{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:56:12Z","timestamp":1787874972688,"version":"build-2784847793"},"reference-count":49,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong province","doi-asserted-by":"crossref","award":["2014A020212306"],"award-info":[{"award-number":["2014A020212306"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602901"],"award-info":[{"award-number":["81602901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and technology innovation funds of Longhua District","award":["20151229A1030122"],"award-info":[{"award-number":["20151229A1030122"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.vaccine.2018.02.109","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T23:25:58Z","timestamp":1520292358000},"page":"1941-1948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Molecular characteristics of Streptococcus agalactiae in a mother-baby prospective cohort study: Implication for vaccine development and insights into vertical transmission"],"prefix":"10.1016","volume":"36","author":[{"given":"Shunming","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoming","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjiang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan'an","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2018.02.109_b0005","unstructured":"Verani JR, McGee L, Schrag SJ. Prevention of perinatal group B streptococcal disease-revised guidelines from CDC, 2010. MMWR Morb Mortal Wkly Rep 2010;59(RR-10):1\u201336."},{"issue":"2","key":"10.1016\/j.vaccine.2018.02.109_b0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00404-004-0705-z","article-title":"Serotype distribution and mother-to-baby transmission rate of Streptococcus agalactiae among expectant mothers in Kuwait","volume":"272","author":"Al-Sweih","year":"2005","journal-title":"Arch Gynecol Obstet"},{"issue":"2","key":"10.1016\/j.vaccine.2018.02.109_b0015","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5455\/medarh.2013.67.124-125","article-title":"Group B Streptococci Investigation in Pre-term Labors","volume":"67","author":"Seyyed","year":"2013","journal-title":"Med Arch"},{"issue":"4","key":"10.1016\/j.vaccine.2018.02.109_b0020","first-page":"285","article-title":"The incidence of Streptococcus Group B in 100 parturient women and the transmission of pathogens to the newborn","volume":"80","author":"Kra\u015bnianin","year":"2009","journal-title":"Ginekol Pol"},{"issue":"4","key":"10.1016\/j.vaccine.2018.02.109_b0025","first-page":"167","article-title":"Vaginal carriage rate of group B Streptococcus in pregnant women and its transmission to neonates","volume":"22","author":"Chaudhry","year":"2010","journal-title":"J Ayub Med Coll Abbottabad"},{"issue":"9815","key":"10.1016\/j.vaccine.2018.02.109_b0030","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0140-6736(11)61651-6","article-title":"Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis","volume":"379","author":"Edmond","year":"2012","journal-title":"Lancet"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2018.02.109_b0035","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0928-8244(03)00099-3","article-title":"Genetic analysis of Streptococcus agalactiaestrains isolated from neonates and their mothers","volume":"36","author":"Melchers","year":"2003","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"4","key":"10.1016\/j.vaccine.2018.02.109_b0040","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1001\/archpedi.1981.02130280045015","article-title":"Transmission of group B streptococci. Traced by use of multiple epidemiologic markers","volume":"135","author":"Band","year":"1981","journal-title":"Am J Dis Child"},{"issue":"4","key":"10.1016\/j.vaccine.2018.02.109_b0045","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1515\/jpm.2011.037","article-title":"Colonization, serotypes and transmission rates of group B streptococci in pregnant women and their infants born at a single University Center in Germany","volume":"39","author":"Kunze","year":"2011","journal-title":"J Perinat Med"},{"issue":"Pt 2","key":"10.1016\/j.vaccine.2018.02.109_b0050","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1099\/jmm.0.002865-0","article-title":"Group B streptococcus colonization of pregnant women and their children observed on obstetric and neonatal wards of the University Hospital in Krakow, Poland","volume":"58","author":"Strus","year":"2009","journal-title":"J Med Microbiol"},{"issue":"12","key":"10.1016\/j.vaccine.2018.02.109_b0055","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1128\/JCM.00419-10","article-title":"Phenotypic