{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T14:29:46Z","timestamp":1794666586860,"version":"4.9.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"35","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T00:00:00Z","timestamp":1496880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.vaccine.2017.05.088","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T11:15:13Z","timestamp":1500635713000},"page":"4652-4657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"PB","title":["Pneumococcal conjugate vaccine induced IgG and nasopharyngeal carriage of pneumococci: Hyporesponsiveness and immune correlates of protection for carriage"],"prefix":"10.1016","volume":"35","author":[{"given":"John","family":"Ojal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L.","family":"Hammitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gaitho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Anthony G.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2017.05.088_b0005","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12325-013-0007-6","article-title":"The impact of 7-valent pneumococcal conjugate vaccine on invasive pneumococcal disease: a literature review","volume":"30","author":"Myint","year":"2013","journal-title":"Adv Ther"},{"issue":"778\u2013783","key":"10.1016\/j.vaccine.2017.05.088_b0010","first-page":"e1","article-title":"Serotype-specific hyporesponsiveness to pneumococcal conjugate vaccine in infants carrying pneumococcus at the time of vaccination","volume":"157","author":"V\u00e4kev\u00e4inen","year":"2010","journal-title":"J Pediatr"},{"key":"10.1016\/j.vaccine.2017.05.088_b0015","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1086\/652006","article-title":"Nasopharyngeal carriage of Streptococcus pneumoniae shortly before vaccination with a pneumococcal conjugate vaccine causes serotype-specific hyporesponsiveness in early infancy","volume":"201","author":"Dagan","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2017.05.088_b0020","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/j.vaccine.2014.02.064","article-title":"Impaired serotype-specific immune function following pneumococcal vaccination in infants with prior carriage","volume":"32","author":"Licciardi","year":"2014","journal-title":"Vaccine"},{"issue":"965\u201370","key":"10.1016\/j.vaccine.2017.05.088_b0025","first-page":"e1","article-title":"Lower immunoglobulin G antibody responses to pneumococcal conjugate vaccination at the age of 2 years after previous nasopharyngeal carriage of Streptococcus pneumoniae","volume":"159","author":"Rodenburg","year":"2011","journal-title":"J Pediatr"},{"key":"10.1016\/j.vaccine.2017.05.088_b0030","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1086\/315009","article-title":"Immunogenicity and impact on nasopharyngeal carriage of a nonavalent pneumococcal conjugate vaccine","volume":"180","author":"Mbelle","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2017.05.088_b0035","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00006454-200003000-00003","article-title":"Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group","volume":"19","author":"O\u2019Brien","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2017.05.088_b0040","doi-asserted-by":"crossref","unstructured":"Obaro SK, Adegbola RA, Chang I, Banya WA, Jaffar S, Mcadam KW, et al. Safety and immunogenicity of a nonavalent pneumococcal vaccine conjugated to CRM197 administered simultaneously but in a separate syringe with diphtheria, tetanus and pertussis vaccines in Gambian infants. Pediatr Infect Dis J 2000;19:463\u20139.","DOI":"10.1097\/00006454-200005000-00014"},{"key":"10.1016\/j.vaccine.2017.05.088_b0045","doi-asserted-by":"crossref","unstructured":"Nurkka A, Ahman H, Korkeila M, J\u00e4ntti V, K\u00e4yhty H, Eskola J. Serum and salivary anti-capsular antibodies in infants and children immunized with the heptavalent pneumococcal conjugate vaccine. Pediatr Infect Dis J 2001;20:25\u201333. 10.1097\/00006454-200101000-00006.","DOI":"10.1097\/00006454-200101000-00006"},{"key":"10.1016\/j.vaccine.2017.05.088_b0050","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1086\/528688","article-title":"Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants: a longitudinal study","volume":"46","author":"Hill","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2017.05.088_b0055","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/cid\/cis371","article-title":"Rates of acquisition of pneumococcal colonization and transmission probabilities, by serotype, among newborn infants in Kilifi District, Kenya","volume":"55","author":"Tigoi","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2017.05.088_b0060","first-page":"8","article-title":"Population effect of 10-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae and non-typeable Haemophilus influenzae in Kilifi, Kenya: findings from cross-sectional carriage studies","author":"Hammitt","year":"2014","journal-title":"Lancet Glob Heal"},{"key":"10.1016\/j.vaccine.2017.05.088_b0065","doi-asserted-by":"crossref","first-page":"e00188","DOI":"10.1128\/mBio.00188-17","article-title":"Streptococcus pneumoniae transmission is blocked by type-specific immunity in an infant mouse model","volume":"8","author":"Zangari","year":"2017","journal-title":"MBio"},{"key":"10.1016\/j.vaccine.2017.05.088_b0070","doi-asserted-by":"crossref","unstructured":"Pido-Lopez J, Kwok WW, Mitchell TJ, Heyderman RS, Williams NA. Acquisition of pneumococci specific effector and regulatory Cd4 + T cells localising within human upper respiratory-tract mucosal lymphoid tissue. PLoS Pathog 2011;7. 