{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T05:14:34Z","timestamp":1784438074870,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56-AI103382-01A1"],"award-info":[{"award-number":["R56-AI103382-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21-AI117459-01A1"],"award-info":[{"award-number":["R21-AI117459-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yerkes National Primate Research Center Base","award":["RR00165"],"award-info":[{"award-number":["RR00165"]}]},{"name":"National Center for Research Resources of the National Institutes of Health"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.vaccine.2018.03.091","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T15:54:20Z","timestamp":1523548460000},"page":"2799-2808","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Inclusion of the murine IgG\u03ba signal peptide increases the cellular immunogenicity of a simian adenoviral vectored Plasmodium vivax multistage vaccine"],"prefix":"10.1016","volume":"36","author":[{"given":"Jairo A.","family":"Fonseca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica N.","family":"McCaffery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Caceres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Kashentseva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balwan","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor P.","family":"Dmitriev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Curiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2018.03.091_b0005","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/192733a0","article-title":"Gamma-globulin and acquired immunity to human malaria","volume":"192","author":"Cohen","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2018.03.091_b0010","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJMoa0805832","article-title":"Protection against a malaria challenge by sporozoite inoculation","volume":"361","author":"Roestenberg","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2018.03.091_b0015","doi-asserted-by":"crossref","first-page":"e1001994","DOI":"10.1371\/journal.pmed.1001994","article-title":"The future of the RTS, S\/AS01 malaria vaccine: an alternative development plan","volume":"13","author":"Gosling","year":"2016","journal-title":"PLoS Med"},{"key":"10.1016\/j.vaccine.2018.03.091_b0020","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/1475-2875-8-312","article-title":"Immunological mechanisms underlying protection mediated by RTS, S: a review of the available data","volume":"8","author":"Moorthy","year":"2009","journal-title":"Malaria J"},{"key":"10.1016\/j.vaccine.2018.03.091_b0025","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12936-017-1841-9","article-title":"Seasonal vaccination against malaria: a potential use for an imperfect malaria vaccine","volume":"16","author":"Greenwood","year":"2017","journal-title":"Malaria J"},{"key":"10.1016\/j.vaccine.2018.03.091_b0030","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/jphp.12350","article-title":"Adenoviral vectors as novel vaccines for influenza","volume":"67","author":"Coughlan","year":"2015","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.vaccine.2018.03.091_b0035","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1517\/14712598.2015.993374","article-title":"Adenoviruses as gene\/vaccine delivery vectors: promises and pitfalls","volume":"15","author":"Appaiahgari","year":"2015","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.vaccine.2018.03.091_b0040","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/hum.2013.235","article-title":"Adenovirus-based vaccines for fighting infectious diseases and cancer: progress in the field","volume":"25","author":"Majhen","year":"2014","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.vaccine.2018.03.091_b0045","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1586\/erv.13.15","article-title":"Development of chimpanzee adenoviruses as vaccine vectors: challenges and successes emerging from clinical trials","volume":"12","author":"Capone","year":"2013","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2018.03.091_b0050","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1016\/j.vaccine.2017.04.062","article-title":"A prime-boost immunization regimen based on a simian adenovirus 36 vectored multi-stage malaria vaccine induces protective immunity in mice","volume":"35","author":"Fonseca","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2018.03.091_b0055","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1038\/ncomms3836","article-title":"Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation","volume":"4","author":"Ewer","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.vaccine.2018.03.091_b0060","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1128\/IAI.00740-09","article-title":"Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8+ T-cell responses","volume":"78","author":"Reyes-Sandoval","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2018.03.091_b0065","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01132-16","article-title":"Adenovirus serotype 5 vaccination results in suboptimal CD4 T helper 1 responses in mice","volume":"91","author":"Lee","year":"2017","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2018.03.091_b0070","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tibs.2006.08.004","article-title":"The surprising complexity of signal sequences","volume":"31","author":"Hegde","year":"2006","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.vaccine.2018.03.091_b0075","doi-asserted-by":"crossref","first-page":"e0155340","DOI":"10.1371\/journal.pone.0155340","article-title":"Overcoming the refractory expression of secreted recombinant proteins in mammalian cells through modification of the signal peptide and adjacent amino acids","volume":"11","author":"Guler-Gane","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.vaccine.2018.03.091_b0080","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jbiosc.2015.05.016","article-title":"Enhanced production of secretory glycoprotein VSTM1-v2 with mouse IgGkappa signal peptide in optimized HEK293F transient transfection","volume":"121","author":"Liu","year":"2016","journal-title":"J Biosci Bioeng"},{"key":"10.1016\/j.vaccine.2018.03.091_b0085","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/abbs\/gmw007","article-title":"Efficient production of CYTL1 protein using mouse IgGkappa signal peptide in the CHO cell