{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:38:22Z","timestamp":1790375902082,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"25","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"China Mega-projects of Science Research for the R&D of New Drugs","award":["2009ZX09102-237"],"award-info":[{"award-number":["2009ZX09102-237"]}]},{"name":"Natural Science Fund of China","award":["81373229"],"award-info":[{"award-number":["81373229"]}]},{"name":"Natural Science Fund of Hebei Province","award":["H2014206376"],"award-info":[{"award-number":["H2014206376"]}]},{"name":"Foundation of Hebei Educational Department","award":["ZD2016029"],"award-info":[{"award-number":["ZD2016029"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.vaccine.2017.04.059","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T08:30:50Z","timestamp":1494059450000},"page":"3347-3353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Recombinant vaccinia vector-based vaccine (Tiantan) boosting a novel HBV subunit vaccine induced more robust and lasting immunity in rhesus macaques"],"prefix":"10.1016","volume":"35","author":[{"given":"Yao","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Chuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2017.04.059_b0005","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1002\/hep.22946","article-title":"National Institutes of Health consensus development conference statement: management of hepatitis B","volume":"49","author":"Sorrell","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.vaccine.2017.04.059_b0010","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.vaccine.2011.12.116","article-title":"Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity","volume":"30","author":"Ott","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.04.059_b0015","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1016\/j.vaccine.2006.01.007","article-title":"Comparative immunogenicity of a PreS\/S hepatitis B vaccine in non- and low responders to conventional vaccine","volume":"24","author":"Rendi-Wagner","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.04.059_b0020","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jceh.2014.06.008","article-title":"Designing immune therapy for chronic hepatitis B","volume":"4","author":"Fazle Akbar","year":"2014","journal-title":"J Clin Exp Hepatol"},{"key":"10.1016\/j.vaccine.2017.04.059_b0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/hep.26181","article-title":"Myristoylated PreS1-domain of the hepatitis B virus L-protein mediates specific binding to differentiated hepatocytes","volume":"58","author":"Meier","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.vaccine.2017.04.059_b0030","article-title":"Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus","volume":"3","author":"Yan","year":"2012","journal-title":"eLife"},{"key":"10.1016\/j.vaccine.2017.04.059_b0035","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/viro.2000.0250","article-title":"Fine mapping of virus-neutralizing epitopes on hepatitis B virus PreS1","volume":"270","author":"Maeng","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2017.04.059_b0040","first-page":"328","article-title":"Safety and immunogenicity of a new mammalian cell-derived recombinant hepatitis B vaccine containing Pre-S1 and Pre-S2 antigens in adults","volume":"3","author":"Raz","year":"2001","journal-title":"Isr Med Assoc J: IMAJ"},{"key":"10.1016\/j.vaccine.2017.04.059_b0045","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00430-014-0374-x","article-title":"Enhanced immune response to hepatitis B vaccination through immunization with a Pre-S1\/Pre-S2\/S vaccine","volume":"204","author":"Shouval","year":"2015","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.vaccine.2017.04.059_b0050","doi-asserted-by":"crossref","first-page":"e43730","DOI":"10.1371\/journal.pone.0043730","article-title":"Optimisation of prime-boost immunization in mice using novel protein-based and recombinant vaccinia (Tiantan)-based HBV vaccine","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2017.04.059_b0055","doi-asserted-by":"crossref","first-page":"e54126","DOI":"10.1371\/journal.pone.0054126","article-title":"Poly(I:C)\/alum mixed adjuvant priming enhances HBV subunit vaccine-induced immunity in mice when combined with recombinant adenoviral-based HBV vaccine boosting","volume":"8","author":"Chuai","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2017.04.059_b0060","article-title":"Protective efficacy and hepatitis B virus clearance in mice enhanced by cell-mediated immunity with novel prime-boost regimens","author":"Chuai","year":"2016","journal-title":"J Viral Hepatitis"},{"key":"10.1016\/j.vaccine.2017.04.059_b0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.antiviral.2013.10.019","article-title":"Lentiviral backbone-based hepatitis B virus replicon-mediated transfer favours the establishment of persistent hepatitis B virus