{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:32:02Z","timestamp":1792373522253,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"33","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.vaccine.2017.06.052","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T17:00:15Z","timestamp":1498669215000},"page":"4140-4147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vaccination of horses with Lyme vaccines for dogs induces short-lasting antibody responses"],"prefix":"10.1016","volume":"35","author":[{"given":"Cassandra","family":"Guarino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanda","family":"Asbie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2017.06.052_b0005","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM200107123450207","article-title":"Lyme disease","volume":"345","author":"Steere","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2017.06.052_b0010","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jevs.2013.03.187","article-title":"Equine lyme disease","volume":"33","author":"Divers","year":"2013","journal-title":"J Equine Vet Sci"},{"key":"10.1016\/j.vaccine.2017.06.052_b0015","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1939-1676.2006.tb02880.x","article-title":"ACVIM small animal consensus statement on lyme disease in dogs: diagnosis, treatment, and prevention","volume":"20","author":"Littman","year":"2006","journal-title":"J Vet.Int Med"},{"key":"10.1016\/j.vaccine.2017.06.052_b0020","first-page":"253","article-title":"Lyme borreliosis in cattle and horses: a review of the literature","volume":"82","author":"Parker","year":"1992","journal-title":"Cornell Vet"},{"key":"10.1016\/j.vaccine.2017.06.052_b0025","unstructured":"Divers TJ, Mair TS, Chang Y-F. Lyme disease in horses. In: Mair TS, Hutchinson RE, editors. Infect. Dis. Horse, Equine Veterinary Journal Ltd., Fordham [England]; 2009. pp. 286\u20132."},{"key":"10.1016\/j.vaccine.2017.06.052_b0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-3164.2011.01013.x","article-title":"A case of Borrelia-associated cutaneous pseudolymphoma in a horse","volume":"23","author":"Sears","year":"2012","journal-title":"Vet Dermatol"},{"key":"10.1016\/j.vaccine.2017.06.052_b0035","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1463-5224.2012.01000.x","article-title":"Diagnosis of Borrelia-associated uveitis in two horses","volume":"15","author":"Priest","year":"2012","journal-title":"Vet Ophthalmol"},{"key":"10.1016\/j.vaccine.2017.06.052_b0040","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.2460\/javma.237.10.1180","article-title":"Meningitis, cranial neuritis, and radiculoneuritis associated with Borrelia burgdorferi infection in a horse","volume":"237","author":"James","year":"2010","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.vaccine.2017.06.052_b0045","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1177\/0300985811398246","article-title":"Lyme neuroborreliosis in 2 horses","volume":"48","author":"Imai","year":"2011","journal-title":"Vet Pathol Online"},{"key":"10.1016\/j.vaccine.2017.06.052_b0050","doi-asserted-by":"crossref","unstructured":"Johnstone Lk, Engiles Jb, Aceto H, Buechner-Maxwell V, Divers T, Gardner R, et al. Retrospective evaluation of horses diagnosed with neuroborreliosis on postmortem examination: 16 cases (2004\u20132015), J Vet Int Med 30 (2016) 1305\u201312. doi: 10.1111\/jvim.14369.","DOI":"10.1111\/jvim.14369"},{"key":"10.1016\/j.vaccine.2017.06.052_b0055","doi-asserted-by":"crossref","unstructured":"del Castillo JRE. Tetracyclines. In: Medicine SGD, DACVIMessor, Large Animal Internal, J.F.P. VetMB, essor, P.M.D.D. Pharmacology MS, DACVIM, DACVCPessor, Veterinary Clinical (Eds.), Antimicrob. Ther. Vet. Med., John Wiley & Sons, Inc; 2013. p. 257\u201368.","DOI":"10.1002\/9781118675014.ch15"},{"key":"10.1016\/j.vaccine.2017.06.052_b0060","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/evj.12033","article-title":"Antibodies to OspC, OspF and C6 antigens as indicators for infection with Borrelia burgdorferi in horses","volume":"45","author":"Wagner","year":"2013","journal-title":"Equine Vet J"},{"key":"10.1016\/j.vaccine.2017.06.052_b0065","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.vetimm.2011.08.005","article-title":"Development of a multiplex assay for the detection of antibodies to Borrelia burgdorferi in horses and its validation using Bayesian and conventional statistical methods","volume":"144","author":"Wagner","year":"2011","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.vaccine.2017.06.052_b0070","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0264-410X(99)00187-5","article-title":"Vaccination against lyme disease with recombinant Borrelia burgdorferi outer-surface protein A (rOspA) in horses","volume":"18","author":"Chang","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0075","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0264-410X(96)00295-2","article-title":"OspA lipoprotein of Borrelia burgdorferi is a mucosal