{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:15:26Z","timestamp":1790154926290,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"38","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.vaccine.2018.08.016","type":"journal-article","created":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T08:15:14Z","timestamp":1533975314000},"page":"5692-5700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Virus-like particle vaccines expressing Toxoplasma gondii rhoptry protein 18 and microneme protein 8 provide enhanced protection"],"prefix":"10.1016","volume":"36","author":[{"given":"Su-Hwa","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Ji","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Moo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Shi","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.vaccine.2018.08.016_b0005","doi-asserted-by":"crossref","first-page":"e90203","DOI":"10.1371\/journal.pone.0090203","article-title":"Toxoplasmosis\u2013a global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries","volume":"9","author":"Flegr","year":"2014","journal-title":"PloS one"},{"issue":"11","key":"10.1016\/j.vaccine.2018.08.016_b0010","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nrmicro2858","article-title":"Modulation of innate immunity by Toxoplasma gondii virulence effectors","volume":"10","author":"Hunter","year":"2012","journal-title":"Nat Rev Microbiol"},{"issue":"5","key":"10.1016\/j.vaccine.2018.08.016_b0015","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/BF00931830","article-title":"Kinetics and pattern of organelle exocytosis duringToxoplasma gondii\/host-cell interaction","volume":"79","author":"Dubremetz","year":"1993","journal-title":"Parasitol Res"},{"issue":"2","key":"10.1016\/j.vaccine.2018.08.016_b0020","first-page":"114","article-title":"Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts","volume":"73","author":"Carruthers","year":"1997","journal-title":"Eur J Cell Biol"},{"issue":"2","key":"10.1016\/j.vaccine.2018.08.016_b0025","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1371\/journal.ppat.0030014","article-title":"ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondii","volume":"3","author":"El Hajj","year":"2007","journal-title":"PLoS Pathog"},{"issue":"2","key":"10.1016\/j.vaccine.2018.08.016_b0030","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0166-6851(96)02773-9","article-title":"The MIC1 microneme protein of Toxoplasma gondii contains a duplicated receptor-like domain and binds to host cell surface","volume":"83","author":"Fourmaux","year":"1996","journal-title":"Mol Biochem Parasitol"},{"issue":"7","key":"10.1016\/j.vaccine.2018.08.016_b0035","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1128\/IAI.68.7.4005-4011.2000","article-title":"Toxoplasma gondii uses sulfated proteoglycans for substrate and host cell attachment","volume":"68","author":"Carruthers","year":"2000","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.vaccine.2018.08.016_b0040","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1046\/j.1365-2958.2002.03056.x","article-title":"\u2018The glideosome\u2019: a dynamic complex powering gliding motion and host cell invasion by Toxoplasma gondii","volume":"45","author":"Opitz","year":"2002","journal-title":"Mol Microbiol"},{"issue":"6","key":"10.1016\/j.vaccine.2018.08.016_b0045","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1074\/jbc.M008294200","article-title":"The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains","volume":"276","author":"Brecht","year":"2001","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.vaccine.2018.08.016_b0050","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00436-010-1742-0","article-title":"Toxoplasma gondii microneme protein 8 (MIC8) is a potential vaccine candidate against toxoplasmosis","volume":"106","author":"Liu","year":"2010","journal-title":"Parasitol Res"},{"issue":"25","key":"10.1016\/j.vaccine.2018.08.016_b0055","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1016\/j.vaccine.2014.03.042","article-title":"Synergy of mIL-21 and mIL-15 in enhancing DNA vaccine efficacy against acute and chronic Toxoplasma gondii infection in mice","volume":"32","author":"Li","year":"2014","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vaccine.2018.08.016_b0060","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1371\/journal.ppat.0010017","article-title":"Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles","volume":"1","author":"Alexander","year":"2005","journal-title":"PLoS Pathog"},{"issue":"12","key":"10.1016\/j.vaccine.2018.08.016_b0065","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1111\/j.1462-5822.2005.00646.x","article-title":"The rhoptry neck protein RON4 relocalizes at the moving junction during Toxoplasma gondii invasion","volume":"7","author":"Lebrun","year":"2005","journal-title":"Cell Microbiol"},{"issue":"4","key":"10.1016\/j.vaccine.2018.08.016_b0070","first-page":"526","article-title":"Localization of a Toxoplasma gondii rhoptry protein by immunoelectron microscopy during and after host cell penetration","volume":"39","author":"Saffer","year":"1992","journal-title":"J Eukaryot Microbiol"},{"issue":"38","key":"10.1016\/j.vaccine.2018.08.016_b0075","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1016\/j.vaccine.2011.06.110","article-title":"Protective effect against toxoplasmosis in mice induced by DNA immunization with gene encoding Toxoplasma gondii ROP18","volume":"29","author":"Yuan","year":"2011","journal-title":"Vaccine"},{"issue":"5806","key":"10.1016\/j.vaccine.2018.08.016_b0080","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1126\/science.1133690","article-title":"Polymorphic secreted kinases are key virulence factors in toxoplasmosis","volume":"314","author":"Saeij","year":"2006","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.vaccine.2018.08.016_b0085","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.4161\/hv.21006","article-title":"Vaccines against Toxoplasma gondii: status, challenges and future directions","volume":"8","author":"Liu","year":"2012","journal-title":"Hum Vaccines Immunotherap"},{"issue":"6","key":"10.1016\/j.vaccine.2018.08.016_b0090","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1586\/erv.09.27","article-title":"Current status of toxoplasmosis vaccine development","volume":"8","author":"Kur","year":"2009","journal-title":"Exp Rev Vaccines"},{"issue":"8","key":"10.1016\/j.vaccine.2018.08.016_b0095","doi-asserted-by":"crossref","first-page":"e0161231","DOI":"10.1371\/journal.pone.0161231","article-title":"Virus-Like