{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:17:39Z","timestamp":1791919059038,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:00:00Z","timestamp":1481846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.vaccine.2016.12.011","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T16:15:15Z","timestamp":1482509715000},"page":"513-520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":213,"title":["Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"35","author":[{"given":"Alexander","family":"Domnich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Arata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Amicizia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Puig-Barber\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gasparini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Panatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2016.12.011_b0005","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S1473-3099(07)70236-0","article-title":"Mortality benefits of influenza vaccination in elderly people: an ongoing controversy","volume":"7","author":"Simonsen","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.vaccine.2016.12.011_b0010","first-page":"461","article-title":"Vaccines against influenza WHO position paper \u2013 November 2012","volume":"87","author":"World Health Organization (WHO)","year":"2012","journal-title":"Wkly Epidemiol Rec"},{"issue":"Suppl 5","key":"10.1016\/j.vaccine.2016.12.011_b0015","doi-asserted-by":"crossref","first-page":"B50","DOI":"10.1016\/S0264-410X(02)00507-8","article-title":"Cost-benefit evaluation of influenza vaccination in the elderly in the Italian region of Liguria","volume":"20","author":"Gasparini","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0020","unstructured":"Official Journal of the European Union. Council recommendation of 22 December 2009 on seasonal influenza vaccination. <http:\/\/eur-lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2009:348:0071:0072:EN:PDF>."},{"key":"10.1016\/j.vaccine.2016.12.011_b0025","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/1471-2334-13-348","article-title":"Selection of an adjuvant for seasonal influenza vaccine in elderly people: modelling immunogenicity from a randomized trial","volume":"13","author":"R\u00fcmke","year":"2013","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.vaccine.2016.12.011_b0030","series-title":"Influenza vaccines for the future","first-page":"327","article-title":"Emulsion-based adjuvants for improved influenza vaccines","author":"O\u2019Hagan","year":"2011"},{"key":"10.1016\/j.vaccine.2016.12.011_b0035","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1750-2659.2008.00059.x","article-title":"MF59-adjuvanted vaccines for seasonal and pandemic influenza prophylaxis","volume":"2","author":"Banzhoff","year":"2008","journal-title":"Influenza Other Respir Viruses"},{"key":"10.1016\/j.vaccine.2016.12.011_b0040","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3947\/ic.2013.45.2.159","article-title":"Fluad\u00ae-MF59\u00ae-adjuvanted influenza vaccine in older adults","volume":"45","author":"Tsai","year":"2013","journal-title":"Infect Chemother"},{"key":"10.1016\/j.vaccine.2016.12.011_b0045","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0264-410X(00)00499-0","article-title":"The adjuvanted influenza vaccines with novel adjuvants: experience with the MF59-adjuvanted vaccine","volume":"19","author":"Podda","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0050","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1016\/j.vaccine.2009.08.101","article-title":"MF59-adjuvanted versus non-adjuvanted influenza vaccines: integrated analysis from a large safety database","volume":"27","author":"Pellegrini","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0055","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/21645515.2015.1011562","article-title":"Immunogenicity of intramuscular MF59-adjuvanted and intradermal administered influenza enhanced vaccines in subjects aged over 60: a literature review","volume":"11","author":"Camilloni","year":"2015","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2016.12.011_b0060","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1086\/652404","article-title":"Vaccine epidemiology: efficacy, effectiveness, and the translational research roadmap","volume":"201","author":"Weinberg","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2016.12.011_b0065","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.vaccine.2016.12.011_b0070","unstructured":"World health organization (WHO). Definition of an older or elderly person. <http:\/\/www.who.int\/healthinfo\/survey\/ageingdefnolder\/en\/>."},{"key":"10.1016\/j.vaccine.2016.12.011_b0075","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S1473-3099(11)70295-X","article-title":"Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis","volume":"12","author":"Osterholm","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.vaccine.2016.12.011_b0080","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0264-410X(02)00041-5","article-title":"A meta-analysis of effectiveness of influenza vaccine in persons aged 65 years and over living in the community","volume":"20","author":"Vu","year":"2002","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2016.12.011_b0085","first-page":"CD004876","article-title":"Vaccines for preventing influenza in the elderly","author":"Jefferson","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.vaccine.2016.12.011_b0090","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1016\/j.vaccine.2014.07.013","article-title":"Comparison of the safety and immunogenicity of an MF59\u00ae-adjuvanted with a non-adjuvanted seasonal influenza vaccine in elderly subjects","volume":"32","author":"Frey","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0095","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0264-410X(98)00185-6","article-title":"Safety and immunogenicity of an inactivated subunit influenza virus vaccine combined with MF59 adjuvant emulsion in elderly subjects, immunized for three consecutive influenza seasons","volume":"17","author":"Minutello","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0100","unstructured":"An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI). Literature review on pediatric Fluad\u00ae influenza vaccine use in children 6-72 months of age. <http:\/\/www.phac-aspc.gc.ca\/naci-ccni\/assets\/pdf\/pediatric-pediatrique-fluad-eng.pdf>."},{"key":"10.1016\/j.vaccine.2016.12.011_b0105","unstructured":"Wells GA, Shea B, O\u2019Connell D, Peterson JEA, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. <http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp>."},{"key":"10.1016\/j.vaccine.2016.12.011_b0110","doi-asserted-by":"crossref","first-page":"e29249","DOI":"10.1371\/journal.pone.0029249","article-title":"Influenza vaccination for immunocompromised patients: systematic review and meta-analysis from a public health policy perspective","volume":"6","author":"Beck","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2016.12.011_b0115","unstructured":"Barendregt JJ, Suhail AD. MetaXL User Guide. <http:\/\/www.epigear.com\/index_files\/MetaXL%20User%20Guide.pdf>."