{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:38:11Z","timestamp":1790836691178,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"33","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["602825"],"award-info":[{"award-number":["602825"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.vaccine.2017.12.028","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T09:01:54Z","timestamp":1513760514000},"page":"4710-4714","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mannitol treatment is not effective in therapy of rabies virus infection in mice"],"prefix":"10.1016","volume":"37","author":[{"given":"Lucie","family":"Dufkova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Sirmarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Salat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaclav","family":"Honig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Palus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ruzek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R.","family":"Fooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Mansfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00ebl","family":"Tordo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Jochmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Neyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Martina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Koraka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert D.M.E.","family":"Osterhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.vaccine.2017.12.028_b0010","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1089\/neu.2007.9994","article-title":"Guidelines for the management of severe traumatic brain injury. II. Hyperosmolar therapy","volume":"24","author":"Bratton","year":"2007","journal-title":"J Neurotrauma"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2017.12.028_b0015","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.brainres.2004.04.034","article-title":"Mannitol opening of the blood-brain barrier: regional variation in the permeability of sucrose, but not 86Rb+ or albumin","volume":"1014","author":"Brown","year":"2004","journal-title":"Brain Res"},{"issue":"2 Pt 2","key":"10.1016\/j.vaccine.2017.12.028_b0020","first-page":"R443","article-title":"Blood-brain barrier disruption using mannitol: time course and electron microscopy studies","volume":"256","author":"Cosolo","year":"1989","journal-title":"Am J Physiol"},{"issue":"9951","key":"10.1016\/j.vaccine.2017.12.028_b0025","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(13)62707-5","article-title":"Current status of rabies and prospects for elimination","volume":"384","author":"Fooks","year":"2014","journal-title":"Lancet"},{"issue":"4\u20135","key":"10.1016\/j.vaccine.2017.12.028_b0005","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3727\/096368914X678337","article-title":"Mannitol-enhanced delivery of stem cells and their growth factors across the blood-brain barrier","volume":"23","author":"Gonzales-Portillo","year":"2014","journal-title":"Cell Transplant"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2017.12.028_b0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.virusres.2012.12.011","article-title":"Pathobiology of rabies virus and the European bat lyssaviruses in experimentally infected mice","volume":"172","author":"Healy","year":"2013","journal-title":"Virus Res"},{"key":"10.1016\/j.vaccine.2017.12.028_b0035","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.antiviral.2014.07.013","article-title":"Enhancement of blood-brain barrier permeability is required for intravenously administered virus neutralizing antibodies to clear an established rabies virus infection from the brain and prevent the development of rabies in mice","volume":"110","author":"Huang","year":"2014","journal-title":"Antiviral Res"},{"issue":"4","key":"10.1016\/j.vaccine.2017.12.028_b0040","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s11908-009-0044-0","article-title":"Update on rabies diagnosis and treatment","volume":"11","author":"Jackson","year":"2009","journal-title":"Curr Infect Dis Rep"},{"key":"10.1016\/j.vaccine.2017.12.028_b0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-12-387040-7.00003-2","article-title":"Evasive strategies in rabies virus infection","volume":"79","author":"Lafon","year":"2011","journal-title":"Adv Virus Res"},{"issue":"4","key":"10.1016\/j.vaccine.2017.12.028_b0050","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"11","key":"10.1016\/j.vaccine.2017.12.028_b0055","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nmeth.1518","article-title":"Efficient CNS gene delivery by intravenous injection","volume":"7","author":"Louboutin","year":"2010","journal-title":"Nat Methods"},{"issue":"12","key":"10.1016\/j.vaccine.2017.12.028_b0060","doi-asserted-by":"crossref","first-page":"7666","DOI":"10.4049\/jimmunol.176.12.7666","article-title":"Regional differences in blood-brain barrier permeability changes and inflammation in the apathogenic clearance of virus from the central nervous system","volume":"176","author":"Phares","year":"2006","journal-title":"J Immunol"},{"issue":"15","key":"10.1016\/j.vaccine.2017.12.028_b0065","doi-asserted-by":"crossref","first-page":"7993","DOI":"10.1128\/JVI.00710-07","article-title":"Lethal silver-haired bat rabies virus infection can be prevented by opening the blood-brain barrier","volume":"81","author":"Roy","year":"2007","journal-title":"J Virol"},{"issue":"5","key":"10.1016\/j.vaccine.2017.12.028_b0070","doi-asserted-by":"crossref","first-page":"e20472","DOI":"10.1371\/journal.pone.0020472","article-title":"Breakdown of the blood-brain barrier during tick-borne encephalitis in mice is not dependent on CD8+ T-cells","volume":"6","author":"R\u016f\u017eek","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.vaccine.2017.12.028_b0075","doi-asserted-by":"crossref","first-page":"463","DOI":"10.7883\/yoken.64.463","article-title":"Gene expression analysis of host innate immune responses in the central nervous system following lethal CVS-11 infection in mice","volume":"64","author":"Sugiura","year":"2011","journal-title":"Jpn J Infect Dis"},{"issue":"12","key":"10.1016\/j.vaccine.2017.12.028_b0080","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s13238-013-3918-8","article-title":"Role of the blood-brain barrier in rabies virus infection and protection","volume":"4","author":"Wang","year":"2013","journal-title":"Protein Cell"},{"issue":"24","key":"10.1016\/j.vaccine.2017.12.028_b0085","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1056\/NEJMoa050382","article-title":"Survival after treatment of rabies with induction of coma","volume":"352","author":"Willoughby","year":"2005","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.vaccine.2017.12.028_b0090","doi-asserted-by":"crossref","first-page":"12554","DOI":"10.1128\/JVI.79.19.12554-12565.2005","article-title":"Attenuated rabies virus activates, while pathogenic rabies virus evades, the host innate immune responses in the central nervous system","volume":"79","author":"Wang","year":"2005","journal-title":"J Virol"},{"issue":"6","key":"10.1016\/j.vaccine.2017.12.028_b0095","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cimid.2011.09.003","article-title":"Innate immune response gene expression profiles in central nervous system of mice infected with rabies virus","volume":"34","author":"Zhao","year":"2011","journal-title":"Comp Immunol Microbiol Infect Dis"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17317814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X17317814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:33:24Z","timestamp":1759401204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X17317814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":19,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0264410X17317814"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.12.028","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mannitol treatment is not effective in therapy of rabies virus infection in mice","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2017.12.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}