of the ICTV","first-page":"466","article-title":"Virus taxonomy","author":"Mertens","year":"2005"},{"issue":"Pt 3","key":"10.1016\/j.vaccine.2015.09.020_bib0330","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1099\/0022-1317-69-3-573","article-title":"In vitro transcription and translation of bluetongue virus mRNA","volume":"69","author":"Van Dijk","year":"1988","journal-title":"J Gen Virol"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0335","doi-asserted-by":"crossref","first-page":"e1002477","DOI":"10.1371\/journal.ppat.1002477","article-title":"Identification and characterization of a novel non-structural protein of bluetongue virus","volume":"7","author":"Ratinier","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vaccine.2015.09.020_bib0340","doi-asserted-by":"crossref","first-page":"e25697","DOI":"10.1371\/journal.pone.0025697","article-title":"Detection of a fourth orbivirus non-structural protein","volume":"6","author":"Belhouchet","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0345","series-title":"Virus infections of ruminants","author":"Erasmus","year":"1990"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0350","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1099\/vir.0.82456-0","article-title":"Analysis and phylogenetic comparisons of full-length VP2 genes of the 24 bluetongue virus serotypes","volume":"88","author":"Maan","year":"2007","journal-title":"J Gen Virol"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0355","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.vetmic.2009.01.033","article-title":"A DIVA system based on the detection of antibodies to non-structural protein 3 (NS3) of bluetongue virus","volume":"137","author":"Barros","year":"2009","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0360","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2478\/v10181-011-0048-1","article-title":"Bluetongue vaccines in Europe","volume":"14","author":"Niedbalski","year":"2011","journal-title":"Pol J Vet Sci"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0365","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.virusres.2008.05.016","article-title":"A European field strain of bluetongue virus derived from two parental vaccine strains by genome segment reassortment","volume":"137","author":"Batten","year":"2008","journal-title":"Virus Res"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0370","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.vetmic.2010.04.020","article-title":"Risk factors associated with the occurrence of undesired effects in sheep and goats after field vaccination with modified-live vaccine against bluetongue virus serotypes 2, 4 and 16","volume":"146","author":"Savini","year":"2010","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0375","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1016\/j.vaccine.2005.07.039","article-title":"Live attenuated bluetongue vaccine viruses in Dorset Poll sheep, before and after passage in vector midges (Diptera: Ceratopogonidae)","volume":"23","author":"Veronesi","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0380","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.vaccine.2009.10.107","article-title":"Viraemia and clinical disease in Dorset Poll sheep following vaccination with live attenuated bluetongue virus vaccines serotypes 16 and 4","volume":"28","author":"Veronesi","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0385","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cimid.2007.07.006","article-title":"Vaccines against bluetongue in Europe","volume":"31","author":"Savini","year":"2008","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0390","doi-asserted-by":"crossref","first-page":"e44619","DOI":"10.1371\/journal.pone.0044619","article-title":"Bluetongue viruses based on modified-live vaccine serotype 6 with exchanged outer shell proteins confer full protection in sheep against virulent BTV8","volume":"7","author":"van Gennip","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0395","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.vetmic.2012.01.022","article-title":"Bluetongue virus serotype 6 in Europe in 2008-Emergence and disappearance of an unexpected non-virulent BTV","volume":"158","author":"van Rijn","year":"2012","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0400","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1099\/vir.0.065615-0","article-title":"Bluetongue virus without NS3\/NS3a expression is not virulent and protects against virulent bluetongue virus challenge","volume":"95","author":"Feenstra","year":"2014","journal-title":"J Gen Virol"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0405","doi-asserted-by":"crossref","first-page":"7108","DOI":"10.1016\/j.vaccine.2014.10.033","article-title":"VP2-serotyped live-attenuated bluetongue virus without NS3\/NS3a expression provides serotype-specific protection and enables DIVA","volume":"32","author":"Feenstra","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0410","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.vaccine.2014.12.003","article-title":"Application of bluetongue Disabled Infectious Single Animal (DISA) vaccine for different serotypes by VP2 exchange or incorporation of chimeric VP2","volume":"33","author":"Feenstra","year":"2015","journal-title":"Vaccine"},{"issue":"Pt 6","key":"10.1016\/j.vaccine.2015.09.020_bib0415","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1099\/0022-1317-67-6-1179","article-title":"Differentiation of serum antibodies from pigs vaccinated or infected with Aujeszky's disease virus by a competitive enzyme immunoassay","volume":"67","author":"van Oirschot","year":"1986","journal-title":"J