infection in mice after hydrodynamic injection","volume":"101","author":"Chuai","year":"2014","journal-title":"Antiviral Res"},{"key":"10.1016\/j.vaccine.2017.04.059_b0070","doi-asserted-by":"crossref","unstructured":"Wieland SF. The chimpanzee model for hepatitis B virus infection. Cold Spring Harbor perspectives in medicine, vol. 5; 2015.","DOI":"10.1101\/cshperspect.a021469"},{"key":"10.1016\/j.vaccine.2017.04.059_b0075","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.jhep.2016.02.012","article-title":"Experimental in vitro and in vivo models for the study of human hepatitis B virus infection","volume":"64","author":"Allweiss","year":"2016","journal-title":"J Hepatol"},{"key":"10.1016\/j.vaccine.2017.04.059_b0080","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0042-6822(68)90121-9","article-title":"The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12","volume":"36","author":"Maizel","year":"1968","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2017.04.059_b0085","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1128\/AAC.00541-07","article-title":"A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion","volume":"51","author":"Dougherty","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.vaccine.2017.04.059_b0090","first-page":"615","article-title":"Immune mechanisms in chlamydial eye infection. Development of T suppressor cells","volume":"27","author":"Young","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.vaccine.2017.04.059_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-6700-1_1","article-title":"NTCP-reconstituted in vitro HBV infection system","volume":"1540","author":"Sun","year":"2017","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.vaccine.2017.04.059_b0100","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1038\/mt.2013.122","article-title":"The novel replication-defective vaccinia virus (Tiantan strain)-based hepatitis C virus vaccine induces robust immunity in macaques","volume":"21","author":"Wen","year":"2013","journal-title":"Mol Therapy: J Am Soc Gene Therapy"},{"key":"10.1016\/j.vaccine.2017.04.059_b0105","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.vaccine.2015.11.062","article-title":"Prime-boost vaccine strategy against viral infections: mechanisms and benefits","volume":"34","author":"Kardani","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.04.059_b0110","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1016\/j.febslet.2009.08.030","article-title":"Broadly neutralizing anti-HBV antibody binds to non-epitope regions of preS1","volume":"583","author":"Chi","year":"2009","journal-title":"FEBS Lett"},{"key":"10.1016\/j.vaccine.2017.04.059_b0115","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.virol.2003.09.014","article-title":"In vivo neutralization of hepatitis B virus infection by an anti-preS1 humanized antibody in chimpanzees","volume":"318","author":"Hong","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2017.04.059_b0120","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.3390\/ijms15022892","article-title":"NTCP and beyond: opening the door to unveil hepatitis B virus entry","volume":"15","author":"Watashi","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.vaccine.2017.04.059_b0125","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.1016\/j.vaccine.2014.06.076","article-title":"Induction of a robust T- and B-cell immune response in non- and low-responders to conventional vaccination against hepatitis B by using a third generation PreS\/S vaccine","volume":"32","author":"Krawczyk","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.04.059_b0130","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.patbio.2009.11.001","article-title":"Pathogenesis of hepatitis B virus infection","volume":"58","author":"Chisari","year":"2010","journal-title":"Pathol-Biol"},{"key":"10.1016\/j.vaccine.2017.04.059_b0135","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1089\/vim.2008.0064","article-title":"SARS-CoV spike proteins expressed by the vaccinia virus Tiantan strain: secreted sq protein induces robust neutralization antibody in mice","volume":"22","author":"Yan","year":"2009","journal-title":"Viral Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17305510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17305510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T12:52:55Z","timestamp":1569243175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X17305510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":27,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0264410X17305510"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.04.059","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant vaccinia vector-based vaccine (Tiantan) boosting a novel HBV subunit vaccine induced more robust and lasting immunity in rhesus macaques","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.04.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}