{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:59:12Z","timestamp":1793930352162,"version":"4.8.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"26","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007776","name":"Deanship of Academic Research, University of Jordan, Amman-Jordan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007776","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.vaccine.2019.04.097","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T08:09:00Z","timestamp":1557734940000},"page":"3472-3477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Novel adjuvants derived from attenuated lipopolysaccharides and lipid As of purple non-sulfur photosynthetic bacteria"],"prefix":"10.1016","volume":"37","author":[{"given":"Hussein","family":"Masoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2019.04.097_b0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0022-1759(92)90302-A","article-title":"A comparison of commercially available adjuvants for use in research","volume":"153","author":"Bennett","year":"1992","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.vaccine.2019.04.097_b0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/14760584.2016.1213632","article-title":"Adjuvant system AS01: helping to overcome the challenges of modern vaccines","volume":"16","author":"Didierlaurent","year":"2017","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2019.04.097_b0015","first-page":"1","article-title":"Characterization of the structure and immunostimulatory activity of a vaccine adjuvant, de-O-acylated lipooligosaccharide","volume":"9","author":"Han","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2019.04.097_b0020","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2174\/1568005014605991","article-title":"Novel adjuvant systems","volume":"1","author":"McCluskie","year":"2001","journal-title":"Curr Drug Targets Infect Disord"},{"key":"10.1016\/j.vaccine.2019.04.097_b0025","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/1044-579X(95)90007-1","article-title":"Selection of potent immunological adjuvants for vaccine construction","volume":"6","author":"McElrath","year":"1995","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.vaccine.2019.04.097_b0030","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/S0264-410X(99)00526-5","article-title":"CpG DNA induces stronger immune responses with less toxicity than other adjuvants","volume":"18","author":"Weeratna","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2019.04.097_b0035","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1016\/j.vaccine.2005.06.018","article-title":"Modulation of the humoral and cellular immune response in Abeta immunotherapy by the adjuvants monophosphoryl lipid A (MPL), cholera toxin B subunit (CTB) and E. coli enterotoxin LT(R192G)","volume":"23","author":"Maier","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2019.04.097_b0040","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1586\/erv.11.29","article-title":"Recent clinical experience with vaccines using MPL and QS-21-containing adjuvant systems","volume":"10","author":"Garcon","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2019.04.097_b0045","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1351\/pac198961071271","article-title":"Bacterial lipopolysaccharides","volume":"61","author":"Mayer","year":"1989","journal-title":"Pure Appl Chem"},{"key":"10.1016\/j.vaccine.2019.04.097_b0050","series-title":"Surface structure of microorganisms and their interaction with the mammalian host, Proceedings Workshop Conference, Hoechst, Verlag Chemie, Weinheim","first-page":"1","article-title":"Bacterial endotoxin: properties and structure of biologically active domains","author":"Rietschel","year":"1988"},{"key":"10.1016\/j.vaccine.2019.04.097_b0055","first-page":"261","article-title":"DNA immunization in combination with the immunstimulant monophosphoryl lipid A","volume":"29","author":"Lodmell","year":"2000","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.vaccine.2019.04.097_b0060","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s11274-007-9399-2","article-title":"LPS-based conjugate vaccines composed of O-polysaccharide from Pseudomonas aeruginosa IATS 6 and 11 bound to a carrier protein","volume":"23","author":"Al-Zeer","year":"2007","journal-title":"World J Microbiol Biotechnol"},{"key":"10.1016\/j.vaccine.2019.04.097_b0065","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/meth.1999.0834","article-title":"Monophosphoryl lipid A (MPL) formulations for the next generation of vaccines","volume":"19","author":"Baldridge","year":"1999","journal-title":"Methods"},{"key":"10.1016\/j.vaccine.2019.04.097_b0070","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0580-9517(08)70475-6","article-title":"Analysis of lipopolysaccharides of Gram-negative