{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:22:17Z","timestamp":1793013737641,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"40","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2012-53587"],"award-info":[{"award-number":["200-2012-53587"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.vaccine.2017.06.069","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T05:31:12Z","timestamp":1505280672000},"page":"5314-5322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Association of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2010\u201311 and 2011\u201312"],"prefix":"10.1016","volume":"35","author":[{"given":"James G.","family":"Donahue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burney A.","family":"Kieke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer P.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"DeStefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Mascola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Irving","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Craig","family":"Cheetham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Glanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola P.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison L.","family":"Naleway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Belongia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2017.06.069_b0005","first-page":"1","article-title":"Prevention and control of influenza: recommendations of the advisory committee on immunization practices (ACIP)","volume":"53","author":"Harper","year":"2004","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.vaccine.2017.06.069_b0010","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/AOG.0b013e3181fae845","article-title":"Opinion No 468: influenza vaccination during pregnancy","volume":"116","author":"ACOG Committee","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ajog.2010.12.033","article-title":"2009 pandemic influenza A (H1N1) in pregnancy: a systematic review of the literature","volume":"205","author":"Mosby","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0020","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ajog.2012.06.068","article-title":"Effects of influenza on pregnant women and infants","volume":"207","author":"Rasmussen","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0025","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.ajog.2012.07.002","article-title":"Safety of influenza immunization during pregnancy for the fetus and the neonate","volume":"207","author":"Bednarczyk","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0030","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4161\/hv.8.1.18601","article-title":"Benefits to mother and child of influenza vaccination during pregnancy","volume":"8","author":"Omer","year":"2012","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2017.06.069_b0035","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1016\/j.vaccine.2014.04.021","article-title":"Safety of influenza vaccination during pregnancy: a review of subsequent maternal obstetric events and findings from two recent cohort studies","volume":"32","author":"Naleway","year":"2014","journal-title":"Vaccine"},{"issue":"473","key":"10.1016\/j.vaccine.2017.06.069_b0040","first-page":"e1","article-title":"Adverse events following administration to pregnant women of influenza A (H1N1) 2009 monovalent vaccine reported to the vaccine adverse event reporting system","volume":"205","author":"Moro","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0045","article-title":"Maternal influenza immunization and birth outcomes of stillbirth and spontaneous abortion: A systematic review and meta-analysis","author":"Bratton","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2017.06.069_b0050","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1001\/jama.2010.479","article-title":"Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States","volume":"303","author":"Siston","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.vaccine.2017.06.069_b0055","doi-asserted-by":"crossref","first-page":"f393","DOI":"10.1136\/bmj.f393","article-title":"Influenza A\/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study","volume":"346","author":"Rubinstein","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.vaccine.2017.06.069_b0060","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1016\/j.vaccine.2016.06.054","article-title":"Safety of the 2010\u201311, 2011\u201312, 2012\u201313, and 2013\u201314 seasonal influenza vaccines in pregnancy: birth defects, spontaneous abortion, preterm delivery, and small for gestational age infants, a study from the cohort arm of VAMPSS","volume":"34","author":"Chambers","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.069_b0065","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1016\/j.vaccine.2009.03.079","article-title":"Is routine influenza immunization warranted in early pregnancy?","volume":"27","author":"Skowronski","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.069_b0070","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/AOG.0b013e318279f56f","article-title":"Trivalent inactivated influenza vaccine and spontaneous abortion","volume":"121","author":"Irving","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0075","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJMoa1207210","article-title":"Risk of fetal death after pandemic influenza virus infection or vaccination","volume":"368","author":"H\u00e5berg","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2017.06.069_b0080","doi-asserted-by":"crossref","first-page":"e2794","DOI":"10.1136\/bmj.e2794","article-title":"Vaccination against pandemic A\/H1N1 2009 influenza in pregnancy and risk of fetal death: cohort study in