{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T02:21:22Z","timestamp":1772677282567,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Medigen Vaccine Biologics Corp."}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.vaccine.2019.02.023","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T22:25:47Z","timestamp":1550874347000},"page":"1827-1835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Immunogenicity, safety, cross-reaction, and immune persistence of an inactivated enterovirus A71 vaccine in children aged from two months to 11 years in Taiwan"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-260X","authenticated-orcid":false,"given":"Li-Min","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4324-7743","authenticated-orcid":false,"given":"Cheng-Hsun","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan-Chang","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Ta","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsun-Yung","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Jen","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erh-Fang","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Chen","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2019.02.023_b0005","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12250-011-3195-8","article-title":"Hand foot and mouth disease due to enterovirus 71 in Malaysia","volume":"26","author":"Chua","year":"2011","journal-title":"Virol Sin"},{"key":"10.1016\/j.vaccine.2019.02.023_b0010","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working","volume":"341","author":"Ho","year":"1999","journal-title":"Group N Engl J Med"},{"key":"10.1016\/j.vaccine.2019.02.023_b0015","doi-asserted-by":"crossref","first-page":"e1476","DOI":"10.1371\/journal.pntd.0001476","article-title":"Incidence rates of enterovirus 71 infections in young children during a nationwide epidemic in Taiwan, 2008\u201309","volume":"6","author":"Lee","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.vaccine.2019.02.023_b0020","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF01314873","article-title":"Virological diagnosis of enterovirus type 71 infections: experiences gained during an epidemic of acute CNS diseases in Hungary in 1978","volume":"71","author":"Nagy","year":"1982","journal-title":"Arch Virol"},{"key":"10.1016\/j.vaccine.2019.02.023_b0025","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3201\/eid0809.010397","article-title":"Seroepidemiology of human enterovirus 71, Singapore","volume":"8","author":"Ooi","year":"2002","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2019.02.023_b0030","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.vaccine.2019.02.023_b0035","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1743-422X-7-94","article-title":"An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China","volume":"7","author":"Zhang","year":"2010","journal-title":"Virol J"},{"issue":"Suppl. 2","key":"10.1016\/j.vaccine.2019.02.023_b0040","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1086\/338819","article-title":"The 1998 enterovirus 71 outbreak in Taiwan: pathogenesis and management","volume":"34","author":"Lin","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2019.02.023_b0045","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/EDE.0b013e318231d67a","article-title":"Hand, foot, and mouth disease in China: patterns of spread and transmissibility","volume":"22","author":"Wang","year":"2011","journal-title":"Epidemiology"},{"key":"10.1016\/j.vaccine.2019.02.023_b0050","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.3201\/eid1812.120929","article-title":"Enterovirus 71-associated hand, foot, and mouth disease, Southern Vietnam, 2011","volume":"18","author":"Khanh","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2019.02.023_b0055","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3201\/eid1311.070632","article-title":"Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005","volume":"13","author":"Van Tu","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2019.02.023_b0060","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/1471-2334-14-341","article-title":"Epidemiological and clinical characteristics of children who died from hand, foot and mouth disease in Vietnam, 2011","volume":"14","author":"Nguyen","year":"2014","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.vaccine.2019.02.023_b0065","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/rmv.538","article-title":"Genetic evolution of enterovirus 71: epidemiological and pathological implications","volume":"17","author":"Bible","year":"2007","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.vaccine.2019.02.023_b0070","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/S0140-6736(99)04434-7","article-title":"Clinical features and risk factors of pulmonary oedema after enterovirus-71-related hand, foot, and mouth disease","volume":"354","author":"Chang","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2019.02.023_b0075","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/S0140-6736(05)60789-1","article-title":"Neurogenic pulmonary oedema and enterovirus 71 encephalomyelitis","volume":"352","author":"Lum","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2019.02.023_b0080","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","article-title":"Clinical features, diagnosis, and management of enterovirus 71","volume":"9","author":"Ooi","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.vaccine.2019.02.023_b0085","unstructured":"Centers for Disease C, Prevention. Deaths among children during an outbreak of hand, foot, and mouth disease \u2013 Taiwan, Republic of China, April-July 1998. MMWR Morb Mortal Wkly Rep. vol. 47; 1998. p. 629\u201332."