bacteria","volume":"18","author":"Mayer","year":"1985","journal-title":"Meth Microbiol"},{"key":"10.1016\/j.vaccine.2019.04.097_b0075","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1432-1033.1983.tb07726.x","article-title":"Structural studies on the non-toxic lipid A from Rhodopseudomonas sphaeroides ATCC 17023","volume":"136","author":"Salimath","year":"1983","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.vaccine.2019.04.097_b0080","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1586\/erv.11.21","article-title":"Trends in vaccine adjuvants","volume":"10","author":"Schijns","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2019.04.097_b0085","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1432-1033.1982.tb05871.x","article-title":"Isolation, purification, and chemical analysis of the lipopolysaccharide and lipid A of Acinetobacter calcoaceticus NCTC 10305","volume":"122","author":"Brade","year":"1982","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.vaccine.2019.04.097_b0090","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1432-1033.1994.tb18616.x","article-title":"Characterization of the lipopolysaccharide of Moraxella catarrhlis: structural analysis of the lipid A from M. catarrhalis serotype A lipopolysaccharide","volume":"220","author":"Masoud","year":"1994","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.vaccine.2019.04.097_b0095","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1432-1033.1975.tb04172.x","article-title":"Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms","volume":"54","author":"Galanos","year":"1975","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.vaccine.2019.04.097_b0100","unstructured":"Garvey JS, Cremer NE, Sussdorf DH. DNP- and TNP-conjugated proteins. In: Garvey JS, Cremer NE, Sussdorf DH, editors. Methods in immunology, 3rd eds. Reading, MA: W.A. Benjamin; 1977. p.153\u201358."},{"key":"10.1016\/j.vaccine.2019.04.097_b0105","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.vaccine.2019.04.097_b0110","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.4049\/jimmunol.147.7.2136","article-title":"Enhancement of monophosphoryl lipid A (MPL) as an adjuvant. Enhancement of the serum antibody response in mice to polysaccharide-protein conjugates by concurrent injection with MPL","volume":"147","author":"Schneerson","year":"1991","journal-title":"J Immun"},{"key":"10.1016\/j.vaccine.2019.04.097_b0115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0022-1759(00)00142-3","article-title":"Enzyme \u2013Linked Immunosorbent Assay (ELISA) for the detection of serum antibodies to the inner core lipopolysacchride of Neisseria meningitidis group B","volume":"237","author":"Plested","year":"2000","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.vaccine.2019.04.097_b0120","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/eji.1830160117","article-title":"Molecular requirement for interleukin 1 induction by lipopolysaccharide-stimulated human monocytes: involvement of the heptosyl-2-keto-3-deoxyoctulosonate region","volume":"16","author":"Lebbar","year":"1986","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.vaccine.2019.04.097_b0125","doi-asserted-by":"crossref","first-page":"855","DOI":"10.4049\/jimmunol.119.3.855","article-title":"Immunocycte stimulation in vitro by nontoxic bacterial lipopolysaccharide derivatives","volume":"119","author":"Frank","year":"1977","journal-title":"J Immunol"},{"key":"10.1016\/j.vaccine.2019.04.097_b0130","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1128\/jb.145.1.138-144.1981","article-title":"Structure of the heptose region of lipopolysaccharides from Rhodospirillum tenue","volume":"145","author":"Radziejewska-Lebrecht","year":"1981","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2019.04.097_b0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1432-1033.1984.tb08454.x","article-title":"The structure of the polysaccharide moiety of Rhodopseudomonas sphaeroides ATCC 17023 lipopolysaccharide","volume":"144","author":"Salimath","year":"1984","journal-title":"Eur J Biochem"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X19306176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X19306176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:33:18Z","timestamp":1759401198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X19306176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":27,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0264410X19306176"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2019.04.097","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel adjuvants derived from attenuated lipopolysaccharides and lipid As of purple non-sulfur photosynthetic bacteria","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2019.04.097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}