immunogen and adjuvant","volume":"15","author":"Erdile","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0080","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/S0264-410X(96)00045-X","article-title":"Safety, efficacy, and immunogenicity of a recombinant Osp subunit canine Lyme disease vaccine","volume":"14","author":"Ma","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0085","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1128\/IAI.66.11.5119-5124.1998","article-title":"Differential expression of borrelia burgdorferi proteins during growth in vitro","volume":"66","author":"Ramamoorthy","year":"1998","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2017.06.052_b0090","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1046\/j.1365-2958.2003.03537.x","article-title":"Transcriptional regulation of the ospAB and ospC promoters from Borrelia burgdorferi","volume":"48","author":"Alverson","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2017.06.052_b0095","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1016\/S0264-410X(00)00520-X","article-title":"The prevention of Lyme disease with vaccine","volume":"19","author":"Poland","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0100","doi-asserted-by":"crossref","first-page":"5982","DOI":"10.1016\/j.vaccine.2015.07.095","article-title":"Characterization and optimization of a novel vaccine for protection against Lyme borreliosis","volume":"33","author":"Comstedt","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0105","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1126\/science.2237407","article-title":"Protection of mice against the lyme disease agent by immunizing with recombinant OspA","volume":"250","author":"Fikrig","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2017.06.052_b0110","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1073\/pnas.87.10.3768","article-title":"Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice","volume":"87","author":"Schaible","year":"1990","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.vaccine.2017.06.052_b0115","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1096-2867(96)80030-2","article-title":"Lyme disease: laboratory diagnosis of infected and vaccinated symptomatic dogs","volume":"11","author":"Jacobson","year":"1996","journal-title":"Semin Vet Med Surg (Small Anim)"},{"key":"10.1016\/j.vaccine.2017.06.052_b0120","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.vaccine.2006.07.031","article-title":"Characterization of the humoral immune response in dogs after vaccination against the Lyme borreliosis agent: a study with five commercial vaccines using two different vaccination schedules","volume":"25","author":"T\u00f6pfer","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0125","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI9427","article-title":"Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A","volume":"106","author":"Pal","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2017.06.052_b0130","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1084\/jem.20031960","article-title":"Essential role for OspA\/B in the life cycle of the lyme disease spirochete","volume":"199","author":"Yang","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2017.06.052_b0135","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S1286-4579(03)00097-2","article-title":"Adaptation of Borrelia burgdorferi in the vector and vertebrate host","volume":"5","author":"Pal","year":"2003","journal-title":"Microbes Infect"},{"key":"10.1016\/j.vaccine.2017.06.052_b0140","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1128\/CVI.00373-08","article-title":"Bacterin that induces anti-OspA and anti-OspC borreliacidal antibodies provides a high level of protection against canine Lyme disease","volume":"16","author":"LaFleur","year":"2009","journal-title":"Clin Vaccine Immunol CVI"},{"key":"10.1016\/j.vaccine.2017.06.052_b0145","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1172\/JCI200419894","article-title":"OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands","volume":"113","author":"Pal","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vaccine.2017.06.052_b0150","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1128\/IAI.68.1.411-414.2000","article-title":"Inhibition of Borrelia burgdorferi migration from the midgut to the salivary glands following feeding by ticks on OspC-immunized mice","volume":"68","author":"Gilmore","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2017.06.052_b0155","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1016\/j.vaccine.2006.12.051","article-title":"Construction and analysis of variants of a polyvalent Lyme disease vaccine: approaches for improving the immune response to chimeric vaccinogens","volume":"25","author":"Earnhart","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0160","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.vaccine.2006.07.052","article-title":"Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains","volume":"25","author":"Earnhart","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0165","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1016\/j.vaccine.2015.09.009","article-title":"Antibody