Gen Virol"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0420","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0168-1656(99)00121-2","article-title":"Diva vaccines that reduce virus transmission","volume":"73","author":"van Oirschot","year":"1999","journal-title":"J Biotechnol"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0425","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF01314778","article-title":"Persistent infection of BHK21\/WI-2 cells with rubella virus and characterization of rubella variants","volume":"54","author":"Sato","year":"1977","journal-title":"Arch Virol"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0430","doi-asserted-by":"crossref","first-page":"e30540","DOI":"10.1371\/journal.pone.0030540","article-title":"Rescue of recent virulent and avirulent field strains of bluetongue virus by reverse genetics","volume":"7","author":"van Gennip","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0435","doi-asserted-by":"crossref","first-page":"e85788","DOI":"10.1371\/journal.pone.0085788","article-title":"Bluetongue virus nonstructural protein NS3\/NS3a is not essential for virus replication","volume":"9","author":"van Gennip","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0440","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1016\/j.vaccine.2013.08.089","article-title":"Bluetongue virus with mutated genome segment 10 to differentiate infected from vaccinated animals: a genetic DIVA approach","volume":"31","author":"van Rijn","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0445","doi-asserted-by":"crossref","first-page":"e92377","DOI":"10.1371\/journal.pone.0092377","article-title":"RNA elements in open reading frames of the bluetongue virus genome are essential for virus replication","volume":"9","author":"Feenstra","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0450","doi-asserted-by":"crossref","first-page":"8764","DOI":"10.1128\/JVI.01052-15","article-title":"VP2 exchange and NS3\/NS3a deletion in African horse sickness virus (AHSV) in development of Disabled Infectious Single Animal vaccine candidates for AHSV","volume":"89","author":"van de Water","year":"2015","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0455","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/vr.122.22.536","article-title":"Detection of antibodies against African swine fever virus using infected monolayers and monoclonal-antibodies","volume":"122","author":"Wensvoort","year":"1988","journal-title":"Vet Rec"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0460","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1136\/vr.161.17.591","article-title":"Clinical signs of bluetongue virus serotype 8 infection in sheep and goats","volume":"161","author":"Backx","year":"2007","journal-title":"Vet Rec"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0465","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1177\/1040638712440986","article-title":"Sustained high-throughput polymerase chain reaction diagnostics during the European epidemic of bluetongue virus serotype 8","volume":"24","author":"van Rijn","year":"2012","journal-title":"J Vet Diagn Invest"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0470","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.rvsc.2013.06.026","article-title":"Epizootic hemorrhagic disease virus serotype 6 experimentation on adult cattle","volume":"95","author":"Breard","year":"2013","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0475","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1016\/j.vaccine.2010.06.034","article-title":"Bluetongue virus RNA detection by RT-qPCR in blood samples of sheep vaccinated with a commercially available inactivated BTV-8 vaccine","volume":"28","author":"Steinrigl","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0480","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/tbed.12100","article-title":"Bluetongue virus RNA detection by real-time rt-PCR in post-vaccination samples from cattle","volume":"62","author":"De Leeuw","year":"2015","journal-title":"Transboundary Emerg Dis"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0485","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jviromet.2006.05.028","article-title":"Rapid detection and quantitation of bluetongue virus (BTV) using a molecular beacon fluorescent probe assay","volume":"137","author":"Orru","year":"2006","journal-title":"J Virol Methods"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0490","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jviromet.2010.03.032","article-title":"Development of a real-time RT-PCR assay based on primer-probe energy transfer for the detection of all serotypes of bluetongue virus","volume":"167","author":"Leblanc","year":"2010","journal-title":"J Virol Methods"},{"key":"10.1016\/j.vaccine.2015.09.020_bib0495","series-title":"Manual of diagnostic tests and vaccines for terrestrial animals","author":"OIE","year":"2014"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15012827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15012827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T04:42:19Z","timestamp":1565412139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X15012827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":49,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0264410X15012827"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.09.020","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a competitive ELISA for NS3 antibodies as DIVA test accompanying the novel Disabled Infectious Single Animal (DISA) vaccine for Bluetongue","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}