{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:49:23Z","timestamp":1772088563058,"version":"3.50.1"},"reference-count":16,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.vaccine.2018.02.011","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T08:22:58Z","timestamp":1518855778000},"page":"1528-1532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of serum bactericidal and antibody titers induced by two Haemophilus influenzae type b conjugate vaccines: A phase III randomized double-blind study"],"prefix":"10.1016","volume":"36","author":[{"given":"Yukihiro","family":"Akeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Takanami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Sumino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Sugizaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nodoka","family":"Mitsuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2018.02.011_b0005","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1016\/j.vaccine.2014.07.100","article-title":"The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines","volume":"32","author":"Ishiwada","year":"2014","journal-title":"Vaccine"},{"issue":"38","key":"10.1016\/j.vaccine.2018.02.011_b0010","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1016\/j.vaccine.2016.05.050","article-title":"Immunogenicity and safety of a fully liquid aluminum phosphate adjuvanted Haemophilus influenzae type b PRP-CRM197 conjugate vaccine in healthy Japanease children: a phease III, ramdamized, observer-blind, multicenter, parallel-group study","volume":"34","author":"Togashi","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2018.02.011_b0015","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/infdis\/147.6.1100","article-title":"The protective level of serum antibodies to the capsular polysaccharide of Haemophilus influenzae type b","volume":"147","author":"Kayhty","year":"1983","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2018.02.011_b0020","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1128\/CVI.05675-11","article-title":"Risk of invasive Haemophilus influenzae type b (Hib) disease in adults with secondary immunodeficiency in the post-Hib vaccine era","volume":"19","author":"Nix","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2018.02.011_b0025","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1046\/j.1365-2249.1996.d01-788.x","article-title":"Expression of Haemophilus influenzae type b idiotype 1 on naturally acquired antibodies","volume":"105","author":"Ulanova","year":"1996","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.vaccine.2018.02.011_b0030","first-page":"190","article-title":"Evaluation of immunity-inducing capacity of Hib vaccine including its clinical consequence-analysis of Hib vaccine failure case","volume":"34","author":"Koizumi","year":"2013","journal-title":"Infect Agents Surveillnace Rep"},{"key":"10.1016\/j.vaccine.2018.02.011_b0035","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.1016\/j.vaccine.2014.08.010","article-title":"Evaluation and validation of a serum bactericidal antibody assay for Haemophilus influenzae type b and the threshold of protection","volume":"32","author":"Townsend","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2018.02.011_b0040","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1203\/00006450-199004000-00008","article-title":"Variability in the functional activity of vaccine-induced antibody to Haemophilus influenzae type b","volume":"27","author":"Amir","year":"1990","journal-title":"Pediatr Res"},{"key":"10.1016\/j.vaccine.2018.02.011_b0045","first-page":"89","article-title":"Measurement of serum bactericidal activity specific for Haemophilus influenzae type b by using a chromogenic and fluorescent metabolic indicator","volume":"11","author":"Romero-Steiner","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.vaccine.2018.02.011_b0050","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1128\/CDLI.8.6.1115-1119.2001","article-title":"Functional antibody activity elicited by fractional doses of Haemophilus influenzae type b conjugate vaccine (polyribosylribitol phosphate-tetanus toxoid conjugate)","volume":"8","author":"Romero-Steiner","year":"2001","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.vaccine.2018.02.011_b0055","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1586\/erv.11.142","article-title":"Glycoconjugate vaccines and immune interactions, and implications for vaccination schedules","volume":"10","author":"Borrow","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2018.02.011_b0060","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1442-200X.2003.01706.x","article-title":"Effect of aluminum adjuvants on safety and immunogenicity of Haemophilus influenzae type b-CRM197 conjugate vaccine","volume":"45","author":"Kanra","year":"2003","journal-title":"Ped Int"},{"key":"10.1016\/j.vaccine.2018.02.011_b0065","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0022-3476(05)80424-X","article-title":"Comparative trial in infants of four conjugate Haemophilus influenzae type b vaccines","volume":"120","author":"Decker","year":"1992","journal-title":"J Pediatr"},{"key":"10.1016\/j.vaccine.2018.02.011_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2013.12.007","article-title":"Immunomodulatory properties of the vaccine adjuvant alum","volume":"28","author":"Oleszycka","year":"2014","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.vaccine.2018.02.011_b0075","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/21645515.2014.1004026","article-title":"Advances in aluminum hydroxide-based adjuvant research and its mechanism","volume":"11","author":"He","year":"2015","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2018.02.011_b0080","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/00006454-199306000-00006","article-title":"Comparative immunogenicity of four Haemophilus influenzae type b conjugate vaccines in Alasaka Native infants","volume":"12","author":"Bulkow","year":"1993","journal-title":"Pediatr Infect Dis J"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18301853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18301853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:26:47Z","timestamp":1759400807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X18301853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0264410X18301853"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.02.011","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of serum bactericidal and antibody titers induced by two Haemophilus influenzae type b conjugate vaccines: A phase III randomized double-blind study","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}