{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:55:53Z","timestamp":1782489353075,"version":"3.54.5"},"reference-count":20,"publisher":"Elsevier BV","issue":"47","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271839"],"award-info":[{"award-number":["81271839"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301435"],"award-info":[{"award-number":["81301435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471957"],"award-info":[{"award-number":["81471957"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372935"],"award-info":[{"award-number":["81372935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401676"],"award-info":[{"award-number":["81401676"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.vaccine.2016.10.001","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T03:38:43Z","timestamp":1476675523000},"page":"5751-5757","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Electroporation enhances protective immune response of a DNA vaccine against Japanese encephalitis in mice and pigs"],"prefix":"10.1016","volume":"34","author":[{"given":"Ziyang","family":"Sheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongying","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2016.10.001_b0005","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/tropej\/fmp133","article-title":"Disability from Japanese encephalitis in Cambodia and Viet Nam","volume":"57","author":"Hills","year":"2011","journal-title":"J Trop Pediatr"},{"key":"10.1016\/j.vaccine.2016.10.001_b0010","unstructured":"WHO. Japanese encephalitis; 2015. <http:\/\/www.who.int\/mediacentre\/factsheets\/fs386\/en\/> [accessed December 2015]."},{"key":"10.1016\/j.vaccine.2016.10.001_b0015","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/QCO.0b013e32833c1d01","article-title":"Japanese encephalitis: update on vaccines and vaccine recommendations","volume":"23","author":"Wilder-Smith","year":"2010","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.vaccine.2016.10.001_b0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev.ento.54.110807.090510","article-title":"Ecology and geographical expansion of Japanese encephalitis virus","volume":"54","author":"van den Hurk","year":"2009","journal-title":"Annu Rev Entomol"},{"key":"10.1016\/j.vaccine.2016.10.001_b0025","doi-asserted-by":"crossref","first-page":"e85399","DOI":"10.1371\/journal.pone.0085399","article-title":"Regional variation in pig farmer awareness and actions regarding Japanese encephalitis in Nepal: implications for public health education","volume":"9","author":"Dhakal","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2016.10.001_b0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.11599\/germs.2013.1034","article-title":"DNA vaccines: roles against diseases","volume":"3","author":"Khan","year":"2013","journal-title":"Germs"},{"key":"10.1016\/j.vaccine.2016.10.001_b0035","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-065X.2010.00980.x","article-title":"DNA vaccines: an historical perspective and view to the future","volume":"239","author":"Liu","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.vaccine.2016.10.001_b0040","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nrg2432","article-title":"DNA vaccines: ready for prime time?","volume":"9","author":"Kutzler","year":"2008","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.vaccine.2016.10.001_b0045","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1038\/mt.2013.119","article-title":"Therapeutic DNA vaccination using in vivo electroporation followed by standard of care therapy in patients with genotype 1 chronic hepatitis C","volume":"21","author":"Weiland","year":"2013","journal-title":"Mol Ther"},{"key":"10.1016\/j.vaccine.2016.10.001_b0050","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/S0140-6736(15)00239-1","article-title":"Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2\/3: a randomised, double-blind, placebo-controlled phase 2b trial","volume":"386","author":"Trimble","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2016.10.001_b0055","doi-asserted-by":"crossref","first-page":"e0134287","DOI":"10.1371\/journal.pone.0134287","article-title":"A phase i double blind, placebo-controlled, randomized study of the safety and immunogenicity of electroporated HIV DNA with or without interleukin 12 in prime-boost combinations with an Ad35 HIV vaccine in healthy HIV-seronegative African adults","volume":"10","author":"Mpendo","year":"2015","journal-title":"PLoS ONE"},{"issue":"suppl 5","key":"10.1016\/j.vaccine.2016.10.001_b0060","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/1469-0691.12553","article-title":"A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for haemorrhagic fever with renal syndrome delivered by intramuscular electroporation","volume":"20","author":"Hooper","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.vaccine.2016.10.001_b0065","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1016\/j.vaccine.2013.06.099","article-title":"Characterization of immune responses induced by inactivated, live attenuated and DNA vaccines against Japanese encephalitis virus in mice","volume":"31","author":"Li","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.10.001_b0070","doi-asserted-by":"crossref","first-page":"e34602","DOI":"10.1371\/journal.pone.0034602","article-title":"Suppressive effects on the immune response and protective immunity to a JEV DNA vaccine by co-administration of a GM-CSF-expressing plasmid in mice","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2016.10.001_b0075","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.imlet.2009.12.023","article-title":"Co-expression of Japanese encephalitis virus prM-E-NS1 antigen with granulocyte-macrophage colony-stimulating factor enhances humoral and anti-virus immunity after DNA vaccination","volume":"129","author":"Gao","year":"2010","journal-title":"Immunol Lett"},{"key":"10.1016\/j.vaccine.2016.10.001_b0080","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1038\/mt.2008.178","article-title":"Growth hormone-releasing hormone plasmid treatment by electroporation decreases offspring mortality over three pregnancies","volume":"16","author":"Person","year":"2008","journal-title":"Mol Ther"},{"key":"10.1016\/j.vaccine.2016.10.001_b0085","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1128\/JVI.73.7.5527-5534.1999","article-title":"The anamnestic neutralizing antibody response is critical for protection of mice from challenge following vaccination with a plasmid encoding the Japanese encephalitis virus premembrane and envelope genes","volume":"73","author":"Konishi","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2016.10.001_b0090","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/0035-9203(69)90031-5","article-title":"Assay of arbovirus neutralizing antibody by micro methods","volume":"63","author":"Sukhavachana","year":"1969","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2016.10.001_b0095","doi-asserted-by":"crossref","unstructured":"Bolhassani A, Khavari A, Orafa Z. Electroporation \u2013 advantages and drawbacks for delivery of drug, gene and vaccine, application of nanotechnology in drug delivery; 2014. p. 369\u201398.","DOI":"10.5772\/58376"},{"key":"10.1016\/j.vaccine.2016.10.001_b0100","doi-asserted-by":"crossref","first-page":"7373","DOI":"10.1016\/j.vaccine.2010.09.008","article-title":"Needle-free jet injection of small doses of Japanese encephalitis DNA and inactivated vaccine mixture induces neutralizing antibodies in miniature pigs and protects against fetal death and mummification in pregnant sows","volume":"28","author":"Imoto","year":"2010","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X16308921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X16308921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T17:58:23Z","timestamp":1601143103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X16308921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":20,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0264410X16308921"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2016.10.001","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electroporation enhances protective immune response of a DNA vaccine against Japanese encephalitis in mice and pigs","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2016.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}