{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T02:21:23Z","timestamp":1772677283738,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Enimmune Corporation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vaccine"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.vaccine.2019.07.096","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T18:27:45Z","timestamp":1565116065000},"page":"5559-5566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immunogenicity and safety of an inactivated enterovirus A71 vaccine in children 3\u20136\u202fyears and 2\u201335\u202fmonths of age- an open-label, randomized phase IIb clinical trial"],"prefix":"10.1016","volume":"37","author":[{"given":"Miao-Chiu","family":"Hung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Yi","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chou-Cheng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keh-Gong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vaccine.2019.07.096_b0005","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1128\/JVI.01019-09","article-title":"Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene","volume":"84","author":"Tee","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.vaccine.2019.07.096_b0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090624","article-title":"Molecular comparison and evolutionary analyses of VP1 nucleotide sequences of new African human enterovirus 71 isolates reveal a wide genetic diversity","volume":"9","author":"Bessaud","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2019.07.096_b0015","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/infdis\/129.3.304","article-title":"An apparently new enterovirus isolated from patients with disease of the central nervous system","volume":"129","author":"Schmidt","year":"1974","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vaccine.2019.07.096_b0020","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.vaccine.2019.07.096_b0025","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","article-title":"Clinical features, diagnosis, and management of enterovirus 71","volume":"9","author":"Ooi","year":"2010","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.vaccine.2019.07.096_b0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1574-6976.2002.tb00601.x","article-title":"An overview of the evolution of enterovirus 71 and its clinical and public health significance","volume":"26","author":"McMinn","year":"2002","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.vaccine.2019.07.096_b0035","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/JCM.40.1.10-15.2002","article-title":"Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000","volume":"40","author":"Wang","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.vaccine.2019.07.096_b0040","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3201\/eid0904.020395","article-title":"Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes","volume":"9","author":"Cardosa","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2019.07.096_b0045","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group","volume":"341","author":"Ho","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2019.07.096_b0050","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/cid\/ciu852","article-title":"Review of enterovirus 71 vaccines","volume":"60","author":"Chong","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.vaccine.2019.07.096_b0055","doi-asserted-by":"crossref","first-page":"4","DOI":"10.7774\/cevr.2017.6.1.4","article-title":"Enterovirus 71 infection and vaccines","volume":"6","author":"Yi","year":"2017","journal-title":"Clin Exp Vaccine Res"},{"key":"10.1016\/j.vaccine.2019.07.096_b0060","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/14760584.2018.1510326","article-title":"Recent development of enterovirus A vaccine candidates for the prevention of hand, foot, and mouth disease","volume":"17","author":"Fang","year":"2018","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.vaccine.2019.07.096_b0065","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.virol.2017.03.017","article-title":"Impact of genetic changes, pathogenicity and antigenicity on Enterovirus- A71 vaccine development","volume":"506","author":"Yee","year":"2017","journal-title":"Virology"},{"key":"10.1016\/j.vaccine.2019.07.096_b0070","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1016\/j.vaccine.2019.06.023","article-title":"An inactivated enterovirus 71 vaccine is safe and immunogenic in healthy adults: a phase I, double blind, randomized, placebo-controlled, study of two dosages","volume":"37","author":"Tambyah","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2019.07.096_b0075","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.vaccine.2011.11.087","article-title":"Selection and characterization of vaccine strain for Enterovirus 71 vaccine development","volume":"30","author":"Chang","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2019.07.096_b0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034834","article-title":"Pilot scale production of highly efficacious and stable enterovirus 71 vaccine candidates","volume":"7","author":"Chou","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2019.07.096_b0085","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1016\/j.vaccine.2013.03.015","article-title":"A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine","volume":"31","author":"Cheng","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2019.07.096_b0090","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/S0140-6736(13)61049-1","article-title":"Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","volume":"381","author":"Zhu","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.vaccine.2019.07.096_b0095","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa1303224","article-title":"An inactivated enterovirus 71 vaccine in healthy children","volume":"370","author":"Li","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2019.07.096_b0100","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJMoa1304923","article-title":"Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China","volume":"370","author":"Zhu","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2019.07.096_b0105","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3201\/1504.081550","article-title":"Enterovirus 71 maternal antibodies in infants, Taiwan","volume":"15","author":"Luo","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.vaccine.2019.07.096_b0110","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1056\/NEJMoa065954","article-title":"Neurodevelopment and cognition in children after enterovirus 71 infection","volume":"356","author":"Chang","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.vaccine.2019.07.096_b0115","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4269\/ajtmh.2007.77.188","article-title":"An eight-year study of epidemiologic features of enterovirus 71 infection in Taiwan","volume":"77","author":"Chen","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.vaccine.2019.07.096_b0120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jmv.2210","article-title":"Incidence and case-fatality rates resulting from the 1998 enterovirus 71 outbreak in Taiwan","volume":"67","author":"Lu","year":"2002","journal-title":"J Med Virol"},{"key":"10.1016\/j.vaccine.2019.07.096_b0125","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.vaccine.2019.02.023","article-title":"Immunogenicity, safety, cross-reaction, and immune persistence of an inactivated enterovirus A71 vaccine in children aged from two months to 11 years in Taiwan","volume":"37","author":"Huang","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2019.07.096_b0130","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1016\/j.vaccine.2017.02.042","article-title":"Enhancing enterovirus A71 vaccine production yield by microcarrier profusion bioreactor culture","volume":"36","author":"Liu","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.vaccine.2019.07.096_b0135","doi-asserted-by":"crossref","first-page":"e0136420","DOI":"10.1371\/journal.pone.0136420","article-title":"Inactivated enterovirus 71 vaccine produced by 200-L scale serum-free microcarrier bioreactor system provides cross-protective efficacy in human SCARB2 transgenic mouse","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vaccine.2019.07.096_b0140","doi-asserted-by":"crossref","first-page":"e79783","DOI":"10.1371\/journal.pone.0079783","article-title":"Formalin-inactivated EV71 vaccine candidate induced cross-neutralizing antibody against subgenotypes B1, B4, B5 and C4A in adult volunteers","volume":"8","author":"Chou","year":"2013","journal-title":"PLoS ONE"}],"container-title":["Vaccine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X19310175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0264410X19310175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:34:36Z","timestamp":1759401276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0264410X19310175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":28,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0264410X19310175"],"URL":"https:\/\/doi.org\/10.1016\/j.vaccine.2019.07.096","relation":{},"ISSN":["0264-410X"],"issn-type":[{"value":"0264-410X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunogenicity and safety of an inactivated enterovirus A71 vaccine in children 3\u20136\u202fyears and 2\u201335\u202fmonths of age- an open-label, randomized phase IIb clinical trial","name":"articletitle","label":"Article Title"},{"value":"Vaccine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vaccine.2019.07.096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}