expression system","volume":"48","author":"Wang","year":"2016","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.vaccine.2018.03.091_b0090","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.virol.2017.02.021","article-title":"The tripartite leader sequence is required for ectopic expression of HAdV-B and HAdV-E E3 CR1 genes","volume":"505","author":"Bair","year":"2017","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2018.03.091_b0095","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/CJI.0000000000000156","article-title":"DNA vaccine encoding HPV16 oncogenes E6 and e7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection","volume":"40","author":"Chandra","year":"2017","journal-title":"J Immunother"},{"key":"10.1016\/j.vaccine.2018.03.091_b0100","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1128\/IAI.00480-15","article-title":"Induction of multifunctional broadly reactive T cell responses by a Plasmodium vivax circumsporozoite protein recombinant chimera","volume":"83","author":"Cabrera-Mora","year":"2015","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2018.03.091_b0105","doi-asserted-by":"crossref","first-page":"34527","DOI":"10.1038\/srep34527","article-title":"A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119","volume":"6","author":"Fonseca","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.vaccine.2018.03.091_b0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jgm.1530","article-title":"Creation of a panel of vectors based on ape adenovirus isolates","volume":"13","author":"Roy","year":"2011","journal-title":"J Gene Med"},{"key":"10.1016\/j.vaccine.2018.03.091_b0115","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jmb.2009.03.016","article-title":"Targeting of adenovirus serotype 5 pseudotyped with short fiber from serotype 41 to c-erbB2-positive cells using bispecific single-chain diabody","volume":"388","author":"Kashentseva","year":"2009","journal-title":"J Mol Biol"},{"key":"10.1016\/j.vaccine.2018.03.091_b0120","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0042-6822(68)90121-9","article-title":"The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12","volume":"36","author":"Maizel","year":"1968","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2018.03.091_b0125","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2018.03.091_b0130","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0022-1759(95)00186-4","article-title":"The assessment of antibody affinity distribution by thiocyanate elution: a simple dose-response approach","volume":"187","author":"Ferreira","year":"1995","journal-title":"J Immun Methods"},{"key":"10.1016\/j.vaccine.2018.03.091_b0135","doi-asserted-by":"crossref","first-page":"e0154819","DOI":"10.1371\/journal.pone.0154819","article-title":"A plasmodium promiscuous T cell epitope delivered within the Ad5 hexon protein enhances the protective efficacy of a protein based malaria vaccine","volume":"11","author":"Fonseca","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2018.03.091_b0140","first-page":"265","article-title":"Dissection and 2-photon imaging of peripheral lymph nodes in mice","author":"Matheu","year":"2007","journal-title":"J Vis Exp"},{"key":"10.1016\/j.vaccine.2018.03.091_b0145","doi-asserted-by":"crossref","DOI":"10.3791\/53796","article-title":"myeloid cell isolation from mouse skin and draining lymph node following intradermal immunization with live attenuated plasmodium sporozoites","author":"Mac-Daniel","year":"2016","journal-title":"J Vis Exp"},{"key":"10.1016\/j.vaccine.2018.03.091_b0150","doi-asserted-by":"crossref","first-page":"18848","DOI":"10.1038\/srep18848","article-title":"Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology","volume":"6","author":"Li","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.vaccine.2018.03.091_b0155","doi-asserted-by":"crossref","DOI":"10.3791\/54987","article-title":"The use of ex vivo whole-organ imaging and quantitative tissue histology to determine the bio-distribution of fluorescently labeled molecules","author":"McGowan","year":"2016","journal-title":"J Vis Exp"},{"key":"10.1016\/j.vaccine.2018.03.091_b0160","doi-asserted-by":"crossref","first-page":"e111020","DOI":"10.1371\/journal.pone.0111020","article-title":"IgG2 antibodies against a clinical grade Plasmodium falciparum CSP vaccine antigen associate with protection against transgenic sporozoite challenge in mice","volume":"9","author":"Schwenk","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.vaccine.2018.03.091_b0165","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1128\/IAI.01129-08","article-title":"Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness","volume":"77","author":"Stanisic","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2018.03.091_b0170","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1128\/IAI.00461-13","article-title":"Development of a chimeric Plasmodium berghei strain expressing the repeat region of the P. vivax circumsporozoite protein for in vivo evaluation of vaccine efficacy","volume":"81","author":"Espinosa","year":"2013","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2018.03.091_b0175","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1073\/pnas.1621489114","article-title":"Systems analysis of protective immune responses to RTS, S malaria vaccination in humans","volume":"114","author":"Kazmin","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2018.03.091_b0180","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/mt.2013.284","article-title":"Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens","volume":"22","author":"Antrobus","year":"2014","journal-title":"Mol Ther: J Am Soc Gene Ther"},{"key":"10.1016\/j.vaccine.2018.03.091_b0185","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/S0264-410X(98)00181-9","article-title":"Efficient induction of protective anti-malaria immunity by recombinant adenovirus","volume":"16","author":"Rodrigues","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2018.03.091_b0190","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1128\/IAI.01879-06","article-title":"Priming with an adenovirus 35-circumsporozoite protein (CS) vaccine followed by RTS, S\/AS01B boosting significantly improves immunogenicity to Plasmodium falciparum CS compared to that with either malaria vaccine alone","volume":"75","author":"Stewart","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2018.03.091_b0195","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1016\/j.vaccine.2009.07.106","article-title":"Evaluation