and cellular immune responses of na\u00efve mares to repeated vaccination with an inactivated equine herpesvirus vaccine","volume":"33","author":"Wagner","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0170","doi-asserted-by":"crossref","first-page":"e0169072","DOI":"10.1371\/journal.pone.0169072","article-title":"Neonatal immunization with a single IL-4\/antigen dose induces increased antibody responses after challenge infection with equine herpesvirus type 1 (EHV-1) at weanling age","volume":"12","author":"Wagner","year":"2017","journal-title":"PLOS ONE."},{"key":"10.1016\/j.vaccine.2017.06.052_b0175","unstructured":"OIE World Animal Health Information System, (n.d.). http:\/\/www.oie.int\/wahis_2\/public\/wahidwild.php\/Countryinformation\/Animalsituation [accessed January 25, 2017]."},{"key":"10.1016\/j.vaccine.2017.06.052_b0180","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1128\/CVI.05653-11","article-title":"Antibodies to Borrelia burgdorferi OspA, OspC, OspF, and C6 antigens as markers for early and late infection in dogs","volume":"19","author":"Wagner","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2017.06.052_b0185","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1128\/IAI.63.9.3543-3549.1995","article-title":"Recombinant OspA protects dogs against infection and disease caused by Borrelia burgdorferi","volume":"63","author":"Chang","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2017.06.052_b0190","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2460\/ajvr.76.1.92","article-title":"West Nile virus\u2013specific immunoglobulin isotype responses in vaccinated and infected horses","volume":"76","author":"Khatibzadeh","year":"2014","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.vaccine.2017.06.052_b0195","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1128\/CDLI.11.3.458-462.2004","article-title":"Dogs vaccinated with common lyme disease vaccines do not respond to IR6, the conserved immunodominant region of the VlsE surface protein of Borrelia burgdorferi","volume":"11","author":"O\u2019Connor","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.vaccine.2017.06.052_b0200","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1128\/JCM.30.2.370-376.1992","article-title":"Serodiagnosis of Lyme borreliosis by western immunoblot: reactivity of various significant antibodies against Borrelia burgdorferi","volume":"30","author":"Ma","year":"1992","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2017.06.052_b0205","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/infdis\/167.2.392","article-title":"Western blotting in the serodiagnosis of Lyme disease","volume":"167","author":"Dressler","year":"1993","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2017.06.052_b0210","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.vaccine.2005.11.057","article-title":"Reactogenicity and immunogenicity of an inactivated influenza vaccine administered by intramuscular or subcutaneous injection in elderly adults","volume":"24","author":"Cook","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0215","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.vaccine.2015.12.057","article-title":"Comparable immune responsiveness but increased reactogenicity after subcutaneous versus intramuscular administration of tick borne encephalitis (TBE) vaccine","volume":"34","author":"Hopf","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0220","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.vaccine.2014.12.024","article-title":"Comparison of intramuscular and subcutaneous administration of a herpes zoster live-attenuated vaccine in adults aged \u226550 years: a randomised non-inferiority clinical trial","volume":"33","author":"Diez-Domingo","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.052_b0225","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1016\/S0264-410X(98)00410-1","article-title":"Subcutaneous versus intramuscular injection for booster DT vaccination of adolescents","volume":"17","author":"Mark","year":"1999","journal-title":"Vaccine"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17308496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17308496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T03:33:39Z","timestamp":1602387219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X17308496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":45,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0264410X17308496"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.06.052","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vaccination of horses with Lyme vaccines for dogs induces short-lasting antibody responses","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.06.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}