{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T03:20:15Z","timestamp":1784517615372,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,26]],"date-time":"2017-01-26T00:00:00Z","timestamp":1485388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.vaccine.2016.11.098","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T22:02:21Z","timestamp":1486591341000},"page":"1789-1796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Vial usage, device dead space, vaccine wastage, and dose accuracy of intradermal delivery devices for inactivated poliovirus vaccine (IPV)"],"prefix":"10.1016","volume":"35","author":[{"given":"Courtney","family":"Jarrahian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6416-3277","authenticated-orcid":false,"given":"Annie","family":"Rein-Weston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene","family":"Saxon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Creelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Kachmarik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijeet","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin","family":"Zehrung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2016.11.098_b0005","unstructured":"World Health Organization (WHO). Meeting of the strategic advisory group of experts on immunization, April 2013\u2014conclusions and recommendations. Wkly Epidemiol Rec. 2013;88(20):201\u2013216. Available at: <http:\/\/www.who.int\/wer\/2013\/wer8820.pdf?ua=1> [accessed November 11, 2016]."},{"issue":"Suppl 1","key":"10.1016\/j.vaccine.2016.11.098_b0010","doi-asserted-by":"crossref","first-page":"S434","DOI":"10.1093\/infdis\/jiu222","article-title":"The new polio eradication end game: rationale and supporting evidence","volume":"210","author":"Sutter","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2016.11.098_b0015","unstructured":"Immunization Systems Management Group of the Global Polio Eradication Initiative. Introduction of inactivated poliovirus vaccine and switch from trivalent to bivalent oral poliovirus vaccine\u2014worldwide, 2013\u20132016. Morb Mortal Wkly Rep 2015;64(25):699\u2013702."},{"key":"10.1016\/j.vaccine.2016.11.098_b0020","unstructured":"Oliver Wyman, Inc. Global Post-eradication IPV Supply and Demand Assessment: Integrated Findings; 2009. Available at: <http:\/\/polioeradication.org\/wp-content\/uploads\/2016\/07\/Post-Eradication-IPV-Supply-Demand-March-2009-FINAL.pdf> [accessed March 16, 2016]."},{"key":"10.1016\/j.vaccine.2016.11.098_b0025","unstructured":"United Nations Children\u2019s Emergency Fund (UNICEF). Inactivated Polio Vaccine: Supply Update. May 2015. Available at: <http:\/\/www.unicef.org\/supply\/files\/IPV_supply_update_May_2015.pdf> [accessed March 16, 2016]."},{"key":"10.1016\/j.vaccine.2016.11.098_b0030","unstructured":"Chang Blanc D. Objective 2 update: Implementation of OPV2 withdrawal and IPV introduction. Presented at: Meeting of the Strategic Advisory Group of Experts on Immunization, October 18, 2016; Geneva, Switzerland. Available at: <http:\/\/www.who.int\/immunization\/sage\/meetings\/2016\/october\/Session5-Updates-on-implementation-of-OPV2-withdrawal.pdf?ua=1> [accessed November 11, 2016]."},{"key":"10.1016\/j.vaccine.2016.11.098_b0035","unstructured":"UNICEF. Vaccine Price Data. Available at: <http:\/\/www.unicef.org\/supply\/index_57476.html> [accessed March 16, 2016]."},{"issue":"Suppl. 1","key":"10.1016\/j.vaccine.2016.11.098_b0040","doi-asserted-by":"crossref","first-page":"S459","DOI":"10.1093\/infdis\/jiu128","article-title":"Affordable inactivated poliovirus vaccine: strategies and progress","volume":"210","author":"Okayasu","year":"2014","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.vaccine.2016.11.098_b0045","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.vaccine.2014.11.025","article-title":"Immune responses after fractional doses of inactivated poliovirus vaccine using newly developed intradermal jet injectors: a randomized controlled trial in Cuba","volume":"33","author":"Resik","year":"2015","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2016.11.098_b0050","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.vaccine.2011.11.018","article-title":"Intradermal fractional dose inactivated polio vaccine: a review of the literature","volume":"30","author":"Nelson","year":"2012","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2016.11.098_b0055","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1016\/j.ijid.2011.10.002","article-title":"Randomized