{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:18:14Z","timestamp":1786997894652,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000725","name":"The Ministry of Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Prototype Development Research Grant Scheme","award":["PRGS\/2\/2015\/SKK10\/AIMST\/02\/1"],"award-info":[{"award-number":["PRGS\/2\/2015\/SKK10\/AIMST\/02\/1"]}]},{"name":"AIMST University"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.vaccine.2018.12.027","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T20:06:05Z","timestamp":1546977965000},"page":"711-720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Repeated dose toxicity evaluation of a cold chain-free, live, attenuated oral cholera vaccine in Sprague Dawley rats"],"prefix":"10.1016","volume":"37","author":[{"given":"Tew Hui","family":"Xian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramani","family":"Parasuraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurunathan","family":"Sinniah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-1344","authenticated-orcid":false,"given":"Manickam","family":"Ravichandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guruswamy","family":"Prabhakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.vaccine.2018.12.027_b0005","doi-asserted-by":"crossref","first-page":"e0003832","DOI":"10.1371\/journal.pntd.0003832","article-title":"Updated global burden of cholera in endemic countries","volume":"9","author":"Ali","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2018.12.027_b0010","unstructured":"WHO. Global health observatory (GHO) data. Number of reported cholera cases. http:\/\/www.who.int\/gho\/epidemic_diseases\/cholera\/cases_text\/en\/ [accessed 15 Jan 2018]."},{"issue":"8","key":"10.1016\/j.vaccine.2018.12.027_b0015","doi-asserted-by":"crossref","first-page":"e1001867","DOI":"10.1371\/journal.pmed.1001867","article-title":"The impact of a one-dose versus two-dose oral cholera vaccine regimen in outbreak settings: a modeling study","volume":"12","author":"Azman","year":"2015","journal-title":"PLoS Med"},{"issue":"12","key":"10.1016\/j.vaccine.2018.12.027_b0020","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1093\/cid\/cix1039","article-title":"Immunogenicity and protection from a single dose of internationally available killed oral cholera vaccine: a systematic review and metaanalysis","volume":"66","author":"Lopez","year":"2018","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.1016\/j.vaccine.2018.12.027_b0025","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2471\/BLT.11.030511","article-title":"Vaccination: rattling the supply chain","volume":"89","author":"Humphreys","year":"2011","journal-title":"Bull World Health Organ"},{"issue":"Suppl 2","key":"10.1016\/j.vaccine.2018.12.027_b0030","doi-asserted-by":"crossref","first-page":"B73","DOI":"10.1016\/j.vaccine.2012.11.036","article-title":"The imperative for stronger vaccine supply and logistics systems","volume":"31","author":"Zaffran","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2018.12.027_b0035","unstructured":"M. Ravichandran, S. Atif Ali, N.H. Abdul Rashid, L. Pattabiraman, Z.F. Zainuddin. Vibrio cholerae strains VCUSM1 and VCUSM4 method of making same and vaccine derivatives thereof. European patent filed on 25.10.2004 with the number 04025319.7."},{"key":"10.1016\/j.vaccine.2018.12.027_b0040","unstructured":"M. Ravichandran, S. Atif Ali, N.H. Abdul Rashid, L. Pattabiraman, Z.F. Zainuddin. Vibrio cholerae strains VCUSM1 and VCUSM4 method of making same and vaccine derivatives thereof. USA patent filed on 5.11.2004 with the number 10\/981,760."},{"issue":"5","key":"10.1016\/j.vaccine.2018.12.027_b0045","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.micpath.2010.06.001","article-title":"Construction and characterization of an auxotrophic ctxA mutant of O139 Vibrio cholerae","volume":"49","author":"Chan","year":"2010","journal-title":"Microb Pathog"},{"key":"10.1016\/j.vaccine.2018.12.027_b0050","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1128\/IAI.67.8.3733-3739.1999","article-title":"Vibrio cholerae intestinal population dynamics in the suckling mouse model of infection","volume":"67","author":"Angelichio","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.vaccine.2018.12.027_b0055","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0165-2478(99)00076-0","article-title":"Construction of a recombinant live oral vaccine from a non-toxigenic strain of Vibrio cholerae O1 serotype inaba biotype E1 Tor and assessment of its reactogenicity and immunogenicity in the rabbit model","volume":"68","author":"Thungapathra","year":"1999","journal-title":"Immunol Lett"},{"key":"10.1016\/j.vaccine.2018.12.027_b0060","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/IAI.32.2.739-747.1981","article-title":"Simple adult rabbit model for Vibrio cholerae and enterotoxigenic Escherichia coli diarrhea","volume":"32","author":"Spira","year":"1981","journal-title":"Infect Immun"},{"issue":"7","key":"10.1016\/j.vaccine.2018.12.027_b0065","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.arcmed.2009.09.003","article-title":"Repeated dose toxicity study of a live attenuated oral cholera vaccine in Sprague Dawley rats","volume":"40","author":"Sifontes-Rodr\u00edguez","year":"2009","journal-title":"Arch Med Res"},{"issue":"19","key":"10.1016\/j.vaccine.2018.12.027_b0070","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1016\/j.vaccine.2011.02.074","article-title":"Pharmacology and toxicology of an oral tablet whole cells inactivated cholera vaccine in Sprague Dawley rats","volume":"29","author":"L\u00f3pez","year":"2011","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vaccine.2018.12.027_b0075","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5487\/TR.2012.28.4.225","article-title":"A 6-week oral toxicity study of oral cholera vaccine in sprague-dawley rats","volume":"28","author":"Baek","year":"2012","journal-title":"Toxicol Res"},{"issue":"2","key":"10.1016\/j.vaccine.2018.12.027_b0080","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0976-500X.72350","article-title":"Blood sample collection in small laboratory animals","volume":"1","author":"Parasuraman","year":"2010","journal-title":"J Pharmacol Pharmacother"},{"issue":"3","key":"10.1016\/j.vaccine.2018.12.027_b0085","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.etp.2005.10.002","article-title":"Clinical chemistry and haematology historical data in control Sprague-Dawley rats from pre-clinical toxicity studies","volume":"57","author":"Petterino","year":"2006","journal-title":"Exp Toxicol Pathol"},{"issue":"24","key":"10.1016\/j.vaccine.2018.12.027_b0090","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1080\/15287394.2012.722520","article-title":"Age-specific absolute and relative organ weight distributions for Fischer 344 rats","volume":"75","author":"Marino","year":"2012","journal-title":"J Toxicol Environ Health A"},{"key":"10.1016\/j.vaccine.2018.12.027_b0095","volume":"vol. 1","author":"Mukherjee","year":"1988"},{"issue":"10","key":"10.1016\/j.vaccine.2018.12.027_b0100","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1371\/journal.ppat.0030147","article-title":"Pathogenesis, virulence, and infective dose","volume":"3","author":"Schmid-Hempel","year":"2007","journal-title":"PLoS Pathog"},{"issue":"2","key":"10.1016\/j.vaccine.2018.12.027_b0105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3797\/scipharm.aut-02-16","article-title":"Effect of prolonged vigabatrin treatment on hematological and biochemical parameters in plasma, liver and kidney of Swiss albino mice","volume":"70","author":"Raza","year":"2002","journal-title":"Sci Pharm"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18317006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X18317006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T20:32:38Z","timestamp":1605990758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X18317006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0264410X18317006"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.12.027","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repeated dose toxicity evaluation of a cold chain-free, live, attenuated oral cholera vaccine in Sprague Dawley rats","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2018.12.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}