{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:36:25Z","timestamp":1777329385211,"version":"3.51.4"},"reference-count":91,"publisher":"Elsevier BV","issue":"52","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.vaccine.2015.09.094","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T23:57:29Z","timestamp":1445731049000},"page":"7444-7451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Progress with viral vectored malaria vaccines: A multi-stage approach involving \u201cunnatural immunity\u201d"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-9836","authenticated-orcid":false,"given":"Katie J.","family":"Ewer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailan","family":"Sierra-Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Salman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Illingworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J.","family":"Draper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumi","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian V.S.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2015.09.094_bib0460","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1038\/ncomms3836","article-title":"Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation","volume":"4","author":"Ewer","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0465","doi-asserted-by":"crossref","first-page":"286re285","DOI":"10.1126\/scitranslmed.aaa2373","article-title":"Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults","volume":"7","author":"Ogwang","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0470","doi-asserted-by":"crossref","first-page":"9952","DOI":"10.1073\/pnas.1633254100","article-title":"Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data","volume":"100","author":"Doolan","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0475","doi-asserted-by":"crossref","first-page":"e1371","DOI":"10.1371\/journal.pone.0001371","article-title":"Sterile protection against malaria is independent of immune responses to the circumsporozoite protein","volume":"2","author":"Gruner","year":"2007","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0480","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1128\/IAI.01415-09","article-title":"Minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites","volume":"78","author":"Mauduit","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0485","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1074\/mcp.M112.024505","article-title":"Total and putative surface proteomics of malaria parasite salivary gland sporozoites","volume":"12","author":"Lindner","year":"2013","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0490","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1126\/science.3880923","article-title":"Complete development of hepatic stages of Plasmodium falciparum in vitro","volume":"227","author":"Mazier","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0495","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1172\/JCI62684","article-title":"Complete Plasmodium falciparum liver-stage development in liver-chimeric mice","volume":"122","author":"Vaughan","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0500","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1186\/1475-2875-13-386","article-title":"Humanized HLA-DR4.RagKO.IL2RgammacKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria","volume":"13","author":"Wijayalath","year":"2014","journal-title":"Malar J"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0505","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature01099","article-title":"Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii","volume":"419","author":"Carlton","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0510","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nrmicro1392","article-title":"Plasmodium post-genomics: better the bug you know?","volume":"4","author":"Kooij","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0515","doi-asserted-by":"crossref","first-page":"9090","DOI":"10.1073\/pnas.1303858110","article-title":"In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages","volume":"110","author":"Cockburn","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0520","doi-asserted-by":"crossref","first-page":"e12294","DOI":"10.1371\/journal.pone.0012294","article-title":"Immunization with pre-erythrocytic antigen CelTOS from Plasmodium falciparum elicits cross-species protection against heterologous challenge with Plasmodium berghei","volume":"5","author":"Bergmann-Leitner","year":"2010","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0525","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nature05361","article-title":"The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites","volume":"444","author":"Kumar","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0530","doi-asserted-by":"crossref","first-page":"11820","DOI":"10.1038\/srep11820","article-title":"Comparative assessment of vaccine vectors encoding ten malaria antigens identifies two protective liver-stage candidates","volume":"5","author":"Longley","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0535","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1128\/IAI.62.11.4844-4847.1994","article-title":"Susceptibility of different strains of mice to hepatic infection with Plasmodium berghei","volume":"62","author":"Scheller","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0540","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1475-2875-10-65","article-title":"Identification of two new protective pre-erythrocytic malaria vaccine antigen candidates","volume":"10","author":"Limbach","year":"2011","journal-title":"Malar J"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0545","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1128\/IAI.69.2.1202-1206.2001","article-title":"DNA immunization by Plasmodium falciparum liver-stage antigen 3 induces protection against Plasmodium yoelii sporozoite challenge","volume":"69","author":"Sauzet","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0550","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fimmu.2013.00176","article-title":"Self-adjuvanting bacterial vectors expressing pre-erythrocytic antigens induce sterile protection against malaria","volume":"4","author":"Bergmann-Leitner","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0555","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1016\/j.vaccine.2005.11.028","article-title":"Phase I safety and immunogenicity trial of FMP1\/AS02A, a Plasmodium falciparum MSP-1 asexual blood stage vaccine","volume":"24","author":"Ockenhouse","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0560","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1038\/mt.2012.223","article-title":"ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans","volume":"20","author":"Sheehy","year":"2012","journal-title":"Mol Ther"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0565","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1056\/NEJMoa1008115","article-title":"A