{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:32:22Z","timestamp":1790314342726,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Natural Sciences Foundation of China","award":["21336010"],"award-info":[{"award-number":["21336010"]}]},{"name":"Natural Sciences Foundation of China","award":["21406239"],"award-info":[{"award-number":["21406239"]}]},{"DOI":"10.13039\/501100010042","name":"Special Fund for Agro-scientific Research in the Public Interest","doi-asserted-by":"crossref","award":["201303046"],"award-info":[{"award-number":["201303046"]}],"id":[{"id":"10.13039\/501100010042","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key R & D Program","award":["2016YFD0500809"],"award-info":[{"award-number":["2016YFD0500809"]}]},{"name":"STS Grant","award":["KFJ-SW-STS-162"],"award-info":[{"award-number":["KFJ-SW-STS-162"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.vaccine.2017.03.037","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T16:19:57Z","timestamp":1490199597000},"page":"2413-2419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Stabilization study of inactivated foot and mouth disease virus vaccine by size-exclusion HPLC and differential scanning calorimetry"],"prefix":"10.1016","volume":"35","author":[{"given":"Yanli","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2017.03.037_b0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1586\/erv.10.146","article-title":"The current state of vaccines used in the field for foot and mouth disease virus in China","volume":"10","author":"Li","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2017.03.037_b0010","first-page":"475","article-title":"Progress for a cheaper, more stable foot-and-mouth disease vaccine","volume":"12","author":"Rees","year":"2013","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2017.03.037_b0015","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.antiviral.2012.09.019","article-title":"Development of foot-and-mouth disease virus (FMDV) serotype O virus-like-particles (VLPs) vaccine and evaluation of its potency","volume":"96","author":"Mohana Subramanian","year":"2012","journal-title":"Antiviral Res"},{"key":"10.1016\/j.vaccine.2017.03.037_b0020","doi-asserted-by":"crossref","first-page":"e43849","DOI":"10.1371\/journal.pone.0043849","article-title":"Development of a foot-and-mouth disease virus serotype A empty capsid subunit vaccine using silkworm (Bombyx mori) pupae","volume":"7","author":"Li","year":"2012","journal-title":"Plos One"},{"key":"10.1016\/j.vaccine.2017.03.037_b0025","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1016\/j.vaccine.2011.05.078","article-title":"Foot and mouth disease (FMD) virus: quantification of whole virus particles during the vaccine manufacturing process by size exclusion chromatography","volume":"29","author":"Spitteler","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.03.037_b0030","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0378-1135(94)90094-9","article-title":"Antibody-response to 146s particle, 12s protein subunit and isolated Vp1 polypeptide of foot-and-mouth-disease virus type Asia-1","volume":"39","author":"Rao","year":"1994","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.vaccine.2017.03.037_b0035","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/1921163a0","article-title":"Dissociation of foot-and-mouth disease virus into its nucleic acid and protein components","volume":"192","author":"Brown","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2017.03.037_b0040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF01320790","article-title":"Thermal stability of foot-and-mouth disease virus","volume":"70","author":"Doel","year":"1981","journal-title":"Arch Virol"},{"key":"10.1016\/j.vaccine.2017.03.037_b0045","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF01314726","article-title":"Comparative immunogenicity of 146s, 75s and 12s particles of foot-and-mouth-disease virus","volume":"73","author":"Doel","year":"1982","journal-title":"Arch Virol"},{"key":"10.1016\/j.vaccine.2017.03.037_b0050","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/BF01241550","article-title":"Stabilizing the immunizing antigen of foot-and-mouth disease virus by fixation with formaldehyde","volume":"39","author":"Rowlands","year":"1972","journal-title":"Archiv fur die gesamte Virusforschung"},{"key":"10.1016\/j.vaccine.2017.03.037_b0055","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00705-013-1872-7","article-title":"Selection and characterization of an acid-resistant mutant of serotype O foot-and-mouth disease virus","volume":"159","author":"Liang","year":"2014","journal-title":"Arch Virol"},{"key":"10.1016\/j.vaccine.2017.03.037_b0060","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1099\/0022-1317-17-3-281","article-title":"The effects of various protecting agents on the inactivation of foot-and-mouth disease virus in aerosols and during freeze-drying","volume":"17","author":"Barlow","year":"1972","journal-title":"J Gen Virol"},{"key":"10.1016\/j.vaccine.2017.03.037_b0065","first-page":"183","article-title":"Studies on the storage stability of foot and mouth-disease virus type-O and Asia-1 with various preservatives","volume":"65","author":"Nair","year":"1988","journal-title":"Indian Vet J"},{"key":"10.1016\/j.vaccine.2017.03.037_b0070","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.vaccine.2015.01.031","article-title":"Size-exclusion