{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:18:15Z","timestamp":1786997895232,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["BT\/MB\/THSTI\/HMC-SFC\/2011"],"award-info":[{"award-number":["BT\/MB\/THSTI\/HMC-SFC\/2011"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["MLP118"],"award-info":[{"award-number":["MLP118"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.vaccine.2019.06.034","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T16:53:36Z","timestamp":1562000016000},"page":"A7-A12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"S1","title":["CTX phage of Vibrio cholerae: Genomics and applications"],"prefix":"10.1016","volume":"38","author":[{"given":"Archana","family":"Pant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2447-5380","authenticated-orcid":false,"given":"Bhabatosh","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupak K.","family":"Bhadra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2019.06.034_b0005","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/35020000","article-title":"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae","volume":"406","author":"Heidelberg","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2019.06.034_b0010","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1126\/science.272.5270.1910","article-title":"Lysogenic conversion by a filamentous phage encoding cholera toxin","volume":"272","author":"Waldor","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2019.06.034_b0015","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tim.2003.09.003","article-title":"Pathogenicity islands and phages in Vibrio cholerae evolution","volume":"11","author":"Faruque","year":"2003","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.vaccine.2019.06.034_b0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-genet-102209-163504","article-title":"Integrons","volume":"44","author":"Cambray","year":"2010","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.vaccine.2019.06.034_b0025","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrmicro2109","article-title":"Principles of c-di-GMP signalling in bacteria","volume":"7","author":"Hengge","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.vaccine.2019.06.034_b0030","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cell.2012.01.053","article-title":"Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence","volume":"149","author":"Davies","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.vaccine.2019.06.034_b0035","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3389\/fmicb.2014.00650","article-title":"Mechanistic insights into filamentous phage integration in Vibrio cholerae","volume":"5","author":"Das","year":"2014","journal-title":"Front Microbiol"},{"key":"10.1016\/j.vaccine.2019.06.034_b0040","doi-asserted-by":"crossref","first-page":"15442","DOI":"10.1073\/pnas.0907787106","article-title":"Comparative genomics reveals mechanism for short-term and long-term clonal transitions in pandemic Vibrio cholerae","volume":"106","author":"Chun","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2019.06.034_b0045","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/QCO.0000000000000306","article-title":"Molecular evolution and functional divergence of Vibrio cholerae","volume":"29","author":"Das","year":"2016","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.vaccine.2019.06.034_b0050","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nature09469","article-title":"Satellite phage TLC\u03c6 enables toxigenic conversion by CTX phage through dif site alteration","volume":"467","author":"Hassan","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2019.06.034_b0055","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1073\/pnas.1701335114","article-title":"Replication of Vibrio cholerae classical CTX phage","volume":"114","author":"Kim","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2019.06.034_b0060","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nrmicro1235","article-title":"Mobile genetic elements: the agents of open source evolution","volume":"3","author":"Frost","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.vaccine.2019.06.034_b0065","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1073\/pnas.042667999","article-title":"Comparative genomic analysis of Vibrio cholerae: genes that correlate with cholera endemic and pandemic disease","volume":"99","author":"Dziejman","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2019.06.034_b0070","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrmicro2382","article-title":"Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow","volume":"8","author":"Wozniak","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.vaccine.2019.06.034_b0075","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature00782","article-title":"Filamentous phage integration requires the host recombinases XerC and XerD","volume":"417","author":"Huber","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2019.06.034_b0080","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.molcel.2005.07.002","article-title":"The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae","volume":"19","author":"Val","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.vaccine.2019.06.034_b0085","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1073\/pnas.0910212107","article-title":"Molecular keys of the tropism of integration of the cholera toxin phage","volume":"107","author":"Das","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2019.06.034_b0090","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1073\/pnas.1017061108","article-title":"VGJ\u03d5 integration and excision mechanisms contribute to the genetic diversity of Vibrio cholerae epidemic strains","volume":"108","author":"Das","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2019.06.034_b0095","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1073\/pnas.1404047111","article-title":"XerD-mediated FtsK-independent integration of TLCvarphi into the Vibrio cholerae genome","volume":"111","author":"Midonet","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2019.06.034_b0100","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.molcel.2004.11.046","article-title":"LexA cleavage is required for CTX prophage induction","volume":"17","author":"Quinones","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.vaccine.2019.06.034_b0105","doi-asserted-by":"crossref","first-page":"8572","DOI":"10.1073\/pnas.140109997","article-title":"CTX\u03c6contains a hybrid genome derived from tandemly integrated elements","volume":"97","author":"Davis","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2019.06.034_b0110","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S0140-6736(17)30559-7","article-title":"Cholera","volume":"390","author":"Clemens","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2019.06.034_b0115","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1046\/j.1365-2958.1997.3911758.x","article-title":"Regulation, replication, and integration functions of the Vibrio cholerae CTX\u03c6 are encoded by region RS2","volume":"24","author":"Waldor","year":"1997","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.vaccine.2019.06.034_b0120","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1099\/mic.0.2006\/000117-0","article-title":"Genetic organization of pre-CTX and CTX prophages in the genome of an environmental Vibrio cholerae non-O1, non-O139 strain","volume":"152","author":"Maiti","year":"2006","journal-title":"Microbiology"},{"key":"10.1016\/j.vaccine.2019.06.034_b0125","doi-asserted-by":"crossref","first-page":"556","DOI":"10.4161\/viru.22351","article-title":"Phage-bacterial interactions