{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:58:37Z","timestamp":1791316717411,"version":"4.3.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"50","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2012-39444-C01\/02"],"award-info":[{"award-number":["SAF2012-39444-C01\/02"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.vaccine.2016.11.001","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T18:00:21Z","timestamp":1478800821000},"page":"6148-6157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Immunization with LytB protein of Streptococcus pneumoniae activates complement-mediated phagocytosis and induces protection against pneumonia and sepsis"],"prefix":"10.1016","volume":"34","author":[{"given":"Bruno","family":"Corsini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Aguinagalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian","family":"Domenech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Antequera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asunci\u00f3n","family":"Fenoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Yuste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2016.11.001_b0005","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0140-6736(09)61114-4","article-title":"Pathogenesis, treatment, and prevention of pneumococcal pneumonia","volume":"374","author":"van der Poll","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2016.11.001_b0010","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1473-3099(02)00450-4","article-title":"Pathogenesis and pathophysiology of pneumococcal meningitis","volume":"2","author":"Koedel","year":"2002","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.vaccine.2016.11.001_b0015","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0140-6736(09)61204-6","article-title":"Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates","volume":"374","author":"O\u2019Brien","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2016.11.001_b0020","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0140-6736(06)69614-1","article-title":"Effectiveness of pneumococcal conjugate vaccine","volume":"368","author":"O\u2019Brien","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2016.11.001_b0025","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1128\/CVI.00647-14","article-title":"Genetic, biochemical, and serological characterization of a new pneumococcal serotype, 6H, and generation of a pneumococcal strain producing three different capsular repeat units","volume":"22","author":"Park","year":"2015","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2016.11.001_b0030","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1371\/journal.ppat.0030168","article-title":"Vaccine escape recombinants emerge after pneumococcal vaccination in the United States","volume":"3","author":"Brueggemann","year":"2007","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.vaccine.2016.11.001_b0035","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ng.1072","article-title":"Pneumococcal genome sequencing tracks a vaccine escape variant formed through a multi-fragment recombination event","volume":"44","author":"Golubchik","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.vaccine.2016.11.001_b0040","doi-asserted-by":"crossref","first-page":"e0137565","DOI":"10.1371\/journal.pone.0137565","article-title":"Emergence of amoxicillin-resistant variants of Spain9V-ST156 pneumococci expressing serotype 11A correlates with their ability to evade the host immune response","volume":"10","author":"Aguinagalde","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2016.11.001_b0045","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1128\/JB.184.18.4988-5000.2002","article-title":"Purification and polar localization of pneumococcal LytB, a putative endo-\u03b2-N-acetylglucosaminidase: the chain-dispersing murein hydrolase","volume":"184","author":"De Las Rivas","year":"2002","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2016.11.001_b0050","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1046\/j.1365-2958.1999.01238.x","article-title":"LytB, a novel pneumococcal murein hydrolase essential for cell separation","volume":"31","author":"Garc\u00eda","year":"1999","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2016.11.001_b0055","doi-asserted-by":"crossref","first-page":"e23626","DOI":"10.1371\/journal.pone.0023626","article-title":"Nasopharyngeal colonization and invasive disease are enhanced by the cell wall hydrolases LytB and LytC of Streptococcus pneumoniae","volume":"6","author":"Ramos-Sevillano","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2016.11.001_b0060","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1128\/JB.00673-06","article-title":"Biofilm formation by Streptococcus pneumoniae: role of choline, extracellular DNA, and capsular polysaccharide in microbial accretion","volume":"188","author":"Moscoso","year":"2006","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2016.11.001_b0065","doi-asserted-by":"crossref","first-page":"23403","DOI":"10.1074\/jbc.M114.579714","article-title":"Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis","volume":"289","author":"Bai","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.vaccine.2016.11.001_b0070","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1128\/IAI.69.3.1593-1598.2001","article-title":"Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection","volume":"69","author":"Wizemann","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0075","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.1128\/IAI.73.10.6852-6859.2005","article-title":"Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae","volume":"73","author":"Jomaa","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0080","doi-asserted-by":"crossref","first-page":"e12041","DOI":"10.1371\/journal.pone.0012041","article-title":"Enhanced in vivo activity of cefditoren in pre-immunized mice against penicillin-resistant S. pneumoniae (serotypes 6B, 19F and 23F) in a sepsis