{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T05:16:35Z","timestamp":1720242995993},"reference-count":48,"publisher":"Elsevier BV","issue":"50","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.vaccine.2016.10.061","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T16:30:29Z","timestamp":1478104229000},"page":"6292-6300","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["In vivo screen of genetically conserved Streptococcus pneumoniae proteins for protective immunogenicity"],"prefix":"10.1016","volume":"34","author":[{"given":"Richard J.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siradanahalli","family":"Guru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risini","family":"Weeratna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"Makinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek J.","family":"Falconer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil C.","family":"Sheppard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingsheng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Laure","family":"Goenaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Merson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Gracheck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim E.","family":"Eyles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2016.10.061_b0005","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/S0140-6736(04)16357-5","article-title":"Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children","volume":"363","author":"Bogaert","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2016.10.061_b0010","doi-asserted-by":"crossref","first-page":"a010215","DOI":"10.1101\/cshperspect.a010215","article-title":"The pneumococcus: epidemiology, microbiology, and pathogenesis","volume":"3","author":"Henriques-Normark","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.vaccine.2016.10.061_b0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1749-6632.2012.06673.x","article-title":"Development and clinical evaluation of Prevnar 13, a 13-valent pneumococcal CRM197 conjugate vaccine","volume":"1263","author":"Gruber","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.vaccine.2016.10.061_b0020","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1056\/NEJMoa1408544","article-title":"Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults","volume":"372","author":"Bonten","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2016.10.061_b0025","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1097\/INF.0000000000000078","article-title":"Systematic review of the effect of pneumococcal conjugate vaccine dosing schedules on vaccine-type invasive pneumococcal disease among young children","volume":"33","author":"Conklin","year":"2014","journal-title":"Pediatr Infect Dis J"},{"issue":"3","key":"10.1016\/j.vaccine.2016.10.061_b0030","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1358\/dot.2011.47.3.1556471","article-title":"New conjugate vaccines for the prevention of pneumococcal disease in developing countries","volume":"47","author":"Ginsburg","year":"2011","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.vaccine.2016.10.061_b0035","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1128\/CVI.00131-10","article-title":"Correlates of protection induced by vaccination","volume":"17","author":"Plotkin","year":"2010","journal-title":"Clin Vaccine Immunol"},{"issue":"27","key":"10.1016\/j.vaccine.2016.10.061_b0040","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1016\/j.vaccine.2009.03.087","article-title":"WHO consultation on serological criteria for evaluation and licensing of new pneumococcal vaccines. challenges in the evaluation and licensing of new pneumococcal vaccines, 7\u20138 July 2008, Ottawa, Canada","volume":"8","author":"Feavers","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.10.061_b0045","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1586\/erv.12.5","article-title":"Issues and challenges in the development of pneumococcal protein vaccines","volume":"11","author":"Ginsburg","year":"2012","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2016.10.061_b0050","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jinf.2014.06.006","article-title":"Review: current and new generation pneumococcal vaccines","volume":"69","author":"Feldman","year":"2014","journal-title":"J Infect"},{"key":"10.1016\/j.vaccine.2016.10.061_b0055","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1128\/IAI.00378-10","article-title":"Preclinical evaluation of the Pht proteins as potential cross-protective pneumococcal vaccine antigens","volume":"79","author":"Godfroid","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0060","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1016\/j.vaccine.2014.03.066","article-title":"Safety and immunogenicity of an investigational vaccine containing two common pneumococcal proteins in toddlers: a phase II randomized clinical trial","volume":"32","author":"Prymula","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.10.061_b0065","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1096\/fj.08-119537","article-title":"Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H","volume":"23","author":"Ogunniyi","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.vaccine.2016.10.061_b0070","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1099\/mic.0.042184-0","article-title":"Transcriptional regulation, occurrence and putative role of the Pht family of Streptococcus pneumoniae","volume":"157","author":"Rioux","year":"2011","journal-title":"Microbiology"},{"key":"10.1016\/j.vaccine.2016.10.061_b0075","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1128\/IAI.00699-13","article-title":"Role of Pht proteins in attachment of Streptococcus pneumoniae to respiratory epithelial cells","volume":"82","author":"Kallio","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0080","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1128\/IAI.01516-08","article-title":"Sortase A confers protection against Streptococcus pneumoniae in mice","volume":"77","author":"Gianfaldoni","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0085","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/10408410600822942","article-title":"Streptococcus pneumoniae protein vaccine candidates: properties, activities and animal studies","volume":"32","author":"Tai","year":"2006","journal-title":"Crit Rev Microbiol"},{"issue":"2","key":"10.1016\/j.vaccine.2016.10.061_b0090","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/713609215","article-title":"Analysis of structure and function of putative surface-exposed proteins encoded in the Streptococcus pneumoniae genome: a bioinformatics-based approach to vaccine and drug design","volume":"38","author":"Rigden","year":"2003","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.vaccine.2016.10.061_b0095","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1128\/IAI.69.6.3827-3836.2001","article-title":"Recombinant PhpA protein, a unique histidine motif-containing protein from Streptococcus pneumoniae, protects mice against intranasal pneumococcal challenge","volume":"69","author":"Zhang","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0100","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1128\/CDLI.12.2.287-295.2005","article-title":"Approach to validating an opsonophagocytic assay for Streptococcus pneumoniae","volume":"12","author":"Hu","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.vaccine.2016.10.061_b0105","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1128\/IAI.69.3.1593-1598.2001","article-title":"Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection","volume":"69","author":"Wizemann","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0110","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1084\/jem.20071168","article-title":"Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies","volume":"205","author":"Giefing","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2016.10.061_b0115","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01040-13","article-title":"Live attenuated influenza vaccine enhances colonization of Streptococcus pneumoniae and Staphylococcus