HPLC provides a simple, rapid, and versatile alternative method for quality control of vaccines by characterizing the assembly of antigens","volume":"33","author":"Yang","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.03.037_b0075","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1016\/j.vaccine.2011.01.069","article-title":"Effect of thiomersal on dissociation of intact (146S) foot-and-mouth disease virions into 12S particles as assessed by novel ELISAs specific for either 146S or 12S particles","volume":"29","author":"Harmsen","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.03.037_b0080","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.vaccine.2015.03.066","article-title":"Stabilizing effects of excipients on dissociation of intact (146S) foot-and-mouth disease virions into 12S particles during storage as oil-emulsion vaccine","volume":"33","author":"Harmsen","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.03.037_b0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pep.2015.04.011","article-title":"A hydrophobic interaction chromatography strategy for purification of inactivated foot-and-mouth disease virus","volume":"113","author":"Li","year":"2015","journal-title":"Protein Expr Purif"},{"key":"10.1016\/j.vaccine.2017.03.037_b0090","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ymeth.2013.04.019","article-title":"Virus-like particle formulation optimization by miniaturized high-throughput screening","volume":"60","author":"Mohr","year":"2013","journal-title":"Methods"},{"key":"10.1016\/j.vaccine.2017.03.037_b0095","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/jps.20377","article-title":"Stabilization of human papillomavirus virus-like particles by non-ionic surfactants","volume":"94","author":"Shi","year":"2005","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.vaccine.2017.03.037_b0100","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/BF01242879","article-title":"A simple method for the quantification of 140S particles of foot-and-mouth disease virus (FMDV)","volume":"45","author":"Barteling","year":"1974","journal-title":"Archiv fur die gesamte Virusforschung"},{"key":"10.1016\/j.vaccine.2017.03.037_b0105","first-page":"333","article-title":"Chemical physical properties of virtually pure foot-and-mouth disease virus","volume":"25","author":"Bachrach","year":"1964","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaccine.2017.03.037_b0110","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1128\/JVI.02311-09","article-title":"A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid lability and confer resistance to acid-dependent uncoating inhibition","volume":"84","author":"Mart\u00edn-Acebes","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2017.03.037_b0115","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1006\/jmbi.1997.1418","article-title":"Titration calculations of foot-and-mouth disease virus capsids and their stabilities as a function of pH","volume":"275","author":"van Vlijmen","year":"1998","journal-title":"J Mol Biol"},{"key":"10.1016\/j.vaccine.2017.03.037_b0120","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0969-2126(96)00017-2","article-title":"Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity","volume":"4","author":"Curry","year":"1996","journal-title":"Structure"},{"key":"10.1016\/j.vaccine.2017.03.037_b0125","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.bb.22.060193.000435","article-title":"The control of protein stability and association by weak-interactions with water-how do solvents affect these processes","volume":"22","author":"Timasheff","year":"1993","journal-title":"Ann Rev Bioph Biom"},{"key":"10.1016\/j.vaccine.2017.03.037_b0130","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0022-2836(81)90226-6","article-title":"Interaction of calf brain tubulin with glycerol","volume":"151","author":"Na","year":"1981","journal-title":"J Mol Biol"},{"key":"10.1016\/j.vaccine.2017.03.037_b0135","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1021\/bi00459a037","article-title":"Why preferential hydration does not always stabilize the native structure of globular proteins","volume":"29","author":"Arakawa","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.vaccine.2017.03.037_b0140","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1021\/bi00519a023","article-title":"Mechanism of protein stabilization by glycerol: preferential hydration in glycerol-water mixtures","volume":"20","author":"Gekko","year":"1981","journal-title":"Biochemistry-Us"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17303432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17303432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T09:00:48Z","timestamp":1535965248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X17303432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":28,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0264410X17303432"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.03.037","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stabilization study of inactivated foot and mouth disease virus vaccine by size-exclusion HPLC and differential scanning calorimetry","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.03.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}