model","volume":"5","author":"Cafini","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2016.11.001_b0085","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1128\/IAI.02811-14","article-title":"Pleiotropic effects of cell wall amidase LytA on Streptococcus pneumoniae sensitivity to the host immune response","volume":"83","author":"Ramos-Sevillano","year":"2015","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0090","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1128\/IAI.00291-08","article-title":"Impaired opsonization with C3b and phagocytosis of Streptococcus pneumoniae in sera from subjects with defects in the classical complement pathway","volume":"76","author":"Yuste","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0095","doi-asserted-by":"crossref","first-page":"e44135","DOI":"10.1371\/journal.pone.0044135","article-title":"Cefditoren and ceftriaxone enhance complement-mediated immunity in the presence of specific antibodies against antibiotic-resistant pneumococcal strains","volume":"7","author":"Ramos-Sevillano","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2016.11.001_b0100","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1084\/jem.20041548","article-title":"Available carbon source influences the resistance of Neisseria meningitidis against complement","volume":"201","author":"Exley","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2016.11.001_b0105","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1128\/CDLI.4.4.415-422.1997","article-title":"Standardization of an opsonophagocytic assay for the measurement of functional antibody activity against Streptococcus pneumoniae using differentiated HL-60 cells","volume":"4","author":"Romero-Steiner","year":"1997","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.vaccine.2016.11.001_b0110","doi-asserted-by":"crossref","first-page":"16969","DOI":"10.1073\/pnas.012669199","article-title":"The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice","volume":"99","author":"Brown","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2016.11.001_b0115","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0140-6736(06)69334-3","article-title":"Pneumonia: the leading killer of children","volume":"368","author":"Wardlaw","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2016.11.001_b0120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jinf.2014.06.006","article-title":"Review: current and new generation pneumococcal vaccines","volume":"69","author":"Feldman","year":"2014","journal-title":"J Infect"},{"key":"10.1016\/j.vaccine.2016.11.001_b0125","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1749-6632.1996.tb52954.x","article-title":"Systemic and mucosal protective immunity to pneumococcal surface protein A","volume":"797","author":"Briles","year":"1996","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.vaccine.2016.11.001_b0130","doi-asserted-by":"crossref","first-page":"6533","DOI":"10.1128\/IAI.67.12.6533-6542.1999","article-title":"The pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, PspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteremia","volume":"67","author":"Brooks-Walter","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0135","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1128\/IAI.01126-07","article-title":"Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsis","volume":"76","author":"Glover","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12026-011-8234-x","article-title":"Intranasal immunization with autolysin (LytA) in mice model induced protection against five prevalent Streptococcus pneumoniae serotypes in China","volume":"51","author":"Yuan","year":"2011","journal-title":"Immunol Res"},{"key":"10.1016\/j.vaccine.2016.11.001_b0145","doi-asserted-by":"crossref","first-page":"8706","DOI":"10.1128\/AEM.71.12.8706-8713.2005","article-title":"Allelic variation of polymorphic locus lytB, encoding a choline-binding protein, from streptococci of the mitis group","volume":"71","author":"Moscoso","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.vaccine.2016.11.001_b0150","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1016\/j.vaccine.2012.10.076","article-title":"Safety and immunogenicity of pneumococcal protein vaccine candidates: monovalent choline-binding protein A (PcpA) vaccine and bivalent PcpA-pneumococcal histidine triad protein D vaccine","volume":"30","author":"Bologa","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.11.001_b0155","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.vaccine.2012.11.005","article-title":"Safety and immunogenicity of the pneumococcal pneumolysin derivative PlyD1 in a single-antigen protein vaccine candidate in adults","volume":"31","author":"Kamtchoua","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.11.001_b0160","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1016\/j.vaccine.2006.03.088","article-title":"Total and serotype-specific pneumococcal antibody titres in children with normal and abnormal humoral immunity","volume":"24","author":"Uddin","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.11.001_b0165","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1128\/IAI.67.9.4935-4938.1999","article-title":"Age-associated differences in immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to pneumococcal polysaccharides following vaccination","volume":"67","author":"Lottenbach","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0170","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1086\/374785","article-title":"Significant variation in serotype-specific immunogenicity of the seven-valent Streptococcus pneumoniae capsular polysaccharide-CRM197 conjugate vaccine occurs despite vigorous T cell help induced by the carrier protein","volume":"187","author":"Kamboj","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2016.11.001_b0175","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1128\/IAI.65.1.242-247.1997","article-title":"Comparison of pneumococcal polysaccharide and CRM197-conjugated pneumococcal oligosaccharide vaccines in young and elderly