{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:29:34Z","timestamp":1793816974970,"version":"4.6.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501770"],"award-info":[{"award-number":["81501770"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2015YL051"],"award-info":[{"award-number":["ZR2015YL051"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Project of Shandong Academy of Medical Sciences"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.vaccine.2018.05.072","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T23:25:52Z","timestamp":1526945152000},"page":"3943-3948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Protective immune response against Toxoplasma gondii elicited by a novel yeast-based vaccine with microneme protein 16"],"prefix":"10.1016","volume":"36","author":[{"given":"Long-jiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong-zhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-kuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2018.05.072_b0005","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: from animals to humans","volume":"30","author":"Tenter","year":"2000","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.vaccine.2018.05.072_b0010","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1550-7408.2008.00345.x","article-title":"The history of Toxoplasma gondii-the first 100 years","volume":"55","author":"Dubey","year":"2008","journal-title":"J Eukaryot Microbiol"},{"key":"10.1016\/j.vaccine.2018.05.072_b0015","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"Montoya","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2018.05.072_b0020","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.micinf.2008.07.015","article-title":"Toxoplasma: the next 100years","volume":"10","author":"Kim","year":"2008","journal-title":"Microbes Infect"},{"key":"10.1016\/j.vaccine.2018.05.072_b0025","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pt.2013.01.007","article-title":"How and why Toxoplasma makes us crazy","volume":"29","author":"Flegr","year":"2013","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.vaccine.2018.05.072_b0030","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.pt.2013.06.001","article-title":"Toxoplasma oocysts as a public health problem","volume":"29","author":"Torrey","year":"2013","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.vaccine.2018.05.072_b0035","doi-asserted-by":"crossref","first-page":"129","DOI":"10.14411\/fp.2010.016","article-title":"The diagnosis of a personality disorder increases the likelihood for seropositivity to Toxoplasma gondii in psychiatric patients","volume":"57","author":"Hinze-Selch","year":"2010","journal-title":"Folia Parasitol"},{"key":"10.1016\/j.vaccine.2018.05.072_b0040","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neulet.2010.03.057","article-title":"The probable relation between Toxoplasma gondii and Parkinson\u2019s disease","volume":"475","author":"Miman","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.vaccine.2018.05.072_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/WAD.0b013e3181f73bc2","article-title":"Could Toxoplasma gondii have any role in Alzheimer disease?","volume":"25","author":"Kusbeci","year":"2011","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"7","key":"10.1016\/j.vaccine.2018.05.072_b0050","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1089\/fpd.2010.0795","article-title":"Toxoplasma in animals, food, and humans: an old parasite of new concern","volume":"8","author":"Cenci-Goga","year":"2011","journal-title":"Foodborne Pathog Dis"},{"issue":"3","key":"10.1016\/j.vaccine.2018.05.072_b0055","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2174\/1574891X10666150410120321","article-title":"Anti-Toxoplasma activity of natural products: a review","volume":"9","author":"Sepulveda-Arias","year":"2014","journal-title":"Recent Pat Antiinfect Drug Discov"},{"key":"10.1016\/j.vaccine.2018.05.072_b0060","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.vaccine.2012.01.004","article-title":"Protective immune response against Toxoplasma gondii elicited by a recombinant DNA vaccine with a novel genetic adjuvant","volume":"30","author":"Zhou","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2018.05.072_b0065","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.exppara.2012.01.001","article-title":"Toxoplasma gondii: protective immunity against toxoplasmosis with recombinant actin depolymerizing factor protein in BALB\/c mice","volume":"130","author":"Huang","year":"2012","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.vaccine.2018.05.072_b0070","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-1-4939-3389-1_10","article-title":"Towards