of a prime-boost vaccine schedule with distinct adenovirus vectors against malaria in rhesus monkeys","volume":"27","author":"Rodriguez","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2018.03.091_b0200","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/infdis\/jir850","article-title":"Clinical assessment of a recombinant simian adenovirus ChAd63: a potent new vaccine vector","volume":"205","author":"O'Hara","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2018.03.091_b0205","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1073\/pnas.1722627115","article-title":"Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120","volume":"115","author":"Yolitz","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2018.03.091_b0210","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/21645515.2017.1264766","article-title":"A plant protein signal sequence improved humoral immune response to HPV prophylactic and therapeutic DNA vaccines","volume":"13","author":"Massa","year":"2017","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.vaccine.2018.03.091_b0215","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.molmed.2016.09.002","article-title":"Modulating antibody functionality in infectious disease and vaccination","volume":"22","author":"Gunn","year":"2016","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.vaccine.2018.03.091_b0220","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.cell.2015.10.027","article-title":"Dissecting polyclonal vaccine-induced humoral immunity against HIV using systems serology","volume":"163","author":"Chung","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.vaccine.2018.03.091_b0225","doi-asserted-by":"crossref","first-page":"e1005456","DOI":"10.1371\/journal.ppat.1005456","article-title":"Antigen-specific antibody glycosylation is regulated via vaccination","volume":"12","author":"Mahan","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.vaccine.2018.03.091_b0230","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/bit.1119","article-title":"Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FC gamma RIII","volume":"74","author":"Davies","year":"2001","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.vaccine.2018.03.091_b0235","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1128\/CVI.00066-13","article-title":"Transgenic parasites stably expressing full-length Plasmodium falciparum circumsporozoite protein as a model for vaccine down-selection in mice using sterile protection as an endpoint","volume":"20","author":"Porter","year":"2013","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.vaccine.2018.03.091_b0240","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1371\/journal.pmed.0020344","article-title":"A malaria vaccine that elicits in humans antibodies able to kill Plasmodium falciparum","volume":"2","author":"Druilhe","year":"2005","journal-title":"PLoS Med"},{"key":"10.1016\/j.vaccine.2018.03.091_b0245","doi-asserted-by":"crossref","first-page":"e61395","DOI":"10.1371\/journal.pone.0061395","article-title":"The relationship between RTS, S vaccine-induced antibodies, CD4(+) T cell responses and protection against Plasmodium falciparum infection","volume":"8","author":"White","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2018.03.091_b0250","doi-asserted-by":"crossref","first-page":"e1005118","DOI":"10.1371\/journal.ppat.1005118","article-title":"Interferon-gamma: the Jekyll and Hyde of malaria","volume":"11","author":"King","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.vaccine.2018.03.091_b0255","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1189\/jlb.0310137","article-title":"Interferon-gamma\u2013central mediator of protective immune responses against the pre-erythrocytic and blood stage of malaria","volume":"88","author":"McCall","year":"2010","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.vaccine.2018.03.091_b0260","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.immuni.2013.01.004","article-title":"Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy","volume":"38","author":"Liao","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.vaccine.2018.03.091_b0265","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/ni.2180","article-title":"Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection","volume":"13","author":"Butler","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.vaccine.2018.03.091_b0270","doi-asserted-by":"crossref","first-page":"e1006484","DOI":"10.1371\/journal.ppat.1006484","article-title":"T follicular helper cells regulate the activation of B lymphocytes and antibody production during Plasmodium vivax infection","volume":"13","author":"Figueiredo","year":"2017","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.vaccine.2018.03.091_b0275","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ebiom.2017.08.030","article-title":"Follicular helper T cells are essential for the elimination of plasmodium infection","volume":"24","author":"Perez-Mazliah","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.vaccine.2018.03.091_b0280","doi-asserted-by":"crossref","first-page":"e1004715","DOI":"10.1371\/journal.ppat.1004715","article-title":"Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria","volume":"11","author":"Perez-Mazliah","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.vaccine.2018.03.091_b0285","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.a.21015","article-title":"SPICE: exploration and analysis of post-cytometric complex multivariate datasets","volume":"79","author":"Roederer","year":"2011","journal-title":"Cytometry A"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18304742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18304742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T16:51:51Z","timestamp":1604163111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X18304742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":57,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0264410X18304742"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.03.091","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inclusion of the murine IgG\u03ba signal peptide increases the cellular immunogenicity of a simian adenoviral vectored Plasmodium vivax multistage vaccine","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.03.091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}