{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:55:21Z","timestamp":1761490521164,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00c3\u00ada","doi-asserted-by":"publisher","award":["290616 -CIATEJ","432019"],"award-info":[{"award-number":["290616 -CIATEJ","432019"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008134","name":"California State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008134","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.vaccine.2018.03.014","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T15:27:13Z","timestamp":1521386833000},"page":"2069-2078","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Immune response elicited by two rBCG strains devoid of genes involved in c-di-GMP metabolism affect protection versus challenge with M. tuberculosis strains of different virulence"],"prefix":"10.1016","volume":"36","author":[{"given":"Cristian Alfredo","family":"Segura-Cerda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel de Jes\u00fas","family":"Aceves-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Marquina-Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulce","family":"Mata-Espinoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Barrios-Pay\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perla Jazm\u00edn","family":"Vega-Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Pedroza-Rold\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Bravo-Madrigal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba Adriana","family":"Vallejo-Cardona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogelio","family":"Hern\u00e1ndez-Pando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Alberto","family":"Flores-Valdez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2018.03.014_b0005","unstructured":"WHO. Global tuberculosis report 2016. World Health Organization; 2016."},{"key":"10.1016\/j.vaccine.2018.03.014_b0010","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1365-2958.2008.06274.x","article-title":"Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria","volume":"69","author":"Ojha","year":"2008","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2018.03.014_b0015","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ijid.2016.10.018","article-title":"Novel approaches to tuberculosis vaccine development","volume":"56","author":"Kaufmann","year":"2017","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.vaccine.2018.03.014_b0020","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00411-17","article-title":"Biofilms and Mycobacterium tuberculosis","volume":"85","author":"Brennan","year":"2017","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2018.03.014_b0025","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1016\/j.vaccine.2013.07.051","article-title":"Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials","volume":"31","author":"Arbues","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2018.03.014_b0030","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiw153","article-title":"The type of growth medium affects the presence of a mycobacterial capsule and is associated with differences in protective efficacy of BCG vaccination against Mycobacterium tuberculosis","author":"Prados-Rosales","year":"2016","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2018.03.014_b0035","doi-asserted-by":"crossref","unstructured":"Richards JP, Ojha AK. Mycobacterial biofilms. Microbiol Spectr 2014;2.","DOI":"10.1128\/microbiolspec.MGM2-0004-2013"},{"key":"10.1016\/j.vaccine.2018.03.014_b0040","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/2049-632X.12142","article-title":"Mycobacterium tuberculosis pellicles express unique proteins recognized by the host humoral response","volume":"70","author":"Kerns","year":"2014","journal-title":"Pathog Dis"},{"key":"10.1016\/j.vaccine.2018.03.014_b0045","article-title":"A new unifying theory of the pathogenesis of tuberculosis","author":"Orme","year":"2013","journal-title":"Tuberculosis"},{"key":"10.1016\/j.vaccine.2018.03.014_b0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tube.2015.11.010","article-title":"Tuberculosis as a three-act play: a new paradigm for the pathogenesis of pulmonary tuberculosis","volume":"97","author":"Hunter","year":"2016","journal-title":"Tuberculosis"},{"key":"10.1016\/j.vaccine.2018.03.014_b0055","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1016\/j.tube.2016.09.015","article-title":"Association of pellicle growth morphological characteristics and clinical presentation of Mycobacterium tuberculosis isolates","volume":"101S","author":"Arora","year":"2016","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.vaccine.2018.03.014_b0060","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-cellbio-101011-155705","article-title":"Second messenger regulation of biofilm formation: breakthroughs in understanding c-di-GMP effector systems","volume":"28","author":"Boyd","year":"2012","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.vaccine.2018.03.014_b0065","doi-asserted-by":"crossref","first-page":"e15072","DOI":"10.1371\/journal.pone.0015072","article-title":"Identification, activity and disulfide connectivity of C-di-GMP regulating proteins in Mycobacterium tuberculosis","volume":"5","author":"Gupta","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2018.03.014_b0070","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1371\/journal.ppat.0010033","article-title":"Mycobacterial