and genotypic characterization of group B streptococcal isolates in southern Brazil","volume":"48","author":"Palmeiro","year":"2010","journal-title":"J Clin Microbiol"},{"issue":"6","key":"10.1016\/j.vaccine.2018.02.109_b0060","doi-asserted-by":"crossref","first-page":"444","DOI":"10.4161\/hv.4.6.6507","article-title":"Group B streptococcal conjugate vaccine: a timely concept for which the time has come","volume":"4","author":"Edwards","year":"2014","journal-title":"Hum Vacci"},{"issue":"21","key":"10.1016\/j.vaccine.2018.02.109_b0065","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1016\/j.vaccine.2011.02.102","article-title":"Maternal group B streptococcal immunization: capsular polysaccharide (CPS)-based vaccines and their implications on prevention","volume":"29","author":"Palmeiro","year":"2011","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.vaccine.2018.02.109_b0070","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1128\/JCM.00277-10","article-title":"Clonal analysis of colonizing group B Streptococcus, serotype IV, an emerging pathogen in the United States","volume":"48","author":"Diedrick","year":"2010","journal-title":"J Clin Microbiol"},{"issue":"1","key":"10.1016\/j.vaccine.2018.02.109_b0075","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1086\/595564","article-title":"Preventing bacterial infections with pilus-based vaccines: the group B streptococcus paradigm","volume":"199","author":"Margarit","year":"2009","journal-title":"J Infect Dis"},{"issue":"Pt 2","key":"10.1016\/j.vaccine.2018.02.109_b0080","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1099\/jmm.0.052951-0","article-title":"Distribution of pilus islands of group B streptococcus associated with maternal colonization and invasive disease in South Africa","volume":"62","author":"Madzivhandila","year":"2013","journal-title":"J Med Microbiol"},{"issue":"2","key":"10.1016\/j.vaccine.2018.02.109_b0085","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1128\/CVI.00529-12","article-title":"Distribution of pilus islands in Streptococcus agalactiae that cause human infections: insights into evolution and implication for vaccine development","volume":"20","author":"Martins","year":"2013","journal-title":"Clin Vaccine Immunol"},{"issue":"26","key":"10.1016\/j.vaccine.2018.02.109_b0090","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1016\/j.vaccine.2015.12.072","article-title":"Status of vaccine research and development of vaccines for GBS","volume":"34","author":"Heath","year":"2016","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.vaccine.2018.02.109_b0095","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1128\/IAI.67.5.2491-2496.1999","article-title":"Alpha C protein as a carrier for type III capsular polysaccharide and as a protective protein in group B streptococcal vaccines","volume":"67","author":"Gravekamp","year":"1999","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.vaccine.2018.02.109_b0100","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.mimet.2009.11.010","article-title":"A multiplex PCR assay for the direct identification of the capsular type (Ia to IX) of Streptococcus agalactiae","volume":"80","author":"Imperi","year":"2010","journal-title":"J Microbiol Methods"},{"issue":"3","key":"10.1016\/j.vaccine.2018.02.109_b0105","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1128\/JCM.42.3.1326-1329.2004","article-title":"Multiplex PCR Assay for Direct Identification of Group B Streptococcal Alpha-Protein-Like Protein Genes","volume":"42","author":"Creti","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"4","key":"10.1016\/j.vaccine.2018.02.109_b0110","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1590\/S0074-02762009000400011","article-title":"Pulsed-field gel electrophoresis, virulence determinants and antimicrobial susceptibility profiles of type Ia group B streptococci isolated from humans in Brazil","volume":"104","author":"Corr\u00eaa","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"5","key":"10.1016\/j.vaccine.2018.02.109_b0115","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1128\/JB.01130-09","article-title":"Evidence for rare capsular switching in Streptococcus agalactiae","volume":"192","author":"Martins","year":"2010","journal-title":"J Bacteriol"},{"issue":"6","key":"10.1016\/j.vaccine.2018.02.109_b0120","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1128\/JCM.41.6.2530-2536.2003","article-title":"Multilocus sequence typing system for group B streptococcus","volume":"41","author":"Jones","year":"2003","journal-title":"J Clin