a preventive strategy for toxoplasmosis: current trends, challenges, and future perspectives for vaccine development","volume":"1404","author":"Fereig","year":"2016","journal-title":"Methods Mol Biol"},{"issue":"5","key":"10.1016\/j.vaccine.2018.05.072_b0075","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/87974","article-title":"Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity","volume":"7","author":"Stubbs","year":"2001","journal-title":"Nat Med"},{"issue":"1\u20132","key":"10.1016\/j.vaccine.2018.05.072_b0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0165-2427(01)00406-8","article-title":"Oral administration of yeast. Saccharomyces cerevisiae, enhances the cellular innate immuneresponse of gilthead seabream (Sparusaurata L.)","volume":"85","author":"Ortuno","year":"2002","journal-title":"Vet Immunol Immunopathol"},{"issue":"5872","key":"10.1016\/j.vaccine.2018.05.072_b0085","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/298347a0","article-title":"Synthesis and assembly of hepatitis B virus surface antigen particles in yeast","volume":"298","author":"Valenzuela","year":"1982","journal-title":"Nature"},{"issue":"40","key":"10.1016\/j.vaccine.2018.05.072_b0090","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1016\/j.vaccine.2013.07.029","article-title":"Animal vaccines based on orally presented yeast recombinants","volume":"31","author":"Shin","year":"2013","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.vaccine.2018.05.072_b0095","doi-asserted-by":"crossref","first-page":"e42870","DOI":"10.1371\/journal.pone.0042870","article-title":"Protective vaccination against infectious bursal disease virus with whole recombinant Kluyveromyces lactis yeast expressing the viral VP2 subunit","volume":"7","author":"Arnold","year":"2012","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.vaccine.2018.05.072_b0100","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.femsim.2004.07.004","article-title":"Induction of antigen specific immune responses by oral vaccination with Saccharomyces cerevisiae expressing Actinobacilluspleuro pneumoniae ApxIIA","volume":"43","author":"Shin","year":"2005","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.vaccine.2018.05.072_b0105","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.vaccine.2014.01.068","article-title":"Display of Eimeria tenella EtMic2 protein on the surface of Saccharomyces cerevisiae as a potential oral vaccine against chicken coccidiosis","volume":"32","author":"Sun","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2018.05.072_b0110","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0020-7519(01)00257-0","article-title":"Microneme proteins: structural and functional requirements to promote adhesion and invasion by the apicomplexan parasite Toxoplasma gondii","volume":"31","author":"Soldati","year":"2001","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.vaccine.2018.05.072_b0115","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1471-4922(00)01761-X","article-title":"Mix and match modules: structure and function of microneme proteins in apicomplexan parasites","volume":"17","author":"Tomley","year":"2001","journal-title":"Trends Parasitol"},{"issue":"5","key":"10.1016\/j.vaccine.2018.05.072_b0120","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.micinf.2005.11.013","article-title":"Immunization with MIC1 and MIC4 induces protective immunity against Toxoplasma gondii","volume":"8","author":"Louren\u00e7o","year":"2006","journal-title":"Microbes Infect"},{"issue":"41","key":"10.1016\/j.vaccine.2018.05.072_b0125","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1016\/j.vaccine.2008.07.032","article-title":"Protective Th1 immune responses against chronic toxoplasmosis induced by a protein-protein vaccine combination but not by its DNA-protein counterpart","volume":"26","author":"Jongert","year":"2008","journal-title":"Vaccine"},{"issue":"2\u20134","key":"10.1016\/j.vaccine.2018.05.072_b0130","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.vetpar.2009.06.012","article-title":"Protective immune response in BALB\/c mice induced by a suicidal DNA vaccine of the MIC3 gene of Toxoplasma gondii","volume":"164","author":"Fang","year":"2009","journal-title":"Vet Parasitol"},{"issue":"47","key":"10.1016\/j.vaccine.2018.05.072_b0135","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.1016\/j.vaccine.2009.08.043","article-title":"Toxoplasma gondii microneme protein 6 (MIC6) is a potential vaccine candidate against toxoplasmosis in mice","volume":"27","author":"Peng","year":"2009","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2018.05.072_b0140","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/j.1365-2958.2010.07255.x","article-title":"Toxoplasma gondii transmembrane microneme proteins and their modular design","volume":"77","author":"Sheiner","year":"2010","journal-title":"Mol Microbiol"},{"issue":"3","key":"10.1016\/j.vaccine.2018.05.072_b0145","first-page":"198","article-title":"Prokaryotic expression, purification and immunological characterization of micronemal protein 16 of Toxoplamas gondii","volume":"34","author":"Li","year":"2016","journal-title":"Chin J Parasitol Parasitic Dis"},{"key":"10.1016\/j.vaccine.2018.05.072_b0150","unstructured":"Liu WG. Gene-sequencing and immunoprotective efficacy of TgMIC5 and TgMIC16. Anhui Agricultural University; 2016 [in Chinese]."