{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:12:29Z","timestamp":1793913149999,"version":"4.8.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"50","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T00:00:00Z","timestamp":1522195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.vaccine.2018.01.001","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T18:05:57Z","timestamp":1522951557000},"page":"7295-7299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"title":["Status of vaccine research and development for Helicobacter pylori"],"prefix":"10.1016","volume":"37","author":[{"given":"Philip","family":"Sutton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M.","family":"Boag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2018.01.001_b0005","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1097\/INF.0b013e31817d756e","article-title":"Predominance of mother-to-child transmission of Helicobacter pylori infection detected by random amplified polymorphic DNA fingerprinting analysis in Japanese families","volume":"27","author":"Konno","year":"2008","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.vaccine.2018.01.001_b0010","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1001\/jama.282.23.2240","article-title":"Fecal and oral shedding of Helicobacter pylori from healthy infected adults","volume":"282","author":"Parsonnet","year":"1999","journal-title":"JAMA"},{"issue":"Suppl. 1","key":"10.1016\/j.vaccine.2018.01.001_b0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/hel.12332","article-title":"Epidemiology of Helicobacter pylori infection","volume":"21","author":"Leja","year":"2016","journal-title":"Helicobacter"},{"key":"10.1016\/j.vaccine.2018.01.001_b0020","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","article-title":"Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis","volume":"153","author":"Hooi","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.vaccine.2018.01.001_b0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13099-016-0091-7","article-title":"Systematic review of time trends in the prevalence of Helicobacter pylori infection in China and the USA","volume":"8","author":"Nagy","year":"2016","journal-title":"Gut Pathogens"},{"key":"10.1016\/j.vaccine.2018.01.001_b0030","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1523-5378.2011.00854.x","article-title":"Helicobacter pylori and the birth cohort effect: evidence for stabilized colonization rates in childhood","volume":"16","author":"den Hoed","year":"2011","journal-title":"Helicobacter"},{"key":"10.1016\/j.vaccine.2018.01.001_b0035","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/gutjnl-2012-302084","article-title":"Management of Helicobacter pylori infection\u2013the Maastricht IV\/Florence consensus report","volume":"61","author":"Malfertheiner","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.vaccine.2018.01.001_b0040","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2018.01.001_b0045","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(05)60004-9","article-title":"Regression of autoimmune thrombocytopenia after eradication of Helicobacter pylori","volume":"352","author":"Gasbarrini","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2018.01.001_b0050","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1182\/blood-2008-07-167155","article-title":"Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review","volume":"113","author":"Stasi","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.vaccine.2018.01.001_b0055","unstructured":"International Agency for Research on Cancer. GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. World Health Organisation; 2012."},{"key":"10.1016\/j.vaccine.2018.01.001_b0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/gutjnl-2015-309197","article-title":"A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication","volume":"65","author":"Pan","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.vaccine.2018.01.001_b0065","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.bpg.2014.10.003","article-title":"The fight against gastric cancer - the IARC Working Group report","volume":"28","author":"Herrero","year":"2014","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.vaccine.2018.01.001_b0070","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ijc.28999","article-title":"Global burden of gastric cancer attributable to Helicobacter pylori","volume":"136","author":"Plummer","year":"2015","journal-title":"Int J Cancer"},{"issue":"Suppl. 1","key":"10.1016\/j.vaccine.2018.01.001_b0075","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/hel.12336","article-title":"Inflammation, immunity, and vaccines for Helicobacter pylori infection","volume":"21","author":"Velin","year":"2016","journal-title":"Helicobacter"},{"key":"10.1016\/j.vaccine.2018.01.001_b0080","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1080\/1040841X.2017.1291578","article-title":"The study of H. pylori putative candidate factors for single- and multi-component vaccine development","volume":"43","author":"Mirzaei","year":"2017","journal-title":"Crit Rev Microbiol"},{"issue":"Suppl. 1","key":"10.1016\/j.vaccine.2018.01.001_b0085","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/hel.12252","article-title":"Inflammation, Immunity, and Vaccines for Helicobacter pylori Infection","volume":"20","author":"Walduck","year":"2015","journal-title":"Helicobacter"},{"issue":"Suppl. 1","key":"10.1016\/j.vaccine.2018.01.001_b0090","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/hel.12156","article-title":"Immunity, inflammation, and vaccines for Helicobacter pylori","volume":"19","author":"D'Elios","year":"2014","journal-title":"Helicobacter"},{"key":"10.1016\/j.vaccine.2018.01.001_b0095","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1586\/erv.13.20","article-title":"Why can't we make an effective vaccine against Helicobacter pylori?","volume":"12","author":"Sutton","year":"2013","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2018.01.001_b0100","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrgastro.2011.1","article-title":"Vaccinating against Helicobacter pylori infection","volume":"8","author":"Czinn","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.vaccine.2018.01.001_b0105","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S1590-8658(03)00414-6","article-title":"Helicobacter pylori vaccines spiral into the new millennium","volume":"35","author":"Sutton","year":"2003","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.vaccine.2018.01.001_b0110","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/infdis\/166.1.149","article-title":"Epidemiology of Helicobacter pylori in southern China: identification of early childhood as the critical period for acquisition","volume":"166","author":"Mitchell","year":"1992","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2018.01.001_b0115","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S0140-6736(15)60310-5","article-title":"Efficacy, safety, and immunogenicity of an oral recombinant Helicobacter pylori vaccine in children in China: a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"386","author":"Zeng","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2018.01.001_b0120","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1053\/j.gastro.2016.01.028","article-title":"Association between Helicobacter pylori eradication and gastric cancer incidence: a systematic review and meta-analysis","volume":"150","author":"Lee","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.vaccine.2018.01.001_b0125","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1053\/j.gastro.2007.02.031","article-title":"Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase","volume":"132","author":"Schmees","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.vaccine.2018.01.001_b0130","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.1211248110","article-title":"Helicobacter