Microbiol"},{"issue":"4","key":"10.1016\/j.vaccine.2018.02.109_b0125","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.4314\/ahs.v14i4.35","article-title":"Multiple correspondence analysis as a tool for analysis of large health surveys in African settings","volume":"14","author":"Ayele","year":"2014","journal-title":"Afr Health Sci"},{"key":"10.1016\/j.vaccine.2018.02.109_b0130","series-title":"Statistical methods for rates and proportions","first-page":"598","author":"Fleiss","year":"2003"},{"issue":"8","key":"10.1016\/j.vaccine.2018.02.109_b0135","doi-asserted-by":"crossref","first-page":"e0183083","DOI":"10.1371\/journal.pone.0183083","article-title":"Colonization prevalence and antibiotic susceptibility of Group B Streptococcus in pregnant women over a 6-year period in Dongguan, China","volume":"12","author":"Ji","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.vaccine.2018.02.109_b0140","doi-asserted-by":"crossref","first-page":"O370","DOI":"10.1111\/1469-0691.12416","article-title":"Epidemiology of Group B streptococcus isolated from pregnant women in Beijing, China","volume":"20","author":"Lu","year":"2014","journal-title":"Clin Microbiol Infect"},{"issue":"6","key":"10.1016\/j.vaccine.2018.02.109_b0145","doi-asserted-by":"crossref","first-page":"516","DOI":"10.7883\/yoken.65.516","article-title":"Characterization of group B streptococcus isolated from women in Saitama city, Japan","volume":"65","author":"Ueno","year":"2012","journal-title":"Jpn J Infect Dis"},{"issue":"9","key":"10.1016\/j.vaccine.2018.02.109_b0150","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/S1473-3099(16)30055-X","article-title":"Prevalence of maternal colonisation with group B streptococcus: a systematic review and meta-analysis","volume":"16","author":"Kwatra","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"Suppl. 4","key":"10.1016\/j.vaccine.2018.02.109_b0155","doi-asserted-by":"crossref","first-page":"D31","DOI":"10.1016\/j.vaccine.2013.05.012","article-title":"Group B streptococcal epidemiology and vaccine needs in developed countries","volume":"31","author":"Melin","year":"2013","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2018.02.109_b0160","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.diagmicrobio.2016.08.023","article-title":"Molecular characteristics and antimicrobial resistance in invasive and noninvasive Group B Streptococcus between 2008 and 2015 in China","volume":"86","author":"Lu","year":"2016","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"7","key":"10.1016\/j.vaccine.2018.02.109_b0165","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s10096-014-2055-5","article-title":"Molecular epidemiology of group B streptococci in Ireland reveals a diverse population with evidence of capsular switching","volume":"33","author":"Meehan","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"20","key":"10.1016\/j.vaccine.2018.02.109_b0170","doi-asserted-by":"crossref","first-page":"6431","DOI":"10.1073\/pnas.1504725112","article-title":"Sequence type 1 group B Streptococcus, an emerging cause of invasive disease in adults, evolves by small genetic changes","volume":"112","author":"Flores","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.vaccine.2018.02.109_b0175","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s10096-015-2342-9","article-title":"Distribution of pilus islands and alpha-like protein genes of group B Streptococcus colonized in pregnant women in Beijing, China","volume":"34","author":"Lu","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"10.1016\/j.vaccine.2018.02.109_b0180","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1017\/S0950268813000848","article-title":"Serotype and surface protein gene distribution of colonizing group B streptococcus in women in Egypt","volume":"142","author":"Shabayek","year":"2014","journal-title":"Epidemiol Infect"},{"issue":"6","key":"10.1016\/j.vaccine.2018.02.109_b0185","doi-asserted-by":"crossref","first-page":"F403","DOI":"10.1136\/adc.2005.090472","article-title":"Association between low concentrations of antibodies to protein alpha and Rib and invasive neonatal group B streptococcal infection","volume":"91","author":"Larsson","year":"2006","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"9","key":"10.1016\/j.vaccine.2018.02.109_b0190","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1093\/jac\/dkq230","article-title":"Population structure, virulence factors and resistance determinants of invasive, non-invasive and colonizing Streptococcus agalactiae in Poland","volume":"65","author":"Sadowy","year":"2010","journal-title":"J Antimicrob