aureus in mice","volume":"5","author":"Mina","year":"2014","journal-title":"MBio"},{"key":"10.1016\/j.vaccine.2016.10.061_b0120","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1086\/322021","article-title":"Microbiological and inflammatory factors associated with the development of pneumococcal pneumonia","volume":"184","author":"Dallaire","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2016.10.061_b0125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1574-6968.2001.tb10931.x","article-title":"The cell wall-associated serine protease PrtA: a highly conserved virulence factor of Streptococcus pneumoniae","volume":"205","author":"Bethe","year":"2001","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.vaccine.2016.10.061_b0130","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1086\/367701","article-title":"Immune response to capsular polysaccharide and surface proteins of Streptococcus pneumoniae in patients with invasive pneumococcal disease","volume":"187","author":"Zysk","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2016.10.061_b0135","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1023\/A:1018585604073","article-title":"The substrate specificity of the enzyme endo-alpha-N-acetyl-D-galactosaminidase from Diplococcus pneumonia","volume":"14","author":"Brooks","year":"1997","journal-title":"Glycoconj J"},{"key":"10.1016\/j.vaccine.2016.10.061_b0140","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1365-2958.2005.04984.x","article-title":"Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae","volume":"59","author":"King","year":"2006","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2016.10.061_b0145","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.2041-1014.2012.00658.x","article-title":"Pneumococcal neuraminidase A: an essential upper airway colonization factor for Streptococcus pneumoniae","volume":"27","author":"Brittan","year":"2012","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.vaccine.2016.10.061_b0150","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1128\/IAI.01237-05","article-title":"Pneumococcal neuraminidases A and B both have essential roles during infection of the respiratory tract and sepsis","volume":"74","author":"Manco","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0155","doi-asserted-by":"crossref","first-page":"7775","DOI":"10.1128\/IAI.73.11.7775-7778.2005","article-title":"Immunization with recombinant Streptococcus pneumoniae neuraminidase NanA protects chinchillas against nasopharyngeal colonization","volume":"73","author":"Tong","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2958.2010.07190.x","article-title":"Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix","volume":"77","author":"Paterson","year":"2010","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2016.10.061_b0165","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1365-2958.2010.07189.x","article-title":"PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections","volume":"77","author":"Jensch","year":"2010","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2016.10.061_b0170","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1128\/CMR.00012-08","article-title":"Animal models of Streptococcus pneumoniae disease","volume":"21","author":"Chiavolini","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.vaccine.2016.10.061_b0175","series-title":"Pneumococcal vaccines: the impact of conjugate vaccine","article-title":"Animal models of invasive pneumococcal disease","author":"Briles","year":"2008"},{"key":"10.1016\/j.vaccine.2016.10.061_b0180","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1128\/IAI.01126-07","article-title":"Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsis","volume":"76","author":"Glover","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0185","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1128\/IAI.69.2.949-958.2001","article-title":"Identification and characterization of a novel family of pneumococcal proteins that are protective against sepsis","volume":"69","author":"Adamou","year":"2001","journal-title":"Infect Immun"},{"issue":"10","key":"10.1016\/j.vaccine.2016.10.061_b0190","doi-asserted-by":"crossref","first-page":"6082","DOI":"10.1128\/IAI.68.10.6082-6086.2000","article-title":"Peritoneal culture alters Streptococcus pneumoniae protein profiles and virulence properties","volume":"68","author":"Orihuela","year":"2000","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2016.10.061_b0195","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/IAI.00881-09","article-title":"The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms","volume":"78","author":"Hyams","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0200","doi-asserted-by":"crossref","first-page":"6702","DOI":"10.1128\/IAI.69.11.6702-6706.2001","article-title":"Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection","volume":"69","author":"Brown","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0205","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1128\/IAI.73.3.1304-1312.2005","article-title":"Relationship between surface accessibility for PpmA, PsaA, and PspA and antibody-mediated immunity to systemic infection by Streptococcus pneumoniae","volume":"73","author":"Gor","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0210","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/mpat.1996.0038","article-title":"Protection of mice against fatal pneumococcal challenge by immunization with pneumococcal surface adhesin A (PsaA)","volume":"21","author":"Talkington","year":"1996","journal-title":"Microb Pathog"},{"key":"10.1016\/j.vaccine.2016.10.061_b0215","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1128\/IAI.74.1.352-361.2006","article-title":"Involvement of potD in Streptococcus pneumoniae polyamine transport and pathogenesis","volume":"74","author":"Ware","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0220","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1046\/j.1365-2958.2001.02610.x","article-title":"The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence","volume":"41","author":"Holmes","year":"2001","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2016.10.061_b0225","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1128\/IAI.70.12.7176-7178.2002","article-title":"Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae","volume":"70","author":"Vollmer","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0230","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1074\/jbc.M510014200","article-title":"The streptococcal lipoprotein rotamase A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonization","volume":"281","author":"Hermans","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.vaccine.2016.10.061_b0235","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1128\/IAI.01125-09","article-title":"Three surface exoglycosidases from Streptococcus pneumoniae, NanA, BgaA, and StrH, promote resistance to opsonophagocytic killing by human neutrophils","volume":"78","author":"Dalia","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.10.061_b0240","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1128\/IAI.73.2.981-989.2005","article-title":"PppA, a surface-exposed protein of Streptococcus pneumoniae, elicits cross-reactive antibodies that reduce colonization in a murine intranasal immunization and challenge model","volume":"73","author":"Green","year":"2005","journal-title":"Infect Immun"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X16309963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X16309963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T02:58:13Z","timestamp":1601175493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X16309963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":48,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0264410X16309963"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2016.10.061","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo screen of genetically conserved Streptococcus pneumoniae proteins for protective immunogenicity","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2016.10.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}