{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:00:47Z","timestamp":1785812447025,"version":"3.56.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"am","delay-in-days":360,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005825","name":"USDA NIFA","doi-asserted-by":"publisher","award":["2013-67015-30197"],"award-info":[{"award-number":["2013-67015-30197"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.vaccine.2017.01.059","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T01:46:43Z","timestamp":1488851203000},"page":"1954-1963","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["A recombinant subunit vaccine for bovine RSV and Histophilus somni protects calves against dual pathogen challenge"],"prefix":"10.1016","volume":"35","author":[{"given":"Laurel J.","family":"Gershwin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole E.","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"McEligot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco R.","family":"Carvallo-Chaigneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren T.","family":"Crum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna M.","family":"Gunnarson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette B.","family":"Corbeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.vaccine.2017.01.059_b0005","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.vetimm.2005.04.004","article-title":"Immune mechanisms of pathogenetic synergy in concurrent bovine pulmonary infection with Haemophilus somnus and bovine respiratory syncytial virus","volume":"107","author":"Gershwin","year":"2005","journal-title":"Vet Immunol Immunopathol"},{"issue":"2","key":"10.1016\/j.vaccine.2017.01.059_b0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1017\/S1466252314000176","article-title":"Review of BRD pathogenesis: the old and the new","volume":"15","author":"Mosier","year":"2014","journal-title":"Anim Health Res Rev"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2017.01.059_b0015","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.vetimm.2006.05.003","article-title":"Specificity of IgG and IgE antibody responses to Haemophilus somnus infection of calves","volume":"113","author":"Corbeil","year":"2006","journal-title":"Vet Immunol Immunopathol"},{"issue":"11\u201312","key":"10.1016\/j.vaccine.2017.01.059_b0020","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0264-410X(98)80123-0","article-title":"A bovine model of vaccine enhanced respiratory syncytial virus pathophysiology","volume":"16","author":"Gershwin","year":"1998","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2017.01.059_b0025","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/oxfordjournals.aje.a120955","article-title":"Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine","volume":"89","author":"Kim","year":"1969","journal-title":"Am J Epidemiol"},{"issue":"11\u201312","key":"10.1016\/j.vaccine.2017.01.059_b0030","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.vaccine.2003.10.024","article-title":"Formalin-inactivated bovine RSV vaccine enhances a Th2 mediated immune response in infected cattle","volume":"22","author":"Kalina","year":"2004","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2017.01.059_b0035","first-page":"373","article-title":"Haemophilus somnus-induced IgE in calves vaccinated with commercial monovalent H. somnus bacterins","volume":"76","author":"Ruby","year":"2000","journal-title":"VetMicrobiol"},{"issue":"5","key":"10.1016\/j.vaccine.2017.01.059_b0040","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.cimid.2012.04.002","article-title":"Antibody responses of calves to Histophilus somni recombinant IbpA subunits","volume":"35","author":"Lo","year":"2012","journal-title":"Comp Immunol Microbiol Infect Dis"},{"issue":"37","key":"10.1016\/j.vaccine.2017.01.059_b0045","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1016\/j.vaccine.2008.06.100","article-title":"Vaccination of calves using the BRSV nucleocapsid protein in a DNA prime-protein boost strategy stimulates cell-mediated immunity and protects the lungs against BRSV replication and pathology","volume":"26","author":"Letellier","year":"2008","journal-title":"Vaccine"},{"issue":"29\u201330","key":"10.1016\/j.vaccine.2017.01.059_b0050","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1016\/j.vaccine.2011.04.075","article-title":"IbpA DR2 subunit immunization protects calves against Histophilus somni pneumonia","volume":"29","author":"Geertsema","year":"2011","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.vaccine.2017.01.059_b0055","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1128\/AAC.00487-15","article-title":"Antiviral efficacy of a respiratory syncytial virus (RSV) fusion inhibitor in a bovine model of RSV infection","volume":"59","author":"Jordan","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"issue":"33\u201334","key":"10.1016\/j.vaccine.2017.01.059_b0060","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1016\/j.vaccine.2006.03.077","article-title":"Effects of dual vaccination for bovine respiratory syncytial virus and Haemophilus somnus on immune responses","volume":"24","author":"Berghaus","year":"2006","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vaccine.2017.01.059_b0065","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0165-2427(88)90036-0","article-title":"Generation and characterization of murine monoclonal antibodies specific for bovine immunoglobulin E","volume":"18","author":"Thatcher","year":"1988","journal-title":"Vet Immunol Immunopathol"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2017.01.059_b0070","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.vetmic.2010.10.012","article-title":"Histophilus somni IbpA Fic cytotoxin is conserved in disease strains and most carrier strains from cattle, sheep and bison","volume":"149","author":"Zekarias","year":"2011","journal-title":"Vet Microbiol"},{"issue":"1","key":"10.1016\/j.vaccine.2017.01.059_b0075","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.molcel.2009.03.008","article-title":"The fic domain: regulation of cell signaling by adenylylation","volume":"34","author":"Worby","year":"2009","journal-title":"Mol Cell"},{"issue":"5","key":"10.1016\/j.vaccine.2017.01.059_b0080","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1128\/IAI.01277-09","article-title":"Histophilus somni IbpA DR2\/Fic in virulence and immunoprotection at the natural host alveolar epithelial barrier","volume":"78","author":"Zekarias","year":"2010","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.vaccine.2017.01.059_b0085","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.micpath.2009.02.003","article-title":"Virulence attributes of Histophilus somni with a deletion mutation in the ibpA gene","volume":"46","author":"Hoshinoo","year":"2009","journal-title":"Microb Pathog"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17301251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17301251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:22:54Z","timestamp":1759400574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X17301251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":17,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0264410X17301251"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.01.059","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A recombinant subunit vaccine for bovine RSV and Histophilus somni protects calves against dual pathogen challenge","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.01.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}