field trial to assess a blood-stage malaria vaccine","volume":"365","author":"Thera","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0570","doi-asserted-by":"crossref","first-page":"e22271","DOI":"10.1371\/journal.pone.0022271","article-title":"Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1\/Alhydrogel+CPG 7909","volume":"6","author":"Duncan","year":"2011","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0575","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1056\/NEJMc1100670","article-title":"Protection against malaria by MSP3 candidate vaccine","volume":"365","author":"Sirima","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0580","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/284366a0","article-title":"Protective monoclonal antibodies recognising stage-specific merozoite antigens of a rodent malaria parasite","volume":"284","author":"Freeman","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0585","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/294361a0","article-title":"Immunization against blood-stage rodent malaria using purified parasite antigens","volume":"294","author":"Holder","year":"1981","journal-title":"Nature"},{"issue":"Suppl 2","key":"10.1016\/j.vaccine.2015.09.094_bib0590","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1590\/S0074-02761994000600018","article-title":"A novel merozoite surface antigen of Plasmodium falciparum (MSP-3) identified by cellular-antibody cooperative mechanism antigenicity and biological activity of antibodies","volume":"89","author":"Oeuvray","year":"1994","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0595","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1182\/blood.V84.5.1594.1594","article-title":"Merozoite surface protein-3: a malaria protein inducing antibodies that promote Plasmodium falciparum killing by cooperation with blood monocytes","volume":"84","author":"Oeuvray","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0600","first-page":"297","article-title":"Rat monoclonal antibodies which inhibit the in vitro multiplication of Plasmodium knowlesi","volume":"49","author":"Deans","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0605","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0166-6851(84)90065-3","article-title":"Biosynthesis of a putative protective Plasmodium knowlesi merozoite antigen","volume":"11","author":"Deans","year":"1984","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0610","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4049\/jimmunol.127.1.212","article-title":"Monoclonal antibodies against a specific surface determinant on malarial (Plasmodium knowlesi) merozoites block erythrocyte invasion","volume":"127","author":"Epstein","year":"1981","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0615","doi-asserted-by":"crossref","first-page":"247ra102","DOI":"10.1126\/scitranslmed.3008705","article-title":"New antigens for a multicomponent blood-stage malaria vaccine","volume":"6","author":"Osier","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0620","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1126\/science.287.5459.1816","article-title":"Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing","volume":"287","author":"Pizza","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0625","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1179\/2047773214Y.0000000162","article-title":"Bexsero\u00ae chronicle","volume":"108","author":"Vernikos","year":"2014","journal-title":"Pathog Glob Health"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0630","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.molbiopara.2006.03.011","article-title":"Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes","volume":"148","author":"Mehlin","year":"2006","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0635","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1101\/gr.2416604","article-title":"High-throughput generation of P. falciparum functional molecules by recombinational cloning","volume":"14","author":"Aguiar","year":"2004","journal-title":"Genome Res"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0640","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/bit.24342","article-title":"Preventing spontaneous genetic rearrangements in the transgene cassettes of adenovirus vectors","volume":"109","author":"Cottingham","year":"2012","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0645","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1016\/j.vaccine.2010.02.024","article-title":"Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth","volume":"28","author":"Bruder","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0650","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/ncomms1615","article-title":"The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody","volume":"2","author":"Douglas","year":"2011","journal-title":"Nat Commun"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0655","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4049\/jimmunol.1302045","article-title":"Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5","volume":"192","author":"Douglas","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0660","doi-asserted-by":"crossref","first-page":"e3300","DOI":"10.1371\/journal.pone.0003300","article-title":"PfRH5: a novel reticulocyte-binding family homolog of plasmodium falciparum that binds to the erythrocyte, and an investigation of its receptor","volume":"3","author":"Rodriguez","year":"2008","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0665","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijpara.2008.10.006","article-title":"Reticulocyte-binding protein homologue 5 \u2013 an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum","volume":"39","author":"Baum","year":"2009","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0670","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.chom.2014.11.017","article-title":"A PfRH5-based vaccine is efficacious against Heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys","volume":"17","author":"Douglas","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0675","doi-asserted-by":"crossref","first-page":"e29428","DOI":"10.1371\/journal.pone.0029428","article-title":"A viral vectored prime-boost immunization regime targeting the malaria Pfs25 antigen induces transmission-blocking activity","volume":"6","author":"Goodman","year":"2011","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0680","doi-asserted-by":"crossref","first-page":"11193","DOI":"10.1038\/srep11193","article-title":"Comparative assessment of transmission-blocking vaccine candidates against Plasmodium falciparum","volume":"5","author":"Kapulu","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0685","series-title":"62nd annual meeting: American Society of Tropical Medicine and Hygiene","article-title":"Enhancing antibody immunogenicity of transmission-blocking malaria