},{"key":"10.1016\/j.vaccine.2019.02.023_b0090","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1128\/JCM.00563-09","article-title":"Enterovirus 71 outbreak in the People's Republic of China in 2008","volume":"47","author":"Yang","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2019.02.023_b0095","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa1303224","article-title":"An inactivated enterovirus 71 vaccine in healthy children","volume":"370","author":"Li","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2019.02.023_b0100","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1056\/NEJMp1400601","article-title":"Enterovirus vaccines for an emerging cause of brain-stem encephalitis","volume":"370","author":"McMinn","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2019.02.023_b0105","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJMoa1304923","article-title":"Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China","volume":"370","author":"Zhu","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2019.02.023_b0110","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/S0140-6736(13)61049-1","article-title":"Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","volume":"381","author":"Zhu","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2019.02.023_b0115","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1016\/j.vaccine.2013.03.015","article-title":"A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine","volume":"31","author":"Cheng","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2019.02.023_b0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13090890","article-title":"The current status of the disease caused by enterovirus 71 infections: epidemiology, pathogenesis, molecular epidemiology, and vaccine development","volume":"13","author":"Chang","year":"2016","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.vaccine.2019.02.023_b0125","doi-asserted-by":"crossref","first-page":"4","DOI":"10.7774\/cevr.2017.6.1.4","article-title":"Enterovirus 71 infection and vaccines","volume":"6","author":"Yi","year":"2017","journal-title":"Clin Exp Vaccine Res"},{"key":"10.1016\/j.vaccine.2019.02.023_b0130","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/jpids\/pit017","article-title":"Implications of age-dependent immune responses to enterovirus 71 infection for disease pathogenesis and vaccine design","volume":"2","author":"Gantt","year":"2013","journal-title":"J Pediatric Infect Dis Soc"},{"key":"10.1016\/j.vaccine.2019.02.023_b0135","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3201\/eid0903.020285","article-title":"Enterovirus 71 outbreaks, Taiwan: occurrence and recognition","volume":"9","author":"Lin","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2019.02.023_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2016.04.026","article-title":"Genetic characterization of Enterovirus 71 strains circulating in Vietnam in 2012","volume":"495","author":"Donato","year":"2016","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2019.02.023_b0145","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1056\/NEJM199909233411302","article-title":"Neurologic complications in children with enterovirus 71 infection","volume":"341","author":"Huang","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2019.02.023_b0150","doi-asserted-by":"crossref","unstructured":"Sea KH. Communicable Diseases of Interest to the Public: Enterovirus. Center for Disease Control, Taiwan 2005 Annual Report; 2005. p. 53\u20135.","DOI":"10.1002\/9780470755129.ch3"},{"key":"10.1016\/j.vaccine.2019.02.023_b0155","doi-asserted-by":"crossref","first-page":"12","DOI":"10.7883\/yoken.52.12","article-title":"Enterovirus 71 from fatal and nonfatal cases of hand, foot and mouth disease epidemics in Malaysia, Japan and Taiwan in 1997\u20131998","volume":"52","author":"Shimizu","year":"1999","journal-title":"Jpn J Infect Dis"},{"key":"10.1016\/j.vaccine.2019.02.023_b0160","doi-asserted-by":"crossref","first-page":"38874","DOI":"10.1038\/srep38874","article-title":"Placental antibody transfer efficiency and maternal levels: specific for measles, coxsackievirus A16, enterovirus 71, poliomyelitis I-III and HIV-1 antibodies","volume":"6","author":"Fu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.vaccine.2019.02.023_b0165","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF02253368","article-title":"Neutralizing antibody provided protection against enterovirus type 71 lethal challenge in neonatal mice","volume":"7","author":"Yu","year":"2000","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.vaccine.2019.02.023_b0170","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1542\/peds.109.6.e88","article-title":"Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease\/herpangina in children during an epidemic in Taiwan","volume":"109","author":"Chang","year":"2002","journal-title":"Pediatrics"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1930218X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X1930218X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T22:03:58Z","timestamp":1694642638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X1930218X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":34,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0264410X1930218X"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2019.02.023","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunogenicity, safety, cross-reaction, and immune persistence of an inactivated enterovirus A71 vaccine in children aged from two months to 11 years in Taiwan","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2019.02.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}