adults","volume":"65","author":"Shelly","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0180","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/S0264-410X(00)00441-2","article-title":"Tolerability and immunogenicity of an 11-valent pneumococcal conjugate vaccine in adults","volume":"19","author":"Wuorimaa","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.11.001_b0185","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/S0264-410X(98)00475-7","article-title":"IgG subclass distribution of antibodies after vaccination of adults with pneumococcal conjugate vaccines","volume":"17","author":"Soininen","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.11.001_b0190","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1128\/IAI.60.11.4838-4847.1992","article-title":"Complement activation by polyclonal immunoglobulin G1 and G2 antibodies against Staphylococcus aureus, Haemophilus influenzae type b, and tetanus toxoid","volume":"60","author":"Bredius","year":"1992","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0195","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/infdis\/162.1.163","article-title":"Bactericidal and opsonic activity of IgG1 and IgG2 anticapsular antibodies to Haemophilus influenzae type b","volume":"162","author":"Amir","year":"1990","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2016.11.001_b0200","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2016.11.001_b0205","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.4049\/jimmunol.0900688","article-title":"Human neutrophils kill Streptococcus pneumoniae via serine proteases","volume":"183","author":"Standish","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2016.11.001_b0210","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/00365549209061343","article-title":"Septicemia in granulocytopenic patients: a shift in bacterial etiology","volume":"24","author":"Johansson","year":"1992","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.vaccine.2016.11.001_b0215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1471-2334-6-55","article-title":"Neutropenia induced in outbred mice by a simplified low-dose cyclophosphamide regimen: characterization and applicability to diverse experimental models of infectious diseases","volume":"6","author":"Zuluaga","year":"2006","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.vaccine.2016.11.001_b0220","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/294088a0","article-title":"Mouse IgG3 antibodies are highly protective against infection with Streptococcus pneumoniae","volume":"294","author":"Briles","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2016.11.001_b0225","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.chom.2011.09.009","article-title":"Minimization of bacterial size allows for complement evasion and is overcome by the agglutinating effect of antibody","volume":"10","author":"Dalia","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vaccine.2016.11.001_b0230","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1128\/IAI.00587-12","article-title":"Increased chain length promotes pneumococcal adherence and colonization","volume":"80","author":"Rodriguez","year":"2012","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0235","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1016\/j.vaccine.2015.08.009","article-title":"Secular trends (1990\u20132013) in serotypes and associated non-susceptibility of S. pneumoniae isolates causing invasive disease in the pre-\/post-era of pneumococcal conjugate vaccines in Spanish regions without universal paediatric pneumococcal vaccination","volume":"33","author":"Fenoll","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.11.001_b0240","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1016\/j.vaccine.2009.03.017","article-title":"Pneumococcal serotype 3 otitis media, limited effect of polysaccharide conjugate immunisation and strain characteristics","volume":"27","author":"Poolman","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.11.001_b0245","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1128\/CVI.00591-15","article-title":"Capsular polysaccharide release by serotype 3 pneumococcal strains reduces the protective effect of anti-type 3 capsular antibodies","volume":"23","author":"Choi","year":"2016","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2016.11.001_b0250","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/IAI.02124-14","article-title":"Human antibodies to PhtD, PcpA, and Ply reduce adherence to human lung epithelial cells and murine nasopharyngeal colonization by Streptococcus pneumoniae","volume":"82","author":"Kaur","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0255","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1128\/IAI.01103-06","article-title":"Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae","volume":"75","author":"Ogunniyi","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2016.11.001_b0260","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/21645515.2015.1111496","article-title":"Reactogenicity, safety and immunogenicity of a protein-based pneumococcal vaccine in Gambian children aged 2\u20134 years: a phase II randomized study","volume":"12","author":"Odutola","year":"2016","journal-title":"Hum Vaccine Immunother"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X16310180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X16310180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T03:13:42Z","timestamp":1601176422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X16310180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":52,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0264410X16310180"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2016.11.001","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunization with LytB protein of Streptococcus pneumoniae activates complement-mediated phagocytosis and induces protection against pneumonia and sepsis","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2016.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}