controlled study of fractional doses of inactivated poliovirus vaccine administered intradermally with a needle in the Philippines","volume":"16","author":"Cadorna-Carlos","year":"2012","journal-title":"Int J Inf Dis"},{"issue":"36","key":"10.1016\/j.vaccine.2016.11.098_b0060","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1016\/j.vaccine.2013.05.104","article-title":"Intradermal fractional booster dose of inactivated poliomyelitis vaccine with a jet injector in healthy adults","volume":"31","author":"Soonawala","year":"2013","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2016.11.098_b0065","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S1473-3099(11)70190-6","article-title":"Immunogenicity of supplemental doses of poliovirus vaccine for children aged 6\u20139 months in Moradabad, India: a community-based, randomised controlled trial","volume":"12","author":"Est\u00edvariz","year":"2012","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"10.1016\/j.vaccine.2016.11.098_b0070","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/infdis\/jiu841","article-title":"Comparison of the immunogenicity of various booster doses of inactivated polio vaccine delivered intradermally versus intramuscularly to HIV-infected adults","volume":"211","author":"Troy","year":"2015","journal-title":"J Infect Dis"},{"issue":"9","key":"10.1016\/j.vaccine.2016.11.098_b0075","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1086\/651611","article-title":"Randomized controlled clinical trial of fractional doses of inactivated poliovirus vaccine administered intradermally by needle-free device in Cuba","volume":"201","author":"Resik","year":"2010","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.vaccine.2016.11.098_b0080","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1056\/NEJMoa1202541","article-title":"Priming after a fractional dose of inactivated poliovirus vaccine","volume":"368","author":"Resik","year":"2013","journal-title":"N Eng J Med"},{"issue":"25","key":"10.1016\/j.vaccine.2016.11.098_b0085","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1056\/NEJMoa0909383","article-title":"Fractional doses of inactivated poliovirus vaccine in Oman","volume":"362","author":"Mohammed","year":"2010","journal-title":"N Eng J Med"},{"issue":"48","key":"10.1016\/j.vaccine.2016.11.098_b0095","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1016\/j.vaccine.2015.09.039","article-title":"Early priming with inactivated poliovirus vaccine (IPV) and intradermal fractional dose IPV administered by a microneedle device: a randomized controlled trial","volume":"33","author":"Anand","year":"2015","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2016.11.098_b0100","first-page":"175","article-title":"Boosting immune responses following fractional-dose inactivated poliovirus vaccine: a randomized controlled trial","volume":"215","author":"Resik","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2016.11.098_b0105","doi-asserted-by":"crossref","first-page":"e534","DOI":"10.1016\/S2214-109X(16)30075-4","article-title":"Safety and immunogenicity of inactivated poliovirus vaccine when given with measles-rubella combined vaccine and yellow fever vaccine and when given via different administration routes: a phase 4, randomised, non-inferiority trial in The Gambia","volume":"8","author":"Clarke","year":"2016","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.vaccine.2016.11.098_b0110","unstructured":"WHO. Polio vaccines: WHO position paper\u2014March 2016. Wkly Epidemiol Rec. 2016;91(12):145\u2013168. Available at: <http:\/\/www.who.int\/wer\/2016\/wer9112.pdf?ua=1>. [accessed March 16, 2016]."},{"key":"10.1016\/j.vaccine.2016.11.098_b0115","unstructured":"WHO. Summary of the April 2016 Meeting of the Strategic Advisory Group of Experts On immunization (SAGE). 2016. Available at: <http:\/\/www.who.int\/immunization\/sage\/meetings\/2016\/april\/SAGE_April_2016_Meeting_Web_summary.pdf> [accessed March 16, 2016]."},{"key":"10.1016\/j.vaccine.2016.11.098_b0120","unstructured":"Intradermal injectable polio vaccination to debut in April. Times of India. March 29, 2016. Available at: <http:\/\/timesofindia.indiatimes.com\/city\/pune\/Intradermal-injectable-polio-vaccination-to-debut-in-April\/articleshow\/51591404.cms> [accessed November 11, 2016]."},{"key":"10.1016\/j.vaccine.2016.11.098_b0125","unstructured":"WHO, UNICEF. 