in the evolution of toxigenic Vibrio cholerae","volume":"3","author":"Faruque","year":"2012","journal-title":"Virulence"},{"key":"10.1016\/j.vaccine.2019.06.034_b0130","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1073\/pnas.0337468100","article-title":"Emergence and evolution of Vibrio cholerae O139","volume":"100","author":"Faruque","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2019.06.034_b0135","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1073\/pnas.0308485100","article-title":"Genetic diversity and virulence potential of environmental Vibrio cholerae population in a cholera-endemic area","volume":"101","author":"Faruque","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2019.06.034_b0140","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1074\/jbc.M311109200","article-title":"The CTX\u03d5 repressor RstR binds DNA cooperatively to form tetrameric repressor-operator complexes","volume":"279","author":"Kimsey","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.vaccine.2019.06.034_b0145","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nature10392","article-title":"Evidence for several waves of global transmission in the seventh cholera pandemic","volume":"477","author":"Mutreja","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.vaccine.2019.06.034_b0150","article-title":"Molecular insights into the evolutionary pathway of Vibrio cholerae O1 atypical El Tor variants","volume":"10","author":"Kim","year":"2014","journal-title":"PLoSPathog"},{"key":"10.1016\/j.vaccine.2019.06.034_b0155","first-page":"1013","article-title":"TcpApilin sequences and colonization requirements for O1 and O139 Vibrio cholerae","volume":"13","author":"Rhine","year":"1994","journal-title":"MolMicrobiol"},{"key":"10.1016\/j.vaccine.2019.06.034_b0160","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1099\/mic.0.032458-0","article-title":"Molecular evidence favouring step-wise evolution of Mozambique Vibrio cholerae O1 El Tor hybrid strain","volume":"156","author":"Halder","year":"2010","journal-title":"Microbiology"},{"key":"10.1016\/j.vaccine.2019.06.034_b0165","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.1128\/JB.182.19.5530-5538.2000","article-title":"Molecular analyses of a putative CTX\u03c6 precursor and evidence for independent acquisition of distinct CTX\u03c6s by toxigenic Vibrio cholerae","volume":"182","author":"Boyd","year":"2000","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2019.06.034_b0170","doi-asserted-by":"crossref","DOI":"10.1080\/21597081.2015.1128512","article-title":"CTX\u03d5: Exploring new alternatives in host factor-mediated filamentous phage replications","volume":"6","author":"Martinez","year":"2016","journal-title":"Bacteriophage"},{"key":"10.1016\/j.vaccine.2019.06.034_b0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006531","article-title":"The dif\/Xer recombination systems in proteobacteria","volume":"4","author":"Carnoy","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.vaccine.2019.06.034_b0180","first-page":"1","article-title":"Effect of LexA on chromosomal integration of CTX\u03d5 in Vibrio cholerae","volume":"198","author":"Pant","year":"2015","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2019.06.034_b0185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.virol.2012.09.017","article-title":"Tools from viruses: bacteriophage successes and beyond","volume":"434","author":"Henry","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2019.06.034_b0190","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1128\/JB.01966-14","article-title":"A novel, broad-range, CTX\u03d5-derived stable integrative expression vector for functional studies","volume":"196","author":"Das","year":"2014","journal-title":"J Bacteriol"},{"key":"10.1016\/j.vaccine.2019.06.034_b0195","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1073\/pnas.1500107112","article-title":"Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria","volume":"112","author":"Yosef","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2019.06.034_b0200","doi-asserted-by":"crossref","first-page":"44929","DOI":"10.1038\/srep44929","article-title":"Genetic engineering of a temperate phage-based delivery system for CRISPR\/Cas9 antimicrobials against Staphylococcus aureus","volume":"7","author":"Park","year":"2017","journal-title":"Sci Rep"},{"issue":"13","key":"10.1016\/j.vaccine.2019.06.034_b0205","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1073\/pnas.1900141116","article-title":"Genomic plasticity associated with antimicrobial resistance in Vibrio cholerae","volume":"116","author":"Verma","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.vaccine.2019.06.034_b0210","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.aao2136","article-title":"Integrated view of Vibrio cholerae in the Americas","volume":"358","author":"Domman","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2019.06.034_b0215","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1126\/science.aad5901","article-title":"Genomic history of the seventh pandemic of cholera in Africa","volume":"358","author":"Weill","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2019.06.034_b0220","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1126\/science.359.6376.620","article-title":"Use of cholera vaccines expands, raising hopes","volume":"359","author":"Kupferschmidt","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.vaccine.2019.06.034_b0225","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/14760584.2017.1291348","article-title":"PaxVax CVD 103-HgR single-dose live oral cholera vaccine","volume":"16","author":"Levine","year":"2017","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2019.06.034_b0230","doi-asserted-by":"crossref","first-page":"6360","DOI":"10.1016\/j.vaccine.2015.08.075","article-title":"A randomized, non-inferiority trial comparing two bivalent killed, whole cell, oral cholera vaccines (EuvicholvsShanchol) in the Philippines","volume":"33","author":"Baik","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2019.06.034_b0235","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1016\/j.vaccine.2003.11.070","article-title":"Can oral cholera vaccination play a role in controlling a cholera outbreak?","volume":"22","author":"Calain","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2019.06.034_b0240","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tim.2012.10.003","article-title":"Integrative mobile elements exploiting Xer recombination","volume":"21","author":"Das","year":"2013","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.vaccine.2019.06.034_b0245","first-page":"195","article-title":"Molecular mechanism of acquisition of the cholera toxin genes","volume":"133","author":"Das","year":"2011","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.vaccine.2019.06.034_b0250","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201847427","article-title":"Filamentous phages: masters of a microbial sharing economy","author":"Hay","year":"2019","journal-title":"EMBO Rep"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X19307960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X19307960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:31:30Z","timestamp":1778679090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X19307960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":50,"alternative-id":["S0264410X19307960"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2019.06.034","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CTX phage of Vibrio cholerae: Genomics and applications","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2019.06.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}