mutants with defective control of phagosomal acidification","volume":"1","author":"Stewart","year":"2005","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.vaccine.2018.03.014_b0075","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/iub.1353","article-title":"The cyclic Di-GMP phosphodiesterase gene Rv1357c\/BCG1419c affects BCG pellicle production and in vivo maintenance","volume":"67","author":"Flores-Valdez","year":"2015","journal-title":"IUBMB Life"},{"key":"10.1016\/j.vaccine.2018.03.014_b0080","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1016\/j.vaccine.2016.08.035","article-title":"The BCG Delta BCG1419c strain, which produces more pellicle in vitro, improves control of chronic tuberculosis in vivo","volume":"34","author":"Pedroza-Roldan","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2018.03.014_b0085","doi-asserted-by":"crossref","unstructured":"Singh PP, Goyal A. Interleukin-6: a potent biomarker of mycobacterial infection. Springerplus 2013;2.","DOI":"10.1186\/2193-1801-2-686"},{"key":"10.1016\/j.vaccine.2018.03.014_b0090","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1128\/iai.65.11.4843-4849.1997","article-title":"Lethal tuberculosis in interleukin-6-deficient mutant mice","volume":"65","author":"Ladel","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2018.03.014_b0095","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/mi.2011.13","article-title":"Role of innate cytokines in mycobacterial infection","volume":"4","author":"Cooper","year":"2011","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.vaccine.2018.03.014_b0100","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1099\/00221287-148-10-3007","article-title":"Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis","volume":"148","author":"Bardarov","year":"2002","journal-title":"Microbiology"},{"key":"10.1016\/j.vaccine.2018.03.014_b0105","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2567.2008.03004.x","article-title":"Virulence, immunopathology and transmissibility of selected strains of Mycobacterium tuberculosis in a murine model","volume":"128","author":"Marquina-Castillo","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.vaccine.2018.03.014_b0110","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"Nesvizhskii","year":"2003","journal-title":"Anal Chem"},{"key":"10.1016\/j.vaccine.2018.03.014_b0115","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1021\/pr700734f","article-title":"Statistical analysis of relative labeled mass spectrometry data from complex samples using ANOVA","volume":"7","author":"Oberg","year":"2008","journal-title":"J Proteome Res"},{"key":"10.1016\/j.vaccine.2018.03.014_b0120","doi-asserted-by":"crossref","first-page":"D1063","DOI":"10.1093\/nar\/gks1262","article-title":"The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013","volume":"41","author":"Vizcaino","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.vaccine.2018.03.014_b0125","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.4049\/jimmunol.1100926","article-title":"Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1beta production in human macrophages","volume":"187","author":"Novikov","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2018.03.014_b0130","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.4049\/jimmunol.168.9.4620","article-title":"TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection","volume":"168","author":"Roach","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2018.03.014_b0135","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1086\/593174","article-title":"Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis","volume":"198","author":"Harris","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2018.03.014_b0140","doi-asserted-by":"crossref","unstructured":"Smith CM, Proulx MK, Olive AJ, Laddy D, Mishra BB, Moss C, et al. Tuberculosis susceptibility and vaccine protection are independently controlled by host genotype. MBio 2016;7.","DOI":"10.1128\/mBio.01516-16"},{"key":"10.1016\/j.vaccine.2018.03.014_b0145","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/pmic.201100544","article-title":"Deciphering the proteome of the in vivo diagnostic reagent \u201cpurified protein derivative\u201d from Mycobacterium tuberculosis","volume":"12","author":"Cho","year":"2012","journal-title":"Proteomics"},{"key":"10.1016\/j.vaccine.2018.03.014_b0150","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/eji.201747062","article-title":"CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails","volume":"47","author":"Van Rhijn","year":"2017","journal-title":"Eur J Immunol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18303505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18303505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:26:13Z","timestamp":1759400773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X18303505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":30,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0264410X18303505"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.03.014","relation":{},"ISSN":["0264-410X"],"issn-type":[{"type":"print","value":"0264-410X"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune response elicited by two rBCG strains devoid of genes involved in c-di-GMP metabolism affect protection versus challenge with M. tuberculosis strains of different virulence","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}