Chemother"},{"issue":"8","key":"10.1016\/j.vaccine.2018.02.109_b0195","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s10096-011-1495-4","article-title":"Phenotypes, genotypes, serotypes and molecular epidemiology of erythromycin-resistant Streptococcus agalactiae in Italy","volume":"31","author":"De Francesco","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"10.1016\/j.vaccine.2018.02.109_b0200","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jcma.2011.10.011","article-title":"Prevalence of maternal group B streptococcus colonization and vertical transmission in low-risk women in a single institute","volume":"75","author":"Yang","year":"2012","journal-title":"J Chin Med Assoc"},{"issue":"3","key":"10.1016\/j.vaccine.2018.02.109_b0205","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3109\/00016340903560008","article-title":"Prenatal and neonatal Group B Streptococcus screening and serotyping in Lebanon: incidence and implications","volume":"89","author":"Seoud","year":"2010","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.vaccine.2018.02.109_b0210","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1186\/1471-2458-9-437","article-title":"Maternal and neonatal colonisation of group B streptococcus at Muhimbili National Hospital in Dar es Salaam, Tanzania: prevalence, risk factors and antimicrobial resistance","volume":"9","author":"Joachim","year":"2009","journal-title":"BMC Publ Health"},{"issue":"4","key":"10.1016\/j.vaccine.2018.02.109_b0215","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1368-5031.2005.00395.x","article-title":"Maternal carriage and neonatal colonisation of group B streptococcus in eastern Turkey: prevalence, risk factors and antimicrobial resistance","volume":"59","author":"Kadanali","year":"2005","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.vaccine.2018.02.109_b0220","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jgar.2016.08.010","article-title":"Alarming regional differences in prevalence and antimicrobial susceptibility of group B streptococci in pregnant women: a systematic review and meta-analysis","volume":"7","author":"Huang","year":"2016","journal-title":"J Glob Antimicrob Resist"},{"issue":"15","key":"10.1016\/j.vaccine.2018.02.109_b0225","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1001\/jama.1976.03270160022022","article-title":"Infection control in small hospitals. Prevalence surveys in 18 institutions","volume":"236","author":"Britt","year":"1976","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.vaccine.2018.02.109_b0230","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1086\/500371","article-title":"Favorable impact of an infection control network on nosocomial infection rates in community hospitals","volume":"27","author":"Kaye","year":"2006","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"5","key":"10.1016\/j.vaccine.2018.02.109_b0235","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ajic.2003.10.016","article-title":"Assessing the status of infection control programs in small rural hospitals in the western United States","volume":"32","author":"Stevenson","year":"2004","journal-title":"Am J Infect Control"},{"issue":"1","key":"10.1016\/j.vaccine.2018.02.109_b0240","first-page":"28","article-title":"The carriage of group B streptococci in Turkish pregnant women and its transmission rate in newborns and serotype distribution","volume":"47","author":"Eren","year":"2005","journal-title":"Turk J Pediatr"},{"issue":"Pt 1","key":"10.1016\/j.vaccine.2018.02.109_b0245","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1099\/jmm.0.035477-0","article-title":"Serotypes and antibiotic resistance in Group B streptococcus isolated from patients at the Maternity Hospital, Kuwait","volume":"61","author":"Boswihi","year":"2012","journal-title":"J Med Microbiol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18303190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18303190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:20:26Z","timestamp":1603930826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X18303190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":49,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0264410X18303190"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.02.109","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characteristics of Streptococcus agalactiae in a mother-baby prospective cohort study: Implication for vaccine development and insights into vertical transmission","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.02.109","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}