Denmark","volume":"344","author":"Pasternak","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.vaccine.2017.06.069_b0085","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1016\/j.vaccine.2011.04.114","article-title":"Pregnancy and safety outcomes in women vaccinated with an AS03-adjuvanted split virion H1N1 (2009) pandemic influenza vaccine during pregnancy: a prospective cohort study","volume":"29","author":"Tavares","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.069_b0090","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/1471-0528.12977","article-title":"Fetal death and preterm birth associated with maternal influenza vaccination: systematic review","volume":"122","author":"Fell","year":"2015","journal-title":"Br J Obstet Gynecol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0095","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1016\/j.vaccine.2012.04.081","article-title":"A(H1N1)v2009: a controlled observational prospective cohort study on vaccine safety in pregnancy","volume":"30","author":"Oppermann","year":"2012","journal-title":"Vaccine"},{"issue":"Suppl 1","key":"10.1016\/j.vaccine.2017.06.069_b0100","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1542\/peds.2010-1722H","article-title":"The vaccine safety datalink: a model for monitoring immunization safety","volume":"127","author":"Baggs","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.vaccine.2017.06.069_b0105","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1053\/j.semperi.2013.06.006","article-title":"Should a first trimester dating scan be routine for all pregnancies?","volume":"37","author":"Doubilet","year":"2013","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0110","first-page":"1","article-title":"Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010","volume":"59","author":"Fiore","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.vaccine.2017.06.069_b0115","first-page":"1128","article-title":"recommendations of the Advisory Committee on Immunization Practices (ACIP), 2011","volume":"60","author":"Prevention and control of influenza with vaccines","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.vaccine.2017.06.069_b0120","first-page":"1","article-title":"Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009","volume":"58","author":"Fiore","year":"2009","journal-title":"MMWR Recomm Rep"},{"key":"10.1016\/j.vaccine.2017.06.069_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0300-9475.2004.01382.x","article-title":"Influenza virus: immunity and vaccination strategies. comparison of the immune response to inactivated and live, attenuated influenza vaccines","volume":"59","author":"Cox","year":"2004","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0130","doi-asserted-by":"crossref","first-page":"e56700","DOI":"10.1371\/journal.pone.0056700","article-title":"Altered response to A(H1N1)pnd09 vaccination in pregnant women: a single blinded randomized controlled trial","volume":"8","author":"Bischoff","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2017.06.069_b0135","unstructured":"Tulandi T, Al-Fozan HM. Spontaneous abortion: risk factors, etiology, clinical manifestations, and diagnostic evaluation. UpToDate. Waltham, MA: Wolters Kluwer; 2013."},{"key":"10.1016\/j.vaccine.2017.06.069_b0140","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00001648-199507000-00005","article-title":"Dose-response and trend analysis in epidemiology: alternatives to categorical analysis","volume":"6","author":"Greenland","year":"1995","journal-title":"Epidemiology"},{"key":"10.1016\/j.vaccine.2017.06.069_b0145","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/oxfordjournals.aje.a116813","article-title":"Simulation study of confounder-selection strategies","volume":"138","author":"Maldonado","year":"1993","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oxfordjournals.aje.a116591","article-title":"Toward a clearer definition of confounding","volume":"137","author":"Weinberg","year":"1993","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0155","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000149575","article-title":"Multifactorial etiology of recurrent miscarriage and its scientific and clinical implications","volume":"66","author":"Christiansen","year":"2008","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.vaccine.2017.06.069_b0160","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0002-9343(80)90363-0","article-title":"The problem of \u201cprotopathic bias\u201d in case-control studies","volume":"68","author":"Horwitz","year":"1980","journal-title":"Am J Med"},{"key":"10.1016\/j.vaccine.2017.06.069_b0165","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1016\/j.vaccine.2010.05.031","article-title":"The 2009 A (H1N1) influenza virus pandemic: a review","volume":"28","author":"Girard","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.069_b0170","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.ajog.2012.06.069","article-title":"Monitoring seasonal influenza vaccination coverage among pregnant women in the United States","volume":"207","author":"Kennedy","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0175","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1016\/j.vaccine.2013.08.097","article-title":"Risks and safety of pandemic H1N1 influenza vaccine in pregnancy: birth defects, spontaneous abortion, preterm delivery, and small for gestational age infants","volume":"31","author":"Chambers","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.069_b0180","doi-asserted-by":"crossref","first-page":"e51734","DOI":"10.1371\/journal.pone.0051734","article-title":"Evaluating the hazard of foetal death following H1N1 influenza vaccination; a population based cohort study in the UK