},{"issue":"9","key":"10.1016\/j.vaccine.2018.05.072_b0155","first-page":"774","article-title":"Prediction and yeast surface display of antigenic epitope region of TgMIC16","volume":"33","author":"Sun","year":"2017","journal-title":"Chin J Zoonoses"},{"issue":"6","key":"10.1016\/j.vaccine.2018.05.072_b0160","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1286-4579(00)00362-2","article-title":"The journey of the malaria sporozoite through its hosts: two parasite proteins lead the way","volume":"2","author":"Menard","year":"2000","journal-title":"Microbes Infect"},{"issue":"2","key":"10.1016\/j.vaccine.2018.05.072_b0165","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pt.2008.11.004","article-title":"No TRAP, no invasion","volume":"25","author":"Morahan","year":"2009","journal-title":"Trends Parasitol"},{"issue":"7","key":"10.1016\/j.vaccine.2018.05.072_b0170","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1002\/j.1460-2075.1993.tb05950.x","article-title":"Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum binds specifically to sulfated glycoconjugates and to HepG2 hepatoma cells suggesting a role for this molecule in sporozoite invasion of hepatocytes","volume":"12","author":"M\u00fcller","year":"1993","journal-title":"EMBO J"},{"issue":"16","key":"10.1016\/j.vaccine.2018.05.072_b0175","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1002\/j.1460-2075.1995.tb00060.x","article-title":"Thrombospondin-related adhesive protein (TRAP) of Plasmodium falciparum: expression during sporozoite ontogeny and binding to human hepatocytes","volume":"14","author":"Robson","year":"1995","journal-title":"EMBO J"},{"issue":"7","key":"10.1016\/j.vaccine.2018.05.072_b0180","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1110\/ps.052068506","article-title":"The layered fold of the TSR domain of P. falciparum TRAP contains a heparin binding site","volume":"15","author":"Tossavainen","year":"2006","journal-title":"Protein Sci"},{"issue":"3","key":"10.1016\/j.vaccine.2018.05.072_b0185","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1074\/jbc.M114.613646","article-title":"Structural basis of Toxoplasma gondii MIC2-associated protein interaction with MIC2","volume":"290","author":"Huynh","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.vaccine.2018.05.072_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exppara.2015.04.020","article-title":"Evaluation of immune protective efficacies of Eimeria tenella EtMic1 polypeptides with different domain recombination displayed on yeast surface","volume":"155","author":"Chen","year":"2015","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.vaccine.2018.05.072_b0195","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-065X.2010.00990.x","article-title":"Invasion and intracellular survival by protozoan parasites","volume":"240","author":"Sibley","year":"2011","journal-title":"Immunol Rev"},{"issue":"3","key":"10.1016\/j.vaccine.2018.05.072_b0200","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.exppara.2007.01.017","article-title":"Toxoplasma gondii: DNA vaccination with genes encoding antigens MIC2, M2AP, AMA1 and BAG1 and evaluation of their immunogenic potential","volume":"116","author":"Dautu","year":"2007","journal-title":"Exp Parasitol"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18307151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18307151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T22:18:44Z","timestamp":1720304324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X18307151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":40,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0264410X18307151"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.05.072","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective immune response against Toxoplasma gondii elicited by a novel yeast-based vaccine with microneme protein 16","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.05.072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}