{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:36:38Z","timestamp":1773948998182,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Canadian Institutes of Health Research and Natural Sciences and Engineering Research Council of Canada"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.vaccine.2017.04.026","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T03:15:18Z","timestamp":1492830918000},"page":"2916-2924","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Spray dried human and chimpanzee adenoviral-vectored vaccines are thermally stable and immunogenic in vivo"],"prefix":"10.1016","volume":"35","author":[{"given":"Sam","family":"Afkhami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"LeClair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siamak","family":"Haddadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocky","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven P.","family":"Toniolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hildegund C.","family":"Ertl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily D.","family":"Cranston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2017.04.026_b0005","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4081\/idr.2016.6570","article-title":"Tuberculosis 2015: burden, challenges and strategy for control and elimination","volume":"8","author":"Raviglione","year":"2016","journal-title":"Infect Dis Rep"},{"key":"10.1016\/j.vaccine.2017.04.026_b0010","unstructured":"World Health Organization. Global Tuberculosis Report 2015; 2015."},{"key":"10.1016\/j.vaccine.2017.04.026_b0015","doi-asserted-by":"publisher","first-page":"16030","DOI":"10.1038\/mtm.2016.30","article-title":"Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens","volume":"3","author":"Afkhami","year":"2016","journal-title":"Mol Ther \u2014 Meth Clin Dev"},{"key":"10.1016\/j.vaccine.2017.04.026_b0020","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1089\/hum.2013.235","article-title":"Adenovirus-based vaccines for fighting infectious diseases and cancer: progress in the field","volume":"25","author":"Majhen","year":"2014","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.vaccine.2017.04.026_b0025","doi-asserted-by":"publisher","first-page":"205ra134","DOI":"10.1126\/scitranslmed.3006843","article-title":"A human type 5 adenovirus-based tuberculosis vaccine induces robust T cell responses in humans despite preexisting anti-adenovirus immunity","volume":"5","author":"Smaill","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.vaccine.2017.04.026_b0030","doi-asserted-by":"publisher","first-page":"6357","DOI":"10.4049\/jimmunol.173.10.6357","article-title":"Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis","volume":"173","author":"Wang","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2017.04.026_b0035","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/mi.2015.29","article-title":"Novel chimpanzee adenovirus-vectored respiratory mucosal tuberculosis vaccine: overcoming local anti-human adenovirus immunity for potent TB protection","volume":"8","author":"Jeyanathan","year":"2015","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.vaccine.2017.04.026_b0040","doi-asserted-by":"publisher","first-page":"4955","DOI":"10.4049\/jimmunol.181.7.4955","article-title":"Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice","volume":"181","author":"Forbes","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2017.04.026_b0045","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.biologicals.2014.05.007","article-title":"Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies","volume":"42","author":"Kumru","year":"2014","journal-title":"Biologicals"},{"key":"10.1016\/j.vaccine.2017.04.026_b0050","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/11400","article-title":"Instability of adenoviral vectors during transport and its implication for clinical studies","volume":"5","author":"Nyberg-Hoffman","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.vaccine.2017.04.026_b0055","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1073\/pnas.0611430104","article-title":"Drying a tuberculosis vaccine without freezing","volume":"104","author":"Wong","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2017.04.026_b0060","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ijpharm.2016.04.067","article-title":"Evaluation of excipients for enhanced thermal stabilization of a human type 5 adenoviral vector through spray drying","volume":"506","author":"LeClair","year":"2016","journal-title":"Int J Pharm"},{"key":"10.1016\/j.vaccine.2017.04.026_b0065","doi-asserted-by":"publisher","first-page":"19ra12","DOI":"10.1126\/scitranslmed.3000490","article-title":"Long-term thermostabilization of live poxviral and adenoviral vaccine vectors at supraphysiological temperatures in carbohydrate glass","volume":"2","author":"Alcock","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.vaccine.2017.04.026_b0070","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1002\/jps.21963","article-title":"Spray drying technique: II. Current applications in pharmaceutical technology","volume":"99","author":"Sollohub","year":"2010","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.vaccine.2017.04.026_b0075","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1111\/j.1365-2621.1997.tb12235.x","article-title":"Freeze-drying for b-carotene encapsulation and preservation introduction","volume":"62","author":"Desobry","year":"1997","journal-title":"J Food Sci"},{"key":"10.1016\/j.vaccine.2017.04.026_b0080","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1007\/s11095-016-2003-4","article-title":"Optimization of spray drying conditions for yield, particle size and biological activity of thermally stable viral vectors","volume":"33","author":"LeClair","year":"2016","journal-title":"Pharm Res"},{"key":"10.1016\/j.vaccine.2017.04.026_b0085","doi-asserted-by":"publisher","first-page":"59","DOI":"10.5731\/pdajpst.2015.01003","article-title":"Manufacturing of high-concentration mAb formulations via spray drying \u2013 the road to manufacturing scale","volume":"69","author":"Gikanga","year":"2015","journal-title":"PDA J Pharm Sci Technol"},{"key":"10.1016\/j.vaccine.2017.04.026_b0090","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.jaerosci.2007.04.005","article-title":"Particle formation in spray drying","volume":"38","author":"Vehring","year":"2007","journal-title":"J Aerosol Sci"},{"key":"10.1016\/j.vaccine.2017.04.026_b0095","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.bbagen.2005.06.006","article-title":"Comparative thermal stabilities of recombinant adenoviruses and hexon protein","volume":"1726","author":"Ihnat","year":"2005","journal-title":"Biochem Biophys Acta"},{"key":"10.1016\/j.vaccine.2017.04.026_b0100","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1023\/A:1018941810744","article-title":"The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids","volume":"11","author":"Hancock","year":"1994","journal-title":"Pharm Res"},{"key":"10.1016\/j.vaccine.2017.04.026_b0105","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.vaccine.2009.11.024","article-title":"Heat-stable measles vaccine produced by spray drying","volume":"28","author":"Ohtake","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.04.026_b0110","doi-asserted-by":"publisher","first-page":"4369","DOI":"10.1016\/j.vaccine.2010.04.059","article-title":"Stabilizing formulations for inhalable powders of an adenovirus 35-vectored tuberculosis (TB) vaccine (AERAS-402)","volume":"28","author":"Jin","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.04.026_b0115","doi-asserted-by":"publisher","first-page":"E81","DOI":"10.1208\/pt0804081","article-title":"Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination","volume":"8","author":"Garmise","year":"2007","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.vaccine.2017.04.026_b0120","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jconrel.2010.02.025","article-title":"A comparison between spray drying and spray freeze drying to produce an influenza subunit vaccine powder for inhalation","volume":"144","author":"Saluja","year":"2010","journal-title":"J Control Release"},{"key":"10.1016\/j.vaccine.2017.04.026_b0125","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.vaccine.2004.06.049","article-title":"A novel dry powder influenza vaccine and intranasal delivery technology: induction of systemic and mucosal immune responses in rats","volume":"23","author":"Huang","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.04.026_b0130","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1002\/jps.20104","article-title":"Influenza vaccine powder formulation development: spray-freeze-drying and stability evaluation","volume":"93","author":"Maa","year":"2004","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.vaccine.2017.04.026_b0135","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.vaccine.2017.04.026_b0140","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1080\/03639040802516491","article-title":"The characterization and comparison of spray-dried mannitol samples","volume":"35","author":"Hulse","year":"2009","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.vaccine.2017.04.026_b0145","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1021\/js980001d","article-title":"The physical state of mannitol after freeze-drying: effects of mannitol concentration, freezing rate, and a noncrystallizing cosolute","volume":"87","author":"Kim","year":"1998","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.vaccine.2017.04.026_b0150","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1002\/jps.10218","article-title":"Water sorption and glass transition behaviors of freeze-dried sucrose-dextran mixtures","volume":"91","author":"Imamura","year":"2002","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.vaccine.2017.04.026_b0155","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1002\/jps.20418","article-title":"Particle size and density in spray drying-effects of carbohydrate properties","volume":"94","author":"Elversson","year":"2005","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.vaccine.2017.04.026_b0160","doi-asserted-by":"publisher","first-page":"8707","DOI":"10.1016\/j.vaccine.2007.10.035","article-title":"Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated immune responses in BALB\/c mice","volume":"25","author":"Amorij","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.04.026_b0165","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1128\/JVI.72.2.926-933.1998","article-title":"Production and characterization of improved adenovirus vectors with the E1, E2b, and E3 genes deleted","volume":"72","author":"Amalfitano","year":"1998","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2017.04.026_b0170","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/jps.10340","article-title":"Structural stability of adenovirus type 5","volume":"92","author":"Rexroad","year":"2003","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.vaccine.2017.04.026_b0175","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/0092-8674(90)90112-R","article-title":"Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation","volume":"62","author":"Bagchi","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.vaccine.2017.04.026_b0180","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1172\/JCI119625","article-title":"Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection","volume":"100","author":"Zabner","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2017.04.026_b0185","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1126\/science.286.5444.1579","article-title":"Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR","volume":"286","author":"Bewley","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2017.04.026_b0190","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/0042-6822(92)90082-Z","article-title":"The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2","volume":"186","author":"Chroboczek","year":"1992","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2017.04.026_b0195","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0042-6822(68)90121-9","article-title":"The polypeptides of adenovirus: I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12","volume":"36","author":"Maizel","year":"1968","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2017.04.026_b0200","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1038\/nature02261","article-title":"Protein folding and misfolding","volume":"426","author":"Dobson","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2017.04.026_b0205","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0169-409X(93)90003-M","article-title":"Factors affecting short-term and long term stabilities of proteins","volume":"10","author":"Arakawa","year":"1993","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.vaccine.2017.04.026_b0210","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1146\/annurev.bi.60.070191.004051","article-title":"Denatured states of proteins","volume":"60","author":"Dill","year":"1991","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.vaccine.2017.04.026_b0215","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1051\/lait:2002025","article-title":"Importance of glass transition and water activity to spray drying and stability of dairy powders","volume":"82","author":"Roos","year":"2002","journal-title":"Lait"},{"key":"10.1016\/j.vaccine.2017.04.026_b0220","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1023\/A:1018805232453","article-title":"The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody","volume":"16","author":"Andya","year":"1999","journal-title":"Pharm Res"},{"key":"10.1016\/j.vaccine.2017.04.026_b0225","doi-asserted-by":"publisher","first-page":"19678","DOI":"10.1021\/jp063134t","article-title":"Glass transition temperature of glucose, sucrose, and trehalose: an experimental and in silico study","volume":"110","author":"Simperler","year":"2006","journal-title":"J Phys Chem"},{"key":"10.1016\/j.vaccine.2017.04.026_b0230","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1023\/A:1012196826905","article-title":"The relationship between protein aggregation and molecular mobility below the glass transition temperature of lyophilized formulations containing a monoclonal antibody","volume":"14","author":"Duddu","year":"1997","journal-title":"Pharm Res"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17305005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17305005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T02:44:54Z","timestamp":1601952294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X17305005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":46,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0264410X17305005"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.04.026","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spray dried human and chimpanzee adenoviral-vectored vaccines are thermally stable and immunogenic in vivo","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}