{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:13:38Z","timestamp":1792653218450,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"29","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.vaccine.2018.06.008","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T07:51:57Z","timestamp":1528444317000},"page":"4215-4221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Ultraviolet-C irradiation for inactivation of viruses in foetal bovine serum"],"prefix":"10.1016","volume":"36","author":[{"given":"Vivek","family":"Vaidya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Dhere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal","family":"Agnihotri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Muley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Pawar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.vaccine.2018.06.008_b0005","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1022969101804","article-title":"Virus contaminations of cell cultures \u2013 a biotechnological view","volume":"39","author":"Merten","year":"2002","journal-title":"Cytotechnology"},{"key":"10.1016\/j.vaccine.2018.06.008_b0010","first-page":"21","article-title":"Raw materials as a source of contamination in large-scale cell culture","volume":"93","author":"Garnick","year":"1998","journal-title":"Dev Biol Stand"},{"key":"10.1016\/j.vaccine.2018.06.008_b0015","first-page":"177","article-title":"Bovine viral diarrhea virus contamination of nutrient serum, cell cultures and viral vaccines","volume":"75","author":"Levings","year":"1991","journal-title":"Dev Biol Stand"},{"issue":"6","key":"10.1016\/j.vaccine.2018.06.008_b0020","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.biologicals.2013.08.005","article-title":"Detection of contaminants in cell cultures, sera and trypsin","volume":"41","author":"Pinheiro de Oliveira","year":"2013","journal-title":"Biologicals"},{"issue":"1","key":"10.1016\/j.vaccine.2018.06.008_b0025","first-page":"27","article-title":"Contamination of bovine fetal serum with bovine viral diarrhea virus","volume":"32","author":"Zabal","year":"2000","journal-title":"Rev Argent Microbiol"},{"key":"10.1016\/j.vaccine.2018.06.008_b0030","first-page":"293","article-title":"Isolation of BVDV from bovine serum by EMEA\/CVMP and 9 CFR: a comparison","volume":"126","author":"Black","year":"2006","journal-title":"Dev Biol (Basel)"},{"key":"10.1016\/j.vaccine.2018.06.008_b0035","unstructured":"World Health Organization. Technical Report Series No. 978, 2013 Annexure 3. Available at http:\/\/www.who.int\/biologicals\/vaccines\/TRS_978_Annex_3.pdf"},{"key":"10.1016\/j.vaccine.2018.06.008_b0040","unstructured":"CFR Title 9 Section 113.53. Available at https:\/\/www.law.cornell.edu\/cfr\/text\/9\/113.53."},{"key":"10.1016\/j.vaccine.2018.06.008_b0045","unstructured":"United States Pharmacopoeia, USP general chapter <1024>. Bovine Serum. Available at http:\/\/www.drugfuture.com\/Pharmacopoeia\/USP35\/data\/v35300\/usp35nf30s0_c1024.html"},{"key":"10.1016\/j.vaccine.2018.06.008_b0050","unstructured":"Bovine Serum 01\/2008:2262. European Pharmacopoeia. 7th ed. 2011 Jan;2:1506\u20137."},{"key":"10.1016\/j.vaccine.2018.06.008_b0055","unstructured":"Guidelines on the use of bovine serum in the manufacture of human biological medicinal products, EMA\/CHMP\/BWP\/457920\/2012 rev 1, 2013. Available at http:\/\/www.ema.europa.eu\/docs\/en_GB\/document...guideline\/2013\/...\/WC500143930.pdf"},{"key":"10.1016\/j.vaccine.2018.06.008_b0060","unstructured":"Goetschalckx S, Fabre V, Wynants M, Bertaux L, Plavsic M, Boussif O, et al. A holistic biosafety risk mitigation approach. Am Pharm Rev 2014(Jun). Available at https:\/\/www.americanpharmaceuticalreview.com\/Featured-Articles\/163582-A-Holistic-Biosafety-Risk-Mitigation-Approach\/."},{"issue":"2","key":"10.1016\/j.vaccine.2018.06.008_b0065","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/btpr.1676","article-title":"Fluid flow in a spiral device for irradiation of biological fluids","volume":"29","author":"Nikolof","year":"2013","journal-title":"Biotechnol Prog"},{"key":"10.1016\/j.vaccine.2018.06.008_b0070","doi-asserted-by":"crossref","unstructured":"Hermann H, Burian R, Waldmann R. Virus inactivation in foetal calf serum by a combined treatment of gamma irradiation and UV-C irradiation. In: Animal cell technology meets genomics. ESACT proceeding, vol. 2; 2005. p. 555\u20139.","DOI":"10.1007\/1-4020-3103-3_109"},{"issue":"4","key":"10.1016\/j.vaccine.2018.06.008_b0075","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.biologicals.2006.09.003","article-title":"UV-C treatment of protein solutions","volume":"35","author":"MacLeod","year":"2007","journal-title":"Biologicals"},{"key":"10.1016\/j.vaccine.2018.06.008_b0080","first-page":"111","article-title":"Efficient inactivation of viruses and mycoplasma in animal sera using UV-C irradiation","volume":"99","author":"Kurth","year":"1999","journal-title":"Dev Biol Stand"},{"issue":"8","key":"10.1016\/j.vaccine.2018.06.008_b0085","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1001\/jama.1947.02890080006003","article-title":"Ultraviolet irradiation of human plasma to control homologous serum jaundice","volume":"135","author":"Wolf","year":"1947","journal-title":"JAMA"},{"issue":"3\u20134","key":"10.1016\/j.vaccine.2018.06.008_b0090","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2166\/wst.1993.0371","article-title":"The inactivation of hepatitis A virus and other model viruses by UV irradiation","volume":"27","author":"Battigelli","year":"1993","journal-title":"Water