Nanoparticle Vaccine Confers Protection against Toxoplasma gondii","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2018.08.016_b0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.actatropica.2016.08.025","article-title":"Cross-protection induced by Toxoplasma gondii virus-like particle vaccine upon intraperitoneal route challenge","volume":"164","author":"Lee","year":"2016","journal-title":"Acta Trop"},{"issue":"4","key":"10.1016\/j.vaccine.2018.08.016_b0105","doi-asserted-by":"crossref","first-page":"e0175644","DOI":"10.1371\/journal.pone.0175644","article-title":"Protection induced by virus-like particles containing Toxoplasma gondii microneme protein 8 against highly virulent RH strain of Toxoplasma gondii infection","volume":"12","author":"Lee","year":"2017","journal-title":"PLoS ONE"},{"issue":"14","key":"10.1016\/j.vaccine.2018.08.016_b0110","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1016\/j.biomaterials.2012.01.054","article-title":"Stability of influenza vaccine coated onto microneedles","volume":"33","author":"Choi","year":"2012","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.vaccine.2018.08.016_b0115","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7705\/biomedica.v32i3.485","article-title":"Eficiencia de cultivo in vitro de Toxoplasma gondii en las l\u00edneas celulares THP1 y Vero","volume":"32","author":"Cuellar","year":"2012","journal-title":"Biom\u00e9dica"},{"issue":"4","key":"10.1016\/j.vaccine.2018.08.016_b0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0966-842X(99)01470-5","article-title":"Perspective: virus infections and the death of neurons","volume":"7","author":"Griffin","year":"1999","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.vaccine.2018.08.016_b0125","doi-asserted-by":"crossref","unstructured":"Hardwick JM. Viral interference with apoptosis 1998; 9(3):339\u201349.","DOI":"10.1006\/scdb.1998.0243"},{"issue":"13","key":"10.1016\/j.vaccine.2018.08.016_b0130","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.vaccine.2013.01.027","article-title":"Protective immunity induced by a DNA vaccine expressing eIF4A of Toxoplasma gondii against acute toxoplasmosis in mice","volume":"31","author":"Chen","year":"2013","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.vaccine.2018.08.016_b0135","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1128\/CVI.00397-12","article-title":"Protective efficacy of a Toxoplasma gondii rhoptry protein 13 plasmid DNA vaccine in mice","volume":"19","author":"Wang","year":"2012","journal-title":"Clin Vaccine Immunol"},{"issue":"40","key":"10.1016\/j.vaccine.2018.08.016_b0140","doi-asserted-by":"crossref","first-page":"17200","DOI":"10.1073\/pnas.1007610107","article-title":"Phosphorylation of eukaryotic initiation factor-2{alpha} promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii","volume":"107","author":"Joyce","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.vaccine.2018.08.016_b0145","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.exppara.2012.01.005","article-title":"Toxoplasma gondii antigens: recovery analysis of tachyzoites cultivated in Vero cell maintained in serum free medium","volume":"130","author":"da Costa-Silva","year":"2012","journal-title":"Exp Parasitol"},{"issue":"2","key":"10.1016\/j.vaccine.2018.08.016_b0150","doi-asserted-by":"crossref","first-page":"902","DOI":"10.4049\/jimmunol.167.2.902","article-title":"IFN-gamma overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection","volume":"167","author":"Gavrilescu","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2018.08.016_b0155","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3389\/fimmu.2015.00336","article-title":"B cells and functional antibody responses to combat influenza","volume":"6","author":"Lofano","year":"2015","journal-title":"Front Immunol"},{"issue":"35","key":"10.1016\/j.vaccine.2018.08.016_b0160","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1016\/j.vaccine.2014.06.043","article-title":"Squalene-adjuvanted H7N9 virus vaccine induces robust humoral immune response against H7N9 and H7N7 viruses","volume":"32","author":"Wu","year":"2014","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vaccine.2018.08.016_b0165","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jconrel.2010.07.125","article-title":"Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles","volume":"147","author":"Quan","year":"2010","journal-title":"J Controlled Release"},{"issue":"1","key":"10.1016\/j.vaccine.2018.08.016_b0170","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1556\/EuJMI.3.2013.1.4","article-title":"Effect of route of infection on outcome of Toxoplasma gondii infection in hu-PBL SCID mice","volume":"3","author":"Meyer","year":"2013","journal-title":"Eur J Microbiol Immunol"},{"issue":"7","key":"10.1016\/j.vaccine.2018.08.016_b0175","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/infdis\/jir474","article-title":"Viruslike particle vaccine induces protection against respiratory syncytial virus infection in mice","volume":"204","author":"Quan","year":"2011","journal-title":"J Infect Dis"},{"issue":"26","key":"10.1016\/j.vaccine.2018.08.016_b0180","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1016\/j.vaccine.2008.03.055","article-title":"A bivalent influenza VLP vaccine confers complete inhibition of virus replication in lungs","volume":"26","author":"Quan","year":"2008","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.vaccine.2018.08.016_b0185","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1128\/JVI.02035-08","article-title":"Kinetics of immune responses to influenza virus-like particles and dose-dependence of protection with a single vaccination","volume":"83","author":"Quan","year":"2009","journal-title":"J Virol"}],"updated-by":[{"DOI":"10.1016\/j.vaccine.2020.05.034","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000}}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18311253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18311253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:53:17Z","timestamp":1571705597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X18311253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":37,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0264410X18311253"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.08.016","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Virus-like particle vaccines expressing Toxoplasma gondii rhoptry protein 18 and microneme protein 8 provide enhanced protection","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}