{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:29:31Z","timestamp":1793212171212,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.vaccine.2015.09.073","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T08:19:33Z","timestamp":1443773973000},"page":"863-868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["Long-term immunogenicity and safety of an investigational herpes zoster subunit vaccine in older adults"],"prefix":"10.1016","volume":"34","author":[{"given":"Roman","family":"Chlibek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlis","family":"Pauksens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Rombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gini","family":"van Rijckevorsel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Richardus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Plassmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tino F.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Catteau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himal","family":"Lal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Heineman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"RR\u20135","key":"10.1016\/j.vaccine.2015.09.073_bib0130","first-page":"1","article-title":"Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"57","author":"Harpaz","year":"2008","journal-title":"MMWR Recomm Rep"},{"issue":"Suppl. 1","key":"10.1016\/j.vaccine.2015.09.073_bib0135","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S1386-6532(10)70002-0","article-title":"Advances in the understanding of the pathogenesis and epidemiology of herpes zoster","volume":"48","author":"Gershon","year":"2010","journal-title":"J Clin Virol"},{"issue":"22","key":"10.1016\/j.vaccine.2015.09.073_bib0140","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1056\/NEJMoa051016","article-title":"A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults","volume":"352","author":"Oxman","year":"2005","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.vaccine.2015.09.073_bib0145","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1086\/605611","article-title":"Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccine","volume":"200","author":"Weinberg","year":"2009","journal-title":"J Infect Dis"},{"issue":"6 (Suppl. 2)","key":"10.1016\/j.vaccine.2015.09.073_bib0150","first-page":"S13","article-title":"Herpes zoster pathogenesis and cell-mediated immunity and immunosenescence","volume":"109","author":"Oxman","year":"2009","journal-title":"J Am Osteopath Assoc"},{"issue":"44","key":"10.1016\/j.vaccine.2015.09.073_bib0155","first-page":"1528","article-title":"Update on herpes zoster vaccine: licensure for persons aged 50 through 59 years","volume":"60","author":"Centers for Disease Control and Prevention","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"4","key":"10.1016\/j.vaccine.2015.09.073_bib0160","doi-asserted-by":"crossref","first-page":"e1001420","DOI":"10.1371\/journal.pmed.1001420","article-title":"Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study","volume":"10","author":"Langan","year":"2013","journal-title":"PLoS Med"},{"issue":"10","key":"10.1016\/j.vaccine.2015.09.073_bib0165","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/cid\/cis638","article-title":"Persistence of the efficacy of zoster vaccine in the shingles prevention study and the short-term persistence substudy","volume":"55","author":"Schmader","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.vaccine.2015.09.073_bib0170","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1093\/cid\/ciu918","article-title":"Long-term persistence of zoster vaccine efficacy","volume":"60","author":"Morrison","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2015.09.073_bib0175","first-page":"153","article-title":"Recombinant subunit vaccines: potentials and constraints","volume":"121","author":"Clark","year":"2005","journal-title":"Dev Biol (Basel)"},{"issue":"3","key":"10.1016\/j.vaccine.2015.09.073_bib0180","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1365-2249.2008.03633.x","article-title":"Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donors","volume":"152","author":"Malavige","year":"2008","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"10.1016\/j.vaccine.2015.09.073_bib0185","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0264-410X(93)90382-8","article-title":"Antigenicity of a candidate varicella-zoster virus glycoprotein subunit vaccine","volume":"11","author":"Vafai","year":"1993","journal-title":"Vaccine"},{"issue":"14","key":"10.1016\/j.vaccine.2015.09.073_bib0190","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/0264-410X(94)00073-V","article-title":"Boosting immune response with a candidate varicella-zoster virus glycoprotein subunit vaccine","volume":"13","author":"Vafai","year":"1995","journal-title":"Vaccine"},{"issue":"15","key":"10.1016\/j.vaccine.2015.09.073_bib0195","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.vaccine.2014.01.019","article-title":"Safety and immunogenicity of three different formulations of an adjuvanted varicella-zoster virus subunit candidate vaccine in older adults: a phase II, randomized, controlled study","volume":"32","author":"Chlibek","year":"2014","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.vaccine.2015.09.073_bib0200","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/infdis\/jit365","article-title":"Safety and immunogenicity of an AS01-adjuvanted varicella-zoster virus subunit candidate vaccine against herpes zoster in adults \u226550 years of age","volume":"208","author":"Chlibek","year":"2013","journal-title":"J Infect Dis"},{"issue":"22","key":"10.1016\/j.vaccine.2015.09.073_bib0205","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1056\/NEJMoa1501184","article-title":"Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults","volume":"372","author":"Lal","year":"2015","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.vaccine.2015.09.073_bib0210","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1093\/infdis\/jis497","article-title":"A phase 1\/2 clinical trial evaluating safety and immunogenicity of a varicella zoster glycoprotein E subunit vaccine candidate in young and older adults","volume":"206","author":"Leroux-Roels","year":"2012","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.vaccine.2015.09.073_bib0215","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/ni.2588","article-title":"Understanding immunosenescence to improve responses to vaccines","volume":"14","author":"Goronzy","year":"2013","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.vaccine.2015.09.073_bib0220","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.coi.2012.06.002","article-title":"Immune senescence and vaccines to prevent herpes zoster in older persons","volume":"24","author":"Levin","year":"2012","journal-title":"Curr Opin Immunol"},{"issue":"2","key":"10.1016\/j.vaccine.2015.09.073_bib0225","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1086\/653605","article-title":"Zoster vaccine: current status and future prospects","volume":"51","author":"Oxman","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.1016\/j.vaccine.2015.09.073_bib0230","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1586\/erv.09.12","article-title":"Prevention of infectious diseases in older adults through immunization: the challenge of the senescent immune response","volume":"8","author":"McElhaney","year":"2009","journal-title":"Expert Rev Vaccines"},{"issue":"9967","key":"10.1016\/j.vaccine.2015.09.073_bib0235","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0140-6736(14)61347-7","article-title":"The burden of disease in older people and implications for health policy and practice","volume":"385","author":"Prince","year":"2015","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.vaccine.2015.09.073_bib0240","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/infdis\/jiu606","article-title":"Safety and immunogenicity of an adjuvanted herpes zoster subunit candidate vaccine in HIV-infected adults: a phase 1\/2a randomized, placebo-controlled study","volume":"211","author":"Berkowitz","year":"2014","journal-title":"J Infect Dis"},{"issue":"19","key":"10.1016\/j.vaccine.2015.09.073_bib0245","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1182\/blood-2014-04-573048","article-title":"A phase 1\/2 study of an adjuvanted varicella-zoster virus subunit vaccine in autologous hematopoietic cell transplant recipients","volume":"124","author":"Stadtmauer","year":"2014","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.vaccine.2015.09.073_bib0250","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1289\/ehp.01109757","article-title":"Vaccine-induced antibody responses as parameters of the influence of endogenous and environmental factors","volume":"109","author":"Van Loveren","year":"2001","journal-title":"Environ Health Perspect"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15013493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15013493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T05:37:02Z","timestamp":1567229822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X15013493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0264410X15013493"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.09.073","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term immunogenicity and safety of an investigational herpes zoster subunit vaccine in older adults","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.09.073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}