Sci Technol"},{"issue":"1","key":"10.1016\/j.vaccine.2018.06.008_b0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.watres.2005.10.030","article-title":"Inactivation credit of UV radiation for viruses, bacteria and protozoan (oo)cysts in water: a review","volume":"40","author":"Hinjen","year":"2006","journal-title":"Water Res"},{"key":"10.1016\/j.vaccine.2018.06.008_b0100","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1751-1097.1997.tb08584.x","article-title":"Virucidal treatment of blood protein products with UVC radiation","volume":"65","author":"Chin","year":"1997","journal-title":"Photochem Photobiol"},{"issue":"2","key":"10.1016\/j.vaccine.2018.06.008_b0105","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1423-0410.1993.tb02523.x","article-title":"Inactivation of viruses during ultraviolet light treatment of human intravenous immunoglobulin and albumin","volume":"64","author":"Hart","year":"1993","journal-title":"Vox Sang"},{"issue":"2","key":"10.1016\/j.vaccine.2018.06.008_b0110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jviromet.2004.02.002","article-title":"Continuous flow UVC irradiation: a new, effective, protein activity-preserving system for inactivating bacteria and viruses, including erythrovirus B19","volume":"118","author":"Caillet-Fauquet","year":"2004","journal-title":"J Virol Methods"},{"key":"10.1016\/j.vaccine.2018.06.008_b0115","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.0042-9007.2004.00485.x","article-title":"Virus inactivation and protein recovery in a novel ultraviolet-C reactor","volume":"86","author":"Wang","year":"2004","journal-title":"Vox Sang"},{"issue":"5","key":"10.1016\/j.vaccine.2018.06.008_b0120","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.biologicals.2014.07.003","article-title":"Adventitious agents in viral vaccines: lessons learned from 4 case studies","volume":"42","author":"Petricciani","year":"2014","journal-title":"Biologicals"},{"issue":"3","key":"10.1016\/j.vaccine.2018.06.008_b0125","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1042\/bj1140535","article-title":"A comparison of the effects of ultraviolet and ionizing radiations on trypsin activity and on its constituent amino acids","volume":"114","author":"Burke","year":"1969","journal-title":"Biochem J"},{"issue":"4","key":"10.1016\/j.vaccine.2018.06.008_b0130","first-page":"377","article-title":"Evaluation of viral inactivation efficacy of a continuous flow ultraviolet-C reactor (UVivatec)","volume":"37","author":"Bae","year":"2009","journal-title":"Kor J Microbiol Biotechnol"},{"issue":"1","key":"10.1016\/j.vaccine.2018.06.008_b0135","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1751-1097.1988.tb02785.x","article-title":"The relative cytotoxicity of (6-4) photoproducts and cyclobutane dimers in mammalian cells","volume":"48","author":"Mitchell","year":"1988","journal-title":"Photochem Photobiol"},{"issue":"1","key":"10.1016\/j.vaccine.2018.06.008_b0140","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0042-6822(03)00512-9","article-title":"Genetic and phylogenetic characterization of the type II cyclobutane pyrimidine dimer photolyases encoded by Leporipoxviruses","volume":"315","author":"Bennett","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2018.06.008_b0145","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ifset.2015.09.004","article-title":"Functional properties and nutritional composition of liquid egg products treated in a coiled tube UV-C reactor","volume":"32","author":"de Souza","year":"2015","journal-title":"Innovative Food Sci Emerg Technol"},{"issue":"1","key":"10.1016\/j.vaccine.2018.06.008_b0150","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/vox.12247","article-title":"Tolerance of platelet concentrates treated with UVC-light only for pathogen reduction\u2013a phase I clinical trial","volume":"109","author":"Thiele","year":"2015","journal-title":"Vox Sang"},{"key":"10.1016\/j.vaccine.2018.06.008_b0155","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cej.2014.09.028","article-title":"Treatment of municipal wastewater reverse osmosis concentrate using UVC-LED\/H2O2 with and without coagulation pre-treatment","volume":"260","author":"Umar","year":"2015","journal-title":"Chem Eng J"},{"key":"10.1016\/j.vaccine.2018.06.008_b0160","unstructured":"Stangl F, Gross A, Hoenes K, Sift M, Schlau D, Hessling M. Advanced photovoltaic water disinfection system based on efficient UVC and ultrasound generation. In: Proceedings 4th symposium small PV applications, at Munich; June 2015."},{"issue":"2","key":"10.1016\/j.vaccine.2018.06.008_b0165","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jfoodeng.2011.05.026","article-title":"UV-C treatment of juices to inactivate microorganisms using Dean vortex technology","volume":"107","author":"M\u00fcller","year":"2011","journal-title":"J Food Eng"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18308193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18308193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:26:00Z","timestamp":1759400760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X18308193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":33,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0264410X18308193"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.06.008","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultraviolet-C irradiation for inactivation of viruses in foetal bovine serum","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}