10.1371\/journal.ppat.1002396.","DOI":"10.1371\/journal.ppat.1002396"},{"key":"10.1016\/j.vaccine.2017.05.088_b0075","doi-asserted-by":"crossref","first-page":"e1000159","DOI":"10.1371\/journal.ppat.1000159","article-title":"Interleukin-17A mediates acquired immunity to pneumococcal colonization","volume":"4","author":"Lu","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.vaccine.2017.05.088_b0080","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1016\/S0264-410X(03)00230-5","article-title":"Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants","volume":"21","author":"J\u00f3dar","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.05.088_b0085","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1016\/j.vaccine.2007.01.119","article-title":"Estimating the protective concentration of anti-pneumococcal capsular polysaccharide antibodies","volume":"25","author":"Siber","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.05.088_b0090","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S1473-3099(14)70822-9","article-title":"Serotype-specific effectiveness and correlates of protection for the 13-valent pneumococcal conjugate vaccine: a postlicensure indirect cohort study","volume":"14","author":"Andrews","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.vaccine.2017.05.088_b0095","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1080\/21645515.2015.1033600","article-title":"Serological criteria and carriage measurement for evaluation of new pneumococcal vaccines","volume":"11","author":"Principi","year":"2015","journal-title":"Hum Vaccines Immunother"},{"key":"10.1016\/j.vaccine.2017.05.088_b0100","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1086\/431524","article-title":"Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study","volume":"192","author":"Goldblatt","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2017.05.088_b0105","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1016\/j.vaccine.2016.06.075","article-title":"Modeling pneumococcal nasopharyngeal acquisition as a function of anticapsular serum antibody concentrations after pneumococcal conjugate vaccine administration","volume":"34","author":"Dagan","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.05.088_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pmed.1001839","article-title":"The potential for reducing the number of pneumococcal conjugate vaccine doses while sustaining herd immunity in high-income countries","volume":"12","author":"Flasche","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.vaccine.2017.05.088_b0115","doi-asserted-by":"crossref","first-page":"e85459","DOI":"10.1371\/journal.pone.0085459","article-title":"Immunogenicity, impact on carriage and reactogenicity of 10-valent pneumococcal non-typeable haemophilus influenzae protein D conjugate vaccine in Kenyan children aged 1\u20134 years: a randomized controlled trial","volume":"9","author":"Hammitt","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2017.05.088_b0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2288-13-29","article-title":"A threshold method for immunological correlates of protection","volume":"13","author":"Chen","year":"2013","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.vaccine.2017.05.088_b0125","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1016\/S0264-410X(00)00046-3","article-title":"Competition among streptococcus pneumoniae for intranasal colonization in a mouse model","volume":"18","author":"Lipsitch","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.05.088_b0130","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/aje\/kwp351","article-title":"S Kaltoft M. Between-strain competition in acquisition and clearance of pneumococcal carriage\u2013epidemiologic evidence from a longitudinal study of day-care children","volume":"171","author":"Auranen","year":"2010","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.vaccine.2017.05.088_b0135","doi-asserted-by":"crossref","first-page":"6994","DOI":"10.1016\/j.vaccine.2011.07.035","article-title":"Inferior quantitative and qualitative immune responses to pneumococcal conjugate vaccine in infants with nasopharyngeal colonization by Streptococcus pneumoniae during the primary series of immunization","volume":"29","author":"Madhi","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.05.088_b0140","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.vaccine.2013.06.040","article-title":"Using the impact of pneumococcal vaccines on nasopharyngeal carriage to aid licensing and vaccine implementation; a Pneumocarr meeting report March 27\u201328, 2012, Geneva","volume":"32","author":"Goldblatt","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.05.088_b0145","unstructured":"Grant L, Burbidge P, Goldblatt D, Donaldson C, Weatherholtz R, Reid R, et al. Levels of anticapsular IgG and protection against acquisition of pneumococcus. In: Int. Symposium pneumococci pneumococcal dis., Glasgow, Scotland.; 2016."}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17307582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17307582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T22:26:08Z","timestamp":1535581568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X17307582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":29,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0264410X17307582"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.05.088","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pneumococcal conjugate vaccine induced IgG and nasopharyngeal carriage of pneumococci: Hyporesponsiveness and immune correlates of protection for carriage","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.05.088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}