pylori gamma-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance","volume":"110","author":"Oertli","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2018.01.001_b0135","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1084\/jem.20030621","article-title":"The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms","volume":"198","author":"Boncristiano","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2018.01.001_b0140","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0140-6736(94)90032-9","article-title":"Therapeutic immunisation against Helicobacter infection","volume":"343","author":"Doidge","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2018.01.001_b0145","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1046\/j.1440-1711.2000.00881.x","article-title":"Therapeutic immunization against Helicobacter pylori infection in the absence of antibodies","volume":"78","author":"Sutton","year":"2000","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.vaccine.2018.01.001_b0150","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1086\/605845","article-title":"Cost-effectiveness of a potential prophylactic Helicobacter pylori vaccine in the United States","volume":"200","author":"Rupnow","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2018.01.001_b0155","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1136\/jcp.39.8.863","article-title":"Local immune response to gastric Campylobacter in non-ulcer dyspepsia","volume":"39","author":"Wyatt","year":"1986","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.vaccine.2018.01.001_b0160","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1086\/515105","article-title":"Natural history of Helicobacter pylori infection in childhood: 12-year follow-up cohort study in a biracial community","volume":"28","author":"Malaty","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2018.01.001_b0165","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1136\/gut.2007.145839","article-title":"Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines","volume":"57","author":"Aebischer","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.vaccine.2018.01.001_b0170","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1046\/j.1365-2036.2000.00825.x","article-title":"Review article: Helicobacter pylori vaccines-the current status","volume":"14","author":"Sutton","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.vaccine.2018.01.001_b0175","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1053\/j.gastro.2008.05.054","article-title":"Safety and immunogenicity of an intramuscular Helicobacter pylori vaccine in noninfected volunteers: a phase I study","volume":"135","author":"Malfertheiner","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.vaccine.2018.01.001_b0180","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1128\/IAI.68.5.2560-2565.2000","article-title":"Immunization with recombinant Helicobacter pylori urease in specific-pathogen-free rhesus monkeys (Macaca mulatta)","volume":"68","author":"Solnick","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2018.01.001_b0185","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1136\/gut.2003.037499","article-title":"Challenge model for Helicobacter pylori infection in human volunteers","volume":"53","author":"Graham","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.vaccine.2018.01.001_b0190","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1084\/jem.188.12.2277","article-title":"Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses","volume":"188","author":"Ermak","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.vaccine.2018.01.001_b0195","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/j.vaccine.2010.12.130","article-title":"HelicoVax: epitope-based therapeutic Helicobacter pylori vaccination in a mouse model","volume":"29","author":"Moss","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2018.01.001_b0200","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.micpath.2017.02.021","article-title":"Surface expression of Helicobacter pylori HpaA adhesion antigen on Vibrio cholerae, enhanced by co-expressed enterotoxigenic Escherichia coli fimbrial antigens","volume":"105","author":"Tobias","year":"2017","journal-title":"Microb Pathog"},{"key":"10.1016\/j.vaccine.2018.01.001_b0205","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftv026","article-title":"Protection against Helicobacter pylori infection in BALB\/c mice by oral administration of multi-epitope vaccine of CTB-UreI-UreB","volume":"73","author":"Yang","year":"2015","journal-title":"Pathog Dis"},{"key":"10.1016\/j.vaccine.2018.01.001_b0210","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/hel.12268","article-title":"Antibody production and Th1-biased response induced by an epitope vaccine composed of cholera toxin B unit and Helicobacter pylori Lpp20 epitopes","volume":"21","author":"Li","year":"2016","journal-title":"Helicobacter"},{"key":"10.1016\/j.vaccine.2018.01.001_b0215","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/2049-632X.12173","article-title":"Oral immunization with recombinant Lactococcus lactis delivering a multi-epitope antigen CTB-UE attenuates Helicobacter pylori infection in mice","volume":"72","author":"Li","year":"2014","journal-title":"Pathog Dis"},{"key":"10.1016\/j.vaccine.2018.01.001_b0220","unstructured":"Murdoch Children's Research Institute. Helicobacter Therapeutic. Patent WO\/2016\/000022 7th Jan 2016."},{"key":"10.1016\/j.vaccine.2018.01.001_b0225","doi-asserted-by":"crossref","first-page":"13636","DOI":"10.1038\/s41598-017-14028-1","article-title":"Helicobacter pylori gamma-glutamyl transferase contributes to colonization and differential recruitment of T cells during persistence","volume":"7","author":"Wustner","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.vaccine.2018.01.001_b0230","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/S0140-6736(15)60579-7","article-title":"At last, vaccine-induced protection against Helicobacter pylori","volume":"386","author":"Sutton","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2018.01.001_b0235","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/gutjnl-2015-310545","article-title":"Dual role of Helicobacter and Campylobacter species in IBD: a systematic review and meta-analysis","volume":"66","author":"Castano-Rodriguez","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.vaccine.2018.01.001_b0240","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/archinte.167.8.821","article-title":"Inverse associations of Helicobacter pylori with asthma and allergy","volume":"167","author":"Chen","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.vaccine.2018.01.001_b0245","first-page":"1195","article-title":"Meta-analysis: eradication of Helicobacter pylori infection is associated with the development of endoscopic gastroesophageal reflux disease","volume":"25","author":"Xie","year":"2013","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18300173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18300173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T17:35:40Z","timestamp":1574271340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X18300173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":49,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0264410X18300173"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.01.001","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Status of vaccine research and development for Helicobacter pylori","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}