15th WHO\/UNICEF Consultation with OPV & IPV Manufacturers and National Regulatory Authorities: July 28, 2016\u2014Note for the record. 2016. Available at: <http:\/\/www.who.int\/immunization\/diseases\/poliomyelitis\/endgame_objective2\/oral_polio_vaccine\/WHO_UNICEF_consultation_28July2016_Note_for_the_record.pdf?ua=1> [accessed November 11, 2016]."},{"key":"10.1016\/j.vaccine.2016.11.098_b0130","unstructured":"WHO. Responding to a Poliovirus Event and Outbreak. PART 1: General SOPs; 2016. Available at: <http:\/\/polioeradication.org\/wp-content\/uploads\/2016\/09\/Responding-to-a-poliovirus-event-and-outbreak-SOPs-Part-1_EN.pdf> [accessed November 11, 2016]."},{"issue":"33","key":"10.1016\/j.vaccine.2016.11.098_b0135","doi-asserted-by":"crossref","first-page":"859","DOI":"10.15585\/mmwr.mm6533a5","article-title":"Fractional-dose inactivated poliovirus vaccine immunization campaign\u2014Telangana State, India, June 2016","volume":"65","author":"Bahl","year":"2016","journal-title":"Morb Mortal Wkly Rep"},{"issue":"34","key":"10.1016\/j.vaccine.2016.11.098_b0140","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1016\/j.vaccine.2012.11.021","article-title":"Intradermal delivery for vaccine dose sparing: overview of current issues","volume":"31","author":"Zehrung","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.11.098_b0145","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2471\/BLT.10.079426","article-title":"Intradermal delivery of vaccines: potential benefits and current challenges","volume":"89","author":"Hickling","year":"2011","journal-title":"Bull World Health Organ"},{"issue":"26","key":"10.1016\/j.vaccine.2016.11.098_b0150","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1016\/j.vaccine.2008.03.095","article-title":"Intradermal vaccine delivery: will new delivery systems transform vaccine administration?","volume":"26","author":"Lambert","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.11.098_b0155","first-page":"77","article-title":"Delivery systems for intradermal vaccination","volume":"351","author":"Kim","year":"2012","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.vaccine.2016.11.098_b0160","unstructured":"PATH, Working In Tandem. Improving the Affordability of Inactivated Poliovirus Vaccines (IPV) for Use in Low- and Middle-Income Countries: An Economic Analysis of Strategies to Reduce the Cost of Routine IPV Immunization; 2010. Available at: <http:\/\/polioeradication.org\/wp-content\/uploads\/2016\/07\/TS_IPV_econ_analysis.pdf> [accessed March 16, 2016]."},{"issue":"8","key":"10.1016\/j.vaccine.2016.11.098_b0165","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1586\/14760584.2016.1158650","article-title":"Alternative administration routes and delivery technologies for polio vaccines","volume":"15","author":"Kraan","year":"2016","journal-title":"Expert Rev Vaccines"},{"issue":"37","key":"10.1016\/j.vaccine.2016.11.098_b0170","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1016\/j.vaccine.2015.01.089","article-title":"Inactivated polio vaccination using a microneedle patch is immunogenic in the rhesus macaque","volume":"33","author":"Edens","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.11.098_b0175","doi-asserted-by":"crossref","first-page":"22094","DOI":"10.1038\/srep22094","article-title":"Inactivated poliovirus type 2 vaccine delivered to rat skin via high density microprojection array elicits potent neutralising antibody responses","volume":"6","author":"Muller","year":"2016","journal-title":"Sci Rep"},{"issue":"52","key":"10.1016\/j.vaccine.2016.11.098_b0180","doi-asserted-by":"crossref","first-page":"8833","DOI":"10.1016\/j.vaccine.2007.10.020","article-title":"Evaluation of the clinical performance of a new intradermal vaccine administration technique and associated delivery system","volume":"25","author":"Laurent","year":"2007","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.vaccine.2016.11.098_b0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.provac.2012.04.017","article-title":"Clinical performance and safety of the ID adapter, a prototype intradermal delivery technology for vaccines, drugs, and diagnostic tests","volume":"2012","author":"Jarrahian","year":"2012","journal-title":"Procedia Vaccinol"},{"issue":"37","key":"10.1016\/j.vaccine.2016.11.098_b0190","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1016\/j.vaccine.2015.04.095","article-title":"Clinical performance and safety of adapters for intradermal delivery with conventional and autodisable syringes","volume":"33","author":"Tsals","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.11.098_b0195","unstructured":"Star ID: Intradermal delivery made easy page. Star Syringe website. Available at: <http:\/\/www.starsyringe.com\/product-starid.htm> [accessed March 16, 2016]."