vaccines","author":"Biswas","year":"2013"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0690","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1016\/j.vaccine.2011.01.083","article-title":"Adenovirus-vectored Plasmodium vivax ookinete surface protein, Pvs25, as a potential transmission-blocking vaccine.","volume":"29","author":"Miyata","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0695","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1128\/IAI.02040-14","article-title":"Baculovirus-vectored multistage Plasmodium vivax vaccine induces both protective and transmission-blocking immunities against transgenic rodent malaria parasites","volume":"82","author":"Mizutani","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0700","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1159\/000058850","article-title":"Transmission-blocking vaccines","volume":"80","author":"Kaslow","year":"2002","journal-title":"Chem Immunol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0705","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nrmicro2240","article-title":"Viruses as vaccine vectors for infectious diseases and cancer","volume":"8","author":"Draper","year":"2010","journal-title":"Nature Rev Microbiol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0710","doi-asserted-by":"crossref","first-page":"e24586","DOI":"10.1371\/journal.pone.0024586","article-title":"Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults","volume":"6","author":"Sedegah","year":"2011","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0715","doi-asserted-by":"crossref","first-page":"e25868","DOI":"10.1371\/journal.pone.0025868","article-title":"Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component","volume":"6","author":"Tamminga","year":"2011","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0720","doi-asserted-by":"crossref","first-page":"e6559","DOI":"10.1371\/journal.pone.0006559","article-title":"Sterile protection against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: comparison of heterologous prime boost strategies","volume":"4","author":"Jiang","year":"2009","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0725","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1128\/IAI.00740-09","article-title":"Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses","volume":"78","author":"Reyes-Sandoval","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0730","first-page":"6","article-title":"Prime-boost vectored malaria vaccines: progress and prospects","author":"Hill","year":"2010","journal-title":"Hum Vaccin"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0735","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.4161\/hv.24941","article-title":"Human adenovirus 5-vectored Plasmodium falciparum NMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection","volume":"9","author":"Tamminga","year":"2013","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0740","doi-asserted-by":"crossref","first-page":"e55571","DOI":"10.1371\/journal.pone.0055571","article-title":"DNA prime\/adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity","volume":"8","author":"Chuang","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0745","doi-asserted-by":"crossref","first-page":"e106241","DOI":"10.1371\/journal.pone.0106241","article-title":"Sterile immunity to malaria after DNA prime\/adenovirus boost immunization is associated with effector memory CD8+ T cells targeting AMA1 class I epitopes","volume":"9","author":"Sedegah","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0750","series-title":"NCT01169077. EP1300 Polyepitope DNA Vaccine Against Plasmodium falciparum Malaria","author":"Clinicaltrials.gov","year":"2012"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0755","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/eji.200737672","article-title":"Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei","volume":"38","author":"Reyes-Sandoval","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0760","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.4049\/jimmunol.1100302","article-title":"CD8+ T effector memory cells protect against liver-stage malaria","volume":"187","author":"Reyes-Sandoval","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0765","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.vaccine.2010.10.041","article-title":"Immune responses against a liver-stage malaria antigen induced by simian adenoviral vector AdCh63 and MVA prime-boost immunisation in non-human primates","volume":"29","author":"Capone","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0770","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/infdis\/jir850","article-title":"Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vector","volume":"205","author":"O\u2019Hara","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0775","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nm881","article-title":"Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans","volume":"9","author":"McConkey","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0780","doi-asserted-by":"crossref","first-page":"4836","DOI":"10.1073\/pnas.0406381102","article-title":"Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara","volume":"102","author":"Webster","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0785","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/330664a0","article-title":"Gamma interferon CD8+ T cells and antibodies required for immunity to malaria sporozoites","volume":"330","author":"Schofield","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0790","doi-asserted-by":"crossref","first-page":"e31247","DOI":"10.1371\/journal.pone.0031247","article-title":"Protective CD8+ T lymphocytes in primates immunized with malaria sporozoites","volume":"7","author":"Weiss","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0795","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1073\/pnas.85.2.573","article-title":"CD8+ T cells (cytotoxic\/suppressors) are required for protection in mice immunized with malaria sporozoites","volume":"85","author":"Weiss","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0800","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.4049\/jimmunol.165.3.1453","article-title":"The complexity of protective immunity against liver-stage malaria","volume":"165","author":"Doolan","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0805","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1073\/pnas.91.1.345","article-title":"Gamma delta T cells contribute to immunity against the liver stages of malaria in alpha beta T-cell-deficient mice","volume":"91","author":"Tsuji","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0810","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3389\/fmicb.2014.00440","article-title":"Tissue signatures influence the activation of intrahepatic CD8(+) T cells against malaria sporozoites","volume":"5","author":"Morrot","year":"2014","journal-title":"Front Microbiol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0815","doi-asserted-by":"crossref","first-page":"e0119880","DOI":"10.1371\/journal.pone.0119880","article-title":"Development