GPRD","volume":"7","author":"Sammon","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2017.06.069_b0185","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.vaccine.2015.02.068","article-title":"Influenza vaccination during pregnancy: a systematic review of fetal death, spontaneous abortion, and congenital malformation safety outcomes","volume":"33","author":"McMillan","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2017.06.069_b0190","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s40264-016-0482-1","article-title":"Surveillance of adverse events after seasonal influenza vaccination in pregnant women and their infants in the Vaccine Adverse Event Reporting System, July 2010\u2013May 2016","volume":"40","author":"Moro","year":"2017","journal-title":"Drug Saf"},{"key":"10.1016\/j.vaccine.2017.06.069_b0195","doi-asserted-by":"crossref","first-page":"e23049","DOI":"10.1371\/journal.pone.0023049","article-title":"Adverse events following pandemic A (H1N1) 2009 monovalent vaccines in pregnant women\u2013Taiwan, November 2009\u2013August 2010","volume":"6","author":"Huang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2017.06.069_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2017.04.039","article-title":"First trimester influenza vaccination and risks for major structural birth defects in offspring","author":"Kharbanda","year":"2017","journal-title":"J Pediatr"},{"key":"10.1016\/j.vaccine.2017.06.069_b0205","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/aji.12117","article-title":"Serum proinflammatory cytokine responses to influenza virus vaccine among women during pregnancy versus non-pregnancy","volume":"70","author":"Christian","year":"2013","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0210","doi-asserted-by":"crossref","first-page":"14506","DOI":"10.1073\/pnas.1416569111","article-title":"Enhanced natural killer-cell and T-cell responses to influenza A virus during pregnancy","volume":"111","author":"Kay","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2017.06.069_b0215","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/intimm\/dxt005","article-title":"CD4+ T cells recognize unique and conserved 2009 H1N1 influenza hemagglutinin epitopes after natural infection and vaccination","volume":"25","author":"Yang","year":"2013","journal-title":"Int Immunol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0220","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/eji.201242393","article-title":"CD4+ T-cell immunity after pandemic influenza vaccination cross-reacts with seasonal antigens and functionally differs from active influenza infection","volume":"42","author":"Schmidt","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0225","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.siny.2006.03.001","article-title":"Inflammation and miscarriage","volume":"11","author":"Christiansen","year":"2006","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.vaccine.2017.06.069_b0230","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2172-11-59","article-title":"Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array","volume":"11","author":"Szarka","year":"2010","journal-title":"BMC Immunol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0235","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/AOG.0b013e3181e6dbc0","article-title":"Inflammatory cytokines and spontaneous preterm birth in asymptomatic women: a systematic review","volume":"116","author":"Wei","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"83","key":"10.1016\/j.vaccine.2017.06.069_b0240","first-page":"e8","article-title":"Pro- and antiinflammatory cytokines in threatened miscarriages","volume":"205","author":"Calleja-Agius","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.vaccine.2017.06.069_b0245","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/CS20130247","article-title":"Profile of maternal CD4 T-cell effector function during normal pregnancy and in women with a history of recurrent miscarriage","volume":"126","author":"Lissauer","year":"2014","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.vaccine.2017.06.069_b0250","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM198807283190401","article-title":"Incidence of early loss of pregnancy","volume":"319","author":"Wilcox","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2017.06.069_b0255","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1728-4465.2007.00130.x","article-title":"Underreporting of induced and spontaneous abortion in the United States: an analysis of the 2002 national survey of family growth","volume":"38","author":"Jones","year":"2007","journal-title":"Stud Fam Plann"},{"key":"10.1016\/j.vaccine.2017.06.069_b0260","first-page":"1","article-title":"Interpregnancy intervals in the United States: Data from the birth certificate and the National Survey of Family Growth","volume":"64","author":"Copen","year":"2015","journal-title":"Natl Vital Stat Rep"},{"key":"10.1016\/j.vaccine.2017.06.069_b0265","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/ije\/22.6.1189","article-title":"What does the odds ratio estimate in a case-control study?","volume":"22","author":"Pearce","year":"1993","journal-title":"Int J Epidemiol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17308666?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17308666?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T07:25:21Z","timestamp":1536045921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X17308666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":53,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0264410X17308666"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.06.069","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2010\u201311 and 2011\u201312","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.06.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}