},{"issue":"4","key":"10.1016\/j.vaccine.2016.11.098_b0200","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1080\/21645515.2015.1010871","article-title":"Intradermal vaccination using the novel microneedle device MicronJet600: past, present, and future","volume":"11","author":"Levin","year":"2015","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2016.11.098_b0205","unstructured":"Vescovo P, Piveteau LD. Your solution for successful intradermal delivery. ONdrugDelivery. 2014;49:10\u201314. Available at: <http:\/\/www.ondrugdelivery.com\/publications\/49\/Debiotech.pdf> [accessed March 16, 2016]."},{"key":"10.1016\/j.vaccine.2016.11.098_b0210","unstructured":"INTANZA\u00ae\/IDflu\u00ae, first intradermal influenza vaccine, approved in the European Union [press release]. Lyon, France: Sanofi Pasteur; February 26, 2009. Available at: <http:\/\/en.sanofi.com\/Images\/13920_20090226_amm_intanza_idflu_en.pdf> [accessed March 16, 2016]."},{"issue":"12","key":"10.1016\/j.vaccine.2016.11.098_b0215","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.4161\/21645515.2014.979655","article-title":"Assessment of acceptability and usability of new delivery prototype device for intradermal vaccination in healthy subjects","volume":"10","author":"Van Mulder","year":"2014","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2016.11.098_b0220","unstructured":"FDA updated communication on use of jet injectors with inactivated influenza vaccines page. US Food and Drug Administration website. Available at: <http:\/\/www.fda.gov\/BiologicsBloodVaccines\/Vaccines\/QuestionsaboutVaccines\/ucm276773.htm> [accessed March 16, 2016]."},{"key":"10.1016\/j.vaccine.2016.11.098_b0225","unstructured":"WHO. Immunization in Practice\u2014A Practical Guide for Health Staff. Module 3: Ensuring Safe Injections. 2015. Available at: <http:\/\/www.who.int\/immunization\/documents\/IIP2015_Module3.pdf?ua=1> [accessed March 16, 2016]."},{"key":"10.1016\/j.vaccine.2016.11.098_b0230","unstructured":"PATH. Giving Safe Injections: Introducing Auto-Disable Syringes. Module 5: Using Auto-Disable Syringes. 2000. Available at: <http:\/\/www.path.org\/publications\/files\/SafeInjPDF-Module5.pdf> [accessed March 16, 2016]."},{"key":"10.1016\/j.vaccine.2016.11.098_b0235","unstructured":"WHO. WHO Best Practices for Injections and Related Procedures Toolkit. WHO\/EHT\/10.02; 2010. Available at: <http:\/\/apps.who.int\/iris\/bitstream\/10665\/44298\/1\/9789241599252_eng.pdf> [accessed March 16, 2016]."},{"issue":"43","key":"10.1016\/j.vaccine.2016.11.098_b0240","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1016\/j.vaccine.2015.06.071","article-title":"Needle-free jet injector intradermal delivery of fractional dose inactivated poliovirus vaccine: association between injection quality and immunogenicity","volume":"33","author":"Resik","year":"2015","journal-title":"Vaccine"},{"issue":"37","key":"10.1016\/j.vaccine.2016.11.098_b0245","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1016\/j.vaccine.2015.03.074","article-title":"A randomized clinical trial in adults and newborns in South Africa to compare the safety and immunogenicity of bacille Calmette-Gu\u00e9rin (BCG) vaccine administration via a disposable-syringe jet injector to conventional technique with needle and syringe","volume":"33","author":"Geldenhuys","year":"2015","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17300506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17300506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T08:51:23Z","timestamp":1536051083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X17300506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":48,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0264410X17300506"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2016.11.098","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vial usage, device dead space, vaccine wastage, and dose accuracy of intradermal delivery devices for inactivated poliovirus vaccine (IPV)","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2016.11.098","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 PATH. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}