of an in vitro assay and demonstration of Plasmodium berghei liver-stage inhibition by TRAP-specific CD8+ T cells","volume":"10","author":"Longley","year":"2015","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0820","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.4049\/jimmunol.1202861","article-title":"Comparative analysis of the magnitude, quality, phenotype, and protective capacity of simian immunodeficiency virus gag-specific CD8+ T cells following human-, simian-, and chimpanzee-derived recombinant adenoviral vector immunization","volume":"190","author":"Quinn","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0825","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1172\/JCI78280","article-title":"Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling","volume":"125","author":"Quinn","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0830","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1371\/journal.pctr.0010029","article-title":"A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya","volume":"1","author":"Bejon","year":"2006","journal-title":"PLoS Clin Trials"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0835","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1371\/journal.pmed.0010033","article-title":"A randomised, double-blind, controlled vaccine efficacy trial of DNA\/MVA ME-TRAP against malaria infection in Gambian adults","volume":"1","author":"Moorthy","year":"2004","journal-title":"PLoS Med"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0840","doi-asserted-by":"crossref","first-page":"486","DOI":"10.4269\/ajtmh.2007.76.486","article-title":"Low-level malaria infections detected by a sensitive polymerase chain reaction assay and use of this technique in the evaluation of malaria vaccines in an endemic area","volume":"76","author":"Imoukhuede","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0845","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1038\/mt.2014.109","article-title":"Translating the immunogenicity of prime-boost immunization with ChAd63 and MVA ME-TRAP from malaria naive to malaria-endemic populations","volume":"22","author":"Kimani","year":"2014","journal-title":"Mol Ther"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0850","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(15)60721-8","article-title":"Efficacy and safety of RTS,S\/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial","volume":"386","author":"RTS, S CTP","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0855","doi-asserted-by":"crossref","first-page":"e87340","DOI":"10.1371\/journal.pone.0087340","article-title":"The candidate TB vaccine, MVA85A, induces highly durable Th1 responses","volume":"9","author":"Tameris","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0860","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/mt.2013.248","article-title":"Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1","volume":"22","author":"Borthwick","year":"2014","journal-title":"Mol Ther"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0865","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1411627","article-title":"A monovalent chimpanzee adenovirus Ebola vaccine \u2013 preliminary report","author":"Rampling","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0870","doi-asserted-by":"crossref","first-page":"e115161","DOI":"10.1371\/journal.pone.0115161","article-title":"A phase Ia study to assess the safety and immunogenicity of new malaria vaccine candidates ChAd63 CS administered alone and with MVA CS","volume":"9","author":"de Barra","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0875","doi-asserted-by":"crossref","first-page":"e78679","DOI":"10.1371\/journal.pone.0078679","article-title":"A phase 1b randomized, controlled, double-blinded dosage-escalation trial to evaluate the safety, reactogenicity and immunogenicity of an adenovirus type 35 based circumsporozoite malaria vaccine in Burkinabe healthy adults 18 to 45 years of age","volume":"8","author":"Ouedraogo","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0880","doi-asserted-by":"crossref","first-page":"e31208","DOI":"10.1371\/journal.pone.0031208","article-title":"Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors","volume":"7","author":"Sheehy","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0885","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1038\/mt.2014.157","article-title":"Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trial","volume":"22","author":"Hodgson","year":"2014","journal-title":"Mol Ther"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0890","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/infdis\/jiu579","article-title":"Evaluation of the efficacy of ChAd63-MVA vectored vaccines expressing circumsporozoite protein and ME-TRAP against controlled human malaria infection in malaria-naive individuals","volume":"211","author":"Hodgson","year":"2015","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0895","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1038\/mt.2011.176","article-title":"Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors","volume":"19","author":"Sheehy","year":"2011","journal-title":"Mol Ther"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0900","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.4049\/jimmunol.1201455","article-title":"Assessment of immune interference, antagonism, and diversion following human immunization with biallelic blood-stage malaria viral-vectored vaccines and controlled malaria infection","volume":"190","author":"Elias","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0905","doi-asserted-by":"crossref","first-page":"e107903","DOI":"10.1371\/journal.pone.0107903","article-title":"Assessment of humoral immune responses to blood-stage malaria antigens following ChAd63-MVA immunization, controlled human malaria infection and natural exposure","volume":"9","author":"Biswas","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.vaccine.2015.09.094_bib0910","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/imm.12226","article-title":"Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1 immunization and controlled malaria infection","volume":"141","author":"Elias","year":"2014","journal-title":"Immunology"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15013845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X15013845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T16:09:47Z","timestamp":1692115787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X15013845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":91,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0264410X15013845"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.09.094","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progress with viral vectored malaria vaccines: A multi-stage approach involving \u201cunnatural immunity\u201d","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2015.09.094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}