},{"key":"10.1016\/j.vaccine.2016.12.011_b0120","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.vaccine.2004.07.017","article-title":"Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age","volume":"23","author":"Puig-Barber\u00e0","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0125","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1017\/S0950268805003936","article-title":"Evidence of increased clinical protection of an MF59-adjuvant influenza vaccine compared to a non-adjuvant vaccine among elderly residents of long-term care facilities in Italy","volume":"133","author":"Iob","year":"2005","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.vaccine.2016.12.011_b0130","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.1016\/j.vaccine.2007.08.039","article-title":"Effectiveness of MF59-adjuvanted subunit influenza vaccine in preventing hospitalisations for cardiovascular disease, cerebrovascular disease and pneumonia in the elderly","volume":"25","author":"Puig-Barber\u00e0","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0135","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1016\/j.vaccine.2012.07.006","article-title":"Effectiveness of the 2010\u20132011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: a case-case comparison, case-control study","volume":"30","author":"Puig-Barber\u00e0","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0140","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/aje\/kws313","article-title":"Effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy","volume":"176","author":"Mannino","year":"2012","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.vaccine.2016.12.011_b0145","doi-asserted-by":"crossref","first-page":"6122","DOI":"10.1016\/j.vaccine.2013.07.059","article-title":"The comparative effectiveness of adjuvanted and unadjuvanted trivalent inactivated influenza vaccine (TIV) in the elderly","volume":"31","author":"Van Buynder","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0150","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4161\/hv.22231","article-title":"Effectiveness of adjuvanted seasonal influenza vaccines (Inflexal V \u00ae and Fluad \u00ae) in preventing hospitalization for influenza and pneumonia in the elderly: a matched case-control study","volume":"9","author":"Gasparini","year":"2013","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2016.12.011_b0155","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1016\/j.vaccine.2013.05.070","article-title":"MF59-adjuvanted and virosomal influenza vaccines for preventing influenza hospitalization in older people: comparative effectiveness using the Valencia health care information system","volume":"31","author":"Puig-Barber\u00e0","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0160","doi-asserted-by":"crossref","first-page":"5290","DOI":"10.1016\/j.vaccine.2014.07.077","article-title":"Is the adjuvanted influenza vaccine more effective than the trivalent inactivated vaccine in the elderly population? Results of a case-control study","volume":"32","author":"Spadea","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0165","doi-asserted-by":"crossref","first-page":"851","DOI":"10.4161\/hv.19917","article-title":"Effectiveness and harms of seasonal and pandemic influenza vaccines in children, adults and elderly: a critical review and re-analysis of 15 meta-analyses","volume":"8","author":"Manzoli","year":"2012","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2016.12.011_b0170","doi-asserted-by":"crossref","first-page":"518","DOI":"10.7326\/0003-4819-123-7-199510010-00008","article-title":"The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature","volume":"123","author":"Gross","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.vaccine.2016.12.011_b0175","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0140-6736(05)67339-4","article-title":"Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review","volume":"366","author":"Jefferson","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2016.12.011_b0180","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1080\/21645515.2015.1091130","article-title":"Evaluating the case for trivalent or quadrivalent influenza vaccines","volume":"12","author":"Baxter","year":"2016","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2016.12.011_b0185","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1016\/j.vaccine.2016.06.064","article-title":"Immunogenicity and safety of inactivated quadrivalent influenza vaccine in adults: a systematic review and meta-analysis of randomised controlled trials","volume":"34","author":"Moa","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0190","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4161\/hv.8.1.17623","article-title":"The rationale for quadrivalent influenza vaccines","volume":"8","author":"Ambrose","year":"2012","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2016.12.011_b0195","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.vaccine.2011.12.098","article-title":"Public health impact of including two lineages of influenza B in a quadrivalent seasonal influenza vaccine","volume":"30","author":"Reed","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2016.12.011_b0200","unstructured":"Beyer WE, Boulfich M, Osterhaus AD. QIV versus TIV: evidence-based impact of lineage mismatch on influenza B vaccine efficacy. An umbrella meta-analysis of published literature. Presented at: The fifth international conference and exhibition on influenza vaccines for the world; 6\u20139 October 2015, Albufeira, Algrave, Portugal."},{"key":"10.1016\/j.vaccine.2016.12.011_b0205","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.vaccine.2016.12.011_b0210","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jclinepi.2013.03.003","article-title":"Testing the Newcastle Ottawa Scale showed low reliability between individual reviewers","volume":"66","author":"Hartling","year":"2013","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.vaccine.2016.12.011_b0215","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1471-2288-14-45","article-title":"Newcastle-Ottawa Scale: comparing reviewers' to authors' assessments","volume":"14","author":"Lo","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.vaccine.2016.12.011_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.jamda.2013.10.008","article-title":"Effectiveness of influenza vaccination in institutionalized older adults: a systematic review","volume":"15","author":"Chan","year":"2014","journal-title":"J Am Med Dir Assoc"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1631218X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1631218X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T08:35:25Z","timestamp":1529915725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X1631218X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0264410X1631218X"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2016.12.011","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2016.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}